公开(公告)号：AU2013370215B2

公开(公告)日：2018-04-05

申请号：AU2013370215

申请日：2013-12-27

Applicant: PORTOLA PHARM INC

Inventor： PANDEY ANJALI ,  ROSE JACK W

IPC: C07D213/75

Abstract: Disclosed herein are compounds, compositions, methods and kits for purifying a protease and serine proteases purified with the compounds, compositions and methods.

公开(公告)号：CY1118559T1

公开(公告)日：2017-07-12

申请号：CY161101026

申请日：2016-10-13

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: ΗπαρούσαεφεύρεσηαναφέρεταισεενώσειςτουτύπουΙ-ΙΙκαιταφαρμακευτικάαποδεκτάταυτομερή, άλατα, ήταστερεοϊσομερήαυτών, ταοποίαείναιαναστολείςτηςκινάσης Syk και/ή JAK. Ηπαρούσαεφεύρεσηεπίσηςαναφέρεταισεενδιάμεσαπουχρησιμοποιούνταιστηνσύνθεσητέτοιωνενώσεων, τηνπαρασκευήμίαςτέτοιαςένωσης, τιςφαρμακευτικέςσυνθέσειςπουπεριέχουνμίατέτοιαένωση, τιςμεθόδουςαναστολήςτηςδραστικότηταςτηςκινάσης Syk και/ή JAK, τιςμεθόδουςαναστολήςτηςσυσσωμάτωσηςτωναιμοπεταλίων, καιτιςμεθόδουςγιατηνπρόληψηή τηθεραπείαενόςαριθμούπαθήσεωνπουπροκαλούνταιτουλάχιστονενμέρειαπότηνδραστικότητατηςκινάσης Syk και/ή JAK, όπωςη καρδιαγγειακήνόσος, ηφλεγμονώδηςνόσος, ηαυτοάνοσηνόσοςκαιη πολλαπλασιαστικήδιαταραχήκυττάρων, ηθρόμβωση, ηαλλεργία, τοάσθμα, ηρευματοειδήςαρθρίτιδα, ηλευχαιμία, ήτολέμφωμαμη-Hodgkin.

公开(公告)号：CA2723205C

公开(公告)日：2017-03-14

申请号：CA2723205

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation,and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as cardiovascular disease, inflammatory disease, autoimmune disease and cell proliferative disorder, thrombosis, allergy, asthma, rheumatoid arthritis, leukemia, or non-Hodgkin's lymphoma.

公开(公告)号：LT2321283T

公开(公告)日：2016-12-12

申请号：LT09755219

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

公开(公告)号：NZ589315A

公开(公告)日：2012-11-30

申请号：NZ58931509

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： JIA ZHAOZHONG J ,  VENKATARAMANI CHANDRASEKAR ,  HUANG WOLIN ,  MEHROTRA MUKUND ,  SONG YONGHONG ,  XU QING ,  BAUER SHAWN M ,  PANDEY ANJALI ,  KANE BRIAN ,  ROSE JACK W

IPC: A61P35/00 ,  A61K31/506 ,  A61P9/00 ,  C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present disclosure is directed to 2,6-diamino-pyrimidin-5-yl-carboxamide derivatives of formula (I) and tautomers thereof or pharmaceutically acceptable salts thereof which are inhibitors of Spleen tryosine kinase (syk) or Janus kinase (JAK). The disclosure is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions such as undesired thrombosis and Non Hodgkin's Lymphoma which are mediated at least in part by syk kinase or JAK kinase activity. These compounds are used in the preparation of a medicament for inhibiting syk or JAK kinase or a signal transduction pathway mediated at least in part by syk kinase activity, wherein the medicament is suitable for treating a condition or disorder selected from the group consisting of cardiovascular disease, inflammatory disease and autoimmune disease and cell proliferative disorder.

公开(公告)号：HK1158179A1

公开(公告)日：2012-07-13

申请号：HK11112350

申请日：2011-11-16

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101

公开(公告)号：MA32442B1

公开(公告)日：2011-07-03

申请号：MA33302

申请日：2010-11-01

Applicant: PORTOLA PHARM INC

Inventor： JIA ZHAOZHONG J ,  VENKATARAMANI CHANDRASEKAR ,  HUANG WOLIN ,  MEHROTRA MUKUND ,  SONG YONGHONG ,  XU QING ,  BAUER SHAWN M ,  PANDEY ANJALI ,  KANE BRIAN ,  ROSE JACK W

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: L'invention concerne des composés représentés par les formules i-v et des tautomères de ceux-ci, ou des sels pharmaceutiquement acceptables, des esters et des promédicaments de ceux-ci qui constituent des inhibiteurs de la syk kinase. L'invention concerne aussi des produits intermédiaires utilisés dans la fabrication de tels composés, la préparation d'un tel composé, des compositions pharmaceutiques contenant un tel composé, des procédés d'inhibition de l'activité de la syk kinase, des procédés d'inhibition de l'agrégation plaquettaire et des procédés destinés à prévenir ou à traiter des états pathologiques dus au moins en partie à l'activité de la syk kinase, tels qu'une thrombose indésirable et un lymphome malin non hodgkinien.

公开(公告)号：AU2009244897A1

公开(公告)日：2009-11-12

申请号：AU2009244897

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： MEHROTRA MUKUND ,  HUANG WOLIN ,  SONG YONGHONG ,  JIA ZHAOZHONG J ,  XU QING ,  VENKATARAMANI CHANDRASEKAR ,  BAUER SHAWN M ,  PANDEY ANJALI ,  ROSE JACK W ,  KANE BRIAN

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention is directed to compounds of formula I-V and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.

公开(公告)号：CA2896512C

公开(公告)日：2021-09-14

申请号：CA2896512

申请日：2013-12-27

Applicant: PORTOLA PHARM INC

Inventor： PANDEY ANJALI ,  ROSE JACK W

IPC: C07D213/75

Abstract: Disclosed herein are compounds, compositions, methods and kits for purifying a serine protease and serine proteases purified with the compounds, compositions and methods, wherein the compounds are of Formula I: (see formula I).

公开(公告)号：PT2323993E

公开(公告)日：2015-10-12

申请号：PT09742982

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： HUANG WOLIN ,  PANDEY ANJALI ,  MEHROTRA MUKUND ,  JIA ZHAOZHONG J ,  VENKATARAMANI CHANDRASEKAR ,  SONG YONGHONG ,  XU QING ,  BAUER SHAWN M ,  KANE BRIAN ,  ROSE JACK W

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12