公开(公告)号：SI2107055T1

公开(公告)日：2011-05-31

申请号：SI200930019

申请日：2009-03-31

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANCOIS

IPC: C07D311/00 ,  A61K31/352 ,  A61K31/7012 ,  A61P9/00 ,  C07D407/00 ,  C07H15/00

公开(公告)号：DE602009000873D1

公开(公告)日：2011-04-28

申请号：DE602009000873

申请日：2009-03-31

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANCOIS

IPC: C07D311/30 ,  A61K31/352 ,  A61K31/7012 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  C07D407/12 ,  C07H15/26

公开(公告)号：FR2821843A1

公开(公告)日：2002-09-13

申请号：FR0103293

申请日：2001-03-12

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D487/06 ,  A61K31/407 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D487/04 ,  A61K31/404

Abstract: Isoindoloindolone derivatives (I), their optical isomers and salts with acids and bases, other than 1,3-dimethoxy-6H-isoindolo(2,1-a)indol-6-one, are new. Isoindoloindolone derivatives (I), their optical isomers and salts with acids and bases, other than 1,3-dimethoxy-6H-isoindolo(2,1-a)indol-6-one are new; R1 - R6 and R8 = H, 1-6C alkyl, arylalkyl, OH, 1-6C alkoxy, arylalkoxy, 1-6C acyloxy, arylcarbonyloxy, carboxyalkyl, or carboxy; R7 = H, OH, 1-6C alkoxy or acyloxy, arylalkoxy, or arylcarbonyloxy, or two groups R1 - R8 may together form 1 or 2C alkylenedioxy With the proviso that one at least of groups R1 - R8 is OH, alkoxy, acyloxy, or arylcarbonyloxy. An Independent claim is also included for the preparation of (I).

公开(公告)号：FR2882654A1

公开(公告)日：2006-09-08

申请号：FR0502044

申请日：2005-03-01

Applicant: SERVIER LAB

Inventor： VERBEUREN TONY ,  RUPIN ALAIN ,  SANSILVESTRI MOREL PATRICIA ,  VALLEZ MARIE ODILE ,  BOUSSARD MARIE FRANCOISE ,  WIERZBICKI MICHEL

IPC: A61K31/352 ,  A61P7/02

Abstract: Utilisation des dérivés de la diosmétine pour l'obtention de compositions pharmaceutiques destinées à la prévention et/ou au traitement des pathologies thrombotiques ainsi que des pathologies à risque thrombotique.

公开(公告)号：FR2822153B1

公开(公告)日：2003-10-31

申请号：FR0103667

申请日：2001-03-19

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D491/056 ,  A61K31/40 ,  A61K31/403 ,  A61K31/407 ,  A61K31/5377 ,  A61P3/04 ,  A61P3/10 ,  A61P5/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D209/80 ,  C07D209/94 ,  A61K31/404

Abstract: Compound of formula (I):wherein:R represents hydrogen or a group selected from alkenyl and optionally substituted alkyl,each of R1 to R8, which may be identical or different, represents hydrogen or a group selected from alkyl, alkenyl, hydroxy, alkoxy, alkenyloxy, arylalkyl, arylalkoxy, carboxy, acyloxy and arylcarbonyloxy,or one of R1 to R8 forms with an adjacent one R1 to R8 an alkylenedioxy group,its optical isomers when they exist, and addition salts thereof with a pharmaceutically acceptable acid or base,with the proviso that:when R does not represent hydrogen, then at least one of R1 to R8 represents hydroxy or acyloxy,and the compounds of formula (I) are other than indeno[1,2-b]indol-10(5H)-one and medicinal products containing the same which are useful for treatment of disorders of the melatoninergic system.

公开(公告)号：FR2822153A1

公开(公告)日：2002-09-20

申请号：FR0103667

申请日：2001-03-19

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D491/056 ,  A61K31/40 ,  A61K31/403 ,  A61K31/407 ,  A61K31/5377 ,  A61P3/04 ,  A61P3/10 ,  A61P5/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D209/80 ,  C07D209/94 ,  A61K31/404

Abstract: Substituted indeno (1,2-b) indol-10(5H)-one derivatives (I) are new. Substituted indeno (1,2-b) indol-10(5H)-one derivatives of formula (I), their optical isomers and acid or base addition salts, are new: R = H, alkenyl or alkyl optionally substituted by COOH or NRaRb; Ra, Rb = H or alkyl, or together complete a heterocycle; R1 - R8 = H, alkenyl(oxy), (aryl)alkyl, (aryl)alkoxy, COOH, acyloxy or arylcarbonyloxy, or two adjacent groups R1 - R8 together form 1-2C alkylenedioxy; aryl = phenyl, biphenylyl or (tetrahydro)naphthyl (all optionally substituted by halo, alkoxy, (polyhalo)alkyl, NH2, mono- or dialkylamino, NO2, acyl and/or 1-2C alkylenedioxy); and provided that: (i) if R is other than H, then at least one of R1 - R8 is OH or acyloxy; (ii) the compound indeno (1,2-b) indol-10(5H)-one (i.e. (I; R, R1 - R8 = H) is excluded; and (iii) alkyl or acyl moieties have 1-6C and alkenyl moieties 2-6C. An Independent claim is also included for the preparation of (I).

公开(公告)号：RS51661B

公开(公告)日：2011-10-31

申请号：RSP20110142

申请日：2009-03-31

Applicant: SERVIER LAB

Inventor： RUPIN ALAIN ,  VERBEUREN TONY ,  WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  SANSILVESTRI-MOREL PATRICIA ,  PAYSANT JEROME ,  LEFOULON FRANCOIS

IPC: C07D311/30 ,  A61K31/352 ,  A61K31/7012 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  C07D407/12 ,  C07H15/26

Abstract: Diosmetin derivatives (I), are new. Diosmetin derivatives of formula (I), are new. R1-R3 : H or (2S,3S,4R,5S)-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid moiety. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Anticoagulant; Antiinflammatory; Vasotropic; Antidiabetic; Hypotensive; Antiarteriosclerotic; Analgesic; Antianginal; Anorectic; Cerebroprotective. MECHANISM OF ACTION : None given.

公开(公告)号：AT502024T

公开(公告)日：2011-04-15

申请号：AT09290237

申请日：2009-03-31

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANCOIS

IPC: C07D311/30 ,  A61K31/352 ,  A61K31/7012 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  C07D407/12 ,  C07H15/26

Abstract: Diosmetin derivatives (I), are new. Diosmetin derivatives of formula (I), are new. R1-R3 : H or (2S,3S,4R,5S)-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid moiety. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Anticoagulant; Antiinflammatory; Vasotropic; Antidiabetic; Hypotensive; Antiarteriosclerotic; Analgesic; Antianginal; Anorectic; Cerebroprotective. MECHANISM OF ACTION : None given.

公开(公告)号：ZA200901947B

公开(公告)日：2010-02-24

申请号：ZA200901947

申请日：2009-03-19

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  VERBEUREN TONY ,  SANSILVESTRI MOREL PATRICIA ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANCOIS

IPC: A61K20060101 ,  C07D20060101

Abstract: Diosmetin derivatives (I), are new. Diosmetin derivatives of formula (I), are new. R1-R3 : H or (2S,3S,4R,5S)-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid moiety. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Anticoagulant; Antiinflammatory; Vasotropic; Antidiabetic; Hypotensive; Antiarteriosclerotic; Analgesic; Antianginal; Anorectic; Cerebroprotective. MECHANISM OF ACTION : None given.

公开(公告)号：FR2826009B1

公开(公告)日：2003-08-15

申请号：FR0107718

申请日：2001-06-13

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  ROUSSEAU ANNE ,  ATASSI GHANEM ,  HICKMAN JOHN ,  PIERRE ALAIN ,  LEONCE STEPHANE ,  GUILBAUD NICOLAS ,  KRAUS BERTHIER LAURENCE

IPC: C07D209/80 ,  A61K31/403 ,  A61K31/433 ,  A61K31/4439 ,  A61P35/00 ,  C07D209/94 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D491/04 ,  C07D491/056 ,  C07D405/14 ,  C07D403/12 ,  A61K31/4045 ,  A61K31/4402 ,  A61K31/4453

Abstract: Indenoindolone derivatives (I), their isomers and salts with acids and bases are new. Indenoindolone derivatives (I), their isomers and salts with acids and bases are new; R = H, alkyl (optionally substituted by carboxy, alkoxycarbonyl, or NR10R11), or alkenyl; R1-R8 = H, alkyl (optionally substituted by aryl, carboxy or alkoxycarbonyl), OH, acyloxy, NR12R13, carboxy, alkoxy (optionally substituted by aryl or NR14R15), alkenyloxy, or to adjacent groups R1-R8 = 1 or 2C alkylenedioxy; R9 = H, aryl, heteroaryl or alkyl (optionally containing one or more unsaturations and optionally substituted by one or more aryl, heteroaryl, 3-8C cycloalkyl, CN, or NR17R18 groups); X = O or NR16; R10, R11, R14, R15, R17, R18 = alkyl; NR10+R11, NR14+R15, NR17+R18 = nitrogen heterocycle; R12, R13 = H, alkyl, or NR14R15; R16 = H, alkyl, aryl, or aryl alkyl. Where alkyl, alkoxy, acyloxy, alkenyl and alkenyloxy groups have up to 6 C atoms, aryl is defined as phenyl, biphenyl, or naphthyl (optionally substituted by one or more halogen, alkyl, alkenyl, alkoxy, phenoxy, nitro, CN, amino, mono- and di-alkylamino or 1-2C alkylenedioxy groups) and heteroaryl groups may be mono- or bicyclic of 5-12 members with 1-3 heteroatoms (O, N, S) and optionally substituted by halogen, alkyl, OH, alkoxy, polyhaloalkyl, amino, mono- and di-alkylamino groups, and nitrogen heterocycles are monocyclic having 5-7 members including 1-3 heteroatoms, one of which is N and the others may be O, N, or S. An Independent claim is also included for the preparation of (I).