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公开(公告)号：CA2716522A1
公开(公告)日：2009-10-15
申请号：CA2716522
申请日：2009-03-04
Applicant: SINGULEX INC
Inventor： GOIX PHILIPPE J , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD A , HELD DOUGLAS , AGEE SARA
Abstract: The present invention discloses methods for the detection and monitoring of a condition in a subject using highly sensitive detection of molecules. The invention provides a method for detecting or monitoring a condition in a subject, comprising detecting a first marker in a first sample from the subject and detecting a second marker, wherein the first marker comprises a biomarker, e.g., Cardiac Troponin-I (cTnl) or Vascular Endothelial Growth Factor (VEGF), and wherein the limit of detection of the first marker is less than about 10 pg/ml. The second marker can be a biomarker, physiological marker, a molecular marker or a genetic marker.
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12.发明申请METHODS AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES 审中-公开高灵敏度分析标记物和检测分子的方法和组合物
公开(公告)号：WO2008048371A9
公开(公告)日：2008-11-27
申请号：PCT/US2007008394
申请日：2007-04-04
Applicant: SINGULEX INC , GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
CPC classification number: G01N33/6887 , G01N15/06 , G01N15/1459 , G01N21/6428 , G01N33/577 , G01N33/582 , G01N2015/0693 , G01N2015/1006 , G01N2015/1486 , G01N2201/1247 , G01N2201/12761 , G01N2800/32 , G01N2800/324 , G01N2800/52 , Y10T436/105831
Abstract: Disclosed are methods, kits, and compositions for fluorescent detection of single biomolecules, e.g. proteins, using highly sensitive fluorescent dyes and a flow cell with one interrogation space for irradiation by focused laser beam. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution.
Abstract translation: 公开了用于单个生物分子的荧光检测的方法，试剂盒和组合物，例如， 使用高度敏感的荧光染料和具有一个询问空间的流动池用于通过聚焦激光束进行照射。 这些方法，试剂盒和组合物可用于确定样品中分子浓度达到1飞摩尔，1摩尔或更低的水平。 该方法，试剂盒和组合物还允许在很宽的范围，例如7个对数范围内测定浓度，而不需要样品稀释。
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公开(公告)号：WO2007114947A2
公开(公告)日：2007-10-11
申请号：PCT/US2007008506
申请日：2007-04-04
Applicant: SINGULEX INC , GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
IPC: G06F15/00
CPC classification number: G01N33/6887 , G01N15/06 , G01N15/1459 , G01N21/6428 , G01N33/577 , G01N33/582 , G01N2015/0693 , G01N2015/1006 , G01N2015/1486 , G01N2201/1247 , G01N2201/12761 , G01N2800/32 , G01N2800/324 , G01N2800/52 , Y10T436/105831
Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
Abstract translation: 本发明提供用于敏感检测心肌肌钙蛋白的方法，组合物，试剂盒和系统。这种方法，组合物，试剂盒和系统可用于诊断，预后和确定涉及心肌肌钙蛋白释放的病症中的治疗方法。
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公开(公告)号：EP2263085A4
公开(公告)日：2011-07-06
申请号：EP09731410
申请日：2009-03-04
Applicant: SINGULEX INC
Inventor： GOIX PHILIPPE J , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD A , HELD DOUGLAS , LE SARA
IPC: G01N33/53
CPC classification number: G01N33/577 , A61B5/00 , A61B5/0402 , A61B5/412 , A61B5/415 , A61B5/418 , A61B5/7264 , A61B5/7275 , G01N21/6428 , G01N33/582 , G01N33/6863 , G01N33/6869 , G01N33/6872 , G01N33/6887 , G01N33/6896 , G01N33/74 , G01N33/92 , G01N2333/4712 , G01N2333/475 , Y02A90/26 , Y10T436/143333
Abstract: The present invention discloses methods for the detection and monitoring of a condition in a subject using highly sensitive detection of molecules. The invention provides a method for detecting or monitoring a condition in a subject, comprising detecting a first marker in a first sample from the subject and detecting a second marker, wherein the first marker comprises a biomarker, e.g., Cardiac Troponin-I (cTnI) or Vascular Endothelial Growth Factor (VEGF), and wherein the limit of detection of the first marker is less than about 10 pg/ml. The second marker can be a biomarker, physiological marker, a molecular marker or a genetic marker.
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15.发明公开METHODS AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES 审中-公开方法和组合物用于分子的检测高敏感性分析和标记
公开(公告)号：EP2016394A4
公开(公告)日：2013-04-24
申请号：EP07861282
申请日：2007-04-04
Applicant: SINGULEX INC
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
CPC classification number: G01N33/6887 , G01N15/06 , G01N15/1459 , G01N21/6428 , G01N33/577 , G01N33/582 , G01N2015/0693 , G01N2015/1006 , G01N2015/1486 , G01N2201/1247 , G01N2201/12761 , G01N2800/32 , G01N2800/324 , G01N2800/52 , Y10T436/105831
Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
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Patent Agency Ranking
公开(公告)号：ES2703813T3
公开(公告)日：2019-03-12
申请号：ES16193284
申请日：2007-04-04
Applicant: SINGULEX INC , UNIV CALIFORNIA
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS , WU ALAN H
IPC: G01N33/68
Abstract: Un método para determinar un diagnóstico o pronóstico en un individuo que comprende: (i) medir la concentración de troponina cardiaca I (cTnI) a partir de una muestra de suero del individuo, en el que dicha concentración se determina mediante un ensayo de cTnI con un límite de detección para dicha cTnI en dicha muestra de menos de 5 pg/ml; (ii) comparar la concentración medida a una concentración umbral de 7 pg/ml; y (iii) determinar un diagnóstico o pronóstico de infarto de miocardio en el individuo, si la concentración de la muestra es mayor que la concentración umbral; en el que el individuo es un ser humano.
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公开(公告)号：AU2010259022B2
公开(公告)日：2016-05-12
申请号：AU2010259022
申请日：2010-06-07
Applicant: SINGULEX INC
Inventor： GOIX PHILIPPE J , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS , LE SARA
Abstract: Cardiovascular disease, e.g., congestive heart failure, is often first diagnosed after the onset of clinical symptoms, eliminating potential for early intervention. The invention provides a multi-marker immunoassay, including cardiac pathology and vascular inflammation biomarkers, yielding a more sensitive assay for early detection of CHF in plasma. A panel consisting of cardiac pathology (cTnl, BNP) and vascular inflammation (IL-6, TNFα, IL- 17a) biomarkers provided a sensitivity of 94% for association with CHF.
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18.发明专利
公开(公告)号：AU2013219225B2
公开(公告)日：2015-04-09
申请号：AU2013219225
申请日：2013-08-23
Applicant: SINGULEX INC
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
Abstract: METHODS AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES 5OF THE DISCLOSURE Disclosed are methods, kits, and compositions for the highly sensitive detection of molecules. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution. WO 2008/048371 PCT/US2007/008394 Figur IA1 308 307 306 305 Figure 1A
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公开(公告)号：AU2014200749A1
公开(公告)日：2014-03-06
申请号：AU2014200749
申请日：2014-02-12
Applicant: UNIV CALIFORNIA , SINGULEX INC
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS , WU ALAN
IPC: G01N33/53
Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin. WO 2007/114947 PCT/US2007/008506 30 3 7 0 630 5 Figure 1A
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公开(公告)号：AU2007233320B2
公开(公告)日：2013-12-12
申请号：AU2007233320
申请日：2007-04-04
Applicant: SINGULEX INC , UNIV CALIFORNIA
Inventor： TODD JOHN , PUSKAS ROBERT , HELD DOUGLAS , GOIX PHILIPPE , LIVINGSTON RICHARD , WU ALAN
IPC: G01N33/53
Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
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