公开(公告)号：ES2304624T3

公开(公告)日：2008-10-16

申请号：ES04766880

申请日：2004-10-07

Applicant: SOLVAY PHARM GMBH

Inventor： BAUM DOMINIQUE ,  BIELENBERG GERHARD-WILHELM ,  BOEDECKER BERND ,  THORMAEHLEN DIRK

IPC: A61K45/06 ,  A61K31/4172 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/506 ,  A61P9/14

Abstract: Una composición farmacéutica que comprende Moxonidina o una de sus sales farmacéuticamente aceptables en calidad de un agonista selectivo del receptor de imidazolina I1 y Eprosartán o una de sus sales farmacéuticamente aceptables en calidad de un bloqueante del receptor de angiotensina II y un excipiente farmacéuticamente aceptable.

公开(公告)号：HU226064B1

公开(公告)日：2008-04-28

申请号：HU9600680

申请日：1996-03-18

Applicant: SOLVAY PHARM GMBH

Inventor： ANTEL JOCHEN ,  HOELTJE DAGMAR ,  MESSINGER JOSEF ,  THORMAEHLEN DIRK ,  WALDECK HARALD ,  WURL MICHAEL

IPC: C07D223/16 ,  C07K5/078 ,  A61K31/33 ,  A61K31/423 ,  A61K31/428 ,  A61K31/55 ,  A61K31/554 ,  A61K38/00 ,  A61K38/05 ,  A61P7/10 ,  A61P9/00 ,  A61P43/00 ,  C07D267/14 ,  C07D281/10

Abstract: Benzazepin-, benzoxazepin- and benzothiazepin-N-acetic acid derivs. of formula (I) and their salts are new. R = lower alkoxy(lower)alkyl (in which the alkoxy is opt. substd. by lower alkoxy) or phenyl(lower)alkyl, or phenoxy(lower)alkyl (opt. ring substd. by lower alkyl or alkoxy or halo) or naphthyl(lower)alkyl; A = CH2, O or S; R , R = H or halogen; R , R = H or a biolabile ester containing gp.

公开(公告)号：AT390148T

公开(公告)日：2008-04-15

申请号：AT04766880

申请日：2004-10-07

Applicant: SOLVAY PHARM GMBH

Inventor： BAUM DOMINIQUE ,  BIELENBERG GERHARD-WILHELM ,  BOEDECKER BERND ,  THORMAEHLEN DIRK

IPC: A61K45/06 ,  A61K31/4172 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/506 ,  A61P9/14

Abstract: Pharmaceutical compositions containing selective imidazoline receptor agonists combined with angiotensin II receptor blockers, particularly, pharmaceutical compositions containing Moxonidine and Eprosartan mesylate, as well as the use of such compositions for the treatment of hypertension, especially in hypertensive patients suffering from type II diabetes or susceptible to developing type II diabetes.

公开(公告)号：AT378053T

公开(公告)日：2007-11-15

申请号：AT04818828

申请日：2004-11-15

Applicant: SOLVAY PHARM GMBH

Inventor： THORMAEHLEN DIRK ,  HOCHER BERTHOLD ,  WALDECK HARALD

IPC: A61K31/55 ,  A61P13/12 ,  A61P43/00

公开(公告)号：BRPI0415198A

公开(公告)日：2006-12-05

申请号：BRPI0415198

申请日：2004-10-07

Applicant: SOLVAY PHARM GMBH

Inventor： BAUM DOMINIQUE ,  BIELENBERG GERHARD-WILHELM ,  BOEDECKER BERND ,  THORMAEHLEN DIRK

IPC: A61K31/4172 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/506 ,  A61K45/06 ,  A61P9/14

Abstract: Pharmaceutical compositions containing selective imidazoline receptor agonists combined with angiotensin II receptor blockers, particularly, pharmaceutical compositions containing Moxonidine and Eprosartan mesylate, as well as the use of such compositions for the treatment of hypertension, especially in hypertensive patients suffering from type II diabetes or susceptible to developing type II diabetes.

公开(公告)号：DE50010284D1

公开(公告)日：2005-06-16

申请号：DE50010284

申请日：2000-02-10

Applicant: SOLVAY PHARM GMBH

Inventor： WILKINS R ,  THORMAEHLEN DIRK ,  WALDECK HARALD

IPC: C07D223/16 ,  A61K31/55 ,  A61P9/00 ,  A61P9/12

Abstract: The present invention relates to the use of benzazepine-N-acetic acid derivatives which contain an oxo-group in the alpha-position to the nitrogen atom and are substituted in position 3 by a 1-(carboxyalkyl)cyclo-entylcarbonylamino radical, and their salts and biolabile esters for the treatment of hypertension, particularly for the treatment of certain forms of secondary hypertension, in larger mammals and particularly humans, and for the production of pharmaceutical compositions suitable for this treatment. The cause of the hypertension to be treated may have a wide variety of origins. The invention particularly relates to the treatment of those forms of secondary hypertension which may occur as a result of various non-cardiac diseases.

公开(公告)号：PL350167A1

公开(公告)日：2002-11-18

申请号：PL35016700

申请日：2000-02-10

Applicant: SOLVAY PHARM GMBH

Inventor： WILKINS MARTIN R ,  THORMAEHLEN DIRK ,  WALDECK HARALD

IPC: C07D223/16 ,  A61K31/55 ,  A61P9/00 ,  A61P9/12

Abstract: The present invention relates to the use of benzazepine-N-acetic acid derivatives which contain an oxo-group in the alpha-position to the nitrogen atom and are substituted in position 3 by a 1-(carboxyalkyl)cyclo-entylcarbonylamino radical, and their salts and biolabile esters for the treatment of hypertension, particularly for the treatment of certain forms of secondary hypertension, in larger mammals and particularly humans, and for the production of pharmaceutical compositions suitable for this treatment. The cause of the hypertension to be treated may have a wide variety of origins. The invention particularly relates to the treatment of those forms of secondary hypertension which may occur as a result of various non-cardiac diseases.

公开(公告)号：PL184336B1

公开(公告)日：2002-10-31

申请号：PL31343396

申请日：1996-03-22

Applicant: SOLVAY PHARM GMBH

Inventor： WALDECK HARALD ,  HOELTJE DAGMAR ,  MESSINGER JOSEF ,  ANTEL JOCHEN ,  WURL MICHAEL ,  THORMAEHLEN DIRK

IPC: C07D223/16 ,  A61K31/33 ,  A61K31/423 ,  A61K31/428 ,  A61K31/55 ,  A61K31/554 ,  A61K38/00 ,  A61K38/05 ,  A61P7/10 ,  A61P9/00 ,  A61P43/00 ,  C07D267/14 ,  C07D281/10 ,  C07K5/078 ,  C07D405/12

Abstract: Benzazepin-, benzoxazepin- and benzothiazepin-N-acetic acid derivs. of formula (I) and their salts are new. R = lower alkoxy(lower)alkyl (in which the alkoxy is opt. substd. by lower alkoxy) or phenyl(lower)alkyl, or phenoxy(lower)alkyl (opt. ring substd. by lower alkyl or alkoxy or halo) or naphthyl(lower)alkyl; A = CH2, O or S; R , R = H or halogen; R , R = H or a biolabile ester containing gp.

公开(公告)号：MXPA02000411A

公开(公告)日：2002-07-02

申请号：MXPA02000411

申请日：2000-07-10

Applicant: SOLVAY PHARM GMBH

Inventor： THORMAEHLEN DIRK

IPC: A61K31/55 ,  A61K31/704 ,  A61K45/00 ,  C07D223/16 ,  A61K45/06 ,  A61P9/00 ,  A61P21/00 ,  A61P35/00 ,  A61P37/04 ,  A61P39/02 ,  A61P39/06 ,  A61K31/70

Abstract: La invencion se refiere al uso de derivados del acido benzacepin-N-acetico que contienen un grupo oxo adicionalmente al atomo de nitrogeno en la posicion ? y que se sustituyen en la tercera posicion mediante un radical 1-(carboxialquilo)-ciclopentilo-carbonil-amino, y a sus sales y esteres bioinestables para la profilaxis y/o tratamiento de lesiones cardiacas ocasionadas por dosis cardiotoxicas de medicamentos o sustancias quimicas en mamiferos mayores, y particularmente en seres humanos. La invencion se refiere en particular a la profilaxis y/o tratamiento de lesiones cardiacas, en particular lesiones al miocardio que pueden ocurrir durante la quimioterapia citostatica. La invencion se refiere ademas al uso de los derivados del acido benzacepin-N-acetico precedentemente mencionado para el tratamiento auxiliar en terapias en las que se usan medicamentos con efectos secundarios toxicos oxidantes. La invencion se refiere adicionalmente a la produccion de medicamentos adecuados para esta profilaxis y/o tratamiento de tratamiento auxiliar.

公开(公告)号：BR0008260A

公开(公告)日：2001-11-06

申请号：BR0008260

申请日：2000-02-10

Applicant: SOLVAY PHARM GMBH

Inventor： WILKINS MARTIN R ,  THORMAEHLEN DIRK ,  WALDECK HARALD

IPC: C07D223/16 ,  A61K31/55 ,  A61P9/00 ,  A61P9/12

Abstract: The present invention relates to the use of benzazepine-N-acetic acid derivatives which contain an oxo-group in the alpha-position to the nitrogen atom and are substituted in position 3 by a 1-(carboxyalkyl)cyclo-entylcarbonylamino radical, and their salts and biolabile esters for the treatment of hypertension, particularly for the treatment of certain forms of secondary hypertension, in larger mammals and particularly humans, and for the production of pharmaceutical compositions suitable for this treatment. The cause of the hypertension to be treated may have a wide variety of origins. The invention particularly relates to the treatment of those forms of secondary hypertension which may occur as a result of various non-cardiac diseases.