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公开(公告)号:AU2003241307A8
公开(公告)日:2003-12-12
申请号:AU2003241307
申请日:2003-04-23
Applicant: SYMYX TECHNOLOGIES INC
Inventor: KOLOSOV OLEG , MAZZOLA LAURA T , CARLSON ERIC D , GALLIPEO JOHN , MATSIEV LEONID , SPITKOVSKY MIKHAIL
Abstract: A method and apparatus for measurement of mass of small sample sizes. The method and apparatus is particularly adapted for providing microbalance measurement of solid materials as part of a combinatorial research program. The method and apparatus contemplate monitoring the response of a resonator holding a sample and correlating the response with mass change in the samples.
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公开(公告)号:AU2003241307A1
公开(公告)日:2003-12-12
申请号:AU2003241307
申请日:2003-04-23
Applicant: SYMYX TECHNOLOGIES INC
Inventor: CARLSON ERIC D , KOLOSOV OLEG , MATSIEV LEONID , MAZZOLA LAURA T , SPITKOVSKY MIKHAIL , GALLIPEO JOHN
Abstract: A method and apparatus for measurement of mass of small sample sizes. The method and apparatus is particularly adapted for providing microbalance measurement of solid materials as part of a combinatorial research program. The method and apparatus contemplate monitoring the response of a resonator holding a sample and correlating the response with mass change in the samples.
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公开(公告)号:DE69814035T2
公开(公告)日:2003-10-23
申请号:DE69814035
申请日:1998-10-02
Applicant: SYMYX TECHNOLOGIES INC
Inventor: MATSIEV LEONID , BENNETT JAMES , MCFARLAND ERIC
IPC: G01H13/00 , G01N5/04 , G01N9/00 , G01N29/02 , G01N29/036 , G01N29/34 , G01N29/42 , G01N29/44 , H03H9/19
Abstract: A method and apparatus for measuring properties of a liquid composition includes a mechanical resonator, such as a thickness shear mode resonator or a tuning fork resonator, connected to a measurement circuit. The measurement circuit provides a variable frequency input signal to the tuning fork, causing the mechanical resonator to oscillate. To test the properties of a liquid composition, the mechanical resonator is placed inside a sample well containing a small amount of the liquid. The input signal is then sent to the mechanical resonator and swept over a selected frequency range, preferably less than 1 MHz to prevent the liquid being tested from exhibiting gel-like characteristics and causing false readings. The mechanical resonator's response over the frequency range depends on various characteristics of the liquid being tested, such as the temperature, viscosity, and other physical properties. Particular mechanical resonators, such as tuning fork resonators, can also be used to measure a liquid composition's electrical properties, such as the dielectric constant and conductivity, because the tuning fork's structure allows a high degree of electrical coupling between the tuning fork and the surrounding liquid. The mechanical resonator can be covered with a coating to impart additional special detection properties to the resonator, and multiple resonators can be attached together as a single sensor to obtain multiple frequency responses. The invention is particularly suitable for combinatorial chemistry applications, which require rapid analysis of chemical properties for screening.
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公开(公告)号:DK1069942T3
公开(公告)日:2003-09-29
申请号:DK99942147
申请日:1999-08-12
Applicant: SYMYX TECHNOLOGIES INC
Inventor: HAJDUK DAMIAN A , DALES G CAMERON , VAN ERDEN LYNN , NIELSEN RALPH B , MANSKY PAUL , WANG PEI , MCFARLAND ERIC , TURNER HOWARD , VAN BEEK JOHANNES A M , MATSIEV LEONID
IPC: B01F13/06 , B01J19/18 , B01F13/08 , B01F15/00 , B01J19/00 , B01J19/26 , B01L3/00 , B01L7/00 , C40B40/14 , C40B40/18 , F28F27/00 , G01K13/00 , G01N21/25 , G01N35/10 , G05B23/02 , G05D21/00
Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
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公开(公告)号:AU5559099A
公开(公告)日:2000-03-06
申请号:AU5559099
申请日:1999-08-12
Applicant: SYMYX TECHNOLOGIES INC
Inventor: TURNER HOWARD , DALES G CAMERON , ERDEN LYNN VAN , BEEK JOHANNES A M VAN , HAJDUK DAMIAN A , NIELSEN RALPH B , MANSKY PAUL , MATSIEV LEONID , WANG PEI , MCFARLAND ERIC
IPC: B01J19/18 , B01F13/06 , B01F13/08 , B01F15/00 , B01J19/00 , B01J19/26 , B01L3/00 , B01L7/00 , C40B40/14 , C40B40/18 , F28F27/00 , G01K13/00 , G01N21/25 , G01N35/10 , G05B23/02 , G05D21/00
Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
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公开(公告)号:CA2381014A1
公开(公告)日:2000-02-24
申请号:CA2381014
申请日:1999-08-12
Applicant: SYMYX TECHNOLOGIES INC
Inventor: VAN BEEK JOHANNES A M , VAN ERDEN LYNN , HAJDUK DAMIAN A , MANSKY PAUL , TURNER HOWARD , MATSIEV LEONID , DALES G CAMERON , MCFARLAND ERIC , NIELSEN RALPH B , WANG PEI
Abstract: Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
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公开(公告)号:DE69927720T2
公开(公告)日:2006-05-04
申请号:DE69927720
申请日:1999-08-12
Applicant: SYMYX TECHNOLOGIES INC
Inventor: TURNER HOWARD , DALES G CAMERON , VAN ERDEN LYNN , VAN BEEK JOHANNES A M , HAJDUK DAMIAN A , NIELSEN RALPH B , MANSKY PAUL , MATSIEV LEONID , WANG PEI , MCFARLAND ERIC
IPC: B01J19/00 , B01J19/18 , B01F13/06 , B01F13/08 , B01F15/00 , B01J19/26 , B01L3/00 , B01L7/00 , C40B40/14 , C40B40/18 , F28F27/00 , G01K13/00 , G01N21/25 , G01N35/10 , G05B23/02 , G05D21/00
Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
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公开(公告)号:AT306316T
公开(公告)日:2005-10-15
申请号:AT01116401
申请日:1999-08-12
Applicant: SYMYX TECHNOLOGIES INC
Inventor: TURNER HOWARD , DALES G CAMERON , VAN ERDEN LYNN , VAN BEEK JOHANNES A M , HAJDUK DAMIAN A , NIELSEN RALPH B , MANSKY PAUL , MATSIEV LEONID , WANG PEI , MCFARLAND ERIC
IPC: B01J19/18 , B01F13/06 , B01F13/08 , B01F15/00 , B01J19/00 , B01J19/26 , B01L3/00 , B01L7/00 , C40B40/14 , C40B40/18 , F28F27/00 , G01K13/00 , G01N21/25 , G01N35/10 , G05B23/02 , G05D21/00
Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
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公开(公告)号:DE69921367D1
公开(公告)日:2004-11-25
申请号:DE69921367
申请日:1999-08-12
Applicant: SYMYX TECHNOLOGIES INC
Inventor: TURNER HOWARD , DALES G CAMERON , VAN ERDEN LYNN , VAN BEEK JOHANNES A M , HAJDUK DAMIAN A , NIELSEN RALPH B , MANSKY PAUL , MATSIEV LEONID , WANG PEI , MCFARLAND ERIC
IPC: B01J19/18 , B01F13/06 , B01F13/08 , B01F15/00 , B01J19/00 , B01J19/26 , B01L3/00 , B01L7/00 , C40B40/14 , C40B40/18 , F28F27/00 , G01K13/00 , G01N21/25 , G01N35/10 , G05B23/02 , G05D21/00 , B01F7/16
Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
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公开(公告)号:CA2381014C
公开(公告)日:2003-07-08
申请号:CA2381014
申请日:1999-08-12
Applicant: SYMYX TECHNOLOGIES INC
Inventor: MATSIEV LEONID , TURNER HOWARD , DALES G CAMERON , WANG PEI , VAN ERDEN LYNN , MANSKY PAUL , MCFARLAND ERIC , NIELSEN RALPH B , HAJDUK DAMIAN A , VAN BEEK JOHANNES A M
Abstract: Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
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