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    11.
    发明专利
    未知

    公开(公告)号：DE3125980A1

    公开(公告)日：1982-04-15

    申请号：DE3125980

    申请日：1981-07-01

    Applicant: TORAY INDUSTRIES

    Inventor： SONODA TAKESHI ,  TANAKA YOSHITAKA ,  TAKENAKA SHIGENORI ,  NOGI TATSUO

    IPC: C08L33/00 ,  B01D69/08 ,  B01D71/28 ,  B01D71/40 ,  B01D71/80 ,  B01D71/82 ,  C08L33/02 ,  C08L33/04 ,  C08L33/12 ,  C08L33/14 ,  B01D13/04 ,  B01D31/00 ,  A61M1/03 ,  C08L33/10 ,  C08J5/22

    Abstract: A membrane for microfiltration, ultrafiltration or dialysis comprises a methyl methacrylate copolymer containing about 0.5 to 10 mol % of a monomer having sulfonate groups, and a methyl methacrylate copolymer containing about 0.5 to 10 mol % of a monomer having quaternary nitrogen-containing groups. It is manufactured by mixing those copolymers, dissolving the mixture in a solvent such as dimethylsulfoxide or dimethylformamide, and forming a membrane from a solution of the copolymers by casting or spinning. The membrane is particularly suitable for use in the purification of blood, and its most preferable form is hollow fibers. A method of preparing hollow fibers comprises extruding the copolymer solution through a spinneret having an annular orifice defined by a thin central tube while a liquid or gas is being injected into the central tube, and coagulating the extrusion product.

    POLYSULFONE HOLLOW FIBER SEMIPERMEABLE MEMBRANE
    14.
    发明专利
    POLYSULFONE HOLLOW FIBER SEMIPERMEABLE MEMBRANE 未知

    公开(公告)号：CA2180222C

    公开(公告)日：2006-10-10

    申请号：CA2180222

    申请日：1996-06-28

    Applicant: TORAY INDUSTRIES

    Inventor： SHIMAGAKI MASAAKI ,  FUKUI FUMIAKI ,  SONODA TAKESHI ,  SUGITA KOJI

    IPC: B01D71/68 ,  A61M1/16 ,  A61M1/18 ,  B01D63/02 ,  B01D65/02 ,  B01D67/00 ,  B01D69/02 ,  B01D69/08

    Abstract: Respective hollow fiber membranes suitable for use in removing undesired contaminants from blood, in particular in an artificial kidney, have: (1) per membrane area of 1.6 m2, in vitro clearances for urea and phosphorus respectively of .gtoreq. 195, and .gtoreq. 180, ml/min, a .beta.2-microglobulin clearance .gtoreq. 44 ml/min and an albumin permeability .ltoreq. 0.5%; (2) an albumin permeability .ltoreq. 1.5% and an overall mass transfer coefficient Ko .gtoreq. 0.0012 cm/min; and (3) a vitamin B12 dialyzance of .gtoreq. 135 ml/min and an albumin permeability .ltoreq. 3%. The membranes can be prepared by spinning hollow fibers from a spinning solution comprising a polysulfone, a hydrophilic polymer, a solvent and water, the spinning solution having a viscosity x at 30.degree.C of 25-130 poise and a quantity y % of water given by: -0.01.times. + 1.45 .ltoreq. y .ltoreq. -0.01.times. + 2.25. The membranes can be incorporated into a hemodialyzer module by a method in which they are preimpregnated with a wetting agent, thereafter kept separate from one another by spacers and then inserted in the module.

    15.
    发明专利
    未知

    公开(公告)号：DE69634352T2

    公开(公告)日：2006-01-12

    申请号：DE69634352

    申请日：1996-06-28

    Applicant: TORAY INDUSTRIES

    Inventor： SHIMAGAKI MASAAKI ,  FUKUI FUMIAKI ,  SONODA TAKESHI ,  SUGITA KOJI

    IPC: A61M1/16 ,  B01D63/02 ,  B01D65/02 ,  B01D67/00 ,  B01D69/02 ,  B01D69/08 ,  B01D71/68

    Abstract: Respective hollow fiber membranes suitable for use in removing undesired contaminants from blood, in particular in an artificial kidney, have: (1) per membrane area of 1.6 m , in vitro clearances for urea and phosphorus respectively of ≥ 195, and ≥ 180, ml/min, a beta 2-microglobulin clearance ≥ 44 ml/min and an albumin permeability ≤ 0.5%; (2) an albumin permeability ≤ 1.5% and an overall mass transfer coefficient Ko ≥ 0.0012 cm/min; and (3) a vitamin B12 dialyzance of ≥ 135 ml/min and an albumin permeability ≤ 3%. The membranes can be prepared by spinning hollow fibers from a spinning solution comprising a polysulfone, a hydrophilic polymer, a solvent and water, the spinning solution having a viscosity x at 30 DEG C of 25-130 poise and a quantity y % of water given by: The membranes can be incorporated into a hemodialyzer module by a method in which they are preimpregnated with a wetting agent, thereafter kept separate from one another by spacers and then inserted in the module.

    16.
    发明专利
    未知

    公开(公告)号：DE69634352D1

    公开(公告)日：2005-03-24

    申请号：DE69634352

    申请日：1996-06-28

    Applicant: TORAY INDUSTRIES

    Inventor： SHIMAGAKI MASAAKI ,  FUKUI FUMIAKI ,  SONODA TAKESHI ,  SUGITA KOJI

    IPC: A61M1/16 ,  B01D63/02 ,  B01D65/02 ,  B01D67/00 ,  B01D69/02 ,  B01D69/08 ,  B01D71/68

    Abstract: Respective hollow fiber membranes suitable for use in removing undesired contaminants from blood, in particular in an artificial kidney, have: (1) per membrane area of 1.6 m , in vitro clearances for urea and phosphorus respectively of ≥ 195, and ≥ 180, ml/min, a beta 2-microglobulin clearance ≥ 44 ml/min and an albumin permeability ≤ 0.5%; (2) an albumin permeability ≤ 1.5% and an overall mass transfer coefficient Ko ≥ 0.0012 cm/min; and (3) a vitamin B12 dialyzance of ≥ 135 ml/min and an albumin permeability ≤ 3%. The membranes can be prepared by spinning hollow fibers from a spinning solution comprising a polysulfone, a hydrophilic polymer, a solvent and water, the spinning solution having a viscosity x at 30 DEG C of 25-130 poise and a quantity y % of water given by: The membranes can be incorporated into a hemodialyzer module by a method in which they are preimpregnated with a wetting agent, thereafter kept separate from one another by spacers and then inserted in the module.

    INCUBATOR USING HOLLOW FIBER
    19.
    发明专利
    INCUBATOR USING HOLLOW FIBER 失效

    公开(公告)号：JPH0541979A

    公开(公告)日：1993-02-23

    申请号：JP20042091

    申请日：1991-08-09

    Applicant: TORAY INDUSTRIES

    Inventor： SONODA TAKESHI ,  AKAMATSU HIROATSU ,  KONO HAJIME

    IPC: C12M1/00 ,  C12M3/00

    Abstract: PURPOSE:To obtain the subject incubator with high culture efficiency, easy to prepare a large surface area even in the case of high packing density for hollow fibers by putting numerous hollow fiber bundles prepared by a specific means from selectively permeable hollow fibers into a cylinder. CONSTITUTION:Firstly, one or two selectively permeable signal hollow fiber(s) 11 is spirally warpped with the first linear material 12 differing from said hollow fiber to form a unit hollow fiber element A. Second, an assembly made up of at least 4 units of the element A is spirally warpped with the second linear material differing from the hollow fiber to prepare a hollow fiber bundle. Then, at least 5 units of the hollow fiber bundle are put into a cylinder to obtain the objective incubator. Said hollow fiber is pref. made from polymethyl methacrylate or a polymer mainly made therefrom; the first and second linear materials are pref. polyester filaments.

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