Patent search ap:("VERTEX PHARMA") AND inv:"FENG YUSHI" Page 2

11.

发明专利
N-[2,4-bisz(1,1-dimetil-etil)-5-hidroxi-fenil]-1,4-dihidro-4-oxo-kinolin-3-karboxamid szilárd formái 未知

公开(公告)号：HUE032813T2

公开(公告)日：2017-11-28

申请号：HUE06848237

申请日：2006-12-28

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN

12.

发明专利
STAŁE POSTACIE N-[2,4-BIS(1,1-DIMETYLOETYLO)-5-HYDROKSYFENYLO]-1,4- DIHYDRO-4-OKSOCHINOLINO-3-KARBOKSYAMIDU 未知

公开(公告)号：PL1993360T3

公开(公告)日：2017-08-31

申请号：PL06848237

申请日：2006-12-28

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN

IPC: C07D215/56 , A61K31/445

13.

发明专利
SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 未知

公开(公告)号：AU2016219571A1

公开(公告)日：2016-09-08

申请号：AU2016219571

申请日：2016-08-23

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA , CONNELLY PATRICK , ROWE WILLIAM , YOUNG CHRISTOPHER R , COSTACHE ADRIANA , KRAWIEC MARIUSZ , GONG YUCHUAN , FENG YUSHI , TRUDEAU MARTIN

IPC: A61K31/445

Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1 -dimethylethyl)-5 hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.

14.

发明专利
SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 未知

公开(公告)号：NZ583848A

公开(公告)日：2012-07-27

申请号：NZ58384808

申请日：2008-09-15

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN , FENG YUSHI , HARRISON CRISTIAN , LOOKER ADAM , MUDUNURI PRAVEEN , ROEPER STEFANIE , ZHANG YUEGANG

IPC: A61P35/00 , A61K31/47 , A61P3/00 , A61P3/10 , A61P25/28 , A61P27/02 , C07D215/233

Abstract: Disclosed is N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide benzene sulfonate and N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide benzene sulfonate H2O. The compounds are used to treat CFTR-mediated diseases, cystic fibrosis, hereditary emphysema, COPD, dry-eye disease or Sjogren's disease.

15.

发明专利
Farmacevtski sestavki amorfne oblike N-(2,4-bis(1,1-dimetiletil)-5- hidroksifenil)-1,4-dihidro-4-oksokinolin-3-karboksamid 未知

公开(公告)号：SI3219705T1

公开(公告)日：2020-08-31

申请号：SI200632370

申请日：2006-12-28

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN

IPC: C07D215/00 , A61K31/00

16.

发明专利
FARMACEUTSKE KOMPOZICIJE AMORFNOG OBLIKA N-[2,4-BIS(1,1-DIMETILETIL)-5-HIDROKSIFENIL]-1,4-DIHIDRO-4-OKSOHINOLIN-3-KARBOKSAMIDA 未知

公开(公告)号：RS60205B1

公开(公告)日：2020-06-30

申请号：RSP20200487

申请日：2006-12-28

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN

IPC: C07D215/56 , A61K31/445

17.

发明专利
Formas sólidas de N-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolina-3-carboxamida 未知

公开(公告)号：ES2624554T3

公开(公告)日：2017-07-14

申请号：ES06848237

申请日：2006-12-28

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN

IPC: C07D215/56 , A61K31/445

Abstract: Una dispersión sólida que comprende N-[2,4-bis(1,11-dimetiletilo)-5-hidroxifenilo]-1,4-dihidro-4-oxoquinolina-3-carboxamida amorfa.

18.

发明专利
Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide 未知

公开(公告)号：NZ620027A

公开(公告)日：2015-05-29

申请号：NZ62002708

申请日：2008-09-15

Applicant: VERTEX PHARMA

Inventor： FENG YUSHI , LOOKER ADAM , ZHANG YUEGANG , DEMATTEI JOHN , MUDUNURI PRAVEEN , ROEPER STEFANIE , HARRISON CRISTIAN

IPC: A61K31/47 , A61P3/00 , A61P3/10 , A61P25/28 , A61P27/02 , A61P35/00 , C07D215/233

Abstract: Disclosed is a compound selected from N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) 2-methylbutyric acid. Also disclosed is a method of making the crystalline forms, pharmaceutical compositions and kits comprising the crystalline forms and the use of the crystalline forms for the manufacture of a medicament for the for treating or lessening the severity of a disease in a patient, wherein said disease is selected from cystic fibrosis, hereditary emphysema, hereditary hemochromatosis, coagulation-fibrinolysis deficiencies, lipid processing deficiencies, lysosomal storage diseases, neurodegenerative diseases, polyglutamine neurological disorders, spongiform encephalopathies, COPD, dry-eye disease, and Sjogren’s disease .

19.

发明专利
SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL] 未知

公开(公告)号：AU2013201426A1

公开(公告)日：2013-04-04

申请号：AU2013201426

申请日：2013-03-12

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA , ROWE WILLIAM , YOUNG CHRISTOPHER R , COSTACHE ADRIANA , CONNELLY PATRICK , KRAWIEC MARIUSZ , GONG YUCHUAN , TRUDEAU MARTIN , FENG YUSHI

IPC: A61K31/445

Abstract: The present invention relates to solid state forms of N-[2,4-bis(1 ,1-dimethylethyl)-5 hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.

20.

发明专利
FORMAS SOLIDAS DE N-[2,4-BIS(1,1-DIMETILETIL)-5-HIDROXIFENIL]-1,4- DIHIDRO-4-OXOQUINOLIN-3-CARBOXAMIDA. 未知

公开(公告)号：MX2010002974A

公开(公告)日：2010-07-29

申请号：MX2010002974

申请日：2008-09-15

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN , HARRISON CRISTIAN , FENG YUSHI , LOOKER ADAM , MUDUNURI PRAVEEN , ROEPER STEFANIE , ZHANG YUEGANG

IPC: A61K31/47 , A61P3/00 , A61P3/10 , A61P25/28 , A61P27/02 , A61P35/00 , C07D215/233

Abstract: Se describen en la presente formas sólidas de N- [2,4-bis (1,1-dimetiletil) -5-hidroxiferxil] -1,4-dihidro-4-oxoquinolin-3-c arboxamida, entre las que se incluyen las formas cristalinas de la misma.

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