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1.发明申请SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 审中-公开N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体形式
公开(公告)号：WO2007079139A9
公开(公告)日：2007-11-29
申请号：PCT/US2006049421
申请日：2006-12-28
Applicant: VERTEX PHARMA , HURTER PATRICIA , ROWE WILLIAM , YOUNG CHRISTOPHER R , COSTACHE ADRIANA , CONNELLY PATRICK , KRAWIEC MARIUSZ , GONG YUCHUAN , FENG YUSHI , TRUDEAU MARTIN
Inventor： HURTER PATRICIA , ROWE WILLIAM , YOUNG CHRISTOPHER R , COSTACHE ADRIANA , CONNELLY PATRICK , KRAWIEC MARIUSZ , GONG YUCHUAN , FENG YUSHI , TRUDEAU MARTIN
IPC: A01N43/40 , A61K31/445
CPC classification number: A61K31/47 , A61K2300/00 , C07B2200/13 , C07D215/56 , Y10T428/2982
Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
Abstract translation: 本发明涉及N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）的固体形式，药物组合物 及其方法。
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2.发明申请SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 审中-公开N- [2,4-BIS（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-羧酰胺的固体形式
公开(公告)号：WO2009038683A3
公开(公告)日：2010-08-26
申请号：PCT/US2008010728
申请日：2008-09-15
Applicant: VERTEX PHARMA , DEMATTEI JOHN , FENG YUSHI , HARRISON CRISTIAN , LOOKER ADAM , MUDUNURI PRAVEEN , ROEPER STEFANIE , ZHANG YUEGANG
Inventor： DEMATTEI JOHN , FENG YUSHI , HARRISON CRISTIAN , LOOKER ADAM , MUDUNURI PRAVEEN , ROEPER STEFANIE , ZHANG YUEGANG
IPC: C07D215/233
CPC classification number: C07D215/56 , A61K31/47 , A61K45/06 , C07D215/233
Abstract: Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof.
Abstract translation: 本文描述了固体形式的N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺，包括其结晶形式。
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3.发明公开SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 有权FESTE FORMEN VON N- [2,4-BIS（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧杂环辛烷-3-羧酸
公开(公告)号：EP1993360A4
公开(公告)日：2010-12-01
申请号：EP06848237
申请日：2006-12-28
Applicant: VERTEX PHARMA
Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN
IPC: C07D215/56 , A61K31/445
CPC classification number: A61K31/47 , A61K2300/00 , C07B2200/13 , C07D215/56 , Y10T428/2982
Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
Abstract translation: 本发明涉及N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）的固体形式，药物组合物 及其方法。
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公开(公告)号：ME03786B
公开(公告)日：2021-04-20
申请号：MEP202088
申请日：2020-12-29
Applicant: VERTEX PHARMA
Inventor： KRAWIEC MARIUSZ , ROWE WILLIAM , HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , COSTACHE ADRIANA , FENG YUSHI , TRUDEAU MARTIN
IPC: A61K31/445 , C07D215/56
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5.发明专利
公开(公告)号：CY1118980T1
公开(公告)日：2018-01-10
申请号：CY171100490
申请日：2017-05-05
Applicant: VERTEX PHARMA
Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN
IPC: C07D215/56 , A61K31/445
Abstract: ΗπαρούσαεφεύρεσηαφοράσεστερεάςκατάστασηςμορφέςτουΝ-[2,4-δις(1,1-διμεθυλαιθυλ)-5-υδροξυφαινυλ]-1,4-διυδρο-4-οξοκινολινο-3-καρβοξαμιδίου (Ένωση 1), φαρμακευτικέςσυνθέσειςαυτούκαιμεθόδουςμεαυτό.
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Patent Agency Ranking
公开(公告)号：BRPI0816345A2
公开(公告)日：2015-02-24
申请号：BRPI0816345
申请日：2008-09-15
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , FENG YUSHI , HARRISON CRISTIAN , LOOKER ADAM , MUDUNURI PRAVEEN , ROEPER STEFANIE , ZHANG YUEGANG
IPC: C07D215/233
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公开(公告)号：HUE049976T2
公开(公告)日：2020-11-30
申请号：HUE17154944
申请日：2006-12-28
Applicant: VERTEX PHARMA
Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN
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公开(公告)号：ES2790700T3
公开(公告)日：2020-10-28
申请号：ES17154944
申请日：2006-12-28
Applicant: VERTEX PHARMA
Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN
IPC: C07D215/56 , A61K31/445
Abstract: Una composición farmacéutica que comprende N-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida amorfa; en la que N-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida amorfa tiene menos del 30 % de N-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolin-3-carboxamida cristalina.
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公开(公告)号：AU2020201314A1
公开(公告)日：2020-03-12
申请号：AU2020201314
申请日：2020-02-21
Applicant: VERTEX PHARMA
Inventor： HURTER PATRICIA , CONNELLY PATRICK , ROWE WILLIAM , YOUNG CHRISTOPHER R , COSTACHE ADRIANA , KRAWIEC MARIUSZ , GONG YUCHUAN , FENG YUSHI , TRUDEAU MARTIN
IPC: A61K31/445
Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5 hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
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10.发明专利
公开(公告)号：AU2018204203A1
公开(公告)日：2018-07-05
申请号：AU2018204203
申请日：2018-06-13
Applicant: VERTEX PHARMA
Inventor： HURTER PATRICIA , CONNELLY PATRICK , ROWE WILLIAM , YOUNG CHRISTOPHER R , COSTACHE ADRIANA , KRAWIEC MARIUSZ , GONG YUCHUAN , FENG YUSHI , TRUDEAU MARTIN
IPC: A61K31/445
Abstract: The present invention relates to solid state forms of N-[2,4-bis(1 ,1 -dimethylethyl)-5 hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
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