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公开(公告)号：SG10201504084QA
公开(公告)日：2015-06-29
申请号：SG10201504084Q
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
Abstract: The invention provides a process for the preparation of a compound of Formula 1; comprising coupling a carboxylic acid of Formula 2; with an aniline of Formula 2; in the presence of a coupling agent.
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公开(公告)号：MX2014005462A
公开(公告)日：2015-03-23
申请号：MX2014005462
申请日：2012-11-08
Applicant: VERTEX PHARMA
Inventor： LOOKER ADAM R , RYAN MICHAEL P , LITTLER BENJAMIN JOSEPH , CHOUDHURY ANUSUYA , VELURI RAVIKANTH , JIANG LICONG , LUSS-LUSIS EDUARD , HARRISON CRISTIAN L
IPC: C07D405/12 , A61K31/405 , A61K31/553 , A61P1/00 , A61P3/00 , A61P11/00 , A61P25/00 , A61P27/00 , A61P35/00 , C07D405/14 , C07D498/04
Abstract: Los compuestos de la presente invención así como las composiciones farmacéuticamente aceptables de estos, son útiles como moduladores de trasportadores de casetes enlazantes de ATP ("ABC") o fragmentos de estos, incluyendo el Regulador de Conducción Transmembrana de la Fibrosis Quística ("RTFQ"). La presente invención también se relaciona con los métodos para tratar enfermedades mediadas por Transportados ABC usando los compuestos de la presente invención.
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公开(公告)号：HK1165803A1
公开(公告)日：2012-10-12
申请号：HK12106626
申请日：2012-07-06
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D20060101
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公开(公告)号：AU2016244296A1
公开(公告)日：2016-11-03
申请号：AU2016244296
申请日：2016-10-13
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA J , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , GUERETTE DAHRIKA MILFRED LAO YAP , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDRICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
Abstract: The invention provides a process for the preparation of a compound of Formula 1, N H (Rx-X H R2 Formula 1 comprising coupling a carboxylic acid of Formula 2 (Rx-X OH Formula 2 with an aniline of Formula 3 Formula 3 in the presence of a coupling agent.
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公开(公告)号：AU2010226400B2
公开(公告)日：2016-07-14
申请号：AU2010226400
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP GUERETTE DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDRICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
Abstract: The invention provides a process for the preparation of a compound of Formula 1; comprising coupling a carboxylic acid of Formula 2; with an aniline of Formula 3; in the presence of a coupling agent.
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Patent Agency Ranking16.发明专利
公开(公告)号：BRPI1011506A8
公开(公告)日：2016-07-05
申请号：BRPI1011506
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , KRUEGER BRIAN R , YAP DAHRIKA MILFRED LAO , GOOR FREDERICK F VAN , ZLOKARNIK GREGOR , DEMATTEI JOHN , TRUDEAU MARTIN , BOTFIELD MARTYN C , RYAN MICHAEL P , GROOTENHUIS PETER D J , ROEPER STEFANIE
IPC: C07D215/233
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17.发明专利
公开(公告)号：PL2408750T3
公开(公告)日：2016-02-29
申请号：PL10710749
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
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18.发明专利
公开(公告)号：DK2408750T3
公开(公告)日：2015-10-05
申请号：DK10710749
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
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公开(公告)号：IN885KON2014A
公开(公告)日：2015-10-02
申请号：IN885KON2014
申请日：2014-04-23
Applicant: VERTEX PHARMA
Inventor： LOOKER ADAM R , LITTLER BENJAMIN JOSEPH , CHOUDHURY ANUSUYA , HARRISON CRISTIAN L , VELURI RAVIKANTH , RYAN MICHAEL P , JIANG LICONG , LUSS LUSIS EDUARD
IPC: C07D405/12 , C07D405/14 , C07D498/04
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof are useful as modulators of ATP Binding Cassette ('ABC') transporters or fragments thereof including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：SG193156A1
公开(公告)日：2013-09-30
申请号：SG2013057393
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
Abstract: The invention provides a process for the preparation of a compound of Formula 1; comprising coupling a carboxylic acid of Formula 2; with an aniline of Formula 3; in the presence of a coupling agent. 0 0 No available figure
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