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11.发明专利
公开(公告)号：ES2654414T3
公开(公告)日：2018-02-13
申请号：ES14182117
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT LANGILLE BOBBIANA , TRUDEAU MARTIN , ROPER STEFANIE , RYAN MICHAEL , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GROOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
Abstract: Un proceso para la preparación de un compuesto de Fórmula 8 **(Ver fórmula)** que comprende nitrar un compuesto de Fórmula 7 usando una mezcla de ácido sulfúrico y ácido nítrico en presencia de diclorometano **(Ver fórmula)** en el que PG es un grupo protector y R2 y R4 son cada uno terc-butilo, y en el que el compuesto nitro de Fórmula 8 se purifica por cristalización, en el que PG es propoxiformilo, metanosulfonilo, 4-nitro-benzoílo, etoxiformilo, butoxiformilo, t-butoxiformilo, i-propoxiformilo o metoxiformilo.
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12.发明专利
公开(公告)号：CY1116954T1
公开(公告)日：2017-04-05
申请号：CY151101043
申请日：2015-11-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
Abstract: ΗεφεύρεσηπαρέχειμίαμέθοδογιατηνπαρασκευήμίαςένωσηςΤύπου 1•πουπεριλαμβάνεισύζευξηενόςκαρβοξυλικούοξέοςΤύπου 2 μεμίαανιλίνηΤύπου 3•παρουσίαενόςπαράγοντασύζευξης.
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13.发明专利
公开(公告)号：SI2408750T1
公开(公告)日：2015-11-30
申请号：SI201031042
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/00
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14.发明专利
公开(公告)号：HRP20151137T1
公开(公告)日：2015-11-20
申请号：HRP20151137
申请日：2015-10-27
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
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15.发明专利
公开(公告)号：BRPI1011506A2
公开(公告)日：2015-08-25
申请号：BRPI1011506
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , GOOR FREDERICK F VAN , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
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Patent Agency Ranking
公开(公告)号：NZ595153A
公开(公告)日：2014-05-30
申请号：NZ59515310
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , BOTFIELD MARTYN C , ZLOKARNIK GREGOR , VAN GOOR FREDRICK F
IPC: C07D215/233 , A61K31/365 , C07D215/56 , C07D307/83
Abstract: The disclosure provides a process for the preparation of a substituted 4-Hydroxy-N-phenylquinoline-3-carboxamide derivative of Formula 1; comprising coupling a substituted 4-Hydroxyquinoline-3-carboxylic acid derivative of Formula 2; with an substituted aniline of Formula 3; in the presence of a coupling agent. The compounds of formula I being useful as cystic fibrosis transmembrane conductance regulators.
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公开(公告)号：CA2984994A1
公开(公告)日：2010-09-23
申请号：CA2984994
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDRICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/56
Abstract: The invention provides a process for the preparation of a compound of Formula 1; (See Formula 1) comprising coupling a carboxylic acid of Formula 2; (See Formula 2) with an aniline of Formula 3; (See Formula 3) in the presence of a coupling agent.
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18.发明专利
公开(公告)号：CY1119796T1
公开(公告)日：2018-06-27
申请号：CY171101344
申请日：2017-12-22
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANA , TRUDEAU MARTIN , ROPER STEFANIE , RYAN MICHAEL , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GROOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
Abstract: ΗεφεύρεσηπαρέχειμίαμέθοδογιατηνπαρασκευήμίαςένωσηςΤύπου 1˙πουπεριλαμβάνεισύζευξηενόςκαρβοξυλικούοξέοςΤύπου 2 μεμίαανιλίνηΤύπου 3˙παρουσίαενόςπαράγοντασύζευξης.
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19.发明专利
公开(公告)号：HRP20171901T1
公开(公告)日：2018-02-23
申请号：HRP20171901
申请日：2017-12-07
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT LANGILLE BOBBIANA , TRUDEAU MARTIN , ROPER STEFANIE , RYAN MICHAEL , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GROOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
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公开(公告)号：DK2821400T3
公开(公告)日：2018-01-02
申请号：DK14182117
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , NEUBERT-LANGILLE BOBBIANA , TRUDEAU MARTIN , RYAN MICHAEL , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GROOR FREDERICK F , BOTFIELD MARTYN C , LOOKER ADAM R , ROPER STEFANIE , ZLOKARNIK GREGOR
IPC: C07D215/233
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