公开(公告)号：US20140354868A1

公开(公告)日：2014-12-04

申请号：US14258204

申请日：2014-04-22

Applicant: Corning Incorporated

Inventor： Leon J. Desmarais ,  Richard Lynton Wiggins ,  Patrick W. Woodman

IPC: H04N5/232

CPC classification number: H04N5/23293 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0248 ,  G01J3/0259 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/18 ,  G01J3/2823

Abstract: A portable hyperspectral imager. The imager is modular and may include a hyperspectral camera and a removably-coupled mobile display module. The hyperspectral camera may include an Offner spectrometer. The mobile display module may be adapted to receive data from the hyperspectral camera and may include an internal camera. The mobile display module may include a cell phone or a tablet computer. The mobile display module may be integrally attached to the hyperspectral camera. The integral attachment may include a data link or USB connection. The length of the data link or USB connection may be less than 6 inches and the imager may weigh less than one pound. The imager may include a battery module or a scanning optical module.

Abstract translation: 便携式超光谱成像仪。 成像器是模块化的，并且可以包括高光谱相机和可拆卸耦合的移动显示模块。 超光谱相机可能包括Offner光谱仪。 移动显示模块可以适于从高光谱相机接收数据，并且可以包括内部相机。 移动显示模块可以包括蜂窝电话或平板计算机。 移动显示模块可以一体地附接到高光谱相机。 整体附件可以包括数据链接或USB连接。 数据链接或USB连接的长度可能小于6英寸，并且成像器的重量可能小于1磅。 成像器可以包括电池模块或扫描光学模块。

公开(公告)号：US20140268104A1

公开(公告)日：2014-09-18

申请号：US13913303

申请日：2013-06-07

Applicant: Chemlmage Corporation

Inventor： Patrick J. Treado ,  Matthew Nelson ,  Charles W. Gardner

IPC: G01J3/44 ,  G01J3/51

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/0221 ,  G01J3/0224 ,  G01J3/0248 ,  G01J3/32 ,  G01N21/21 ,  G01N21/314 ,  G01N21/33 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65 ,  G02B21/0092 ,  G02B21/16 ,  G02B21/361

Abstract: A first location comprising an unknown material may be scanned using SWIR hyperspectral imaging in a dual polarization configuration. Surveying may also be applied to thereby determine whether or not a human is present. This surveying may be achieved my assessing LWIR data, data acquired from motion sensors, and combinations thereof. If no human is present, a second location may be interrogated using Raman spectroscopic techniques to thereby obtain a Raman data set representative of the region of interest. This Raman data set may be assessed to associate an unknown material with a known material. This assessment may be achieved by comparing the Raman data set to one or more reference data sets in a reference database, where each reference data set is associated with a known material.

Abstract translation: 包含未知材料的第一位置可以使用双极化配置中的SWIR高光谱成像进行扫描。 还可以进行测量，从而确定人是否存在。 本次测量可能会实现我对LWIR数据的评估，运动传感器获取的数据及其组合。 如果不存在人，则可以使用拉曼光谱技术询问第二位置，从而获得表示感兴趣区域的拉曼数据集。 可以评估该拉曼数据集以将未知材料与已知材料相关联。 可以通过将拉曼数据集与参考数据库中的一个或多个参考数据集进行比较来实现该评估，其中每个参考数据集与已知材料相关联。

公开(公告)号：US20140198313A1

公开(公告)日：2014-07-17

申请号：US14008964

申请日：2012-03-27

Applicant: David Tracy ,  Peter Lewis Stokes ,  Sepehr Kiani

Inventor： David Tracy ,  Peter Lewis Stokes ,  Sepehr Kiani

IPC: G01J3/42 ,  G01J3/44

CPC classification number: G01J3/42 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0216 ,  G01J3/0248 ,  G01J3/0291 ,  G01J3/06 ,  G01J3/08 ,  G01J3/10 ,  G01J3/14 ,  G01J3/18 ,  G01J3/2803 ,  G01J3/44 ,  G01J3/4406 ,  G01N15/1434 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/6456

Abstract: The present invention generally pertains to a system, method and kit for the detection and measurement of spectroscopic properties of light from a sample, or the scalable detection and measurement of spectroscopic properties of light from each sample present among multiple samples, simultaneously, wherein the system comprises: an optical train comprising a dispersing element; and an image sensor. The light detected and measured may comprise light scattered from a sample, emitted as chemiluminescence by a chemical process within a sample, selectively absorbed by a sample, or emitted as fluorescence from a sample following excitation.

Abstract translation: 本发明一般涉及一种用于检测和测量来自样品的光的光谱特性的系统，方法和试剂盒，或同时进行多个样品中存在的每个样品的光的光谱特性的可伸缩检测和测量，其中系统 包括：包括分散元件的光学系列; 和图像传感器。 检测和测量的光可以包括从样品散射的光，通过样品内的化学过程作为化学发光发射，被样品选择性吸收，或者在激发后作为荧光从样品中发射。

公开(公告)号：US20140028996A1

公开(公告)日：2014-01-30

申请号：US13559211

申请日：2012-07-26

Applicant: Huiwen Liu ,  Peter Gunderson

Inventor： Huiwen Liu ,  Peter Gunderson

IPC: G01J3/44

CPC classification number: G01J3/0248 ,  G01J3/0237 ,  G01J3/0278 ,  G01J3/44 ,  G01N21/65

Abstract: The disclosure is related systems and method for improved accuracy and precision in Raman spectroscopy. In one embodiment, a device may comprise a Raman spectroscopic apparatus configured to determine a property of a sample by directing photons at the sample and measuring a resulting Raman scattering, a positioning apparatus capable of manipulating a position of the sample, and the device being configured to selectively adjust a focus of the Raman spectroscopic apparatus to adjust an intensity of the Raman scattering. Another embodiment may be a method comprising performing a depth focus Raman spectra screening on a sample to determine a depth focus with a maximum-intensity Raman spectra, wherein the depth focus spectra screening comprises performing Raman spectra scans on the sample at a plurality of depth foci, and modifying a process based on a result of the Raman spectra scan at the depth focus with the maximum-intensity Raman spectra.

Abstract translation: 本公开是提高拉曼光谱精度和精度的相关系统和方法。 在一个实施例中，装置可以包括拉曼分光装置，其被配置为通过在样品处引导光子并测量所得到的拉曼散射来确定样品的性质，能够操纵样品的位置的定位装置，以及被配置的装置 选择性地调节拉曼光谱装置的焦点以调节拉曼散射的强度。 另一个实施方案可以是包括对样品进行深度聚焦拉曼光谱筛选以用最大强度拉曼光谱确定深度聚焦的方法，其中深度聚焦谱筛选包括在多个深度焦点上对样品进行拉曼光谱扫描 ，并根据最大强度拉曼光谱在深度焦点处基于拉曼光谱扫描的结果修改工艺。

公开(公告)号：US08638433B1

公开(公告)日：2014-01-28

申请号：US13573485

申请日：2012-09-17

Applicant: John R. Amend ,  Richard A. Hermens

Inventor： John R. Amend ,  Richard A. Hermens

IPC: G01J3/42

CPC classification number: G01J3/0248 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/0235 ,  G01J3/0291 ,  G01J3/04 ,  G01J3/18 ,  G01J3/42 ,  G01J3/4412 ,  G01J3/443 ,  G01J2003/047

Abstract: A spectrophotometer including a light tube having a spectrophotometer head mounted to one end of the light tube and a diffraction grating head mounted to the opposite end. The spectrophotometer head having a bore therethrough for receiving incoming light from a light source providing a light path through the spectrophotometer head and light tube; Further, a slit is disposed in the light path and a vial of colored liquid is suspended halfway through the light path. The diffraction grating includes a bore aligned with the light path and includes a focusing lens and a diffraction grating disposed in the light path. The diffraction grating displaying a spectrum with an upper half displaying the spectrum of the light transmitted through the colored liquid and the lower half displaying the spectrum of the light source.

Abstract translation: 一种分光光度计，包括具有安装在光管一端的分光光度计头的光管和安装在另一端的衍射光栅头。 分光光度计头部具有穿过其的孔，用于接收来自光源的入射光，从而提供通过分光光度计头部和光管的光路; 此外，狭缝设置在光路中，并且一小瓶有色液体被中途穿过光路。 衍射光栅包括与光路对准的孔，并包括设置在光路中的聚焦透镜和衍射光栅。 该衍射光栅显示具有上半部分的光谱，其显示透过有色液体的光的光谱，下半部分显示光源的光谱。

公开(公告)号：US20140016116A1

公开(公告)日：2014-01-16

申请号：US13987046

申请日：2013-06-28

Applicant: Chemlmage Corporation

Inventor： John Maier ,  Jeffrey Cohen ,  Ryan Priore

IPC: G01N21/84

CPC classification number: G01N21/84 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0224 ,  G01J3/0248 ,  G01J3/027 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/1256 ,  G01J3/26 ,  G01J3/2823 ,  G01J3/44 ,  G01J3/4406 ,  G01J5/0846 ,  G01J2005/0077 ,  G01N21/35 ,  G01N21/3581 ,  G01N21/359 ,  G01N21/65 ,  G01N21/658 ,  G01N2201/129 ,  G02B21/0092 ,  G02B21/14 ,  G02B21/16

Abstract: The present disclosure provides for a system and method for assessing chronic exposure of a biological sample, such as a bodily fluid, to an analyte of interest. A biological sample may be illuminated to thereby generate a one or more pluralities of interacted photons. These interacted photons may be detected to thereby generate one or more spectroscopic data sets representative of a biological sample. Spectroscopic data sets generated may be compared to at least one reference data set. Each reference data set may be associated with a known exposure to a known analyte. The present disclosure contemplates that the system and method disclosed herein may be used to analyze exposure of biological samples to at least one analyte over time. Data sets may be obtained at various time intervals to assess changes in a molecular composition as a result of chronic exposure to an analyte.

Abstract translation: 本公开提供了用于评估生物样品（例如体液）到感兴趣分析物的慢性暴露的系统和方法。 可以照射生物样品，从而产生一个或多个相互作用的光子。 可以检测这些相互作用的光子，从而生成代表生物样品的一个或多个光谱数据集。 可以将生成的光谱数据集与至少一个参考数据集进行比较。 每个参考数据集可以与已知分析物的已知暴露相关联。 本公开内容考虑到本文公开的系统和方法可用于分析生物样品随时间的至少一种分析物的暴露。 可以以不同的时间间隔获得数据集，以评估作为慢性暴露于分析物的结果的分子组成的变化。

公开(公告)号：US20130271760A1

公开(公告)日：2013-10-17

申请号：US13995094

申请日：2011-12-20

Applicant: Emmanuel Froigneux ,  Philippe De Bettignies

Inventor： Emmanuel Froigneux ,  Philippe De Bettignies

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0248 ,  G01J3/10 ,  G01N21/65

Abstract: The present invention relates to a method and optical device for Raman spectroscopy and for observing a sample, said device including an optical means for superimposing an excitation laser beam having a spectral band B0 and an observation beam having a spectral band BV so as to form a combined excitation and observation incident beam, and an optical separation means arranged in the path of a collected beam coming from scattering on the sample and including a first filtering means, a second filtering means capable of spatially separating said collected beam into a first secondary beam and two tertiary beams, each of which includes a spectral band selected from the spectral band B0 of the laser, the spectral band BV of the observation beam, and the spectral band BR of the Raman scattering beam, respectively.

Abstract translation: 本发明涉及拉曼光谱法和用于观察样品的方法和光学装置，所述装置包括用于叠加具有光谱带B0的激发激光束和具有光谱带BV的观察光束的光学装置，以形成 组合激励和观察入射光束，以及光学分离装置，布置在来自散射在样本上的收集光束的路径中，并且包括第一滤光装置，第二滤光装置，其能够将所述收集的光束空间分离成第一次光束， 两个三级光束分别包括从激光的光谱带B0选择的光谱带，观察光束的光谱带BV和拉曼散射光束的光谱带BR。

公开(公告)号：US08382812B2

公开(公告)日：2013-02-26

申请号：US12473745

申请日：2009-05-28

Applicant: Uk Kang ,  Garri. V Papayan

Inventor： Uk Kang ,  Garri. V Papayan

IPC: A61N5/06

CPC classification number: G01N21/6486 ,  A61B5/0059 ,  A61N5/0601 ,  A61N5/062 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0248 ,  G01J3/10 ,  G01J3/12 ,  G01J3/36 ,  G01J3/4406 ,  G01N21/255 ,  G01N21/29 ,  G01N21/31 ,  G01N21/4738 ,  G01N21/6456 ,  G01N2201/0618

Abstract: The present invention provides an apparatus for photodynamic therapy and fluorescence detection, in which a combined light source is provided to illuminate an object body and a multispectral fluorescence-reflectance image is provided to reproduce various and complex spectral images for an object tissue, thus performing effective photodynamic therapy for various diseases both outside and inside of the body.For this purpose, the present invention provides an apparatus for photodynamic therapy and photodetection, which provides illumination with light of various wavelengths and multispectral images, the apparatus including: an optical imaging system producing an image of an object tissue and transmitting the image to a naked eye or an imaging device; a combined light source including a plurality of coherent and non-coherent light sources and a light guide guiding incident light emitted from the light sources; a multispectral imaging system including at least one image sensor; and a computer system outputting an image of the object tissue to the outside. Thus, the apparatus for photodynamic therapy and photodetection of the present invention can effectively perform the photodynamic therapy and photodetection by means of the combined light source capable of irradiating light having various spectral components to an object tissue and the multispectral imaging system capable of obtaining images from several spectral portions for these various spectral ranges at the same time, thus improving the accuracy of diagnosis and efficiency of the photodynamic therapy.

Abstract translation: 本发明提供了一种用于光动力学治疗和荧光检测的装置，其中提供组合光源以照射物体，并且提供多光谱荧光反射图像以再现对象组织的各种和复杂的光谱图像，从而执行有效 身体各种疾病的光动力治疗。 为此，本发明提供了一种用于光动力学治疗和光电检测的装置，其提供具有各种波长和多光谱图像的光的照明，所述装置包括：光学成像系统，其产生对象组织的图像并将图像发送到裸体 眼睛或成像装置; 包括多个相干和非相干光源的组合光源和引导从光源发射的入射光的光导; 包括至少一个图像传感器的多光谱成像系统; 以及将对象组织的图像输出到外部的计算机系统。 因此，本发明的光动力学治疗和光电检测装置可以通过能够将具有各种光谱成分的光照射到对象组织上的组合光源和能够获得图像的多光谱成像系统而有效地进行光动力学治疗和光电检测 同时对于这些不同光谱范围的几个光谱部分，从而提高光动力疗法的诊断准确性和效率。

公开(公告)号：US08320637B2

公开(公告)日：2012-11-27

申请号：US12850202

申请日：2010-08-04

Applicant: Charles W. Gardner, Jr. ,  David Exline ,  Sara Nedley

Inventor： Charles W. Gardner, Jr. ,  David Exline ,  Sara Nedley

IPC: G06K9/00 ,  G01J3/44

CPC classification number: G06K9/00442 ,  G01J3/02 ,  G01J3/0248 ,  G01J3/10 ,  G01J3/28 ,  G01J3/32 ,  G01N21/27 ,  G01N21/4738 ,  G01N21/55 ,  G01N21/6456 ,  G01N2021/6423 ,  G01N2021/6493 ,  G06K9/4652

Abstract: The present disclosure provides for a method for analyzing treated fingerprints on a document. A sample document is provided. A digital image of the sample document is obtained. The sample document is treated with a reagent and a hyperspectral image of the document is obtained. The hyperspectral image of the document is analyzed to determine a region of interest and a hyperspectal image is obtained of the region of interest. The present disclosure also provides for a system comprising a carrier frame, an imaging station for obtaining a digital image of the sample document, a first processing station for treating the document and a second processing station for developing the treated document, a second imaging station for obtaining a hyperspectral image of at least one of the document and a region of interest of the document, and a robotic subsystem for transporting the document through the system.

Abstract translation: 本公开提供了一种用于分析文档上经处理的指纹的方法。 提供样品文件。 获得样品文件的数字图像。 样品文件用试剂处理，得到文件的高光谱图像。 分析文档的高光谱图像以确定感兴趣的区域，并且获得感兴趣区域的超光谱图像。 本公开还提供了一种系统，其包括载体框架，用于获得样本文档的数字图像的成像站，用于处理文件的第一处理站和用于开发经处理的文档的第二处理站，用于 获得文档中的至少一个文档和感兴趣区域的超光谱图像，以及用于通过系统传送文档的机器人子系统。

公开(公告)号：US20120133944A1

公开(公告)日：2012-05-31

申请号：US13285512

申请日：2011-10-31

Applicant: Masanori Iwasaki

Inventor： Masanori Iwasaki

IPC: G01N21/55

CPC classification number: G01J3/0294 ,  G01J3/0205 ,  G01J3/0248 ,  G01J3/0256 ,  G01J3/1804 ,  G02B27/108 ,  G02B27/1086

Abstract: An optical device includes: an image-forming optical system forming an image of light from a subject; an imaging unit receiving light of the image formed by the image-forming optical system; a reflection spectroscopic device covering a given area in an imaging area of the imaging unit; and a spectrum detection unit detecting a spectroscopic spectrum of light reflected by the reflection spectroscopic device.

Abstract translation: 光学装置包括：成像光学系统，形成来自被摄体的光的图像; 摄像单元，接收由图像形成光学系统形成的图像的光; 覆盖成像单元的成像区域中的给定区域的反射分光装置; 以及频谱检测单元，其检测由所述反射光谱装置反射的光的光谱。