Abstract:
Arrangement for correlation spectroscopy by means of the absorption or emission spectrum of a gas. Light from the gas is arranged to be fed to an analyzer, comprising a light transmitting disc arranged in front of a detector. One side of the disc is supplied with an interference filter which within at least one segment of the filter has transmission characteristics as a function of the wavelength within a determined range of wavelengths. The range of wavelengths corresponds to the absorption or emission spectrum of a searched ingredient in the gas. The other parts of said filter have different transmission characteristics. These parts have different transmission characteristics relative to one another and are arranged to be alternatively inserted into the beam path in front of the detector.
Abstract:
An optical correlator having an optical wedge or other device for producing a spatially dispersed pattern of light in a plane, the light being characterized by zones of relatively high intensity and low intensity corresponding to spectra present in the incident light or the Fourier transform thereof. The dispersed light is alternately or simultaneously passed through a first mask having a pattern of opaque and transparent regions or lines positioned to correlate with the zones of relatively high intensity light and a second mask having a plurality of opaque and transparent regions or lines positioned to correlate with the relatively low intensity zones of light. A photodetector examines the light passing through the masks and produces and output signal which can be analyzed to determine the character of the incident radiation.
Abstract:
The present disclosure relates to a method of quantitatively analyzing fluorescence dyes labeled on extracellular vesicles by using fluorescence correlation spectroscopy and use thereof, in which the number of the labeled fluorescence dyes per extracellular vesicle can be quantified, and thus the labeling efficiency of the fluorescence dyes can be accurately measured. In addition, extracellular vesicles included in an unidentified sample can be quantified using fluorescence dyes of which the labeling efficiency has been measured, and more accurate biodistribution experimental results can be obtained. Thus, the extracellular vesicles can be used to evaluate a therapeutic candidate material and can also be used in the quantification of a target protein in vivo, and thus can be widely used.
Abstract:
A dispersion measurement apparatus 1A includes a pulse forming unit 3, a correlation optical system 4, a photodetection unit 5, and an operation unit 6. The pulse forming unit 3 forms a light pulse train Pb including a plurality of light pulses having time differences and center wavelengths different from each other from a measurement target light pulse Pa output from a pulsed laser light source 2. The correlation optical system 4 receives the light pulse train Pb output from the pulse forming unit 3 and outputs correlation light Pc including a cross-correlation or an autocorrelation of the light pulse train Pb. The photodetection unit 5 detects a temporal waveform of the correlation light Pc output from the correlation optical system 4. The operation unit 6 estimates a wavelength dispersion amount of the pulsed laser light source 2 based on a feature value of the temporal waveform of the correlation light Pc. Thus, a dispersion measurement apparatus, a pulsed light source, a dispersion measurement method, and a dispersion compensation method capable of measuring a wavelength dispersion by a simple configuration are realized.
Abstract:
The invention relates to a spectroscopy array having a first and a second optical ring resonator (1, 3), each provided with a material having an intensity-dependent refraction index. The spectroscopy array further comprises at least one waveguide (2, 4, 7, 8), which is guided along the optical ring resonator at a distance such that the light of a continuous beam laser (2b, 4b, 20) guided in the waveguide (2, 4, 7) can be coupled into the optical ring resonator (1, 3), and a frequency comb generated from the light of the continuous beam laser in the optical ring resonator can be coupled out of the waveguide (2, 4, 8). The optical ring resonators (1, 3) and the at least one waveguide (2, 4, 7, 8) are provided on a shared substrate (9).
Abstract:
The invention features a method of assaying for the interaction of a probe and an unknown target, said method including a) exciting a sample with radiation, the sample including at least one unknown target, at least one probe, and at least one fluorescent tag, b) measuring the fluorescence from a subvolume of the sample, and c) analyzing the fluctuations of the fluorescence.