公开(公告)号：CZ9903213A3

公开(公告)日：2000-04-12

申请号：CZ321399

申请日：1998-03-05

Applicant: BASF AG

Inventor： RITTER KURT ,  AMBERG WILHELM ,  BARLOZZARI TERESA ,  HAUPT ANDREAS ,  JANNSEN BERN ,  KLING ANDREAS

IPC: A61K38/07 ,  A61P35/00 ,  C07K5/103 ,  C07K7/02

公开(公告)号：NO20001077A

公开(公告)日：2000-03-02

申请号：NO20001077

申请日：2000-03-02

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  HERGENROEDER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: A61K31/421 ,  A61K31/426 ,  A61K31/428 ,  A61K31/496 ,  A61K31/505 ,  A61P9/10 ,  A61P9/12 ,  A61P43/00 ,  C07D239/34 ,  C07D239/52 ,  C07D263/38 ,  C07D277/20 ,  C07D277/34 ,  C07D277/68 ,  C07D409/12 ,  C07D239/04

CPC classification number: C07D239/52 ,  C07D239/34 ,  C07D409/12

公开(公告)号：DE19836044A1

公开(公告)日：2000-02-17

申请号：DE19836044

申请日：1998-08-10

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KETTSCHAU GEORG ,  HERGENROEDER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: C07D251/22 ,  A61K31/505 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K45/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P13/12 ,  A61P35/00 ,  A61P43/00 ,  C07D239/34 ,  C07D239/52 ,  C07D239/60 ,  C07D239/70 ,  C07D251/52 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D491/048 ,  C07D495/04 ,  C07D239/28 ,  C07D405/02 ,  C07D251/14 ,  C07D213/60 ,  C07D227/06 ,  C07D247/02 ,  C07D215/16 ,  C07C235/08

Abstract: 2-(Hetero)aryloxy-3-(oxoalkoxy or oxoalkylthio)-alkanoic acid derivatives (I) are new. Carboxylic acid derivatives of formula (I) are new. R1 = tetrazolyl or -COR; R = OR9, N-bonded 5-membered heteroaryl, -O(CH2)pS(O)kR10 or -NHSO2R11; R9 = H, alkali(ne earth) metal or organic ammonium cation or (all optionally substituted) cycloalkyl, 1-8C alkyl, alkenyl, alkynyl, benzyl or phenyl; k = 0-2; p = 1-4; R10 = T, cycloalkyl, alkenyl, alkynyl or optionally substituted phenyl; T = 1-4C alkyl; R11 = T, alkenyl, alkynyl or cycloalkyl (all optionally substituted by OT, ST and/or Ph); or optionally substituted phenyl; X, Y = CH or N; Z' = N or CR12; R2, R3 = H, OH, NH2, NHT, N(T)2, halo, T', 2-4C alkenyl, 2-4C alkynyl, OT' or ST; T' = T or 1-4C haloalkyl; R12 = H or T; or R2 + R12 or R3 + R12 = group completing a 5- or 6-membered cycloalkane or cycloalkene ring (optionally substituted and optionally having one or more CH2 replaced by O, S, NH or NT); R4, R5 = phenyl or naphthyl (both optionally substituted; or linked together in the ortho position via a direct bond, CH2, CH2CH2CH=CH, O, S, SO2, NH or N(alkyl)); or optionally substituted cycloalkyl; R6 = cycloalkyl, phenyl, naphthyl or 5- or 6-membered heteroaryl (containing 1-3 N and/or one S or O), all optionally substituted; R7, R8 = H or T; W = O or S; alkenyl or alkynyl moieties have 3-6C and cycloalkyl moieties 3-8C. Independent claims are included for: (1) the use of alcohols of formula (IV) as intermediates for endothelin receptor antagonists; (2) the use of a fragment of formula (IV') or (V) as a structural component of endothelin receptor antagonists; and (3) new intermediates of formula (VI). R18, R19 = T; or R18 + R19 = (CH2)3 or (CH2)4 (both optionally substituted by 1-4 Me).

公开(公告)号：CZ9900619A3

公开(公告)日：2000-02-16

申请号：CZ61999

申请日：1997-09-02

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KLING ANDREAS ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  HERGENROEDER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: A61K31/505 ,  A61P9/12 ,  C07D237/22 ,  C07D239/34 ,  C07D239/60 ,  C07D239/70 ,  C07D491/04

公开(公告)号：ZA9805277B

公开(公告)日：1999-12-20

申请号：ZA9805277

申请日：1998-06-18

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  KLING ANDREAS ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  HERGENROEDER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIAN

IPC: C07D251/16 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/505 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61P7/02 ,  A61P9/02 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/08 ,  A61P13/12 ,  A61P25/06 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07C247/12 ,  C07D213/68 ,  C07D237/14 ,  C07D237/16 ,  C07D239/34 ,  C07D239/52 ,  C07D239/56 ,  C07D239/60 ,  C07D239/70 ,  C07D239/80 ,  C07D239/95 ,  C07D241/18 ,  C07D251/22 ,  C07D251/34 ,  C07D251/52 ,  C07D253/06 ,  C07D403/12 ,  C07D491/048 ,  C07D ,  A61K ,  C07C

CPC classification number: C07D403/12 ,  C07C247/12 ,  C07D237/16 ,  C07D239/34 ,  C07D239/52 ,  C07D239/70 ,  C07D251/22

公开(公告)号：NO996268D0

公开(公告)日：1999-12-17

申请号：NO996268

申请日：1999-12-17

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  KLING ANDREAS ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  HERGENROEDER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: C07D251/16 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/505 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61P7/02 ,  A61P9/02 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/08 ,  A61P13/12 ,  A61P25/06 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07C247/12 ,  C07D213/68 ,  C07D237/14 ,  C07D237/16 ,  C07D239/34 ,  C07D239/52 ,  C07D239/56 ,  C07D239/60 ,  C07D239/70 ,  C07D239/80 ,  C07D239/95 ,  C07D241/18 ,  C07D251/22 ,  C07D251/34 ,  C07D251/52 ,  C07D253/06 ,  C07D403/12 ,  C07D491/048 ,  C07D

Abstract: The invention relates to carboxylic acid derivatives of formula (I) wherein the constituents have the meaning given in the description. The invention also relates to the production of said derivatives, and to their use as endothelin receptor antagonists.

公开(公告)号：BG102770A

公开(公告)日：1999-11-30

申请号：BG10277098

申请日：1998-09-15

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  KLING ANDREAS ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  BAUMANN ERNST ,  UNGER LILIANE ,  RASCHACK MANFRED ,  HERGENRODER STEFAN ,  SCHULT SABINE

IPC: A61K31/00 ,  A61K31/47 ,  A61K31/505 ,  A61P9/00 ,  A61P9/12 ,  A61P13/00 ,  A61P13/12 ,  C07D215/22 ,  C07D215/227 ,  C07D239/34 ,  C07D239/60 ,  C07D401/12 ,  C07D403/12

Abstract: The invention relates to derivatives of caboxylic acids withthe formulawhere the radicals have the meanings listed in the descriptionwell as to their preparation and to application as medicamentousforms.10 claims

公开(公告)号：NO994364A

公开(公告)日：1999-11-09

申请号：NO994364

申请日：1999-09-09

Applicant: BASF AG ,  BASF BIORESEARCH CORP

Inventor： RITTER KURT ,  AMBERG WILHELM ,  BARLOZZARI TERESA ,  HAUPT ANDREAS ,  JANSSEN BERND ,  KLING ANDREAS

IPC: A61K38/00 ,  A61P35/00 ,  A61P35/02 ,  C07K5/10 ,  C07K5/103 ,  C07K7/02 ,  A61K38/07

CPC classification number: C07K5/101 ,  A61K38/00 ,  C07K5/1027 ,  C07K7/02

公开(公告)号：AT185349T

公开(公告)日：1999-10-15

申请号：AT96925744

申请日：1996-07-12

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANSSEN BERND ,  ULRICH KARL ,  KLING ANDREAS ,  MUELLER STEFAN ,  RITTER KURT ,  ZIERKE THOMAS

IPC: C07K1/02 ,  C07K1/12 ,  C07K5/06 ,  C07K5/078 ,  C07K5/08 ,  C07K5/083 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06

Abstract: PCT No. PCT/EP96/03073 Sec. 371 Date Jan. 13, 1998 Sec. 102(e) Date Jan. 13, 1998 PCT Filed Jul. 12, 1996 PCT Pub. No. WO97/05162 PCT Pub. Date Feb. 13, 1997A process for preparing pentapeptides of the formula I where A and R1-R3 have the stated meanings, comprises assembling the pentapeptide stepwise starting from a prolinamide of the formula II where R1 and R2 have the abovementioned meanings, and eliminating the group -NR1R2 by hydrolysis where appropriate the peptide obtained in this way.

公开(公告)号：SK25999A3

公开(公告)日：1999-09-10

申请号：SK25999

申请日：1997-09-02

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KLING ANDREAS ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  HERGENRODER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: A61K31/505 ,  A61K31/506 ,  A61K31/519 ,  A61P9/04 ,  A61P9/08 ,  A61P9/12 ,  A61P43/00 ,  C07C59/66 ,  C07C69/734 ,  C07D239/34 ,  C07D239/52 ,  C07D239/60 ,  C07D239/70 ,  C07D491/04 ,  C07D491/048

Abstract: The invention relates to carboxylic acid derivatives of the formula Iwhere the radicals have the meanings stated in the description, and to their use as drugs.