公开(公告)号：US20070007444A1

公开(公告)日：2007-01-11

申请号：US11451621

申请日：2006-06-13

Applicant: Thomas Voigt ,  David Tuschel ,  Chenhui Wang

Inventor： Thomas Voigt ,  David Tuschel ,  Chenhui Wang

IPC: G01N21/25

CPC classification number: G01N21/6428 ,  G01J3/02 ,  G01J3/027 ,  G01J3/10 ,  G01N21/65 ,  G01N2021/6417 ,  G01N2021/6471 ,  G01N2201/067

Abstract: In one embodiment, the disclosure relates to a method for determining illumination parameters for a sample, the method may include obtaining an absorption band of the sample; obtaining an emission band of the sample and determining the illumination parameters for the sample as a function of the absorption band and the emission band of the sample.

公开(公告)号：US07141378B2

公开(公告)日：2006-11-28

申请号：US11173814

申请日：2005-07-01

Applicant: Steven C. Miller ,  Paul B. Comita ,  Evan F. Cromwell ,  Christopher B. Shumate

Inventor： Steven C. Miller ,  Paul B. Comita ,  Evan F. Cromwell ,  Christopher B. Shumate

IPC: C12Q1/68 ,  G01N33/53

CPC classification number: G01N33/582 ,  B82Y5/00 ,  B82Y10/00 ,  C12Q1/6816 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6445 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6432 ,  G01N2021/6441 ,  G01N2021/6478 ,  G01N2021/6484 ,  G01N2201/067 ,  G01N2201/0697 ,  G01N2201/0833 ,  C12Q2563/107 ,  C12Q2561/119

Abstract: Methods, apparatus, and system, implementing and using techniques for detecting a presence of one or more target analytes in particular regions of interest of one or more samples. One or more samples including objects and one or more target analytes are provided. Some of the target analytes are labeled with a fluorophore and are bound to some of the objects in the samples. The samples are illuminated with fluorescence inducing light and fluorescent light is collected from one or more regions of the one or more samples. At least one anisotropy measurement of the samples is performed to identify regions of interest where one or more target analytes are bound to the objects. The collected fluorescent light from the regions of interest is analyzed to determine a presence of target analytes that are bound to the objects in the one or more samples.

Abstract translation: 方法，装置和系统，实施和使用用于检测一个或多个样品的特定感兴趣区域中一种或多种目标分析物的存在的技术。 提供了一个或多个样品，包括物体和一种或多种目标分析物。 一些目标分析物用荧光团标记，并且与样品中的某些对象结合。 用荧光诱导光照射样品，并从一个或多个样品的一个或多个区域采集荧光。 进行样品的至少一个各向异性测量以识别一个或多个目标分析物与物体结合的感兴趣区域。 分析来自感兴趣区域的收集的荧光以确定与一个或多个样品中的物体结合的目标分析物的存在。

公开(公告)号：US07045757B1

公开(公告)日：2006-05-16

申请号：US11097161

申请日：2005-04-04

Applicant: David Tuschel ,  John Maier ,  Joseph Demuth

Inventor： David Tuschel ,  John Maier ,  Joseph Demuth

IPC: H01L27/00

CPC classification number: G01N21/6428 ,  G01J3/02 ,  G01J3/027 ,  G01J3/10 ,  G01N21/65 ,  G01N2021/6417 ,  G01N2021/6471 ,  G01N2201/067

Abstract: In one embodiment, the disclosure relates to a method for determining illumination parameters for a stained sample, the method may include providing a stained sample and obtaining an absorption band of the sample; obtaining an emission band of the sample and determining the illumination parameters for the sample as a function of the absorption band and the emission band of the sample.

Abstract translation: 在一个实施方案中，本公开涉及一种用于确定染色样品的照明参数的方法，所述方法可包括提供染色样品并获得样品的吸收带; 获得样品的发射带，并根据样品的吸收带和发射带确定样品的照射参数。

公开(公告)号：US20060003320A1

公开(公告)日：2006-01-05

申请号：US11173814

申请日：2005-07-01

Applicant: Steven Miller ,  Paul Comita ,  Evan Cromwell ,  Christopher Shumate

Inventor： Steven Miller ,  Paul Comita ,  Evan Cromwell ,  Christopher Shumate

IPC: C12Q1/70 ,  C12Q1/68 ,  G01N33/53

CPC classification number: G01N33/582 ,  B82Y5/00 ,  B82Y10/00 ,  C12Q1/6816 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6445 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6432 ,  G01N2021/6441 ,  G01N2021/6478 ,  G01N2021/6484 ,  G01N2201/067 ,  G01N2201/0697 ,  G01N2201/0833 ,  C12Q2563/107 ,  C12Q2561/119

Abstract: Methods, apparatus, and system, implementing and using techniques for detecting a presence of one or more target analytes in particular regions of interest of one or more samples. One or more samples including objects and one or more target analytes are provided. Some of the target analytes are labeled with a fluorophore and are bound to some of the objects in the samples. The samples are illuminated with fluorescence inducing light and fluorescent light is collected from one or more regions of the one or more samples. At least one anisotropy measurement of the samples is performed to identify regions of interest where one or more target analytes are bound to the objects. The collected fluorescent light from the regions of interest is analyzed to determine a presence of target analytes that are bound to the objects in the one or more samples.

公开(公告)号：US20040218174A1

公开(公告)日：2004-11-04

申请号：US10833717

申请日：2004-04-27

Applicant: Olympus Corporation

Inventor： Yasuaki Natori

IPC: G01N021/64

CPC classification number: G01N21/6458 ,  G01N21/39 ,  G01N21/6428 ,  G01N2021/6423 ,  G01N2021/6441 ,  G01N2201/067

Abstract: A laser beam is scanned on a sample while a wavelength of the laser beam is varied. Quantity of fluorescence from the sample is detected. Absorption wavelength spectral characteristic data of fluorescence indicators whose kinds are known and which dye the sample is acquired. The absorption wavelength spectral characteristic data of a site to be discriminated is compared with the absorption wavelength spectral characteristic data of each of the fluorescence indicators of known kinds. The kind of fluorescence indicator dyeing the site to be discriminated is discriminated from a result of the comparison.

Abstract translation: 在激光束的波长变化的同时，在样品上扫描激光束。 检测来自样品的荧光量。 荧光指示器的吸收波长光谱特征数据，其种类是已知的，并且获取样品的染料。 将要鉴别的部位的吸收波长光谱特征数据与已知种类的每个荧光指示剂的吸收波长光谱特征数据进行比较。 对待鉴定场所的荧光指示剂的种类与比较的结果进行区分。

公开(公告)号：US5245408A

公开(公告)日：1993-09-14

申请号：US647624

申请日：1991-01-11

Applicant: Jonathan D. Cohen

Inventor： Jonathan D. Cohen

IPC: G01J9/02

CPC classification number: G01J9/02 ,  G01J2009/0211 ,  G01J2009/0223 ,  G01N2021/1759 ,  G01N2201/067

Abstract: An apparatus is described which detects the presence or absence of coherent light and provides an estimate of the coherent light's wavelength. The apparatus employs a common-path "polarization interferometer" in which the two linear polarization paths act as interferometer legs. Electro-optic modulation is used to effect periodic differential path length changes in the interferometer. The apparatus performs synchronous time-integrating detection on the light emerging from the interferometer to measure coherent contributions in the presence of obscuring incoherent light.

Abstract translation: 描述了一种检测相干光的存在或不存在并提供相干光的波长的估计的装置。 该装置采用公共路径“偏振干涉仪”，其中两个线性偏振路径用作干涉仪腿。 电光调制用于影响干涉仪中的周期差分路径长度变化。 该装置对从干涉仪出射的光进行同步时间积分检测，以在存在模糊非相干光的情况下测量相干贡献。

公开(公告)号：US5076699A

公开(公告)日：1991-12-31

申请号：US345858

申请日：1989-05-01

Applicant: Frederick M. Ryan ,  Milton S. Gottlieb

Inventor： Frederick M. Ryan ,  Milton S. Gottlieb

IPC: G01N21/27 ,  G01J3/26 ,  G01J3/28 ,  G01N21/35

CPC classification number: G01N21/3504 ,  G01J3/26 ,  G01J2003/2886 ,  G01N2021/3513 ,  G01N2201/067

Abstract: A remote gas measuring apparatus and method utilizes the optical absorption line characteristics to determine an amount of gas of interest as may exist in an area under study. The remote gas measuring apparatus includes a source of electromagnetic radiation that can be projected toward the area in question and a light collecting arrangement. The light signal received is coupled to a fast light switch modulator which modulates the light signal to a first frequency. A second modulating arrangement modulates the light signal to a second frequency and includes a birefringent etalon device having a periodic spacing equal to the periodicity of the absorption lines of the gas of interest. The second modulating means is further effective such that, when an electric field is applied thereto the transmission spectra associated with the light signal is shifted between spectra which coincide with the absorption lines and spectra which fall between the absorption lines. The light signal from the etalon device is then conditioned and input to a detector configuration which distinguishes between the light signal at the first frequency and the light signal at the second frequency in order to determine at least a quantity of the gas of interest.

公开(公告)号：KR101603909B1

公开(公告)日：2016-03-16

申请号：KR1020140133121

申请日：2014-10-02

Applicant: 광주과학기술원

Inventor： 송종인 ,  송하준

IPC: G01N21/3581 ,  G01N21/39 ,  H01S3/02 ,  H01S3/10 ,  G01J1/42 ,  G01J1/44

CPC classification number: G01J3/108 ,  G01N21/3581 ,  G01N21/39 ,  G01N2201/06113 ,  G01N2201/067 ,  G02F1/3534 ,  G02F2203/13 ,  H01S3/0085 ,  H01S3/2308 ,  G01J1/429 ,  G01J1/44 ,  H01S3/02 ,  H01S3/10

Abstract: 본발명의실시예는광혼합기법을이용한연속파테라헤르츠발생및 검출장치로서, 단일파장을가지며서로다른주파수의연속파레이저광원을출력하여광신호를발생시키는제1 및제2 광원부, 제1 광원부에서발생한광신호에대해주파수를천이시키는제1 광전위상변조기및 제2 광원부에서발생한광신호에대해주파수를천이시키는제2 광전위상변조기, 상기제1 광전위상변조기에의해주파수가천이된광신호와제2 광원부에서발생된광신호를받아증폭하는제1 광증폭기및 상기제2 광전위상변조기에의해주파수가천이된광신호와제1 광원부에서발생된광신호를받아증폭하는제2 광증폭기, 상기제1 광증폭기에의해증폭된광신호를테라헤르츠파로발생시키는광전변환기, 상기제2 광증폭기에의해증폭된광신호가들어가며, 상기광전변환기에의해발생한테라헤르츠파를광혼합을통해전기적신호로변환하는포토믹서, 상기제1 및제2 광증폭기에서보내진광신호를결합하는광검출기및 상기광검출기를통해생성된전기신호를필터링하는필터부를포함하고, 상기전치증폭기를통해전달된전기신호와상기광검출기와대역통과필터를통해전달된전기신호를비교하여동일한주파수를갖는위상잡음을제거하는것을특징으로한다.

Abstract translation: 本发明的实施例涉及一种使用光混合技术产生和检测连续波太赫兹的装置，其包括：输出具有单一波长和不同频率的连续波激光光源的第一和第二光源单元， 以产生光信号; 第一光电相位调制器，其移动由第一光源单元产生的光信号的频率;以及第二光电相位调制器，其移位由第二光源单元产生的光信号的频率; 第一光放大器，其接收和放大由第一光电调制器频移的光信号和由第二光源单元产生的光信号;以及第二光放大器，其接收并放大由第二光电子 调制器和由第一光源单元产生的光信号; 光电转换器，将由第一光放大器放大的光信号转换成太赫兹波; 接收由第二光放大器放大的光信号并将由光电转换器产生的太赫兹波转换成电信号的光混合器; 耦合由第一和第二光放大器发送的光信号的光检测器; 以及滤波器单元，其对通过光电检测器产生的电信号进行滤波，其中通过前置放大器传送的电信号与通过光电检测器传送的电信号和带通滤波器进行比较，使得具有相同的相位噪声 频率被删除

公开(公告)号：KR1020140107223A

公开(公告)日：2014-09-04

申请号：KR1020147014742

申请日：2012-11-02

Applicant: 세노 메디컬 인스투르먼츠 인코포레이티드

Inventor： 헤르조그도날드지. ,  밀러토마스지.

IPC: A61B8/00 ,  G01N29/24

CPC classification number: A61B5/0095 ,  A61B5/0035 ,  A61B5/0091 ,  A61B5/14551 ,  A61B5/6844 ,  A61B5/7425 ,  A61B5/7445 ,  A61B5/7475 ,  A61B8/0825 ,  A61B8/4281 ,  A61B8/4444 ,  A61B8/4483 ,  F04C2270/041 ,  G01N21/1702 ,  G01N2201/067 ,  G01N2201/068 ,  G01N2201/0826 ,  G02B6/3624

Abstract: 핸드헬드 광음향 프로브는 초음파 트랜스듀서 어레이 및, 입력부를 제공하는 파이버 번들로 형성된 제1 단부 및 출력부를 제공하는 제2 원위 단부를 갖는 광 파이버들을 포함한다. 광 바 가이드는 동일한 평면 상에 광 파이버들의 원위 단부를 보유한다. 하나 이상의 광학 윈도우들은 결합제 및 광 파이버들의 원위 단부들 사이에서의 접촉을 방지하고, 그에 따라 파이버들로부터 방출한 광에 응답하여 결합제의 잠재적인 음향 효과를 저감시키도록 광 바 가이드와 연관되며 그로부터 이격될 수 있다. 음향 렌즈의 외부 표면을 둘러싸는 반사성 금속을 갖는 TiO
2 로 도핑된 실리콘 고무 음향 렌즈가 제공될 수 있다. 핸드헬드 프로브 셸은 광 바 가이드, 초음파 트랜스듀서 어레이, 및 음향 렌즈를 하우징한다.

公开(公告)号：KR101289253B1

公开(公告)日：2013-07-24

申请号：KR1020120006709

申请日：2012-01-20

Applicant: 한국과학기술원

Inventor： 손훈 ,  이현석 ,  양진열

IPC: G01N29/04 ,  G01B17/04

CPC classification number: G01N21/1702 ,  G01M3/38 ,  G01N29/04 ,  G01N29/041 ,  G01N29/2418 ,  G01N29/34 ,  G01N2021/1706 ,  G01N2201/067 ,  G01N2201/08 ,  G01N2291/0289 ,  G01N2291/2634

Abstract: PURPOSE: A device and a method for sensing damage to a pipe are provided to precisely sense the heated pipe utilized for a nuclear power facility or a chemical plant facility. CONSTITUTION: A device (1) for sensing damage to a pipe includes an ultrasonic wave supply unit (10), an ultrasonic wave receiving unit (20), and an analysis unit (30). The ultrasonic wave supply unit generates ultrasonic signals to the pipe. The ultrasonic wave receiving unit receives the ultrasonic signals of the pipe. The analysis unit analyzes the ultrasonic signals received by the ultrasonic wave receiving unit, thereby determining whether the pipe is damaged or not. The ultrasonic wave supplying unit includes a generating unit (11), a supplying unit (12), and an excitation unit (13). The generating unit generates laser beams. The excitation unit includes an excitation pipe, an excitation lens, an excitation plate, and an excitation strip. [Reference numerals] (11) Generating unit; (13) Excitation unit; (21) Light source unit; (23) Sensing unit; (24) Receiving unit; (30) Analysis unit

Abstract translation: 目的：提供一种用于检测管道损坏的装置和方法，用于精确检测用于核电设施或化工厂设备的加热管道。 构成：用于感测管道损坏的装置（1）包括超声波供给单元（10），超声波接收单元（20）和分析单元（30）。 超声波供给部向管道生成超声波信号。 超声波接收单元接收管道的超声波信号。 分析单元分析由超声波接收单元接收的超声波信号，从而确定管道是否损坏。 超声波供给单元包括发电单元（11），供给单元（12）和励磁单元（13）。 发电机组产生激光束。 激励单元包括激励管，激发透镜，激励板和激励条。 （附图标记）（11）发电机组; （13）励磁机组; （21）光源单元; （23）感应单元; （24）接收单位; （30）分析单位