公开(公告)号：US06355198B1

公开(公告)日：2002-03-12

申请号：US09004583

申请日：1998-01-08

Applicant: Enoch Kim ,  Younan Xia ,  Milan Mrksich ,  Rebecca J. Jackman ,  Xiao-Mei Zhao ,  Stephen P. Smith ,  Mara G. Prentiss ,  George M. Whitesides ,  Christian Marzolin

Inventor： Enoch Kim ,  Younan Xia ,  Milan Mrksich ,  Rebecca J. Jackman ,  Xiao-Mei Zhao ,  Stephen P. Smith ,  Mara G. Prentiss ,  George M. Whitesides ,  Christian Marzolin

IPC: B29C3910

CPC classification number: B81C1/00206 ,  A61K47/6957 ,  B01J19/0046 ,  B01J2219/00382 ,  B01J2219/00416 ,  B01J2219/0043 ,  B01J2219/00466 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00713 ,  B29C31/04 ,  B29C33/42 ,  B29C37/0053 ,  B29C39/24 ,  B29C43/021 ,  B29C67/246 ,  B29D11/00346 ,  B29D11/00663 ,  B29K2105/0002 ,  B29L2011/0016 ,  B81B2201/0214 ,  B81C1/00031 ,  B81C99/0085 ,  B81C2201/034 ,  B82Y30/00 ,  C40B60/14 ,  G01N21/7703 ,  G01N2021/7776 ,  G02B6/138 ,  H05K3/0079 ,  H05K3/061

Abstract: Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or nonplanar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface. Waveguide arrays, combinatorial chemical or biochemical libraris, etc. can be made. Differences in refractive index of waveguide and cladding can be created by subjecting the waveguide and cladding, made of indentical prepolymeric material, to different polymerization or cross-linking conditions. Interferometers are defined by coupling arrays of waveguides, where coupling can be controlled by altering the difference in refractive index between cladding and waveguide at any desired location of the array. Alteration and refractive index can be created photochemically, chemically, or the like. Sensors also are disclosed, including biochemical sensors.

Abstract translation: 化学或生物化学活性剂或其它物质通过提供具有轮廓表面的微胶体并在基底表面上形成结构的化学或生物化学活性剂或流体前体而在基底表面上图案化。 化学或生物化学活性剂或流体前体也可以从敷料器中的凹陷转移到基底表面。 衬底表面可以是平面或非平面的。 聚合物结构，无机陶瓷和盐等的流体前体可用于在表面形成图案化聚合物制品，无机盐和陶瓷，反应离子蚀刻掩模等。 制品可以形成为包括横向尺寸小于约1毫米或更小的部分的图案。 涂抹器的压痕图案可以用于将单独的，不同的化学或生物化学活性剂或流体前体转移到基底表面的分离的，分离的区域。 可以制作波导阵列，组合化学或生化图谱等。 波导和包层的折射率差异可以通过将由凹凸预聚物材料制成的波导和包层进行不同的聚合或交联条件来产生。 干涉仪通过耦合波导阵列来定义，其中可以通过改变阵列的任何所需位置处的包层和波导之间的折射率差来控制耦合。 改变和折射率可以通过光化学，化学等方式产生。 还公开了传感器，包括生化传感器。

公开(公告)号：US20020022124A1

公开(公告)日：2002-02-21

申请号：US09946115

申请日：2001-09-04

Applicant: Washington University

Inventor： Rodney S. Ruoff

IPC: B32B003/00 ,  G03C001/76

CPC classification number: G03F7/00 ,  B81C99/008 ,  B81C2201/034 ,  C23C14/0005 ,  C23C14/042 ,  Y10T428/24372 ,  Y10T428/24802 ,  Y10T428/24893 ,  Y10T428/25 ,  Y10T428/252 ,  Y10T428/259 ,  Y10T428/2982

Abstract: Micron-sized particles are produced in quantity by one of various methods, including generally the steps of preparing a substrate surface through a lithographic process, the surface being characterized by defining a plurality of elements, depositing a layer of particle material on the substrate surface including the elements, processing the substrate surface to isolate the material deposited on the elements, and separating the particles from the elements. The size and shape of the elements predetermine the size and shape of the particles. The elements may comprise, inter alia, pillars of photoresist or spaces on the substrate surrounded and defined by photoresist.

Abstract translation: 通过各种方法之一量产生微米尺寸的颗粒，包括通常通过平版印刷工艺制备衬底表面的步骤，该表面的特征在于限定多个元件，在衬底表面上沉积颗粒材料层，包括 元件，处理衬底表面以分离沉积在元件上的材料，并将颗粒与元件分离。 元素的大小和形状预先决定了粒子的大小和形状。 这些元件尤其可以包括光致抗蚀剂的支柱或被光致抗蚀剂包围和限定的衬底上的空间。

公开(公告)号：US20010029983A1

公开(公告)日：2001-10-18

申请号：US09796666

申请日：2001-02-28

Inventor： Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

IPC: B32B003/10 ,  F16K011/20

CPC classification number: B29C51/00 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/0655 ,  B33Y80/00 ,  B81B5/00 ,  B81B2201/036 ,  B81B2201/054 ,  B81C1/00119 ,  B81C2201/019 ,  B81C2201/034 ,  C12Q1/6874 ,  F04B43/043 ,  F15C1/06 ,  F15C5/00 ,  F16K11/20 ,  F16K13/00 ,  F16K31/126 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0048 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0094 ,  Y10T137/0491 ,  Y10T137/0497 ,  Y10T137/2224 ,  Y10T137/87249 ,  Y10T156/10 ,  Y10T428/24479 ,  Y10T428/24744 ,  C12Q2535/125

Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

公开(公告)号：TWI448585B

公开(公告)日：2014-08-11

申请号：TW099106469

申请日：2010-03-05

Applicant: 尼瓦克斯 法爾公司 ,  NIVAROX-FAR S.A.

Inventor： 卡森 皮爾 ,  CUSIN, PIERRE ,  高菲爾 克萊兒 ,  GOLFIER, CLARE ,  第柏 尚菲利浦 ,  THIEBAUD, JEAN-PHILIPPE

IPC: C25D1/10

CPC classification number: C25D1/10 ,  B29C33/3842 ,  B81C99/009 ,  B81C2201/034

公开(公告)号：TW200936524A

公开(公告)日：2009-09-01

申请号：TW097140230

申请日：2008-10-18

Applicant: 康寧公司 CORNING INCORPORATED

Inventor： 代尼金伯來固亥耳 DIANE KIMBERLIE GUILFIYLE ,  保史詹塔克 PAUL JOHN SHUSTACK ,  吳隆明 LUNG-MING WU

IPC: C03C ,  B81C

CPC classification number: C03C17/28 ,  B81B2201/058 ,  B81C1/00071 ,  B81C2201/034 ,  C03B19/06 ,  C03C11/00 ,  C03C17/04 ,  C03C17/324 ,  C03C23/0005

Abstract: 本發明提出的是形成結構化燒結製品的方法,包括:提供包含可燒結顆粒材料和黏接劑的混合物,根據黏接劑的總樹脂含量,此黏接劑包含至少50%重量比的熱塑性黏接劑材料和輻射固化黏接劑材料;使用鑄模將此混合物成形以形成結構;冷卻此結構或讓此結構變冷以凝結結構;從鑄模分離此結構;照射此結構,以便至少部分固化輻射固化黏接劑材料;及去除黏接並燒結此結構以形成結構化燒結製品。成形包括形成含有一種或多個敞開通道的結構,而燒結可以包含跟至少一個額外的結構接觸一起燒結,以便覆蓋或封閉這些通道。

Abstract in simplified Chinese: 本发明提出的是形成结构化烧结制品的方法,包括:提供包含可烧结颗粒材料和黏接剂的混合物,根据黏接剂的总树脂含量,此黏接剂包含至少50%重量比的热塑性黏接剂材料和辐射固化黏接剂材料;使用铸模将此混合物成形以形成结构;冷却此结构或让此结构变冷以凝结结构;从铸模分离此结构;照射此结构,以便至少部分固化辐射固化黏接剂材料;及去除黏接并烧结此结构以形成结构化烧结制品。成形包括形成含有一种或多个敞开信道的结构,而烧结可以包含跟至少一个额外的结构接触一起烧结,以便覆盖或封闭这些信道。

公开(公告)号：US20230404777A1

公开(公告)日：2023-12-21

申请号：US18043438

申请日：2021-08-27

Applicant: CAMBRIDGE ENTERPRISE LIMITED

Inventor： Sohini KAR-NARAYAN ,  Qingshen JING ,  Jehangir CAMA ,  Liam IVES ,  Vikas KHANDUJA

IPC: A61F2/46 ,  G01L1/14 ,  G01L1/02 ,  B81B3/00 ,  B81B7/00 ,  B81C1/00

CPC classification number: A61F2/468 ,  G01L1/142 ,  G01L1/02 ,  B81B3/0075 ,  B81B7/0025 ,  B81C1/00674 ,  B81C2203/032 ,  B81B2203/0338 ,  B81B2203/04 ,  B81B2207/115 ,  B81C2201/0185 ,  B81C2201/034 ,  B81B2201/05

Abstract: A microfluidic sensor comprising: a first substrate; a second substrate; a cavity formed between the first substrate and the second substrate, the cavity comprising a reservoir portion and a channel portion extending from the reservoir portion; a capacitive element disposed between the first substrate and the second substrate, the capacitive element being at least partially disposed in the channel portion of the cavity; and a dielectric sensing liquid provided in the reservoir portion. Upon application of a force to the first substrate adjacent the reservoir portion, the reservoir portion is configured to deform and displace the sensing liquid along the channel portion, so as to change the capacitance of the capacitive element within the channel portion.

公开(公告)号：US20190185629A1

公开(公告)日：2019-06-20

申请号：US16323481

申请日：2017-08-03

Applicant: MicroOptx Inc.

Inventor： Tingrui Pan ,  Edward Aaron Cohen ,  Ben Bazor ,  Gaomai Yang

IPC: C08J5/12 ,  C08J7/18 ,  C08G81/02 ,  B81C1/00

CPC classification number: C08J5/128 ,  B81C1/00071 ,  B81C3/001 ,  B81C2201/034 ,  B81C2203/036 ,  C08F265/00 ,  C08F265/02 ,  C08F265/04 ,  C08F287/00 ,  C08F291/00 ,  C08F293/00 ,  C08G81/027 ,  C08J7/123 ,  C08J7/16 ,  C08J7/18 ,  C08J2367/02 ,  C08J2433/14 ,  C08J2433/16

Abstract: Some polymeric devices, as described herein, can be made of a first layer and a second layer bonded together with one or more microfluidic channels defined internal to the device. The first layer and the second layer may each include a substrate and a polymer bonded to the substrate. The two layers may be bonded through a polymer network that interpenetrates the polymers in the first and second layers. This disclosure also describes methods of bonding together polymeric articles. The methods include diffusing polymerizable monomers and radical forming initiators into the surfaces of one or both of the polymers, putting the surfaces into contact, and initiating polymerization to create a polymer network that interpenetrates the polymers.

公开(公告)号：US20180265354A1

公开(公告)日：2018-09-20

申请号：US15981393

申请日：2018-05-16

Applicant: Infineon Technologies AG

Inventor： Alexander Breymesser ,  Andre Brockmeier ,  Carsten von Koblinski ,  Francisco Javier Santos Rodriguez

IPC: B81C99/00 ,  H01L21/56 ,  C03B11/08 ,  C03B40/02 ,  H01L23/31 ,  H01L23/29 ,  G02B6/12

CPC classification number: B81C99/008 ,  B81C2201/034 ,  C03B11/082 ,  C03B40/02 ,  C03B2215/07 ,  C03B2215/79 ,  G02B2006/12038 ,  H01L21/56 ,  H01L23/291 ,  H01L23/3178 ,  H01L2924/0002 ,  Y10T428/24479 ,  H01L2924/00

Abstract: A semiconductor element is formed in a mesa portion of a semiconductor substrate. A cavity is formed in a working surface of the semiconductor substrate. The semiconductor substrate is brought in contact with a glass piece made of a glass material and having a protrusion. The glass piece and the semiconductor substrate are arranged such that the protrusion extends into the cavity. The glass piece is bonded to the semiconductor substrate. The glass piece is in-situ bonded to the semiconductor substrate by pressing the glass piece against the semiconductor substrate. During the pressing a temperature of the glass piece exceeds a glass transition temperature and the temperature and a force exerted on the glass piece are controlled to fluidify the glass material and after re-solidifying the protrusion completely fills the cavity.

公开(公告)号：US09981844B2

公开(公告)日：2018-05-29

申请号：US13415376

申请日：2012-03-08

Applicant: Alexander Breymesser ,  Andre Brockmeier ,  Carsten von Koblinski ,  Francisco Javier Santos Rodriguez

Inventor： Alexander Breymesser ,  Andre Brockmeier ,  Carsten von Koblinski ,  Francisco Javier Santos Rodriguez

IPC: H01L21/78 ,  B32B3/30 ,  C03B19/00 ,  C03B23/02 ,  B81C99/00 ,  C03B40/02 ,  C03B11/08 ,  H01L23/31 ,  H01L21/56 ,  H01L23/29 ,  G02B6/12

CPC classification number: B81C99/008 ,  B81C2201/034 ,  C03B11/082 ,  C03B40/02 ,  C03B2215/07 ,  C03B2215/79 ,  G02B2006/12038 ,  H01L21/56 ,  H01L23/291 ,  H01L23/3178 ,  H01L2924/0002 ,  Y10T428/24479 ,  H01L2924/00

Abstract: A source material, which is based on a glass, is arranged on a working surface of a mold substrate. The mold substrate is made of a single-crystalline material. A cavity is formed in the working surface. The source material is pressed against the mold substrate. During pressing a temperature of the source material and a force exerted on the source material are controlled to fluidify source material. The fluidified source material flows into the cavity. Re-solidified source material forms a glass piece with a protrusion extending into the cavity. After re-solidifying, the glass piece may be bonded to the mold substrate. On the glass piece, protrusions and cavities can be formed with slope angles less than 80 degrees, with different slope angles, with different depths and widths of 10 micrometers and more.

公开(公告)号：US20170232189A1

公开(公告)日：2017-08-17

申请号：US15443484

申请日：2017-02-27

Applicant: Cam Med LLC

Inventor： Yanzhe Qin ,  Zhifei Ge

IPC: A61M5/142 ,  A61M5/145 ,  B32B37/12 ,  A61M5/168

CPC classification number: A61M5/14248 ,  A61M5/14586 ,  A61M5/16881 ,  A61M39/24 ,  A61M2005/14252 ,  A61M2205/3334 ,  A61M2205/35 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2207/00 ,  B29C65/08 ,  B29C65/4825 ,  B29C66/301 ,  B29C66/474 ,  B32B37/12 ,  B32B2535/00 ,  B81B2201/036 ,  B81C1/00158 ,  B81C2201/034 ,  F04B43/043 ,  F04B53/10 ,  F16K2099/008 ,  F16K2099/0094

Abstract: A flexible patch pump for controllable accurate subcutaneous delivery of one or more medicaments to a patient includes a laminated layered structure. The pump may have a rigid reservoir layer including a number of rigid reservoirs disposed in a flexible material; a flexible microfluidic layer including a compliant membrane for sealing the rigid reservoirs, a network of microfluidic channels connecting the rigid reservoirs, and a number of inlet and/or outlet valves corresponding to the rigid reservoirs; and a flexible-rigid electronic circuit layer including a number of individually-addressable actuators. In operation, the rigid reservoirs may contain medicament that is dispensed in precise volumes at appropriate times due, for to example, to a pressure change in an addressed reservoir caused by displacement of the compliant membrane or other actuation element.