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    SONOPHORETIC DRUG DELIVERY SYSTEM
    281.
    发明申请
    SONOPHORETIC DRUG DELIVERY SYSTEM 审中-公开
    SONOPHORETIC DRUG交付系统

    公开(公告)号：WO1997034656A1

    公开(公告)日：1997-09-25

    申请号：PCT/US1997003856

    申请日：1997-03-13

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  OGDEN, John, E.

    IPC: A61M37/00

    CPC classification number: A61M37/0092

    Abstract: The present invention relates to devices and methods for enhancing the rate and efficacy of permeation of a drug into and through skin and into the circulatory system utilizing ultrasound. A transducer receives electrical signals from a generator and transforms it into ultrasound at a preselected frequency. The ultra sound is transmitted from the transducer to the application site via an acoustic transmission line. In a closed loop embodiment a sensor, e.g. a temperature sensor, provides a feedback signal via a control electronic circuit to the generator.

    NON-INVASIVE MEASUREMENT OF OPTICALLY ACTIVE COMPOUNDS
    282.
    发明申请
    NON-INVASIVE MEASUREMENT OF OPTICALLY ACTIVE COMPOUNDS 审中-公开
    光学活性化合物的非侵入性测量

    公开(公告)号：WO1997034521A1

    公开(公告)日：1997-09-25

    申请号：PCT/US1997003801

    申请日：1997-03-12

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  PEZZANITI, J., Larry ,  LINDBERG, John, M.

    IPC: A61B05/00

    CPC classification number: A61B5/14558 ,  G01N21/21

    Abstract: An apparatus (8) and a process of determining the concentration of an optically active compound in a biological sample are provided. The process measures the entire polarization state of the sample and compares the measured polarization state of the sample to the polarization state of a sample having a known concentration of that compound. The polarization state of the sample is measured after manipulating the polarization state of light entering and leaving the sample and detecting the light leaving the sample. The apparatus (8) contains a source of light (10), a sample holder (14) for holding the biological sample, a detector (18), a first polarization manipulator (12) between the light source (10) and the sample holder (14), a second polarization manipulator (16) between the sample holder (14) and an analyzer (20) to correlate detected signals with concentration of the optically active compound.

    Abstract translation: 提供了一种设备（8）和确定生物样品中光学活性化合物浓度的方法。 该过程测量样品的整个极化状态，并将样品的测量的偏振状态与具有该化合物的已知浓度的样品的偏振状态进行比较。 在处理进入和离开样品的光的偏振状态并检测离开样品的光之后测量样品的偏振状态。 所述装置（8）包含光源（10），用于保持所述生物样品的样品保持器（14），在所述光源（10）和所述样品架之间的检测器（18），第一偏振机械手（12） （14），所述样品保持器（14）和分析器（20）之间的第二偏振操纵器（16），用于将检测到的信号与所述光学活性化合物的浓度相关联。

    PROCESS FOR THE PREPARATION AND ISOLATION OF ATRACURIUM BESYLATE
    284.
    发明申请
    PROCESS FOR THE PREPARATION AND ISOLATION OF ATRACURIUM BESYLATE 审中-公开
    苯甲酸钠的制备和分离方法

    公开(公告)号：WO1997030033A1

    公开(公告)日：1997-08-21

    申请号：PCT/US1997002196

    申请日：1997-02-12

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  CHAMBERLIN, Steven, A. ,  BHATIA, Ashok, V. ,  DAVIS, Deborah, A. ,  DRENGLER, Keith, A.

    IPC: C07D217/20

    CPC classification number: C07D217/20

    Abstract: A process of producing atracurium besylate that substantially reduces the level of impurities in the final product and avoids the repeated use of ether is provided. In accordance with such a process, N,N'-4,10-dioxa-3,11-dioxotridecylene-1,13-bis-tetrahydropapaverine (Compound 1), methyl benzenesulfonate and a catalytic amount of an insoluble base in a solvent are combined to form a reaction mixture that is maintained for a period of time sufficient for atracurium besylate formation. The reaction mixture is then filtered to remove the insoluble base and the atracurium besylate is precipitated.

    Abstract translation: 提供了大大降低最终产品中杂质水平并避免重复使用乙醚的苯磺酸阿曲库铵的方法。 按照这种方法，N，N'-4,10-二氧杂-3,11-二氧代二亚甲基-1,13-双 - 四氢吡哆胺（化合物1），苯磺酸甲酯和催化量的不溶碱在溶剂中是 合并形成反应混合物，该反应混合物保持足够长的苯磺酸阿卡库铵形成时间。 然后将反应混合物过滤以除去不溶性碱，并沉淀苯甲酸阿卡古铵。

    POLYUNSATURATED FATTY ACIDS AND FATTY ACID ESTERS FREE OF STEROLS AND PHOSPHORUS COMPOUNDS
    285.
    发明申请
    POLYUNSATURATED FATTY ACIDS AND FATTY ACID ESTERS FREE OF STEROLS AND PHOSPHORUS COMPOUNDS 审中-公开
    多余脂肪酸和脂肪酸不含固体和磷酸盐化合物

    公开(公告)号：WO1997027275A1

    公开(公告)日：1997-07-31

    申请号：PCT/US1997001439

    申请日：1997-01-24

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  MAZER, Terrence, Bruce ,  MILLER, Robert, A. ,  MCCOMBS, Charles, A.

    IPC: C11C03/10

    CPC classification number: C11B3/12 ,  C11B7/0008 ,  C11C3/04 ,  C11C3/10

    Abstract: Fatty acid esters such as those containing arachidonic acid (AA) and docosahexaenoic acid (DHA) derived from lipid mixtures and prepared with reduced levels of sterols and phosphorus. A preferred embodiment of the invention comprises extracting lipids from egg with methanol; separating lipids including sterols from insoluble egg components; submitting the methanolic solution of lipids to transesterification and subsequent neutralization to convert the lipids to methyl esters of said free fatty acids together with sterols; separating the said sterols and esters from an aqueous phase including phosphorus compounds formed in the transesterification; subjecting the said fatty acid esters and sterols to distillation to separate sterols from the fatty acid esters; and subjecting the said esters to transesterification in the presence of glycerol to produce triglycerides of said esters thereof including that of AA and DHA wherein the resulting triglycerides contain reduced quantities of sterols and phosphorus.

    Abstract translation: 脂肪酸酯如含有花生四烯酸（AA）和二十二碳六烯酸（DHA）的脂肪酸酯衍生自脂质混合物，并用降低的固醇和磷水平制备。 本发明的优选实施方案包括用甲醇从鸡蛋中提取脂质; 分离包括固醇的脂质不溶于蛋组分; 将脂质的甲醇溶液进行酯交换和随后的中和以将脂质与甾醇一起转化成所述游离脂肪酸的甲酯; 将所述甾醇和酯与包含在酯交换中形成的磷化合物的水相分离; 对所述脂肪酸酯和甾醇进行蒸馏以将甾醇与脂肪酸酯分离; 并在所述甘油存在下使所述酯进行酯交换反应以产生所述酯的甘油三酯，其包括AA和DHA的甘油三酸酯，其中所得甘油三酸酯含有减少量的甾醇和磷。

    IMPROVED PROCESS FOR THE PREPARATION OF ALKYL OR ARYL ALDEHYDE INTERMEDIATES
    288.
    发明申请
    IMPROVED PROCESS FOR THE PREPARATION OF ALKYL OR ARYL ALDEHYDE INTERMEDIATES 审中-公开
    制备烷基或芳基醛中间体的改进方法

    公开(公告)号：WO1997023439A1

    公开(公告)日：1997-07-03

    申请号：PCT/US1996019432

    申请日：1996-12-10

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  MONTE, William, T.

    IPC: C07C45/59

    CPC classification number: C07C45/60 ,  C07C45/59

    Abstract: A process of preparing alkyl or aryl aldehydes using Grignard protected aldehydes and alkyl or benzyl halides is provided. The Grignard protected aldehyde is reacted with the halide in the presence of a copper catalyst and the product of that reaction is selectively deprotected by hydrolysis.

    Abstract translation: 提供了使用格氏保护的醛和烷基或苄基卤制备烷基或芳基醛的方法。 Grignard保护的醛在铜催化剂存在下与卤化物反应，该反应的产物通过水解选择性去保护。

    ORAL ADMINISTRATION OF BENEFICIAL AGENTS
    289.
    发明申请
    ORAL ADMINISTRATION OF BENEFICIAL AGENTS 审中-公开
    受益人的口头管理

    公开(公告)号：WO1997023190A1

    公开(公告)日：1997-07-03

    申请号：PCT/US1996019942

    申请日：1996-12-12

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  MAZER, Terrence, B. ,  WALTON, Joseph, E. ,  GECKLE, Ronita, K. ,  PIONTEK, Joseph

    IPC: A61J07/00

    CPC classification number: A61J9/006 ,  A47G21/183 ,  A61J7/00 ,  A61J7/0038 ,  A61J7/0046 ,  A61J9/00

    Abstract: Apparatus for adding a beneficial agent to a liquid for drinking during oral administration includes a support structure that defines a retention pocket with liquid penetrable walls. At least one beneficial agent is contained in the retention pocket. The support structure is constructed to be placed in an imperforate walled zone through which a liquid for drinking passes before oral ingestion thereof. In the novel method a support structure with a retention pocket containing at least one beneficial agent is provided and placed in a vessel containing a liquid for drinking such that the at least one beneficial agent is in contact with the liquid for drinking.

    Abstract translation: 用于在口服给药期间将有益剂添加到用于饮用的液体中的装置包括限定具有液体可穿透壁的保留袋的支撑结构。 保留口袋中含有至少一种有益剂。 支撑结构被构造成放置在无孔的围壁区域中，用于饮用的液体在其口服摄取之前通过。 在新颖方法中，提供了具有包含至少一种有益剂的保留袋的支撑结构，并将其置于含有用于饮用的液体的容器中，使得至少一种有益剂与用于饮用的液体接触。

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