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    METHOD AND SYSTEM FOR QUANTIFYING TIMING DISCREPANCIES BETWEEN INSPIRATORY EFFORT AND VENTILATORY ASSIST
    21.
    发明申请
    METHOD AND SYSTEM FOR QUANTIFYING TIMING DISCREPANCIES BETWEEN INSPIRATORY EFFORT AND VENTILATORY ASSIST 审中-公开
    用于量化感觉作用与通气辅助之间的时间差异的方法和系统

    公开(公告)号：WO2013071404A1

    公开(公告)日：2013-05-23

    申请号：PCT/CA2012/001043

    申请日：2012-11-16

    Applicant: ST. MICHAEL'S HOSPITAL

    Inventor： SINDERBY, Christer ,  COMTOIS, Norman ,  BECK, Jennifer ,  EMTELL, Pär ,  KOCK, Michael

    IPC: A61B5/08 ,  A61B5/0488 ,  A61M16/00

    CPC classification number: A61M16/0051 ,  A61B5/04001 ,  A61B5/04884 ,  A61B5/08 ,  A61B5/0809 ,  A61B5/742 ,  A61M16/0069 ,  A61M16/021 ,  A61M2016/0021 ,  A61M2205/502 ,  A61M2210/1014 ,  A61M2230/40 ,  A61M2230/60

    Abstract: The present disclosure relates to a method and a system for quantifying timing discrepancies between inspiratory effort and ventilatory assist. A trigger error is determined by comparing a start time of neural inspiration with a start time of the ventilatory assist. A cycling-off error is determined by comparing an end time of the neural inspiration with an end time of the ventilatory assist. The ventilatory assist is synchronized when the trigger error is lower than a first threshold and the cycling-off error is lower than a second threshold. The ventilatory assist may also be characterized in terms of early or late trigger and of early or late cycling-off. A trigger of a ventilator may be adjusted according to the trigger error and a cycling-off of a ventilator may be adjusted according to the cycling-off error.

    Abstract translation: 本公开涉及一种用于量化吸气作用和通气辅助之间的时间差异的方法和系统。 通过将神经吸引的开始时间与通气辅助的开始时间进行比较来确定触发误差。 通过将神经吸引的结束时间与通气辅助的结束时间进行比较来确定循环关闭错误。 当触发错误低于第一阈值并且循环关闭错误低于第二阈值时，通气辅助被同步。 呼吸辅助的特征还可以是早期或晚期触发以及早期或晚期循环。 呼吸机的触发器可以根据触发误差进行调节，并且可以根据循环关闭错误来调整呼吸机的循环。

    METHOD AND SYSTEM FOR MEASURING CHANGES IN INSPIRATORY LOAD
    25.
    发明申请
    METHOD AND SYSTEM FOR MEASURING CHANGES IN INSPIRATORY LOAD 审中-公开
    用于测量感觉负荷变化的方法和系统

    公开(公告)号：WO2010081230A1

    公开(公告)日：2010-07-22

    申请号：PCT/CA2010/000056

    申请日：2010-01-15

    Applicant: ST. MICHAEL'S HOSPITAL ,  SINDERBY, Christer ,  BECK, Jennifer

    Inventor： SINDERBY, Christer ,  BECK, Jennifer

    IPC: A61B5/08 ,  A61B5/0488 ,  A61B5/091

    CPC classification number: A61B5/091 ,  A61B5/037 ,  A61B5/0488 ,  A61B5/087

    Abstract: A method and system for measuring changes in inspiratory load of a patient's respiratory system during mechanical ventilation. The method and system calculate a first relation between a measured inspiratory airway pressure and a measured electrical activity of respiratory muscle, and a second relation between a measured inspiratory volume and the measured electrical activity. A load index is calculated from the first and second relations. Changes in inspiratory load are determined based on the load index.

    Abstract translation: 一种用于测量机械通气期间患者呼吸系统吸气负荷变化的方法和系统。 方法和系统计算测量的吸气气道压力和测量的呼吸肌电活动之间的第一关系，以及测量的吸气体积与所测量的电活动之间的第二关系。 从第一关系和第二关系计算负荷指数。 根据负荷指数确定吸气负荷的变化。

    ULTRASONIC EVALUATION OF VENOUS STRUCTURES
    26.
    发明申请
    ULTRASONIC EVALUATION OF VENOUS STRUCTURES 审中-公开
    超声波结构的超声波评估

    公开(公告)号：WO2007140593A1

    公开(公告)日：2007-12-13

    申请号：PCT/CA2007/000986

    申请日：2007-06-01

    Applicant: ST. MICHAEL'S HOSPITAL ,  DONNELLY, Sandra ,  MURADALI, Derek

    Inventor： DONNELLY, Sandra ,  MURADALI, Derek

    IPC: A61B8/08 ,  A61B8/06 ,  A61M1/14

    CPC classification number: A61B8/04 ,  A61B5/02 ,  A61B5/02007 ,  A61B5/1075 ,  A61B8/06 ,  A61B8/0858 ,  A61B8/14 ,  A61B8/4483 ,  A61B8/461 ,  A61B8/5207 ,  A61B8/5223 ,  A61M1/3655

    Abstract: Provided are methods and systems for detecting a maturing arterio-venous fistula comprising a vein. An exemplary method comprises determining a wall thickness of the fistula and a lumen diameter of the fistula vein using a high frequency ultrasound imaging system. A blood pressure of the subject is determined. A circumferential vessel wall stress is determined from the measured blood pressure, the wall thickness of the fistula and a determined radius of the measured diameter of the fistula. The determined circumferential vessel stress is compared to a predetermined threshold stress to determine if the fistula is mature.

    Abstract translation: 提供了用于检测包括静脉的成熟的动静脉瘘的方法和系统。 示例性方法包括使用高频超声成像系统确定瘘管的壁厚和瘘静脉的管腔直径。 测定受试者的血压。 根据测量的血压，瘘管的壁厚和确定的瘘直径的半径来确定圆周血管壁应力。 将确定的圆周容器应力与预定的阈值应力进行比较，以确定瘘管是否成熟。

    SYSTEMS, DEVICES AND METHODS FOR MODULATING A RESPIRATORY DRIVE OF A PATIENT
    27.
    发明申请
    SYSTEMS, DEVICES AND METHODS FOR MODULATING A RESPIRATORY DRIVE OF A PATIENT 审中-公开

    公开(公告)号：WO2020056511A1

    公开(公告)日：2020-03-26

    申请号：PCT/CA2019/051329

    申请日：2019-09-19

    Applicant: ST. MICHAEL'S HOSPITAL

    Inventor： SINDERBY, Christer ,  BECK, Jennifer ,  COMTOIS, Norman

    IPC: A61M16/00 ,  A61M16/10

    Abstract: A mechanical ventilation system comprises a plurality of ventilation therapy sub-systems. Each of the ventilation therapy sub-systems is adapted to assist a respiratory function of the patient. The system also comprises a detector of the respiratory drive of the patient, an operator interface receiving one or more control parameters, and a main controller. The main controller assigns a therapeutic contribution to each of the ventilation therapy sub-systems based on the respiratory drive of the patient and on the control parameters. The controller modulates the respiratory drive of a patient by controlling each of the plurality of the ventilation therapy sub-systems according to its assigned therapeutic contribution. Distinct ventilation therapy sub-systems may apply negative pressure on the abdomen of the patient, deliver a non-pressurizing inspiratory flow to the patient, or induce a positive pressure in the airways of the patient.

    DEVICE AND METHOD FOR CONTROLLING VENTILATORY ASSIST
    30.
    发明申请
    DEVICE AND METHOD FOR CONTROLLING VENTILATORY ASSIST 审中-公开
    用于控制通气辅助的装置和方法

    公开(公告)号：WO2017113017A1

    公开(公告)日：2017-07-06

    申请号：PCT/CA2016/051549

    申请日：2016-12-29

    Applicant: ST. MICHAEL'S HOSPITAL

    Inventor： SINDERBY, Christer ,  BECK, Jennifer ,  COMTOIS, Norman

    IPC: A61M16/00 ,  A61B5/08 ,  A61B5/091 ,  A61M16/10

    CPC classification number: A61B5/091 ,  A61M16/024 ,  A61M2016/0027 ,  A61M2016/0039

    Abstract: A device and method for controlling a level of ventilatory assist applied to a patient by a mechanical ventilator measures, during patient's assisted breath, an inspiratory volume V assist produced by both the patient and the mechanical ventilator, an inspiratory volume V vent contributed by the mechanical ventilator, and an inspiratory assist pressure P vent produced by the mechanical ventilator. A first relation between pressure P vent and volume V assist and a second relation between pressure P vent and volume V vent are calculated. Using the first and second relations, a ratio is determined between pressure P vent at volume V vent and pressure P vent at volume V assist , with volume V vent equal to volume V assist , for a plurality of volumes V vent and V assist . Values of P vent are multiplied by the corresponding calculated ratios to calculate a third relation between a predicted inspiratory pressure P pred and volume V assist. The mechanical ventilator is responsive to the third relation to control the level of ventilatory assist.

    Abstract translation: 用于在患者的辅助呼吸期间通过机械通气机控制施加到患者的通气辅助的水平的装置和方法在患者的辅助呼吸期间测量由患者的辅助呼吸产生的吸气体积V辅助 患者和机械呼吸机，由机械呼吸机产生的吸气体积V vent和由机械呼吸机产生的吸气辅助压力P vent。 压力P vent与体积V辅助之间的第一关系和压力P vent与体积V vent之间的第二关系计算。 使用第一和第二关系，确定体积V处的压力P vent和压力P vent N之间的比率。 具有等于​​体积V 辅助的体积V vent ，对于多个体积V vent 和V 辅助 。 将P vent的值乘以相应的计算比率以计算预测的吸气压力P pred和体积V assist之间的第三关系。 机械呼吸机响应第三个关系来控制通气辅助水平。

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