公开(公告)号：JP2000119216A

公开(公告)日：2000-04-25

申请号：JP28945899

申请日：1999-10-12

Applicant: UCB SA

Inventor： TWEEDY HARREL E

IPC: B01J27/02 ,  B01J31/02 ,  B01J31/10 ,  C07B61/00 ,  C07C67/08 ,  C07C67/62 ,  C07C69/54 ,  C08G63/91

Abstract: PROBLEM TO BE SOLVED: To provide an improved method for producing a (meth)acrylate ester and polyester (meth)acrylate. SOLUTION: This method is carried out by reacting an acrylic acid or methacrylic acid with a monohydroxy-containing compound or polyhydroxy- containing compound in the presence of catalyst and polymerization inhibitor in the presence or absence of a solvent by using a microwave energy as a heating means, thus obtaining an acrylate ester, methacrylate ester, polyester acrylate or polyester methacrylate.

公开(公告)号：JPH07149639A

公开(公告)日：1995-06-13

申请号：JP22833194

申请日：1994-09-22

Applicant: UCB SA

Inventor： ERUNSUTO URUFUERUTO ,  JIYAN GOBERU ,  ARUMA GOUAA ,  ERIKU KOSUMAN

IPC: C07D207/27 ,  A61K31/40 ,  A61K31/4015 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22

Abstract: PURPOSE: To provide a method for treating an anxiety by using an anxiolytic agent capable of differentiating the anxiety shown by a healthy living body from a morbid anxiety, and having a large margin between an anxiolytic dosage and a neurotoxic dosage. CONSTITUTION: This method for treating an anxiety is to administer (S)-(-)-α- ethyl-2-oxo-1-pyrrolidine acetamide in an amount necessary for the treatment of a patient requiring the treatment through an oral or a parenteral route. As the anxiety requiring the treatment, the anxiety caused by a stress after an acute trauma and the anxiety induced by the withdrawal of chronically administered benzodiazepine, are cited. The daily dose is 5-70 mg/kg, and an average dose of 250 mg twice daily is effective for alleviating the anxiety in human. This dosage does not develop an adverse effect on a memory even if slightly, and also not develop an awkward motor nerve disturbance.

公开(公告)号：JPH0726125A

公开(公告)日：1995-01-27

申请号：JP3977494

申请日：1994-03-10

Applicant: UCB SA

Inventor： RIYUTSUKU MOAN ,  DANIERU MAETENZU ,  JIYAN RIYUTSUKU DARON ,  JIYAN MARII ROUTSU

IPC: B05D1/04 ,  B05D7/24 ,  C08G59/32 ,  C08G59/40 ,  C08G63/181 ,  C08G63/183 ,  C08L33/04 ,  C08L33/14 ,  C08L63/00 ,  C08L67/00 ,  C08L67/02 ,  C09D133/04 ,  C09D133/14 ,  C09D163/00 ,  C09D167/00 ,  C09D167/02

公开(公告)号：JPH06271811A

公开(公告)日：1994-09-27

申请号：JP119993

申请日：1993-01-07

Applicant: UCB SA

Inventor： JIYAN MARII OEBEKE ,  DANIERU MAETEN ,  MITSUSHIERU BODOUURU ,  JIYAN MARII RUTSU

IPC: C09D5/00 ,  C09D5/03 ,  C09D133/08 ,  C09D163/08 ,  C09D167/02

公开(公告)号：JPH029873A

公开(公告)日：1990-01-12

申请号：JP10327989

申请日：1989-04-21

Applicant: UCB SA

Inventor： JIYANNRUTSUKU DARONZU ,  PIEERU YAKOBUSU ,  YOHAN MARUTENZU ,  POORU TASUTENHOIE ,  IBAN BANDEN EINDE ,  AUGUSUTO BAN GIISERU

IPC: C07D307/33 ,  B01J21/08 ,  B01J23/89 ,  B01J35/10 ,  C07B61/00 ,  C07D307/32 ,  C07D315/00

公开(公告)号：JPH021857A

公开(公告)日：1990-01-08

申请号：JP31833088

申请日：1988-12-16

Applicant: UCB SA

Inventor： BURUNO RORANDO ,  YAN BANDENDORIESUSHIE ,  KIYASARIIN YAKUSU

IPC: G03F7/004 ,  G03F7/022 ,  G03F7/023 ,  H01L21/027

Abstract: PURPOSE: To enhance the contrast and selectivity of a pattern by incorporating a specified arom. polycyclic sulfonic acid (salt) or arom. polycylic carboxylic acid (salt). CONSTITUTION: This compsn. contains a phenolic resin, a diazoquinone compd. and free arom. polycyclic sulfonic acid or carboxylic acid (A) and/or its ammonium salt (B) and/or its halide. When the salt B is contained, a component represented by the formula is used as the cation of the salt B and an acid other than amino acids is used as the acid component. In the formula, each of R1 -R4 is H, a 1-4C alkyl, etc. Naphthalenesulfonic acid, naphthalenecarboxylic acid, diazoquinonesulfonic acid or diazoquinonecarboxylic acid is preferably used as the acid A. After a layer of this compsn. is exposed to UV, a protective layer is preferably formed by selectively adding an Si compd.

公开(公告)号：JPH01313467A

公开(公告)日：1989-12-18

申请号：JP10903089

申请日：1989-04-27

Applicant: UCB SA

Inventor： ERITSUKU KOSUMEN ,  JIYANNPIEERU GEERUTO ,  JIYAN KOBEERU ,  FUIRITSUPU MISHIERU ,  ERUNSUTO URUFUEERU

IPC: C07D233/56 ,  A61K31/415 ,  A61K31/4164 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P25/02 ,  A61P29/00 ,  C07D233/54 ,  C07D233/64

Abstract: New substituted 1-(1H-imidazol-4-yl)alkyl-benzamides and their salts, processes for the preparation thereof and pharmaceutical compositions. These compounds have the formula wherein R1, R2=hydrogen or C1-C4-alkyl, R3=hydrogen, amino, hydroxyl, C1-C4-alkyl or C1-C4-hydroxyalkyl, R4=hydrogen or C1-C4-alkyl, or R3R4N=pyrrolidino, piperidino or morpholino, R5 and R6=hydrogen, hydroxyl, C1-C4-alkyl or C1-C4-alkoxy, at least one of R5 and R6 being other than hydrogen. These compounds are prepared either by reacting a nitrogen compound with an alkyl 1-(1H-imidazol-4-yl)alkyl-benzoate or with a 1-(1H-imidazol-4-yl)alkyl-benzoic acid, or by hydrolyzing in an acid medium a 2-hydroxy-3-[1-(1H-imidazol-4-yl)alkyl]-benzonitrile. The compounds have anti-ischemic and alpha 2-adrenoceptor agonist activities.

公开(公告)号：JPS6416589A

公开(公告)日：1989-01-20

申请号：JP13003388

申请日：1988-05-27

Applicant: UCB SA

Inventor： BOREN ARETSUKUSU ,  GOBEERU JIYAN ,  BURUFUEERU ERUNSUTO

IPC: C12N15/09 ,  A61K38/00 ,  C07K4/12 ,  C07K14/775 ,  C12N1/16 ,  C12N1/20 ,  C12N5/10 ,  C12N15/00 ,  C12N15/12 ,  C12P21/00 ,  C12P21/02 ,  C12R1/19 ,  C12R1/865

Abstract: The present invention provides recombinant DNA sequences comprising a sequence which codes for human proapolipoprotein A-I wherein part of the natural coding sequence has been replaced by a DNA fragment coding for the same amino acids but consisting of a different nucleotide sequence such as to reduce or prevent formation of hairpins, cloning and expression vectors containing these DNA sequences, cell cultures or microorganisms transformed with these expression vectors and processes using the same for the production of proapolipoprotein A-I.

公开(公告)号：JPS63132876A

公开(公告)日：1988-06-04

申请号：JP27814487

申请日：1987-11-02

Applicant: UCB SA

Inventor： ERITSUKU KOSEMENTO ,  JIYAN PIEERU GEERUTSU ,  JIYAN GOBEERU ,  FUIRITSUPU MISHIERU

IPC: A61K31/415 ,  A61K31/4164 ,  A61K31/495 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D233/54 ,  C07D233/58 ,  C07D233/64 ,  C07D405/06 ,  C07D413/06

公开(公告)号：JPS6324248A

公开(公告)日：1988-02-01

申请号：JP11165887

申请日：1987-05-07

Applicant: UCB SA

Inventor： RORANDO BURUNO ,  BURANKUKEN OUGASUTO

IPC: G03F7/008 ,  G03F7/26 ,  G03F7/30 ,  G03F7/36