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公开(公告)号：KR101004362B1
公开(公告)日：2010-12-28
申请号：KR1020100024699
申请日：2010-03-19
Applicant: 한국생명공학연구원 , 가톨릭대학교 산학협력단
Inventor： 박영우 , 조기원 , 유석호 , 유정 , 김동진 , 윤선하 , 송은정 , 이은경 , 오진미 , 조규원 , 조미라 , 김호연 , 박미경 , 오혜좌 , 박진실 , 우윤주
CPC classification number: C07K14/525 , C07K14/70575 , C07K2319/32 , Y10S514/814 , Y10S514/885 , Y10S514/886 , Y10S514/903
Abstract: PURPOSE: A TNFR2-TWEAKR fusion protein is provided to ensure antagonistic function to TNFR2 and TWEAK which is a cause of autoimmune arthritis and to reduce IL-17 secretion. CONSTITUTION: A composition for preventing and treating autoimmune disease contains fusion protein of a fragment having an extracellular region of TNFR2(Tumor necrosis factor receptor type 2) or TNFR2 and a fragment having an extracellular region of TWEAKR(TNF-related weak inducer of apoptosis receptor) protein or TWEAKR as an active ingredient. The extracellular region fragment of TNFR2 has a polypeptide having an amino acid sequence of sequence number 2. The fusion protein has an amino acid sequence of sequence number 1.
Abstract translation: 目的：提供TNFR2-TWEAKR融合蛋白，以确保TNFR2和TWEAK的拮抗作用，这是导致自身免疫性关节炎和降低IL-17分泌的原因。 构成：用于预防和治疗自身免疫性疾病的组合物含有具有TNFR2细胞外区域（2型肿瘤坏死因子受体）或TNFR2的片段的融合蛋白和具有TWEAKR胞外区域的片段（TNF相关的凋亡受体弱诱导剂 ）蛋白质或TWEAKR作为活性成分。 TNFR2的细胞外区片段具有序列号为2的氨基酸序列的多肽。融合蛋白具有序列号1的氨基酸序列。
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公开(公告)号：KR1020120129120A
公开(公告)日：2012-11-28
申请号：KR1020110047180
申请日：2011-05-19
Applicant: 가톨릭대학교 산학협력단
IPC: A61K31/203 , A61K9/127 , A61P29/00 , A61P37/00
Abstract: PURPOSE: An immunotherapeutic agent of a nanosome form containing retinoic acid is provided to ensure high retinoic acid transfer rate to a target site and to effectively suppress TNF-alpha and IL-17 generation. CONSTITUTION: An immunotherapeutic agent of a nanosome form contains a cell suspension and retinoic acid. The cell suspension is a cell membrane in eukaryotic cell lysate. The immune diseases are autoimmune diseases, inflammatory diseases, and cell, tissue, or organ transplantation rejection. A method for manufacturing the immunotherapeutic agent comprises: a step of suspending eukaryotic cells; a step of passing the suspension solution through a membrane filter; a step of adding retinoic acid to the solution; and a step of isolating immunotherapeutic agent of a nanosome from the solution. [Reference numerals] (AA) RA-containing nanosome
Abstract translation: 目的：提供含有视黄酸的纳米体形式的免疫治疗剂，以确保目标部位的高视黄酸转移率，有效抑制TNF-α和IL-17的产生。 构成：纳米体形式的免疫治疗剂含有细胞悬浮液和视黄酸。 细胞悬浮液是真核细胞裂解物中的细胞膜。 免疫疾病是自身免疫疾病，炎性疾病，细胞，组织或器官移植排斥。 制备免疫治疗剂的方法包括：使真核细胞悬浮的步骤; 使悬浮液通过膜过滤器的步骤; 向溶液中加入视黄酸的步骤; 以及从溶液中分离纳米体的免疫治疗剂的步骤。 （AA）RA的纳米体
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公开(公告)号：KR1020120095046A
公开(公告)日：2012-08-28
申请号：KR1020110014438
申请日：2011-02-18
Applicant: 가톨릭대학교 산학협력단
CPC classification number: A61K38/20 , A61K48/005 , Y10S424/81
Abstract: PURPOSE: A composition for preventing or treating immunological rejection diseases including IL-27 is provided to alleviate the immunological rejection disease by suppressing rejection towards the host after the transplanted cell or organ is engrafted. CONSTITUTION: A composition for preventing or treating immunological rejection diseases includes IL-27 as an active component. The IL-27 has amino acid sequence described in the sequence number 1(SEQ ID NO:1). The composition for preventing or treating immunological rejection diseases includes a vector containing polynucleotide which codes the IL-27 as an active ingredient. The polynucleotide has the base sequence described in the sequence number 2. The immunological rejection disease is graft-versus-host disease.
Abstract translation: 目的：提供一种用于预防或治疗免疫排斥疾病（包括IL-27）的组合物，用于通过在移植的细胞或器官移植后抑制对宿主的排斥来减轻免疫排斥疾病。 构成：用于预防或治疗免疫排斥疾病的组合物包括IL-27作为活性成分。 IL-27具有序列号1（SEQ ID NO：1）中描述的氨基酸序列。 用于预防或治疗免疫排斥疾病的组合物包括编码IL-27作为活性成分的含有多核苷酸的载体。 多核苷酸具有序列号2中描述的碱基序列。免疫排斥疾病是移植物抗宿主病。
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24.发明公开유럽종 포도의 씨 추출물 및 레바미피드를 포함하는 류마티스 관절염의 예방 또는 치료용 약학 조성물 有权用于预防或治疗包含VITIS VINIFERA PIP提取物和雷巴米地的含盐酸盐的药物组合物
公开(公告)号：KR1020120032649A
公开(公告)日：2012-04-06
申请号：KR1020100094091
申请日：2010-09-29
Applicant: 한림제약(주) , 가톨릭대학교 산학협력단
Abstract: PURPOSE: A pharmaceutical composition containing rebamipide and Vitis vinifera seed extract is provided to prevent or treat rheumatoid arthritis. CONSTITUTION: A pharmaceutical composition for preventing or treating rheumatoid arthritis contains rebamipide and Vitis vinifera seed extract. The pharmaceutical composition is orally administered in the form of a tablet or capsule. The dosage of rebamipide is 0.3 mg/kg a day.
Abstract translation: 目的：提供含有瑞巴派特和葡萄种子提取物的药物组合物，以预防或治疗类风湿性关节炎。 构成：用于预防或治疗类风湿性关节炎的药物组合物含有瑞巴派特和葡萄籽种子提取物。 药物组合物以片剂或胶囊的形式口服给药。 瑞巴派特的剂量为每天0.3mg / kg。
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公开(公告)号：KR1020120021239A
公开(公告)日：2012-03-08
申请号：KR1020110086459
申请日：2011-08-29
Applicant: 가톨릭대학교 산학협력단
IPC: A61K31/4704 , A61P35/00
CPC classification number: A61K31/4704
Abstract: PURPOSE: A composition containing rebamipide for preventing or treating cancer or immune diseases is provided to suppress Th17 cell differentiation and to enhance immune regulatory T cell activity. CONSTITUTION: A composition for preventing or treating cancer or immune diseases contains rebamipid compounds or pharmaceutically acceptable salt thereof as an active ingredient. The immune diseases include autoimmune disease, inflammatory disease, and transplantation rejection. A method for reducing or suppressing differentiation of immature T cells into Th17 cell in vitro comprises a step of treating rebamipid compounds or pharmaceutically acceptable salt thereof.
Abstract translation: 目的：提供含有用于预防或治疗癌症或免疫疾病的瑞巴派特的组合物以抑制Th17细胞分化并增强免疫调节性T细胞活性。 构成：用于预防或治疗癌症或免疫疾病的组合物含有雷米帕派化合物或其药学上可接受的盐作为活性成分。 免疫疾病包括自身免疫性疾病，炎性疾病和移植排斥反应。 用于在体外降低或抑制未成熟T细胞分化成Th17细胞的方法包括处理rebamipid化合物或其药学上可接受的盐的步骤。
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Patent Agency Ranking26.发明授权
公开(公告)号：KR101044433B1
公开(公告)日：2011-06-27
申请号：KR1020080087109
申请日：2008-09-04
Applicant: 가톨릭대학교 산학협력단 , 에이치 엘 지노믹스(주)
CPC classification number: A61K36/87
Abstract: 본 발명은 유럽종 포도(
Vitis
vinifera )의 씨 추출물의 개선된 제조방법을 제공한다. 또한, 본 발명은 유럽종 포도(
Vitis
vinifera )의 씨 추출물 및 약제학적으로 허용가능한 담체를 포함하는 류마티스 관절염의 예방 또는 치료용 약학 조성물을 제공한다.
유럽종 포도, 류마티스 관절염-
公开(公告)号：KR101654980B1
公开(公告)日：2016-09-06
申请号：KR1020140117469
申请日：2014-09-04
Applicant: 가톨릭대학교 산학협력단
IPC: A61K31/517 , A61K31/513 , A23L1/30
CPC classification number: A61K31/517
Abstract: 본발명은헬로퓨지농을유효성분으로포함하는골질환치료또는예방용조성물에관한것으로, 더상세하게는파골세포분화억제효능및 조골세포분화촉진활성을갖는헬로퓨지농을유효성분으로포함하는골질환치료또는예방용조성물에관한것이다. 본발명에의한헬로퓨지농을유효성분으로포함하는골질환의치료또는예방용조성물은 Th17 세포의발현을감소시키고 Treg 세포의발현을증가시켜파골세포분화를억제하는효과를나타내며파골세포에의한골 흡수도효과적으로억제할수 있고나아가조골세포의분화및 활성을촉진할수 있어골질환의치료또는예방을위한용도로유용하게활용할수 있을것이다.
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公开(公告)号：KR1020150030163A
公开(公告)日：2015-03-19
申请号：KR1020140117469
申请日：2014-09-04
Applicant: 가톨릭대학교 산학협력단
IPC: A61K31/517 , A61K31/513 , A23L1/30
CPC classification number: A61K31/517 , A23L33/10 , A23V2002/00 , A23V2200/306 , A61K31/513
Abstract: 본 발명은 헬로퓨지농을 유효성분으로 포함하는 골질환 치료 또는 예방용 조성물에 관한 것으로, 더 상세하게는 파골세포 분화 억제 효능 및 조골세포 분화 촉진 활성을 갖는 헬로퓨지농을 유효성분으로 포함하는 골질환 치료 또는 예방용 조성물에 관한 것이다. 본 발명에 의한 헬로퓨지농을 유효성분으로 포함하는 골질환의 치료 또는 예방용 조성물은 Th17 세포의 발현을 감소시키고 Treg 세포의 발현을 증가시켜 파골세포 분화를 억제하는 효과를 나타내며 파골세포에 의한 골 흡수도 효과적으로 억제할 수 있고 나아가 조골세포의 분화 및 활성을 촉진할 수 있어 골질환의 치료 또는 예방을 위한 용도로 유용하게 활용할 수 있을 것이다.
Abstract translation: 本发明涉及含有卤氟酮作为治疗或预防骨疾病的活性成分的组合物，更具体地，涉及含有具有破骨细胞分化抑制功效的卤伏酮的作为活性成分的骨病的治疗或预防用组合物， 成骨细胞分化刺激活性。 根据本发明的含有卤代酮作为治疗或预防骨病的活性成分的组合物降低Th17细胞的表达，增加Treg细胞的表达，从而抑制破骨细胞分化抑制作用，有效抑制破骨细胞的骨吸收。 此外，本发明的组合物可以促进成骨细胞的分化和活性，因此可以有利地用作治疗或预防骨疾病的用途。
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公开(公告)号：KR1020130125569A
公开(公告)日：2013-11-19
申请号：KR1020120049198
申请日：2012-05-09
Applicant: 가톨릭대학교 산학협력단
IPC: C12N5/0775 , C12N5/02 , A61K35/12
CPC classification number: C12N5/0668
Abstract: The present invention relates to a method for isolating mesenchymal stem cells from synovial fluid and, more specifically, to a method for isolating and culturing mesenchymal stem cells from synovial fluid of an individual with immune disease; a composition containing the isolated mesenchymal stem cells as active ingredients for preventing and treating immune diseases; and a cell therapeutic agent containing the synovial fluid-derived mesenchymal stem cells as active ingredients for preventing and treating rheumatoid arthritis. The synovial fluid-derived mesenchymal stem cells in the present invention are isolated from an individual with immune diseases. The synovial fluid-derived mesenchymal stem cells reduce abnormal regulation of immune responses such as transplantation rejection, which are an existing problem when the synovial fluid-derived mesenchymal stem cells are used as a cell therapeutic agent, thereby obtaining effective and safe treatment effects.
Abstract translation: 本发明涉及从滑液中分离间充质干细胞的方法，更具体地说，涉及从具有免疫疾病的个体的滑液中分离和培养间充质干细胞的方法; 含有分离的间充质干细胞作为预防和治疗免疫疾病的活性成分的组合物; 以及含有滑膜液间充质干细胞作为预防和治疗类风湿性关节炎的活性成分的细胞治疗剂。 从具有免疫疾病的个体中分离本发明中的滑液来源的间充质干细胞。 滑膜液间充质干细胞减少免疫应答的异常调节，如移植排斥反应，这是使用滑膜液间充质干细胞作为细胞治疗剂时存在的问题，从而获得有效和安全的治疗效果。
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公开(公告)号：KR1020130015337A
公开(公告)日：2013-02-14
申请号：KR1020110077275
申请日：2011-08-03
Applicant: 가톨릭대학교 산학협력단
CPC classification number: A61K9/127 , A61K9/1277 , A61K47/68 , Y10S977/915
Abstract: PURPOSE: An immunotherapeutic agent of a nanosome form containing a cell suspension and abatacept is provided to ensure a high transmission rate of abatacept into a target site and to effectively suppress TNF-alpha and IL-17 generation. CONSTITUTION: An immunotherapeutic agent of a nanosome form contains a cell suspension and abatacept. A composition for preventing or treating immune diseases contains the immunotherapeutic agent. A method for manufacturing the immunotherapeutic agent comprises: a step of suspending macrophage; a step of passing the suspension solution through a membrane filter; a step of adding abatacept to the solution; and a step of isolating the immunotherapeutic agent from the solution. The macrophage is suspended in a PBS solution in a concentration of 1x10^6 to 1x10^7 cells/ml.
Abstract translation: 目的：提供含有细胞悬浮液和abatacept的纳米体形式的免疫治疗剂，以确保abatacept的高透射率进入靶位点，并有效抑制TNF-α和IL-17的产生。 构成：纳米颗粒形式的免疫治疗剂含有细胞悬浮液和阿巴西普（abatacept）。 用于预防或治疗免疫疾病的组合物含有免疫治疗剂。 制备免疫治疗剂的方法包括：悬浮巨噬细胞的步骤; 使悬浮液通过膜过滤器的步骤; 将abatacept加入到溶液中的步骤; 以及从溶液中分离免疫治疗剂的步骤。 将巨噬细胞以1×10 6至1×10 7细胞/ ml的浓度悬浮于PBS溶液中。
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