Abstract:
PURPOSE: A cell therapeutic composition containing a natural killer cell inhibitor and mesenchymal stem cells is provided to effectively suppress immune rejection responses, and to enhance a treatment effect. CONSTITUTION: A cell therapeutic composition for preventing or treating graft-versus-host diseases contains 2.5mg/kg-250mg/kg of a natural killer cell inhibitor and 2x10^5-2x10^7 mesenchymal stem cells as active ingredients. The mesenchymal stem cells are derived from human. The inhibitor is anti-asialo GM1. The composition contains is administered by intravenous or intradural injection.
Abstract:
PURPOSE: A cell therapeutic composition is provided to effectively suppress immune rejection from a transplant process, and to prevent or treat graft-versus-host disease. CONSTITUTION: A pharmaceutical composition for preventing or treating graft-versus-host disease contains 1ug/ul-3ug/ul of genes which suppresses an IL-21 receptor and 2x10^5-2x10^7 mesenchymal stem cells as an active ingredient. The mesenchymal stem cells are derived from human.
Abstract:
PURPOSE: A composition containing retinal for preventing or treating cancer or immune diseases is provided to enhance immune-modulating T cell activity. CONSTITUTION: A composition for preventing or treating cancer or immune disease contains retinal compounds of pharmaceutically acceptable salt thereof as an active ingredient. The retinal promotes or enhances regulatory T cell activity or proliferation. A method for reducing or suppressing differentiation of immature T cell into Th17 cell in vitro comprises a step of treating retinal compound or pharmaceutically acceptable salt to the undifferentiated T cells.
Abstract:
PURPOSE: A mesenchymsal stem cells and a composition containing the same for treating autoimmune diseases are provided to enhance autoantigen-specific CD4+ CD25+ Foxp3+ regulatory T cells and to treat autoimmune diseases. CONSTITUTION: A composition for treating autoimmune diseases contains mesenchymal stem cells in which TFG-beta-encoding nucleotide sequence is introduced and pharmaceutically acceptable carrier. The TGF-beta-encoding nucleotide sequence is sequence number 2. The TGF-beta-encoding nucleotide sequence is introduced by adenovirus-associated vector. The mesenchymal stem cell is derived from bone marrow-derived mesenchymal stem cells or adipose-derived mesenchymal stem cells.