公开(公告)号：KR100343943B1

公开(公告)日：2002-11-16

申请号：KR1019970032177

申请日：1997-07-11

Applicant: 동화약품주식회사

Inventor： 윤성준 ,  김종우 ,  허용 ,  박상진 ,  임경묵

IPC: A61K31/495

Abstract: PURPOSE: A pteridine derivative is provided which is obtained by culturing Streptomyces sp. DWJJ 839 and purification, and shows excellent inhibiting effect on HBV polymerase. Therefore, it can be effectively used as a therapeutic agent for B type hepatitis and formulated into injection, ointment, cream, liquid, etc. CONSTITUTION: Streptomyces sp. DWJJ 839(KFCC 10974) separated from soil is cultured, the culture solution thereof is heat treated and centrifuged to separate a supernatant, the concentrated supernatant is extracted in butanol, purified with column chromatography and separated with HPLC to produce a pteridine derivative of the formula(1-1). In formula, R5 and R6 are CH3; X1 and X2 are nitrogen; X3 and X4 are oxygen. The therapeutic agent for B type hepatitis contains a pteridine derivative of the formula(1) or a salt thereof. In formula, R1 and R2 are each H, C1-4 alkyl or lower alkoxy or can form a benzene ring by binding R1 and R2.

公开(公告)号：KR1020000027306A

公开(公告)日：2000-05-15

申请号：KR1019980045212

申请日：1998-10-28

Applicant: 동화약품주식회사

Inventor： 윤성준 ,  임문정 ,  성희진 ,  신동혁 ,  장환봉 ,  김종우 ,  박상진

IPC: A61K31/34

CPC classification number: A61K31/343 ,  A61K36/53 ,  A61K2236/30 ,  A61K2236/51

Abstract: PURPOSE: A medicinal composition, which is useful for treating hepatitis B, and a method for recovering trapezoid compound are provided. CONSTITUTION: The medicinal composition for treating hepatitis B contains tanshinol B of a following formula 1, tanshinone IIB of a following formula 2, przewaquinone A of a following formula 3, Salvia militarize Bunge extract, Salvia militarize Bunge separated materials as an effective ingredient. The method for recovering tanshinol B of the following formula 1, tanshinone IIB of the following formula 2 and przewaquinone A of the following formula 3 comprises steps of: (i) obtaining Salvia militarize Bunge extract by using water, organic solvent or a mixture solvent thereof as an extracting solvent; (ii) concentrating the extract of step (i); and (iii) performing solvent separation and column chromatography of step (ii) to separate and purify.

Abstract translation: 目的：提供一种可用于治疗乙型肝炎的药物组合物和回收梯形化合物的方法。 构成：用于治疗乙型肝炎的药物组合物含有下式1的丹参醇B，下式2的丹参酮IIB，下式3的靛红醌A，丹参黄芪提取物，丹参麻黄素Bunge分离物作为有效成分。 用于回收下式1的丹宁醇B，下式2的丹参酮IIB和下式3的柚子醌A的方法包括以下步骤：（i）通过使用水，有机溶剂或其混合溶剂来获得丹参武装提取物 作为提取溶剂; （ii）浓缩步骤（i）的提取物; 和（iii）进行步骤（ii）的溶剂分离和柱色谱以分离和纯化。

公开(公告)号：KR1019990023074A

公开(公告)日：1999-03-25

申请号：KR1019980006042

申请日：1998-02-26

Applicant: 동화약품주식회사

Inventor： 윤성준 ,  정용호 ,  이치우 ,  오윤석 ,  김남두 ,  임재경 ,  진윤호 ,  박상진 ,  조성희

IPC: C07D471/04

Abstract: 본 발명은 AIDS(Acquired Immunodeficiency Syndrome)를 유발하는 HIV(Human Immunodeficiency Virus)의 증식에 필수효소인 역전사효소를 저해하는 작용이 우수한 신규 피리돈 카르복실산 유도체에 관한 것으로서, 더욱 상세하기로는 다음 화학식 1로 표시되는 피리돈 카르복실산 유도체, 그의 약제학적으로 허용가능한 염 및 그의 제조방법에 관한 것이다.

상기 화학식에서
X는 CH 또는 질소원자이고, A는 3-아미노피롤리딘, C
1-3 의 저급알킬기가 1-3개 치환 또는 비치환된 피페라진이고, B는 나프틸기 또는 퀴놀릴기이다.