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公开(公告)号：KR101421575B1
公开(公告)日：2014-07-30
申请号：KR1020120023637
申请日：2012-03-07
Applicant: 전남대학교산학협력단
Abstract: 본 발명은 치료용 약독화 살모넬라 균주에 의한 진단 또는 치료용 단백질의 전달 효율을 증가시키기 위해, ara 오페론 및 ppGpp 생산 유전자가 모두 불활성화된 약독화 살모넬라 속 균주 및 그의 용도를를 제공한다.
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公开(公告)号：KR1020130060605A
公开(公告)日：2013-06-10
申请号：KR1020110126747
申请日：2011-11-30
Applicant: 전남대학교산학협력단
IPC: C07K14/255 , C12N15/31 , C12N15/63 , A61P35/00
CPC classification number: C07K14/255 , A61K47/42 , A61K47/62 , C12N15/63
Abstract: PURPOSE: A novel polypeptide and a polynucleotide encoding the same are provided to properly control bacterial lysis and to effectively release a drug transferred by therapeutic bacteria to a lesion. CONSTITUTION: A polypeptide has holin non-dependent cell lysis activities with 70% or more homology with an amino acid sequence of sequence number 3. The polypeptide has 70% or more homology with an amino acid sequence of sequence number 1. A polynucleotide encodes the polypeptide. A vector contains the polynucleotide. A host cell is transformed with the vector. [Reference numerals] (AA) pLT1::ORF1, Control group; (BB) pLT1::ORF1, Induced; (CC,FF,II,LL,OO,RR) Time(hours); (DD) pLT35-1, Control group; (EE) pLT35-1, Induced; (GG) pLT1::ORF2, Control group; (HH) pLT1::ORF2, Induced; (JJ) pLT33, Control group; (KK) pLT33, Induced; (MM) pLT1::ORF3, Control group; (NN) pLT1::ORF3, Induced; (PP) pLT34, Control group; (QQ) pLT34, Induced
Abstract translation: 目的：提供新的多肽和编码该多肽的多核苷酸以适当地控制细菌裂解并有效地将由治疗性细菌转移的药物释放到病变处。 构成：多肽具有与序列号3的氨基酸序列具有70％或更高同源性的完全非依赖性细胞裂解活性。多肽与序列号1的氨基酸序列具有70％或更高的同源性。多核苷酸编码 多肽。 载体含有多核苷酸。 用载体转化宿主细胞。 （标号）（AA）pLT1 :: ORF1，对照组; （BB）pLT1 :: ORF1，诱导; （CC，FF，II，LL，OO，RR）时间（小时）; （DD）pLT35-1，对照组; （EE）pLT35-1，诱导; （GG）pLT1 :: ORF2，对照组; （HH）pLT1 :: ORF2，诱导; （JJ）pLT33，对照组; （KK）pLT33，诱导; （MM）pLT1 :: ORF3，对照组; （NN）pLT1 :: ORF3，诱导; （PP）pLT34，对照组; （QQ）pLT34，诱导
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公开(公告)号：KR1020110130253A
公开(公告)日：2011-12-05
申请号：KR1020100049809
申请日：2010-05-27
Applicant: 전남대학교산학협력단
IPC: C07F9/54 , C07C211/64 , A61K51/04 , A61K101/02
CPC classification number: C07F9/5442 , A61K51/04 , A61K51/1282
Abstract: PURPOSE: A method for manufacturing a radiopharmacy for mitochondria image and a precursor thereof are provided to simply obtain the radiopharmacy with high yield. CONSTITUTION: A method for manufacturing a radiopharmacy for microchondria image comprises a step of substituting X^1 substituent of a compound of chemical formula 1 or salt thereof with radioactive isotope of 18F, 76Br or 123I. The E is phosphorus or nitrogen. The radiopharmacy is 18F-fluoromethyl triphenyl phosphonium, 18F-2-fluoroethyl triphenyl phosphonium, 18F-3-fluoropropyl triphenyl phosphonium, 18F-4-fluorobutyl triphenyl phosphonium, 18F-5-fluoropentyl triphenyl phosphonium, 18F-6-fluorohexyl triphenyl phosphonium, 18F-7-fluoroheptyl phenyl phosphonium, or 18F-8-fluorooctyl triphenyl phosphonium.
Abstract translation: 目的：提供一种制造线粒体图像放射性药物的方法及其前体，以简单地以高产率获得放射性药物。 构成：用于制造用于微型软骨细胞图像的放射性药物的方法包括用放射性同位素18F，76Br或123I替代化学式1化合物或其盐的X 1取代基的步骤。 E是磷或氮。 放射性药物是18F-氟甲基三苯基鏻，18F-2-氟乙基三苯基鏻，18F-3-氟丙基三苯基鏻，18F-4-氟丁基三苯基鏻，18F-5-氟戊基三苯基鏻，18F-6-氟己基三苯基鏻18F -7-氟庚基苯基鏻或18F-8-氟辛基三苯基鏻。
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公开(公告)号：KR1020100097373A
公开(公告)日：2010-09-03
申请号：KR1020090016283
申请日：2009-02-26
Applicant: 전남대학교산학협력단
CPC classification number: A61B6/508
Abstract: PURPOSE: A dual image photographing device is provided to obtain a fluoroscopic image and a gamma-ray image without the interference of external light by arranging a fluoroscopic video camera and a gamma-ray video camera in a divided space. CONSTITUTION: A case(110) includes an upper space, a center space, and a lower space. The upper space and the center space are divided with a fluoroscopic image partition. The center space and the lower space are divided with a gamma-ray image partition. A light source is arranged in the center space in order to irradiate light to a subject. A fluoroscopic video camera(130) is arranged in the upper space in order to obtain the fluoroscopic image of the subject. A gamma-ray video camera(140) is arranged in the lower space in order to obtain the gamma-ray image of the subject.
Abstract translation: 目的：提供双重图像拍摄装置以通过在分割空间中布置荧光透视摄像机和伽马射线摄像机来获得透视图像和伽马射线图像而不受外部光的干扰。 构成：壳体（110）包括上部空间，中心空间和下部空间。 上部空间和中心空间用荧光镜图像分割分割。 中心空间和下部空间用伽马射线图像分割分割。 光源设置在中心空间中，以便将光照射到被摄体。 荧光镜摄像机（130）布置在上部空间中以获得被检体的透视图像。 为了获得被检体的γ射线图像，在下部空间配置有γ射线摄像机（140）。
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公开(公告)号：KR100869782B1
公开(公告)日：2008-11-21
申请号：KR1020070026013
申请日：2007-03-16
Applicant: 전남대학교산학협력단
IPC: A61B5/00
Abstract: 본 발명은 생체광학 영상장치에 관한 것으로, 더욱 상세하게는 암실이 형성된 케이스에 피검체을 놓고 상기 피검체에서 발생하는 바이오 포톤을 검출하는 한편 상기 피검체에 빛을 투과하여 내부 조직 영상을 획득하는 생체광학 영상장치에 관한 것이다. 본 발명에 따른 생체광학 영상장치는 피검체가 출입하는 도어가 구비된 케이스, 상기 케이스 내부에 구비되어 피검체가 놓이는 스테이지, 상기 스테이지 하부에 구비되어 상기 피검체로 투과광을 조사하는 제 1 광원, 상기 제 1 광원을 XY축으로 구동하게 하는 구동수단 및 상기 스테이지 상부에 구비되고 상기 피검체를 투과하는 빛을 검출하는 촬상모듈을 포함한다.
생체영상, 유전자 치료, 바이오 포톤, 냉각CCD, 광학필터-
Patent Agency Ranking
公开(公告)号：KR1020080084359A
公开(公告)日：2008-09-19
申请号：KR1020070026013
申请日：2007-03-16
Applicant: 전남대학교산학협력단
IPC: A61B5/00
Abstract: A bio-optical image system is provided to obtain the light of a user's desired wavelength selectively from the light passing through a subject. A bio-optical image system includes a case(100), a stage(200), a first light source(300), a driving unit(400), and an imaging module(500). The case has a door(110) to allow entrance of a subject. The stage is positioned inside the case to load the subject thereon. The first light source is positioned under the stage to irradiate light to the subject. The driving unit drives the first light source in X-Y axis directions. The imaging module is positioned above the stage to detect the light passing through the subject. The bio-optical image system further includes a lens module(600) and an optical filter module(700). The lens module is positioned at a lower end of the imaging module to condense the light passing through the subject. The optical filter module is positioned at a lower end of the lens module to pass the light of a predetermined wavelength passing through the subject.
Abstract translation: 提供生物光学图像系统以从通过对象的光中选择性地获得用户期望波长的光。 生物光学图像系统包括壳体（100），平台（200），第一光源（300），驱动单元（400）和成像模块（500）。 该情况具有门（110）以允许被摄体进入。 该台被放置在壳体内以将被摄体加载到其上。 第一光源位于舞台下面以向对象照射光。 驱动单元以X-Y轴方向驱动第一光源。 成像模块位于平台上方，以检测穿过被摄体的光线。 生物光学图像系统还包括透镜模块（600）和滤光器模块（700）。 透镜模块位于成像模块的下端，以冷凝通过被摄体的光。 光学滤波器模块位于透镜模块的下端，以通过穿过被摄体的预定波长的光。
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公开(公告)号：KR102050904B1
公开(公告)日：2019-12-03
申请号：KR1020190107681
申请日：2019-08-30
Applicant: 전남대학교산학협력단
IPC: C07C237/34 , A61K51/04
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公开(公告)号：KR102044480B1
公开(公告)日：2019-11-14
申请号：KR1020180003964
申请日：2018-01-11
Applicant: 전남대학교산학협력단
IPC: C07C237/34 , A61K51/04
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公开(公告)号：KR101837636B1
公开(公告)日：2018-03-12
申请号：KR1020160073533
申请日：2016-06-14
Applicant: 전남대학교산학협력단
Abstract: 본발명은코리네박테리움재조합균주를이용하여이종단백질에해당하는대장균또는얼위니아유래아스파라기나제를발현및 분비생산하는방법에관한것으로, 아스파라기나제 N-말단에분비신호서열을결합하는기술을통해재조합코리네박테리움으로부터변형이일어나지않은아스파라기나제를고순도로회수할수 있다.
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公开(公告)号：KR1020170140868A
公开(公告)日：2017-12-22
申请号：KR1020160073533
申请日：2016-06-14
Applicant: 전남대학교산학협력단
CPC classification number: C12N15/77 , C07K2319/02 , C07K2319/35 , C12N9/82 , C12N2510/02 , C12N2511/00 , C12Y305/01001
Abstract: 본발명은코리네박테리움재조합균주를이용하여이종단백질에해당하는대장균또는얼위니아유래아스파라기나제를발현및 분비생산하는방법에관한것으로, 아스파라기나제 N-말단에분비신호서열을결합하는기술을통해재조합코리네박테리움으로부터변형이일어나지않은아스파라기나제를고순도로회수할수 있다.
Abstract translation: 本发明是棒状杆菌，通过使用大肠杆菌或生产冷冻Winiah天冬酰胺酶或jereul表达和派生的异源蛋白质的分泌，天冬酰胺酶技术的方法，所述分泌信号序列结合到N-末端的重组菌株 尚未从重组棒状杆菌转化的天冬酰胺酶可以高纯度回收。
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