-
公开(公告)号：CA2796339C
公开(公告)日：2020-03-31
申请号：CA2796339
申请日：2011-04-13
Applicant: ABBOTT LAB , ABBOTT GMBH & CO KG
Inventor： BARGHORN STEFAN , HILLEN HEINZ , STRIEBINGER ANDREAS , GIAISI SIMONE , EBERT ULRICH , BENATUIL LORENZO
IPC: C07K16/18
Abstract: The present invention relates to amyloid-beta (As) binding proteins. Antibodies of the invention have high affinity to As(20-42) globulomer or any A form that comprises the globulomer epitope. Method of making and method of using the antibodies of the invention are also provided.
-
Patent Agency Ranking">
公开(公告)号：BR112012004546A2
公开(公告)日：2016-11-29
申请号：BR112012004546
申请日：2010-08-27
Applicant: ABBOTT LAB
Inventor： HSIEH CHUNG-MING , BOGHAERT ERWIN R , GU JIJIE , HICKSON JONATHAN A , BENATUIL LORENZO , HARRIS MARIA , MORGAN-LAPPE SUSAN , LI YINGCHUN , KUTSKOVA YULIYA , LIU ZHIHONG
IPC: C07K16/28
-
公开(公告)号：BRPI0910286A2
公开(公告)日：2015-09-29
申请号：BRPI0910286
申请日：2009-03-03
Applicant: ABBOTT LAB
Inventor： HSIEH CHUNGMING , PEREZ JENNIFER M , BELK JONATHAN P , BENATUIL LORENZO
-
公开(公告)号：AR080840A1
公开(公告)日：2012-05-09
申请号：ARP110101162
申请日：2011-04-07
Applicant: ABBOTT LAB
Inventor： SALFELD JOCHEN , GHAYUR TARIQ , GOODREAU CARRIE L , ISAKSON PETER C , BENATUIL LORENZO
IPC: C07K14/475 , A61K39/395 , A61P21/00 , A61P23/00 , A61P11/06 , C12N15/12 , C12N15/63 , C12N15/79 , C12N15/85 , G01N33/53
Abstract: Composiciones basadas en anticuerpos. Moléculas relacionadas. Composiciones farmacéuticas que comprenden dichos anticuerpos. Métodos terapéuticos y de diagnostico donde se emplean dichos anticuerpos. Se provee además un ácido nucleico que codifica la proteína de union humanizada, un vector que comprende dicho ácido nucleico, una célula huésped conteniendo el vector. Reivindicacion 1: Una proteína de union humanizada caracterizada porque comprende un dominio de union al antígeno que puede unirse al factor de necrosis tumoral-alfa humano (TNF-alfa), donde el dominio de union al antígeno comprende al menos un conjunto de CDR que comprende una secuencia de aminoácidos que abarca los residuos 31-35 de SEQ ID N°: 22, los residuos 50- 65 de SEQ ID N°: 22, los residuos 98-106 de SEQ ID N°: 22, los residuos 24-34 de SEQ ID N°: 23, los residuos 50-56 de SEQ ID N°: 23 o los residuos 89-97 de SEQ ID N°:23, donde la proteína de union comprende un marco de trabajo aceptor humano. Reivindicacion 2: La proteína de union de la reivindicacion 1, caracterizada porque la proteína de union comprende al menos 3 CDR.
-
公开(公告)号：SG178930A1
公开(公告)日：2012-04-27
申请号：SG2012014403
申请日：2010-08-27
Applicant: ABBOTT LAB
Inventor： BENATUIL LORENZO , BOGHAERT ERWIN R , GU JIJIE , HARRIS MARIA , HICKSON JONATHAN A , HSIEH CHUNG-MING , KUTSKOVA YULIYA , LI YINGCHUN , LIU ZHIHONG , MORGAN-LAPPE SUSAN
Abstract: Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant DLL4 expression or activity such as autoimmune disorders including multiple sclerosis.
-
公开(公告)号：CA2796339A1
公开(公告)日：2011-10-20
申请号：CA2796339
申请日：2011-04-13
Applicant: ABBOTT LAB , ABBOTT GMBH & CO KG
Inventor： BARGHORN STEFAN , HILLEN HEINZ , STRIEBINGER ANDREAS , GIAISI SIMONE , EBERT ULRICH , BENATUIL LORENZO
IPC: C07K16/18
Abstract: The present invention relates to amyloid-beta (As) binding proteins. Antibodies of the invention have high affinity to As(20-42) globulomer or any A form that comprises the globulomer epitope. Method of making and method of using the antibodies of the invention are also provided.
-
-
-
-
-
Search Results
26
records
(took 0.021 seconds)
