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1.发明申请
公开(公告)号：WO0230959A3
公开(公告)日：2002-09-26
申请号：PCT/US0132121
申请日：2001-10-12
Applicant: ABBOTT LAB
Inventor： FESIK STEPHEN W , MEADOWS ROBERT P , BETZ STEPHEN P , LIU ZHIHONG , OLEJNICZAK EDWARD T , SUN CHAOHONG
CPC classification number: C07K14/8139 , C07K14/4702
Abstract: The present invention relates to peptides derived from the wildtype human smac (DIABLO) protein which binds to a member of an IAP family member. The peptides of the present invention can be used in an assay to identify candidate substances which induce or promote apoptosis in cells.
Abstract translation: 本发明涉及衍生自与IAP家族成员结合的野生型人类smac（DIABLO）蛋白质的肽。 本发明的肽可用于测定诱导或促进细胞凋亡的候选物质。
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公开(公告)号：WO2011025964A3
公开(公告)日：2011-04-21
申请号：PCT/US2010047006
申请日：2010-08-27
Applicant: ABBOTT LAB , BENATUIL LORENZO , BOGHAERT ERWIN R , GU JIJIE , HARRIS MARIA , HICKSON JONATHAN A , HSIEH CHUNG-MING , KUTSKOVA YULIYA , LI YINGCHUN , LIU ZHIHONG , MORGAN-LAPPE SUSAN
Inventor： BENATUIL LORENZO , BOGHAERT ERWIN R , GU JIJIE , HARRIS MARIA , HICKSON JONATHAN A , HSIEH CHUNG-MING , KUTSKOVA YULIYA , LI YINGCHUN , LIU ZHIHONG , MORGAN-LAPPE SUSAN
IPC: C07K16/28
CPC classification number: C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/18 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant DLL4 expression or activity such as autoimmune disorders including multiple sclerosis.
Abstract translation: 描述了改进的DLL4结合蛋白，包括抗体，CDR-移植抗体，人抗体和DLL4结合片段，以高亲和力结合DLL4的蛋白质，以及中和DLL4活性的DLL4结合蛋白。 DLL4结合蛋白可用于治疗或预防癌症和肿瘤，特别是用于治疗或预防肿瘤血管生成和/或其它血管发生依赖性疾病，例如眼新生血管形成或以异常DLL4表达或活性为特征的血管发生非依赖性疾病，例如自身免疫 包括多发性硬化的疾病。
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公开(公告)号：WO2011050262A3
公开(公告)日：2011-06-30
申请号：PCT/US2010053730
申请日：2010-10-22
Applicant: ABBOTT LAB , GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , REILLY EDWARD B , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANG JIEYI , BELL RANDY L , NORVELL SUZANNE M , LI YINGCHUN , LIU JUNJIAN , YING HUA , LIU ZHIHONG
Inventor： GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , REILLY EDWARD B , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANG JIEYI , BELL RANDY L , NORVELL SUZANNE M , LI YINGCHUN , LIU JUNJIAN , YING HUA , LIU ZHIHONG
IPC: C12P21/08
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K16/468 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：EP2491129A4
公开(公告)日：2013-05-29
申请号：EP10825739
申请日：2010-10-22
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , REILLY EDWARD B , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANG JIEYI , BELL RANDY L , NORVELL SUZANNE M , LI YINGCHUN , LIU JUNJIAN , YING HUA , LIU ZHIHONG
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K16/468 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：CL2012000980A1
公开(公告)日：2013-01-11
申请号：CL2012000980
申请日：2012-04-18
Applicant: ABBOTT LAB
Inventor： MORGAN-LAPPE SUSAN E , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANGS JIEVI , BELL RANDY L , NORVELL SUZANNE M , LI YINGCHUN , LIU JUNJIAN , YING HUA , LIU ZHIHONG , GHAYUR TARIQ , REILLY EDWARD B
IPC: A61K39/395
Abstract: Proteina de unión que comprende una cadena de polipéptidos, en donde dicha cadena de polipéptidos comprende dos dominios variables de la cadena pesada y un dominio constante de la cadena pesada; conjugado de una proteína de unión que comprende dicha proteína; célula huesped, vector y ácido nucleico.
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Patent Agency Ranking
公开(公告)号：CO6541599A2
公开(公告)日：2012-10-16
申请号：CO12079711
申请日：2012-05-15
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , LIU ZHIHONG , YING HUA , LIU JUNJIAN , LI YINGCHUN , NORVELL SUZANNE M , BELL RANDY , WANG JIEYI , PHILLIPS ANDREW , KING-SBURY GILLIAN A , REILLY EDWARD B
IPC: C12P21/08
Abstract: Proteínas de unión multivalentes y multiespecíficas diseñadas, métodos para elaborarlas y, específicamente, sus usos en la prevención, el diagnóstico y/o el tratamiento de enfermedades.
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公开(公告)号：CR20120267A
公开(公告)日：2012-08-14
申请号：CR20120267
申请日：2012-05-22
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , REILLY EDWARD B , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANG JIEYI , BELL RANDAY L , NORVELL SUZANNE M , LI YINGEHUN , LIU JUNJIAN , YING HUA , LIU ZHIHONG
IPC: A61K39/395 , A61K51/10 , A61P3/10 , A61P7/00 , A61P9/00 , A61P15/00 , A61P17/00 , A61P17/06 , A61P21/02 , A61P25/20 , A61P29/00 , A61P35/00 , A61P37/06 , C07H21/04 , C07K16/32 , C07K16/46 , C12N15/63
Abstract: Proteínas de unión multivalentes y multiespecíficas diseñadas, métodos para elaborarlas y, específicamente, sus usos en la prevención, el diagnóstico y/o el tratamiento de enfermedades.
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公开(公告)号：CA2778176A1
公开(公告)日：2011-04-28
申请号：CA2778176
申请日：2010-10-22
Applicant: ABBOTT LAB
Inventor： GHAYUR TARIQ , MORGAN-LAPPE SUSAN E , REILLY EDWARD B , KINGSBURY GILLIAN A , PHILLIPS ANDREW , WANG JIEYI , BELL RANDY L , NORVELL SUZANNE M , LI YINGCHUN , LIU JUNJIAN , YING HUA , LIU ZHIHONG
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：DOP2012000052A
公开(公告)日：2012-07-31
申请号：DO2012000052
申请日：2012-02-28
Applicant: ABBOTT LAB
Inventor： LI YINGCHUN , BENATUIL LORENZO , BOGHAERT EWRIN R , GU JIJIE , HARRIS MARIA , HICKSON JONATHAN A , HSIEH CHUNG-MING , KUTSKOVA YULIYA , LIU ZHIHONG , MORGAN-LAPPE SUSAN
Abstract: Proteínas de unión a DLL4 mejoradas, inclusive anticuerpos, anticuerpos con injerto de CDR, anticuerpos humanos y fragmentos de unión a DLL4 de los mismos, proteínas que se unen a DLL4 con gran afinidad y proteínas de unión a DLL4 que neutralizan la actividad de DLL4 y/o VEGF. Las proteínas de unión a DLL4 son de utilidad para tratar o prevenir distintos tipos de cáncer y tumores y en especial para tratar o prevenir la angiogénesis de tumores.
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公开(公告)号：MX2012002605A
公开(公告)日：2012-04-02
申请号：MX2012002605
申请日：2010-08-27
Applicant: ABBOTT LAB
Inventor： HSIEH CHUNG-MING , LI YINGCHUN , GU JIJIE , KUTSKOVA YULIYA , BENATUIL LORENZO , BOGHAERT ERWIN R , HARRIS MARIA , HICKSON JONATHAN A , LIU ZHIHONG , MORGAN-LAPPE SUSAN
IPC: C07K16/28
Abstract: Se describen las proteínas de unión a DLL4 mejoradas, incluyendo los anticuerpos, anticuerpos injertados en CDR, anticuerpos humanos, y fragmentos de unión a DLL4 del mismo, las proteínas que unen a DLL4 con alta afinidad, y las proteínas de unión a DLL4 que neutralizan la actividad de DLL4. Las proteínas de unión a DLL4 son útiles para tratar o prevenir cánceres y tumores y especialmente para tratar o prevenir angiogénesis tumoral, y/o otras enfermedades dependientes de angiogénesis tal como neovascularización ocular, o enfermedades independientes de angiogénesis caracterizadas por la expresión DLL4 o actividad anormal tal como trastornos autoinmunes incluyendo esclerosis múltiple.
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