公开(公告)号：DE69813798T2

公开(公告)日：2004-02-19

申请号：DE69813798

申请日：1998-05-22

Applicant: ABBOTT LAB

Inventor： OR SUN ,  GRIESGRABER W ,  CHU T

IPC: A61K31/70 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Novel multicyclic erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formulae (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), or (XI), pharmaceutical compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formula (I).

公开(公告)号：DE69813798D1

公开(公告)日：2003-05-28

申请号：DE69813798

申请日：1998-05-22

Applicant: ABBOTT LAB

Inventor： OR SUN ,  GRIESGRABER W ,  CHU T

IPC: A61K31/70 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Novel multicyclic erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formulae (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), or (XI), pharmaceutical compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formula (I).

公开(公告)号：DE69802274T2

公开(公告)日：2002-07-18

申请号：DE69802274

申请日：1998-02-06

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  KERDESKY A ,  HSIAO W ,  LI QUN ,  CHU T

IPC: C07D455/02

Abstract: A process for the preparation of a compound having the formula: wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.

公开(公告)号：DE69802274D1

公开(公告)日：2001-12-06

申请号：DE69802274

申请日：1998-02-06

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  KERDESKY A ,  HSIAO W ,  LI QUN ,  CHU T

IPC: C07D455/02

Abstract: A process for the preparation of a compound having the formula: wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.