公开(公告)号：DE69802274T2

公开(公告)日：2002-07-18

申请号：DE69802274

申请日：1998-02-06

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  KERDESKY A ,  HSIAO W ,  LI QUN ,  CHU T

IPC: C07D455/02

Abstract: A process for the preparation of a compound having the formula: wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.

公开(公告)号：DE69802274D1

公开(公告)日：2001-12-06

申请号：DE69802274

申请日：1998-02-06

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  KERDESKY A ,  HSIAO W ,  LI QUN ,  CHU T

IPC: C07D455/02

Abstract: A process for the preparation of a compound having the formula: wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.