公开(公告)号：DE69432611T2

公开(公告)日：2004-03-18

申请号：DE69432611

申请日：1994-09-26

Applicant: ABBOTT LAB

Inventor： STUK L ,  KERDESKY A ,  LIJEWSKI-LINCH M ,  NORBECK W ,  SCARPETTI DAVID ,  TIEN J ,  ALLEN S ,  LANGRIDGE C ,  MELCHER LAURA ,  RENO S ,  SHAM LEUNG ,  ZHAO CHEN ,  HAIGHT R ,  LEANNA ROBERT ,  MORTON E ,  ROBBINS A ,  SOWIN J

IPC: C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C227/18 ,  C07C229/36 ,  C07C231/12 ,  C07C233/35 ,  C07C251/40 ,  C07C255/27 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07D221/14

Abstract: Processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy, and halo; or R6 is as defined above and R7 is R7aOC (O)- wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen, and trifluoromethyl and R8 is hydrogen or -C(O)R'' wherein R'' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.

公开(公告)号：DE69802274T2

公开(公告)日：2002-07-18

申请号：DE69802274

申请日：1998-02-06

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  KERDESKY A ,  HSIAO W ,  LI QUN ,  CHU T

IPC: C07D455/02

Abstract: A process for the preparation of a compound having the formula: wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.

公开(公告)号：DE69802274D1

公开(公告)日：2001-12-06

申请号：DE69802274

申请日：1998-02-06

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  KERDESKY A ,  HSIAO W ,  LI QUN ,  CHU T

IPC: C07D455/02

Abstract: A process for the preparation of a compound having the formula: wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.