公开(公告)号：ES2188788T3

公开(公告)日：2003-07-01

申请号：ES96932335

申请日：1996-09-25

Applicant: ABBOTT LAB

Inventor： BROOKS CLINT D W ,  BHATIA PRAMILA ,  KOLASA THEODOZYJ ,  STEWART ANDREW O ,  GUNN DAVID E ,  CRAIG RICHARD A

IPC: C07D239/26 ,  A61K31/4184 ,  A61K31/421 ,  A61K31/4402 ,  A61K31/454 ,  A61K31/47 ,  A61K31/498 ,  A61K31/506 ,  A61P37/08 ,  A61P43/00 ,  C07D213/30 ,  C07D215/14 ,  C07D215/18 ,  C07D235/12 ,  C07D241/42 ,  C07D263/56 ,  C07D277/24 ,  C07D277/64 ,  C07D417/14 ,  A61K31/395

Abstract: Compounds having the formula: wherein W is the same at each occurrence and is selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, optionally substituted pyridyl, optionally substituted pyrimidyl, and optionally substituted thiazolyl; R1 and R2 are independently selected from hydrogen, alkyl, halolalkyl, alkoxy, halogen; R3 is a valence bond or is selected from hydrogen and alkyl; X is a valence bond or is selected from alkylene, alkenylen, and alkynylene; and Z is selected from (a) COM, (b) CH=N-O-A-COM, (c) CH2-O-N=A-COM wherein A is selected from alkylene and cycloalkylene, and M is selected from (a) a pharmaceutically acceptable metabolically cleavable group, (b) -OR6, (c) -NR7R8, (d)-NR6SO2R9, (e)-NH-Tetrazolyl, and (f) glycinyl inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states. Also disclosed are leukotriene biosynthesis inhibiting compositions and a method of inhibiting leukotriene biosynthesis.

公开(公告)号：DK0862557T3

公开(公告)日：2003-03-24

申请号：DK96932335

申请日：1996-09-25

Applicant: ABBOTT LAB

Inventor： BROOKS CLINT D W ,  BHATIA PRAMILA ,  KOLASA THEODOZYJ ,  STEWART ANDREW O ,  GUNN DAVID E ,  CRAIG RICHARD A

IPC: C07D239/26 ,  A61K31/4184 ,  A61K31/421 ,  A61K31/4402 ,  A61K31/454 ,  A61K31/47 ,  A61K31/498 ,  A61K31/506 ,  A61P37/08 ,  A61P43/00 ,  C07D213/30 ,  C07D215/14 ,  C07D215/18 ,  C07D235/12 ,  C07D241/42 ,  C07D263/56 ,  C07D277/24 ,  C07D277/64 ,  C07D417/14 ,  A61K31/395

Abstract: Compounds having the formula: wherein W is the same at each occurrence and is selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, optionally substituted pyridyl, optionally substituted pyrimidyl, and optionally substituted thiazolyl; R1 and R2 are independently selected from hydrogen, alkyl, halolalkyl, alkoxy, halogen; R3 is a valence bond or is selected from hydrogen and alkyl; X is a valence bond or is selected from alkylene, alkenylen, and alkynylene; and Z is selected from (a) COM, (b) CH=N-O-A-COM, (c) CH2-O-N=A-COM wherein A is selected from alkylene and cycloalkylene, and M is selected from (a) a pharmaceutically acceptable metabolically cleavable group, (b) -OR6, (c) -NR7R8, (d)-NR6SO2R9, (e)-NH-Tetrazolyl, and (f) glycinyl inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states. Also disclosed are leukotriene biosynthesis inhibiting compositions and a method of inhibiting leukotriene biosynthesis.

公开(公告)号：DE69625080D1

公开(公告)日：2003-01-09

申请号：DE69625080

申请日：1996-09-25

Applicant: ABBOTT LAB

Inventor： BROOKS CLINT D W ,  BHATIA PRAMILA ,  KOLASA THEODOZYJ ,  STEWART ANDREW O ,  GUNN DAVID E ,  CRAIG RICHARD A

IPC: C07D239/26 ,  A61K31/4184 ,  A61K31/421 ,  A61K31/4402 ,  A61K31/454 ,  A61K31/47 ,  A61K31/498 ,  A61K31/506 ,  A61P37/08 ,  A61P43/00 ,  C07D213/30 ,  C07D215/14 ,  C07D215/18 ,  C07D235/12 ,  C07D241/42 ,  C07D263/56 ,  C07D277/24 ,  C07D277/64 ,  C07D417/14 ,  A61K31/395

Abstract: Compounds having the formula: wherein W is the same at each occurrence and is selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, optionally substituted pyridyl, optionally substituted pyrimidyl, and optionally substituted thiazolyl; R1 and R2 are independently selected from hydrogen, alkyl, halolalkyl, alkoxy, halogen; R3 is a valence bond or is selected from hydrogen and alkyl; X is a valence bond or is selected from alkylene, alkenylen, and alkynylene; and Z is selected from (a) COM, (b) CH=N-O-A-COM, (c) CH2-O-N=A-COM wherein A is selected from alkylene and cycloalkylene, and M is selected from (a) a pharmaceutically acceptable metabolically cleavable group, (b) -OR6, (c) -NR7R8, (d)-NR6SO2R9, (e)-NH-Tetrazolyl, and (f) glycinyl inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states. Also disclosed are leukotriene biosynthesis inhibiting compositions and a method of inhibiting leukotriene biosynthesis.

公开(公告)号：CA2406442A1

公开(公告)日：2001-10-25

申请号：CA2406442

申请日：2001-04-13

Applicant: ABBOTT LAB

Inventor： CRAIG RICHARD A ,  SHEPPARD GEORGE S ,  LYNCH LINDA M ,  PATEL JYOTI R ,  KAWAI MEGUMI ,  YANG FAN ,  WANG JIEYI ,  BA-MAUNG NWE Y

IPC: C07D295/14 ,  A61K31/15 ,  A61K31/164 ,  A61K31/165 ,  A61K31/18 ,  A61K31/215 ,  A61K31/341 ,  A61K31/343 ,  A61K31/352 ,  A61K31/357 ,  A61K31/381 ,  A61K31/40 ,  A61K31/415 ,  A61K31/42 ,  A61K31/426 ,  A61K31/428 ,  A61K31/4402 ,  A61K31/4409 ,  A61K31/455 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4965 ,  A61K31/498 ,  A61K31/50 ,  A61K31/505 ,  A61K31/5375 ,  A61P9/00 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07C243/28 ,  C07C243/34 ,  C07C243/38 ,  C07C251/86 ,  C07C255/42 ,  C07C255/66 ,  C07C259/06 ,  C07C281/02 ,  C07C281/06 ,  C07C311/37 ,  C07C311/38 ,  C07C323/12 ,  C07C323/18 ,  C07C323/41 ,  C07C323/60 ,  C07C323/62 ,  C07D207/34 ,  C07D207/40 ,  C07D207/416 ,  C07D207/50 ,  C07D209/20 ,  C07D211/12 ,  C07D211/62 ,  C07D213/38 ,  C07D213/54 ,  C07D213/77 ,  C07D213/86 ,  C07D213/87 ,  C07D215/42 ,  C07D231/14 ,  C07D231/38 ,  C07D237/14 ,  C07D237/20 ,  C07D237/24 ,  C07D239/28 ,  C07D239/42 ,  C07D241/24 ,  C07D241/44 ,  C07D261/18 ,  C07D277/20 ,  C07D277/36 ,  C07D277/56 ,  C07D277/82 ,  C07D295/15 ,  C07D295/20 ,  C07D295/32 ,  C07D307/24 ,  C07D307/56 ,  C07D307/68 ,  C07D307/85 ,  C07D311/04 ,  C07D317/68 ,  C07D319/08 ,  C07D333/38 ,  C07D333/40 ,  C07D333/68 ,  C07D333/72 ,  A61K31/175 ,  A61K31/435 ,  C07C239/20 ,  C07C321/14 ,  C07D213/75 ,  C07D215/46

Abstract: Compounds having the formula are methionine aminopeptidase type 2 (MetAP2) inhibitors and are useful for inhibiting angiogenesis. Also disclosed are MetAP2-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.

公开(公告)号：CA2332535A1

公开(公告)日：1999-12-02

申请号：CA2332535

申请日：1999-05-21

Applicant: ABBOTT LAB

Inventor： CRAIG RICHARD A ,  SHEPPARD GEORGE S ,  HENKIN JACK ,  KAWAI MEGUMI

IPC: C07D213/82 ,  A61K31/196 ,  A61K31/198 ,  A61K31/223 ,  A61K31/245 ,  A61K31/4406 ,  A61P27/02 ,  A61P29/02 ,  A61P35/00 ,  C07C237/22 ,  C07C237/42 ,  C07C311/45 ,  C07C311/46 ,  A61K31/195

Abstract: Compounds having Formula (I) or pharmaceutically acceptable salts or prodrug s thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.

公开(公告)号：AU3877899A

公开(公告)日：1999-11-23

申请号：AU3877899

申请日：1999-04-30

Applicant: ABBOTT LAB

Inventor： CRAIG RICHARD A ,  HENKIN JACK ,  KAWAI MEGUMI ,  LYNCH LINDA LIJEWSKI ,  PATEL JYOTI ,  SHEPPARD GEORGE S ,  WANG JIEYI

IPC: C07D295/12 ,  A61K31/16 ,  A61K31/18 ,  A61K31/198 ,  A61K31/22 ,  A61K31/221 ,  A61K31/223 ,  A61K31/341 ,  A61K31/357 ,  A61K31/36 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4166 ,  A61K31/4184 ,  A61K31/426 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/454 ,  A61K31/472 ,  A61K31/5355 ,  A61K31/5375 ,  A61K31/55 ,  A61P9/00 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  C07C20060101 ,  C07C235/16 ,  C07C237/12 ,  C07C237/14 ,  C07C311/19 ,  C07C323/60 ,  C07D207/27 ,  C07D209/16 ,  C07D209/48 ,  C07D211/58 ,  C07D211/82 ,  C07D213/40 ,  C07D213/61 ,  C07D213/74 ,  C07D217/06 ,  C07D231/12 ,  C07D231/40 ,  C07D233/61 ,  C07D233/72 ,  C07D233/95 ,  C07D235/14 ,  C07D265/30 ,  C07D277/20 ,  C07D277/46 ,  C07D277/56 ,  C07D295/18 ,  C07D295/185 ,  C07D307/10 ,  C07D307/52 ,  C07D317/58 ,  C07D319/18 ,  C07D333/20 ,  C07D333/38

Abstract: A class of substituted .beta.-amino acids are potent inhibitors of methionine aminopeptidase type 2 (MetAP2) and are thus useful in inhibiting angiogenesis and disease conditions which depend upon angiogenesis for their development such as diabetic retinopathy, tumor growth, and conditions of inflammation. Pharmaceutical compounds containing the compounds and methods of inhibiting methionine aminopeptidase-2, and angiogenesis are also disclosed.

公开(公告)号：ES2131185T3

公开(公告)日：1999-07-16

申请号：ES94902209

申请日：1993-11-05

Applicant: ABBOTT LAB

Inventor： BASHA ANWER ,  BHATIA PRAMILA ,  BROOKS DEE W ,  CRAIG RICHARD A ,  RATAJCZYK JAMES D ,  STEWART ANDREW O

IPC: A61K31/17 ,  A61K31/38 ,  A61K31/381 ,  A61K31/425 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4433 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P17/00 ,  A61P25/00 ,  A61P27/16 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07C273/18 ,  C07C275/24 ,  C07C275/64 ,  C07D213/61 ,  C07D277/28 ,  C07D307/52 ,  C07D333/20 ,  C07D333/22 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D417/04 ,  C07C275/20

Abstract: PCT No. PCT/US93/10675 Sec. 371 Date Apr. 13, 1995 Sec. 102(e) Date Apr. 13, 1995 PCT Filed Nov. 5, 1993 PCT Pub. No. WO94/11342 PCT Pub. Date May 26, 1994The invention relates to compounds having activity to inhibit lipoxygenase enzyme activity, to pharmaceutical compositions comprising these compounds, and to a medical method of treating. More particularly, this invention concerns certain substituted arylalkynyl- and ((heteroaryl)alkynyl)-N-hydroxy-ureas which inhibit leukotriene biosynthesis, to pharmaceutical compositions of these compounds and to a method of inhibiting leukotriene biosynthesis.

公开(公告)号：CA2233550C

公开(公告)日：2010-06-22

申请号：CA2233550

申请日：1996-09-25

Applicant: ABBOTT LAB

Inventor： BROOKS CLINT D W ,  BHATIA PRAMILA ,  KOLASA THEODOZYJ ,  STEWART ANDREW O ,  GUNN DAVID E ,  CRAIG RICHARD A

IPC: C07D215/14 ,  C07D239/26 ,  A61K31/41 ,  A61K31/4184 ,  A61K31/421 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/454 ,  A61K31/47 ,  A61K31/495 ,  A61K31/498 ,  A61K31/506 ,  A61P37/08 ,  A61P43/00 ,  C07D213/30 ,  C07D213/55 ,  C07D215/18 ,  C07D235/12 ,  C07D235/20 ,  C07D241/42 ,  C07D263/56 ,  C07D277/24 ,  C07D277/30 ,  C07D277/64 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

Abstract: Compounds having formula (I), wherein W is the same at each occurrence and is selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, optionally substituted pyridyl, optionally substituted pyrimidyl, and optionally substituted thiazolyl; R1 and R2 are independently selected from hydrogen, alkyl, haloalkyl, alkoxy, halogen; R3 is a valence bond or is selected from hydrogen and alkyl; X is a valence bond or is selected from alkylene, alkenylen, and alkynylene; and Z is selected from (a) COM, (b) CH=N-O-A-COM, (c) CH2-O-N=A-COM wherein A is selected from alkylene and cycloalkylene, and M is selected from (a) a pharmaceutically acceptable metabolically cleavable group, (b) -OR6, (c) -NR7R8, (d) -NR6SO2R9, (e) -NH-Tetrazolyl, and (f) glycinyl inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states. Also disclosed are leukotriene biosynthesis inhibiting compositions and a method of inhibiting leukotriene biosynthesis.

公开(公告)号：DK1080070T3

公开(公告)日：2007-02-26

申请号：DK99924434

申请日：1999-05-21

Applicant: ABBOTT LAB

Inventor： KAWAI MEGUMI ,  HENKIN JACK ,  SHEPPARD GEORGE S ,  CRAIG RICHARD A

IPC: C07C237/42 ,  C07D213/82 ,  A61K31/195 ,  A61K31/196 ,  A61K31/198 ,  A61K31/223 ,  A61K31/245 ,  A61K31/4406 ,  A61P27/02 ,  A61P29/02 ,  A61P35/00 ,  C07C237/22 ,  C07C311/45 ,  C07C311/46

公开(公告)号：AT346036T

公开(公告)日：2006-12-15

申请号：AT99924434

申请日：1999-05-21

Applicant: ABBOTT LAB

Inventor： KAWAI MEGUMI ,  HENKIN JACK ,  SHEPPARD GEORGE S ,  CRAIG RICHARD A

IPC: C07D213/82 ,  A61K31/196 ,  A61K31/198 ,  A61K31/223 ,  A61K31/245 ,  A61K31/4406 ,  A61P27/02 ,  A61P29/02 ,  A61P35/00 ,  C07C237/22 ,  C07C237/42 ,  C07C311/45 ,  C07C311/46 ,  A61K31/195