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公开(公告)号：WO9962908A3
公开(公告)日：2000-03-30
申请号：PCT/US9912419
申请日：1999-06-03
Applicant: ABBOTT LAB
Inventor： STEWART ANDREW O , BOYD STEVEN A , ARENDSEN DAVID L , BHATIA PRAMILA , CONDROSKI KEVIN R , FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , ZHU GUI-DONG , LARTEY KRAIG , MCCARTY CATHERINE M , MORT NICHOLAS A , PATEL MEENA V , STAEGER MICHAEL A , STOUT DAVID M
IPC: A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/519 , A61K31/5377 , A61P29/00 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , A61K31/44 , A61K31/50 , A61K31/505
CPC classification number: C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
Abstract: Compounds having Formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compouns of Formula (I), and methods of inhibiting/treating inflammatory diseases in a mammal.
Abstract translation: 具有式（I）的化合物可用于治疗炎症。 还公开了包含式（I）的化合物的药物组合物，以及哺乳动物抑制/治疗炎性疾病的方法。
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公开(公告)号：WO2004060859A3
公开(公告)日：2004-09-02
申请号：PCT/US0338906
申请日：2003-12-08
Applicant: ABBOTT LAB
Inventor： ANDERSON STEVEN N , BHATIA PRAMILA , KOLASA TEODOZYJ , NAKANE MASAKI , PATEL MEENA V , ROHDE JEFFREY J , XIA ZHIREN , ZHANG HENRY Q
IPC: C07C323/62 , C07D211/16 , C07D211/34 , C07D211/42 , C07D211/46 , C07D211/62 , C07D213/70 , A61K31/165 , A61K31/44
CPC classification number: C07D213/70 , C07C323/62 , C07D211/16 , C07D211/34 , C07D211/42 , C07D211/46 , C07D211/62
Abstract: Compounds of formula (I) are useful for increasing cGMP levels in a mammal.
Abstract translation: 式（I）化合物可用于增加哺乳动物中的cGMP水平。
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3.发明公开SUBSTITUTED ARYLALKYNYL- AND HETEROARYLALKYNYL-N-HYDROXYUREA INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS. 失效取代芳和杂芳基炔-N-羟基脲衍生物作为抑制剂白三烯的生物合成。
公开(公告)号：EP0667855A4
公开(公告)日：1996-02-21
申请号：EP94902209
申请日：1993-11-05
Applicant: ABBOTT LAB
Inventor： BASHA ANWER , BHATIA PRAMILA , BROOKS DEE W , CRAIG RICHARD A , RATAJCZYK JAMES D , STEWART ANDREW O
IPC: A61K31/17 , A61K31/38 , A61K31/381 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4433 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P25/00 , A61P27/16 , A61P29/00 , A61P37/08 , A61P43/00 , C07C273/18 , C07C275/24 , C07C275/64 , C07D213/61 , C07D277/28 , C07D307/52 , C07D333/20 , C07D333/22 , C07D405/06 , C07D409/04 , C07D409/06 , C07D417/04 , C07C275/20
CPC classification number: C07D405/06 , C07C275/64 , C07D213/61 , C07D277/28 , C07D307/52 , C07D333/20 , C07D409/06
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公开(公告)号：DE69625080T2
公开(公告)日：2003-10-09
申请号：DE69625080
申请日：1996-09-25
Applicant: ABBOTT LAB
Inventor： BROOKS CLINT D W , BHATIA PRAMILA , KOLASA THEODOZYJ , STEWART ANDREW O , GUNN DAVID E , CRAIG RICHARD A
IPC: C07D239/26 , A61K31/4184 , A61K31/421 , A61K31/4402 , A61K31/454 , A61K31/47 , A61K31/498 , A61K31/506 , A61P37/08 , A61P43/00 , C07D213/30 , C07D215/14 , C07D215/18 , C07D235/12 , C07D241/42 , C07D263/56 , C07D277/24 , C07D277/64 , C07D417/14 , A61K31/395
Abstract: Compounds having the formula: wherein W is the same at each occurrence and is selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, optionally substituted pyridyl, optionally substituted pyrimidyl, and optionally substituted thiazolyl; R1 and R2 are independently selected from hydrogen, alkyl, halolalkyl, alkoxy, halogen; R3 is a valence bond or is selected from hydrogen and alkyl; X is a valence bond or is selected from alkylene, alkenylen, and alkynylene; and Z is selected from (a) COM, (b) CH=N-O-A-COM, (c) CH2-O-N=A-COM wherein A is selected from alkylene and cycloalkylene, and M is selected from (a) a pharmaceutically acceptable metabolically cleavable group, (b) -OR6, (c) -NR7R8, (d)-NR6SO2R9, (e)-NH-Tetrazolyl, and (f) glycinyl inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states. Also disclosed are leukotriene biosynthesis inhibiting compositions and a method of inhibiting leukotriene biosynthesis.
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公开(公告)号：AT228504T
公开(公告)日：2002-12-15
申请号：AT96932335
申请日：1996-09-25
Applicant: ABBOTT LAB
Inventor： BROOKS CLINT D W , BHATIA PRAMILA , KOLASA THEODOZYJ , STEWART ANDREW O , GUNN DAVID E , CRAIG RICHARD A
IPC: C07D239/26 , A61K31/4184 , A61K31/421 , A61K31/4402 , A61K31/454 , A61K31/47 , A61K31/498 , A61K31/506 , A61P37/08 , A61P43/00 , C07D213/30 , C07D215/14 , C07D215/18 , C07D235/12 , C07D241/42 , C07D263/56 , C07D277/24 , C07D277/64 , C07D417/14 , A61K31/395
Abstract: Compounds having the formula: wherein W is the same at each occurrence and is selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, optionally substituted pyridyl, optionally substituted pyrimidyl, and optionally substituted thiazolyl; R1 and R2 are independently selected from hydrogen, alkyl, halolalkyl, alkoxy, halogen; R3 is a valence bond or is selected from hydrogen and alkyl; X is a valence bond or is selected from alkylene, alkenylen, and alkynylene; and Z is selected from (a) COM, (b) CH=N-O-A-COM, (c) CH2-O-N=A-COM wherein A is selected from alkylene and cycloalkylene, and M is selected from (a) a pharmaceutically acceptable metabolically cleavable group, (b) -OR6, (c) -NR7R8, (d)-NR6SO2R9, (e)-NH-Tetrazolyl, and (f) glycinyl inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states. Also disclosed are leukotriene biosynthesis inhibiting compositions and a method of inhibiting leukotriene biosynthesis.
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Patent Agency Ranking
公开(公告)号：CA2390948A1
公开(公告)日：2000-12-14
申请号：CA2390948
申请日：1999-06-28
Applicant: ABBOTT LAB
Inventor： FREEMAN JENNIFER C , GUNAWARDANA INDRANI W , ARENDSEN DAVID L , STOUT DAVID M , LARTEY KRAIG , BHATIA PRAMILA , ZHU GUI-DONG , PATEL MEENA V , BOYD STEVEN A , STEWART ANDREW O , STAEGER MICHAEL A , MORT NICHOLAS A , CONDROSKI KEVIN R , MCCARTY CATHERINE M
IPC: C07D491/048 , A61K31/415 , A61K31/425 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/44 , A61K31/50 , A61K31/505 , A61K31/519 , A61K31/5355 , A61P9/00 , A61P29/00 , A61P35/04 , A61P37/00 , C07D221/00 , C07D239/00 , C07D333/00 , C07D471/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04
Abstract: Compounds having formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of formula (I ), and methods of inhibiting/treating inflammatory diseases in a mammal.
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公开(公告)号：CA2333770A1
公开(公告)日：1999-12-09
申请号：CA2333770
申请日：1999-06-03
Applicant: ABBOTT LAB
Inventor： PATEL MEENA V , MORT NICHOLAS A , ZHU GUI-DONG , GUNAWARDANA INDRANI W , ARENDSEN DAVID L , STEWART ANDREW O , BOYD STEVEN A , STAEGER MICHAEL A , MCCARTY CATHERINE M , LARTEY KRAIG , STOUT DAVID M , FREEMAN JENNIFER C , CONDROSKI KEVIN R , BHATIA PRAMILA , MELCHER LAURA M
IPC: A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/519 , A61K31/5377 , A61P29/00 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , C07D221/00 , C07D235/00 , C07D237/00 , C07D239/00 , C07D263/00 , C07D277/00 , C07D307/00 , C07D333/00 , A61K31/44 , A61K31/50 , A61K31/505
Abstract: Compounds having Formula (I) are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compouns of Formula (I) , and methods of inhibiting/treating inflammatory diseases in a mammal.
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公开(公告)号：DK0667855T3
公开(公告)日：1999-10-11
申请号：DK94902209
申请日：1993-11-05
Applicant: ABBOTT LAB
Inventor： BASHA ANWER , BHATIA PRAMILA , BROOKS DEE W , CRAIG RICHARD A , RATAJCZYK JAMES D , STEWART ANDREW O
IPC: A61K31/17 , A61K31/38 , A61K31/381 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4433 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P25/00 , A61P27/16 , A61P29/00 , A61P37/08 , A61P43/00 , C07C273/18 , C07C275/24 , C07C275/64 , C07D213/61 , C07D277/28 , C07D307/52 , C07D333/20 , C07D333/22 , C07D405/06 , C07D409/04 , C07D409/06 , C07D417/04 , C07C275/20
Abstract: PCT No. PCT/US93/10675 Sec. 371 Date Apr. 13, 1995 Sec. 102(e) Date Apr. 13, 1995 PCT Filed Nov. 5, 1993 PCT Pub. No. WO94/11342 PCT Pub. Date May 26, 1994The invention relates to compounds having activity to inhibit lipoxygenase enzyme activity, to pharmaceutical compositions comprising these compounds, and to a medical method of treating. More particularly, this invention concerns certain substituted arylalkynyl- and ((heteroaryl)alkynyl)-N-hydroxy-ureas which inhibit leukotriene biosynthesis, to pharmaceutical compositions of these compounds and to a method of inhibiting leukotriene biosynthesis.
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公开(公告)号：ZA9509262B
公开(公告)日：1996-05-29
申请号：ZA9509262
申请日：1995-11-02
Applicant: ABBOTT LAB
Inventor： BROOKS CLINT D W , BHATIA PRAMILA , KOLASA TEODOZYJ
IPC: A61K20060101 , C07C20060101 , C07C , A61K
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公开(公告)号：MX9203676A
公开(公告)日：1992-09-01
申请号：MX9203676
申请日：1992-06-29
Applicant: ABBOTT LAB
Inventor： BOOKS DEE W , STEWART ANDREW O , KERKMAN DANIEL J , BHATIA PRAMILA , BASHA ANWER
IPC: A61K31/16 , A61K31/17 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/42 , A61K31/423 , A61K31/435 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/505 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , C07C239/08 , C07C275/20 , C07C275/64 , C07C323/44 , C07C333/12 , C07D213/40 , C07D213/64 , C07D213/643 , C07D213/65 , C07D213/68 , C07D213/69 , C07D213/78 , C07D215/20 , C07D215/22 , C07D215/227 , C07D217/24 , C07D239/34 , C07D241/14 , C07D241/18 , C07D263/56 , C07D277/20 , C07D277/34 , C07D307/52 , C07D307/54 , C07D307/56 , C07D307/58 , C07D307/64 , C07D307/81 , C07D307/82 , C07D333/20 , C07D333/24 , C07D333/28 , C07D333/32 , C07D333/34 , C07D333/58 , C07D333/60 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12 , A61K37/64
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