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1.发明专利Pharmaceutical composition for treatment of central nervous system disorder 审中-公开用于治疗中枢神经系统疾病的药物组合物
公开(公告)号：JP2013209377A
公开(公告)日：2013-10-10
申请号：JP2013086296
申请日：2013-04-17
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： BROWMAN KAITLIN E , ROHDE JEFFREY , JACOBSON PEER B , BRUNE MICHAEL E , RUETER LYNNE E , WANG JIAHONG , LINK JAMES T , ROBERT S BITNER , CHEN YIXIAN , DINGES JURGEN , DRESCHER KARLA , JAE HWAN-SOO , KURUKULASURIYA RAVI , MADAR DAVID J , PATEL JYOTI , PLIUSHCHEV MARINA , SHUAI QI , SORENSEN BRYAN , WICKE KARSTEN , WINN MARTIN , WODKA DARIUSZ , YEH VINCE , YONG HONG
CPC classification number: C07D403/12 , A61K31/44 , A61K31/495 , C07D207/267 , C07D401/12 , C07D401/14
Abstract: PROBLEM TO BE SOLVED: To provide a therapeutic agent for a patient suffering from disorders and deficits of the central nervous system associated with diabetes, associated with aging and neurodegeneration, comprising attention deficit disorder in general, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, AIDS dementia, neurodegeneration, and schizophrenia.SOLUTION: A pharmaceutical composition includes an effective amount of a selective inhibitor of the 11-β-hydroxysteroid dehydrogenase type 1 enzyme activity represented by formula.
Abstract translation: 要解决的问题：为患有与衰老和神经变性相关的糖尿病中枢神经系统紊乱和缺陷的患者提供治疗剂，其包括注意力缺陷障碍，注意力缺陷多动障碍（ADHD），阿尔茨海默病 （AD），轻度认知障碍，老年性痴呆，艾滋病痴呆，神经变性和精神分裂症。解决方案：药物组合物包括有效量的由式表示的11-＆bgr-羟基类固醇脱氢酶1型酶活性的选择性抑制剂。
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2.发明专利
公开(公告)号：JP2009046464A
公开(公告)日：2009-03-05
申请号：JP2007241117
申请日：2007-09-18
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： BROWMAN KAITLIN E , ROHDE JEFFREY , JACOBSON PEER B , BRUNE MICHAEL E , RUETER LYNNE E , WANG JIAHONG , LINK JAMES T , ROBERT S BITNER , CHEN YIXIAN , DINGES JURGEN , DRESCHER KARLA , JAE HWAN-SOO , KURUKULASURIYA RAVI , MADAR DAVID J , PATEL JYOTI , PLIUSHCHEV MARINA , SHUAI QI , SORENSEN BRYAN , WICKE KARSTEN , WINN MARTIN , WODKA DARIUSZ , YEH VINCE , YONG HONG
IPC: A61K31/165 , A61K31/496 , A61P25/00 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D213/74
CPC classification number: C07D403/12 , A61K31/44 , A61K31/495 , C07D207/267 , C07D401/12 , C07D401/14
Abstract: PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for treating patients with diabetes-, aging- and neurodegeneration-related central-nervous-system disorders and deletions including ordinary attention-deficit disorders, attention-deficit hyperactivity disorders (ADHD), Alzheimer's disease (AD), mild cognitive damage, senile dementia, AIDS dementia, neurodegeneration and schizophrenia. SOLUTION: The pharmaceutical composition for treating glucocorticoid-related central-nervous-system disorders contains a selective inhibitor for 11-β-hydroxysteroid dehydrogenase 1-type enzyme activity. COPYRIGHT: (C)2009,JPO&INPIT
Abstract translation: 待解决的问题：提供一种用于治疗患有糖尿病，老化和神经变性相关的中枢神经系统疾病和缺失的药物组合物，包括普通注意力缺陷障碍，注意力缺陷多动障碍（ADHD） 阿尔茨海默病（AD），轻度认知损伤，老年痴呆，艾滋病痴呆，神经变性和精神分裂症。 解决方案：用于治疗糖皮质激素相关中枢神经系统疾病的药物组合物含有11-β-羟基类固醇脱氢酶1型酶活性的选择性抑制剂。 版权所有（C）2009，JPO＆INPIT
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3.发明申请
公开(公告)号：WO9957098A3
公开(公告)日：2000-07-27
申请号：PCT/US9909641
申请日：1999-04-30
Applicant: ABBOTT LAB
Inventor： CRAIG RICHARD A , HENKIN JACK , KAWAI MEGUMI , LYNCH LINDA LIJEWSKI , PATEL JYOTI , SHEPPARD GEORGE S , WANG JIEYI
IPC: C07C235/16 , C07C237/12 , C07C237/14 , C07C311/18 , C07C311/19 , C07C323/58 , C07C323/60 , C07D207/26 , C07D207/27 , C07D209/14 , C07D209/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/75 , C07D217/06 , C07D231/40 , C07D233/76 , C07D233/95 , C07D235/14 , C07D241/08 , C07D277/46 , C07D277/56 , C07D295/185 , C07D307/14 , C07D317/58 , C07D317/66 , C07D333/20 , C07D333/38 , C07D521/00 , A61K31/16
CPC classification number: C07D207/27 , C07C235/16 , C07C237/12 , C07C237/14 , C07C311/18 , C07C311/19 , C07C323/58 , C07C323/60 , C07C2601/04 , C07C2601/14 , C07C2603/74 , C07D209/14 , C07D209/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/75 , C07D217/06 , C07D231/12 , C07D231/40 , C07D233/56 , C07D233/76 , C07D233/95 , C07D235/14 , C07D241/08 , C07D249/08 , C07D277/46 , C07D277/56 , C07D295/185 , C07D307/14 , C07D317/58 , C07D317/66 , C07D333/20 , C07D333/38
Abstract: A class of substituted beta -amino acids are potent inhibitors of methionine aminopeptidase type 2 (MetAP2) and are thus useful in inhibiting angiogenesis and disease conditions which depend upon angiogenesis for their development such as diabetic retinopathy, tumor growth, and conditions of inflammation. Pharmaceutical compounds containing the compounds and methods of inhibiting methionine aminopeptidase-2, and angiogenesis are also disclosed.
Abstract translation: 一类取代的β-氨基酸是甲硫氨酸氨基肽酶2（MetAP2）的有效抑制剂，因此可用于抑制血管发生和疾病状况，其依赖于血管生成发展，例如糖尿病性视网膜病变，肿瘤生长和炎症状况。 还公开了含有化合物的药物化合物和抑制甲硫氨酸氨基肽酶-2的方法和血管发生。
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公开(公告)号：AU3877899A
公开(公告)日：1999-11-23
申请号：AU3877899
申请日：1999-04-30
Applicant: ABBOTT LAB
Inventor： CRAIG RICHARD A , HENKIN JACK , KAWAI MEGUMI , LYNCH LINDA LIJEWSKI , PATEL JYOTI , SHEPPARD GEORGE S , WANG JIEYI
IPC: C07D295/12 , A61K31/16 , A61K31/18 , A61K31/198 , A61K31/22 , A61K31/221 , A61K31/223 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/4015 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/4045 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/4184 , A61K31/426 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4468 , A61K31/451 , A61K31/454 , A61K31/472 , A61K31/5355 , A61K31/5375 , A61K31/55 , A61P9/00 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , C07C20060101 , C07C235/16 , C07C237/12 , C07C237/14 , C07C311/19 , C07C323/60 , C07D207/27 , C07D209/16 , C07D209/48 , C07D211/58 , C07D211/82 , C07D213/40 , C07D213/61 , C07D213/74 , C07D217/06 , C07D231/12 , C07D231/40 , C07D233/61 , C07D233/72 , C07D233/95 , C07D235/14 , C07D265/30 , C07D277/20 , C07D277/46 , C07D277/56 , C07D295/18 , C07D295/185 , C07D307/10 , C07D307/52 , C07D317/58 , C07D319/18 , C07D333/20 , C07D333/38
Abstract: A class of substituted .beta.-amino acids are potent inhibitors of methionine aminopeptidase type 2 (MetAP2) and are thus useful in inhibiting angiogenesis and disease conditions which depend upon angiogenesis for their development such as diabetic retinopathy, tumor growth, and conditions of inflammation. Pharmaceutical compounds containing the compounds and methods of inhibiting methionine aminopeptidase-2, and angiogenesis are also disclosed.
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公开(公告)号：BG104981A
公开(公告)日：2001-07-31
申请号：BG10498100
申请日：2000-11-24
Applicant: ABBOTT LAB
Inventor： CRAIG RICHARD A , HENKIN JACK , KAWAI MEGUMI , LYNCH LINDA L , PATEL JYOTI , SHEPPARD GEORGE S , WANG JIEYI
IPC: C07C235/16 , C07C237/12 , C07C237/14 , C07C311/18 , C07C311/19 , C07C323/58 , C07C323/60 , C07D207/26 , C07D207/27 , C07D209/14 , C07D209/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/75 , C07D217/06 , C07D231/40 , C07D233/76 , C07D233/95 , C07D235/14 , C07D241/08 , C07D277/46 , C07D277/56 , C07D295/185 , C07D307/14 , C07D317/58 , C07D317/66 , C07D333/20 , C07D333/38 , C07D521/00 , A61K31/16
Abstract: A class of substituted beta-amino acids are potent inhibitors of methionine aminopeptidase type 2 (MetAP2) and are thus useful in inhibiting angiogenesis and disease conditions which depend upon angiogenesis for their development such as diabetic retinopathy, tumor growth, and conditions of inflammation. Pharmaceutical compounds containing the compounds and methods of inhibiting methionine aminopeptidase-2, and angiogenesis are also disclosed. 18 claims
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Patent Agency Ranking
公开(公告)号：NO20005506A
公开(公告)日：2000-12-29
申请号：NO20005506
申请日：2000-11-01
Applicant: ABBOTT LAB
Inventor： CRAIG RICHARD A , HENKIN JACK , KAWAI MEGUMI , LYNCH LINDA M , PATEL JYOTI , SHEPPARD GEORGE S , WANG JIEYI
IPC: C07C235/16 , C07C237/12 , C07C237/14 , C07C311/18 , C07C311/19 , C07C323/58 , C07C323/60 , C07D207/26 , C07D207/27 , C07D209/14 , C07D209/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/75 , C07D217/06 , C07D231/40 , C07D233/76 , C07D233/95 , C07D235/14 , C07D241/08 , C07D277/46 , C07D277/56 , C07D295/185 , C07D307/14 , C07D317/58 , C07D317/66 , C07D333/20 , C07D333/38 , C07D521/00 , A61K31/16
CPC classification number: C07D207/27 , C07C235/16 , C07C237/12 , C07C237/14 , C07C311/18 , C07C311/19 , C07C323/58 , C07C323/60 , C07C2601/04 , C07C2601/14 , C07C2603/74 , C07D209/14 , C07D209/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/75 , C07D217/06 , C07D231/12 , C07D231/40 , C07D233/56 , C07D233/76 , C07D233/95 , C07D235/14 , C07D241/08 , C07D249/08 , C07D277/46 , C07D277/56 , C07D295/185 , C07D307/14 , C07D317/58 , C07D317/66 , C07D333/20 , C07D333/38
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公开(公告)号：PL346444A1
公开(公告)日：2002-02-11
申请号：PL34644499
申请日：1999-04-30
Applicant: ABBOTT LAB
Inventor： CRAIG RICHARD A , HENKIN JACK , KAWAI MEGUMI , LYNCH LINDA LIJEWSKI , PATEL JYOTI , SHEPPARD GEORGE S , WANG JIEYI
IPC: C07D295/12 , A61K31/16 , A61K31/18 , A61K31/198 , A61K31/22 , A61K31/221 , A61K31/223 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/4015 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/4045 , A61K31/415 , A61K31/4164 , A61K31/4166 , A61K31/4184 , A61K31/426 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/4468 , A61K31/451 , A61K31/454 , A61K31/472 , A61K31/5355 , A61K31/5375 , A61K31/55 , A61P9/00 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , C07C20060101 , C07C235/16 , C07C237/12 , C07C237/14 , C07C311/19 , C07C323/60 , C07D207/27 , C07D209/16 , C07D209/48 , C07D211/58 , C07D211/82 , C07D213/40 , C07D213/61 , C07D213/74 , C07D217/06 , C07D231/12 , C07D231/40 , C07D233/61 , C07D233/72 , C07D233/95 , C07D235/14 , C07D265/30 , C07D277/20 , C07D277/46 , C07D277/56 , C07D295/18 , C07D295/185 , C07D307/10 , C07D307/52 , C07D317/58 , C07D319/18 , C07D333/20 , C07D333/38
Abstract: A class of substituted .beta.-amino acids are potent inhibitors of methionine aminopeptidase type 2 (MetAP2) and are thus useful in inhibiting angiogenesis and disease conditions which depend upon angiogenesis for their development such as diabetic retinopathy, tumor growth, and conditions of inflammation. Pharmaceutical compounds containing the compounds and methods of inhibiting methionine aminopeptidase-2, and angiogenesis are also disclosed.
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公开(公告)号：NO20005506L
公开(公告)日：2000-12-29
申请号：NO20005506
申请日：2000-11-01
Applicant: ABBOTT LAB
Inventor： CRAIG RICHARD A , HENKIN JACK , KAWAI MEGUMI , LYNCH LINDA M , PATEL JYOTI , SHEPPARD GEORGE S , WANG JIEYI
IPC: C07C235/16 , C07C237/12 , C07C237/14 , C07C311/18 , C07C311/19 , C07C323/58 , C07C323/60 , C07D207/26 , C07D207/27 , C07D209/14 , C07D209/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/75 , C07D217/06 , C07D231/40 , C07D233/76 , C07D233/95 , C07D235/14 , C07D241/08 , C07D277/46 , C07D277/56 , C07D295/185 , C07D307/14 , C07D317/58 , C07D317/66 , C07D333/20 , C07D333/38 , C07D521/00 , A61K31/16
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公开(公告)号：AT555081T
公开(公告)日：2012-05-15
申请号：AT06717418
申请日：2006-01-05
Applicant: ABBOTT LAB
Inventor： PATEL JYOTI , SHUAI QI , LINK JAMES , ROHDE JEFFREY , DINGES JURGEN , SORENSEN BRYAN , WINN MARTIN , YONG HONG , YEH VINCE
IPC: C07C235/14 , C07C317/16 , C07C323/41 , C07D207/48 , C07D213/64 , C07D233/54 , C07D257/04 , C07D261/08
Abstract: The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.
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公开(公告)号：BR9910092A
公开(公告)日：2002-01-22
申请号：BR9910092
申请日：1999-04-30
Applicant: ABBOTT LAB
Inventor： CRAIG RICHARD A , KAWAI MEGUMI , HENKIN JACK , LYNCH LINDA LIJEWSKI , PATEL JYOTI , SHEPPARD GEORGE S , WANG JIEYI
IPC: C07C235/16 , C07C237/12 , C07C237/14 , C07C311/18 , C07C311/19 , C07C323/58 , C07C323/60 , C07D207/26 , C07D207/27 , C07D209/14 , C07D209/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D213/40 , C07D213/74 , C07D213/75 , C07D217/06 , C07D231/40 , C07D233/76 , C07D233/95 , C07D235/14 , C07D241/08 , C07D277/46 , C07D277/56 , C07D295/185 , C07D307/14 , C07D317/58 , C07D317/66 , C07D333/20 , C07D333/38 , C07D521/00 , A61K31/16
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