公开(公告)号：AU2010258769A1

公开(公告)日：2010-12-16

申请号：AU2010258769

申请日：2010-06-10

Applicant: ABBOTT LAB ,  JOHN RANDOLPH

Inventor： RANDOLPH JOHN T ,  DEGOEY DAVID A ,  KATI WARREN M ,  HUTCHINS CHARLES W ,  DONNER PAMELA L ,  KRUEGER ALLAN C ,  MOTTER CHRISTOPHER E ,  NELSON LISSA T ,  PATEL SACHIN V ,  MATULENKO MARK A ,  KEDDY RYAN G ,  JINKERSON TAMMIE K ,  SOLTWEDEL TODD N ,  HUTCHINSON DOUGLAS K ,  FLENTGE CHARLES A ,  WAGNER ROLF ,  MARING CLARENCE J ,  TUFANO MICHAEL D ,  BETEBENNER DAVID A ,  ROCKWAY TODD W ,  LIU DACHUN ,  PRATT JOHN K ,  LAVIN MICHAEL J ,  SARRIS KATHY ,  WOLLER KEVIN R ,  WAGAW SEBLE H ,  CALIFANO JEAN C ,  LI WENKE ,  CASPI DANIEL D ,  BELLIZZI MARY E

IPC: C07D403/14

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：CA2760464A1

公开(公告)日：2010-11-11

申请号：CA2760464

申请日：2010-05-06

Applicant: ABBOTT GMBH & CO KG ,  ABBOTT LAB

Inventor： MACK HELMUT ,  KLING ANDREAS ,  JANTOS KATJA ,  MOELLER ACHIM ,  HORNBERGER WILFRIED ,  HUTCHINS CHARLES W

IPC: C07D207/26 ,  A61K31/4412 ,  C07D211/76 ,  C07D233/34 ,  C07D239/10

Abstract: The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula (I) in which R1, R2, R3a, R3b, R4, Q, Y, A and X have the meanings mentioned in the claims and the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula (Ia) and (Ib) in which R1, r, R2b, R3a, R3b, R4, Y and X have the meanings mentioned in the claims, including the tautomers thereof and the pharmaceutically suitable salts thereof. Of these compounds those are preferred wherein Y is a moiety CH2-CH2, CH2-CH2-CH2, N(Ry#)-CH2, N(Ry#)-CH2-CH2 or CH=CH-CH=, each optionally having 1 or 2 H-atoms replaced with identical or different radicals Ry, wherein Ry and Ry# have the meanings mentioned in the claims.

公开(公告)号：CA2740193A1

公开(公告)日：2010-07-01

申请号：CA2740193

申请日：2009-12-22

Applicant: ABBOTT LAB

Inventor： DEGOEY DAVID A ,  DONNER PAMELA L ,  KATI WARREN M ,  HUTCHINS CHARLES W ,  MATULENKO MARK A ,  JINKERSON TAMMIE K ,  KEDDY RYAN G

IPC: C07D471/04 ,  A61K31/519 ,  A61P31/14

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：HU226888B1

公开(公告)日：2010-01-28

申请号：HU9901580

申请日：1997-02-12

Applicant: ABBOTT LAB

Inventor： BOYD STEVEN A ,  HENRY KENNETH JR ,  HUTCHINS CHARLES W ,  JAE HWAN-SOO ,  KESTER JEFFREY A ,  KING STEVEN A ,  LIU GANG ,  SORENSEN BRYAN K ,  SZCZEPANKIEWICZ BRUCE G ,  TASKER ANDREW S ,  WINN MARTIN ,  WITTENBERGER STEVEN J ,  VON GELDERN THOMAS W

IPC: A61K31/40 ,  A61K31/4025 ,  A61K31/435 ,  A61K31/4439 ,  A61P9/00 ,  A61P35/00 ,  C07D207/04 ,  C07D207/16 ,  C07D211/06 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07F9/572 ,  C07F9/59

公开(公告)号：CA2720004A1

公开(公告)日：2009-10-08

申请号：CA2720004

申请日：2009-03-31

Applicant: ABBOTT GMBH & CO KG ,  ABBOTT LAB

Inventor： AMBERG WILHELM ,  OCHSE MICHAEL ,  LANGE UDO ,  BRAJE WILFRIED ,  BEHL BERTHOLD ,  HORNBERGER WILFRIED ,  MEZLER MARIO ,  HUTCHINS CHARLES W

IPC: C07D217/18 ,  A61K31/472 ,  A61P25/28 ,  C07D401/06 ,  C07D401/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D498/04 ,  C07D513/04

Abstract: The present invention relates to tetrahydroisoquinoline of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such tetrahydroisoquinolines, and the use of such tetrahydroisoquinolines for therapeutic purposes. The tetrahydroisoquinolines are GIyT1 inhibitors.

公开(公告)号：ES2259803T3

公开(公告)日：2006-10-16

申请号：ES97905816

申请日：1997-02-12

Applicant: ABBOTT LAB

Inventor： WINN MARTIN ,  BOYD STEVEN A ,  HUTCHINS CHARLES W ,  JAE HWAN-SOO ,  TASKER ANDREW S ,  VON GELDERN THOMAS W

IPC: A61K31/395 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4035 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4166 ,  A61K31/421 ,  A61K31/425 ,  A61K31/435 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/495 ,  A61K31/506 ,  A61K31/675 ,  A61P1/00 ,  A61P1/04 ,  A61P7/02 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P25/06 ,  A61P43/00 ,  C07D207/16 ,  C07D211/60 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D419/14 ,  C07D453/02 ,  C07D471/04 ,  C07D491/04 ,  C07F9/572 ,  C07F9/59

Abstract: SE DESCRIBE UN COMPUESTO DE FORMULA (I), O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, ASI COMO PROCEDIMIENTOS E INTERMEDIOS PARA LA PREPARACION DEL MISMO Y UN METODO PARA ANTAGONIZAR LA ENDOTELINA.

公开(公告)号：CZ296660B6

公开(公告)日：2006-05-17

申请号：CZ253798

申请日：1997-02-12

Applicant: ABBOTT LAB

Inventor： WINN MARTIN ,  BOYD STEVEN A ,  HUTCHINS CHARLES W ,  JAE HWAN-SOO ,  TASKER ANDREW S ,  VON GELDERN THOMAS W ,  KESTER JEFFREY A ,  SORENSEN BRYAN K ,  SZCZEPANKIEWICZ BRUCE G ,  HENRY KENNETH J ,  LIU GANG ,  WITTENBERGER STEVEN J ,  KING STEVEN A

IPC: C07D405/04 ,  A61K31/34 ,  A61K31/395 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4025 ,  A61K31/4035 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4166 ,  A61K31/421 ,  A61K31/425 ,  A61K31/435 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/495 ,  A61K31/506 ,  A61K31/675 ,  A61P1/00 ,  A61P1/04 ,  A61P7/02 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P25/06 ,  A61P35/00 ,  A61P43/00 ,  C07D207/16 ,  C07D211/60 ,  C07D401/04 ,  C07D403/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D419/14 ,  C07D453/02 ,  C07D471/04 ,  C07D491/04 ,  C07F9/572

Abstract: Benzo-1,3-dioxolyl- a benzofuranyl-substituované pyrrolidinové deriváty vzorce I nebo jejich farmaceuticky prijatelné soli, farmaceutický prostredek a jejich pouzití k výrobe léciva pro antagonizaci endothelinu a lécbe hypertenze, mestnavého selhánísrdce, aterosklerózy, rakoviny prostaty, atd. Resení se také týká meziproduktu vzorce II.

公开(公告)号：TR200501137T2

公开(公告)日：2005-12-21

申请号：TR200501137

申请日：1998-07-27

Applicant: ABBOTT LAB

Inventor： WINN MARTIN ,  BOYD STEVEN A ,  HUTCHINS CHARLES W ,  JAE HWAN-SOO ,  TASKER ANDREW S ,  GELDERN THOMAS W VON ,  KESTER JEFFREY A ,  SORENSEN BRYAN K ,  SZCZEPANKIEWICZ BRUCE G ,  HENRY KENNETH J ,  LIU GANG ,  WITTENBERGER STEVEN J ,  KING STEVEN A

IPC: C07D491/048 ,  A61K31/40 ,  A61K31/41 ,  A61K31/423 ,  A61K31/435 ,  A61K31/4355 ,  A61K31/495 ,  A61K31/506 ,  A61K31/535 ,  A61K31/55 ,  A61P1/00 ,  A61P1/04 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P9/14 ,  A61P13/08 ,  A61P13/12 ,  A61P21/00 ,  A61P21/04 ,  A61P25/06 ,  A61P35/00 ,  A61P43/00 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D403/04 ,  C07D405/00 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D491/056

公开(公告)号：CA2195677C

公开(公告)日：2005-11-08

申请号：CA2195677

申请日：1995-08-04

Applicant: ABBOTT LAB

Inventor： WINN MARTIN ,  BOYD STEVEN A ,  HUTCHINS CHARLES W ,  JAE HWAN-SOO ,  TASKER ANDREW S ,  VONGELDERN THOMAS W ,  KESTER JEFFREY A ,  SORENSEN BRYAN K

IPC: A61K31/40 ,  A61K31/402 ,  A61K31/4025 ,  A61K31/403 ,  A61K31/41 ,  A61K31/415 ,  A61K31/422 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/454 ,  A61K31/47 ,  A61K31/505 ,  A61K31/506 ,  A61K31/535 ,  A61K31/5377 ,  A61P9/00 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D20060101 ,  C07D207/14 ,  C07D207/16 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D405/14 ,  C07D413/04 ,  C07D419/04 ,  C07D471/04 ,  C07F9/572 ,  C07F9/59

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.

公开(公告)号：AT219077T

公开(公告)日：2002-06-15

申请号：AT95928323

申请日：1995-08-04

Applicant: ABBOTT LAB

Inventor： WINN MARTIN ,  BOYD STEVEN A ,  HUTCHINS CHARLES W ,  JAE HWAN-SOO ,  TASKER ANDREW S ,  VONGELDERN THOMAS W ,  KESTER JEFFREY A ,  SORENSEN BRYAN K

IPC: A61K31/40 ,  A61K31/402 ,  A61K31/4025 ,  A61K31/403 ,  A61K31/41 ,  A61K31/415 ,  A61K31/422 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/454 ,  A61K31/47 ,  A61K31/505 ,  A61K31/506 ,  A61K31/535 ,  A61K31/5377 ,  A61P9/00 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D20060101 ,  C07D207/14 ,  C07D207/16 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D405/14 ,  C07D413/04 ,  C07D419/04 ,  C07D471/04 ,  C07F9/572 ,  C07F9/59

Abstract: Processes for preparing endothelin antagonists of formula (I) and pharmaceutically acceptable salts thereof and processes for preparing intermediates thereof.