公开(公告)号：MX2009005941A

公开(公告)日：2009-07-24

申请号：MX2009005941

申请日：2007-12-04

Applicant: ABBOTT LAB

Inventor： ANDERSON MARK GERALD ,  KROEGER PAUL E ,  ROSENBERG SAUL HOWARD ,  TAHIR STEPHEN KENNETH ,  TSE CHRISTIN ,  WASS JOHN A

IPC: C12Q1/68

Abstract: Se describen métodos para identificar pacientes con cáncer elegibles para recibir la terapia del inhibidor de la familia Bcl-2 y para supervisar la respuesta del paciente a la terapia del inhibidor de la familia Bcl-2, que comprende la evaluación de los niveles de expresión del conjunto de combinaciones del marcador biológico en las tablas 1, 2, 3, 4, 5, ó 6 en una muestra de tejido del paciente. Los métodos de la invención permiten más eficiencia en la identificación de pacientes para recibir la terapia del inhibidor de la familia Bcl-2 y de la determinación de la respuesta del paciente a la terapia.

公开(公告)号：CA2671399A1

公开(公告)日：2008-06-12

申请号：CA2671399

申请日：2007-12-04

Applicant: ABBOTT LAB

Inventor： KROEGER PAUL E ,  TAHIR STEPHEN KENNETH ,  ROSENBERG SAUL HOWARD ,  TSE CHRISTIN ,  WASS JOHN A ,  ANDERSON MARK GERALD

IPC: C12Q1/68 ,  C40B30/04 ,  G06F19/00

Abstract: Methods for identifying cancer patients eligible to receive Bcl-2 family inhibitor therapy and for monitoring patient response to Bcl-2 family inhibi tor therapy comprise assessment of the expression levels of the biomarker co mbinations set out in TABLES 1, 2, 3, 4, 5 or 6 in a patient tissue sample. The methods of the invention allow more effective identification of patients to receive Bcl-2 family inhibitor therapy and of determination of patient r esponse to the therapy.

公开(公告)号：NZ226002A

公开(公告)日：1990-06-26

申请号：NZ22600288

申请日：1988-08-31

Applicant: ABBOTT LAB

Inventor： ROSENBERG SAUL HOWARD ,  DELLARIA JOSEPH F ,  HING LEUNG SHAM ,  KEMPF DALE J ,  BAKER WILLIAM R

IPC: C07C271/10 ,  A61K31/395 ,  A61K31/415 ,  A61K31/42 ,  A61K31/421 ,  A61K31/535 ,  A61K31/536 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/54 ,  A61K38/00 ,  A61P9/12 ,  C07C67/00 ,  C07C69/24 ,  C07C213/00 ,  C07C215/10 ,  C07C215/20 ,  C07C215/28 ,  C07C217/08 ,  C07C217/28 ,  C07C229/22 ,  C07C229/26 ,  C07C229/30 ,  C07C229/32 ,  C07C229/34 ,  C07C229/36 ,  C07C231/00 ,  C07C231/02 ,  C07C233/11 ,  C07C233/22 ,  C07C233/40 ,  C07C233/47 ,  C07C233/51 ,  C07C235/20 ,  C07C237/12 ,  C07C237/20 ,  C07C239/20 ,  C07C255/46 ,  C07C265/02 ,  C07C265/04 ,  C07C271/16 ,  C07C271/20 ,  C07C271/22 ,  C07C275/24 ,  C07C317/28 ,  C07C317/44 ,  C07C317/48 ,  C07C323/24 ,  C07C323/41 ,  C07C323/56 ,  C07C323/59 ,  C07C323/60 ,  C07D207/12 ,  C07D211/76 ,  C07D213/40 ,  C07D233/32 ,  C07D233/61 ,  C07D263/04 ,  C07D263/06 ,  C07D263/16 ,  C07D263/22 ,  C07D263/24 ,  C07D263/28 ,  C07D265/10 ,  C07D273/04 ,  C07D277/24 ,  C07D285/10 ,  C07D295/12 ,  C07D295/13 ,  C07D295/185 ,  C07D295/205 ,  C07D295/215 ,  C07D295/22 ,  C07D309/14 ,  C07D319/06 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D521/00 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  C07D277/04 ,  C07D307/14 ,  A61K31/425 ,  A61K31/495 ,  A61K37/02

Abstract: A renin inhibiting compound of the formula: wherein A is a substituent; W is C=O, CHOH or NR2 wherein R2 is hydrogen or loweralkyl; U is C=O, CH2 or NR2 wherein R2 is hydrogen or loweralkyl, with the proviso that when W is CHOH then U is CH2 and with the proviso that U is C=O or CH2 when W is NR2; V is CH, C(OH) or C(halogen) with the proviso that V is CH when U is NR2; R1 is loweralkyl, cycloalkylalkyl, benzyl, (alpha, alpha)-dimethylbenzyl, 4-methoxybenzyl, halobenzyl, 4-hydroxybenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (unsubstituted heterocyclic)methyl, (substituted heterocyclic)methyl, phenethyl, 1-benzyloxyethyl, phenoxy, thiophenoxy or anilino, provided that B is CH2 or CHOH or A is hydrogen when R1 is phenoxy, thiophenoxy or anilino; R3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)alkyl, carboxyalkyl, (thioalkoxy)alkyl, azidoalkyl, aminoalkyl, (alkyl)aminoalkyl, dialkylaminoalkyl, (alkoxy)(alkyl)aminoalkyl, (alkoxy)aminoalkyl, benzyl or heterocyclic ring substituted methyl; R4 is loweralkyl, cycloalkylmethyl or benzyl; R5 is OH or NH2; and Z is a substituent. Also disclosed are compositions for and a method of treating hypertension, methods of making the renin inhibiting compounds and intermediates useful in making the renin inhibiting compounds.

公开(公告)号：NZ218937A

公开(公告)日：1990-03-27

申请号：NZ21893787

申请日：1987-01-14

Applicant: ABBOTT LAB

Inventor： ROSENBERG SAUL HOWARD ,  LULY JAY RICHARD ,  PLATTNER JACOB JOHN

IPC: A61K38/00 ,  C07D233/54 ,  C07K20060101 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/083 ,  C07K5/08 ,  C07C103/44 ,  C07C103/50 ,  C07C103/76 ,  C07C143/72 ,  C07C143/21 ,  C07C143/68 ,  C07C149/14 ,  C07C149/24 ,  C07C107/02 ,  C07D295/18 ,  C07D231/18 ,  C07D233/18 ,  C07F7/02 ,  A61K31/16 ,  A61K31/165 ,  A61K31/18 ,  A61K31/195 ,  A61K31/215 ,  A61K31/255 ,  A61K31/415 ,  A61K31/42 ,  A61K31/44 ,  A61K31/495 ,  A61K31/655 ,  A61K31/695

Abstract: The invention relates to renin inhibiting compounds of the formula wherein A is hydrogen; loweralkyl; arylalkyl; OR8 or SR8 wherein R8 is hydrogen, loweralkyl or aminoalkyl; NR9R10 wherein R9 and R10 are independently selected from hydrogen, loweralkyl, aminoalkyl, cyanoalkyl and hydroxyalkyl; wherein B is NH, alkylamino, S, O, CH2 or CHOH and R11 is loweralkyl, cycloalkyl, aryl, arylalkyl, alkoxy, alkenyloxy, hydroxyalkoxy, dihydroxyalkoxy, arylalkoxy, arylalkoxyalkyl, amino, alkylamino, dialkylamino, (hydroxyalkyl)(alkyl)amino, (dihydroxyalkyl)(alkyl)amino, carboxylic acid-substituted alkyl, alkoxycarbonylalkyl, aminoalkyl, N-protected aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, (N-protected) alkyl)aminoalkyl, (heterocyclic)alkyl or a substituted or unsubstituted heterocyclic; R1 is loweralkyl, cycloalkylmethyl, benzyl, alpha -methylbenzyl, alpha , alpha -dimethylbenzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, phenethyl, phenoxy, thiophenoxy or anilino; provided if R1 is phenoxy, thiophenoxy or anilino, B is CH2 or CHOH or A is hydrogen; R3 is loweralkyl, benzyl or heterocyclic ring-substituted methyl; R4 is loweralkyl, cycloalkyl- methyl or benzyl; R2, R5 and R6 are independently hydrogen or loweralkyl; X is O, NH or S; R7 is hydrogen, loweralkyl, alkanoyl, alkylsulfonyl. wherein R12 and R13 are independently hydrogen or loweralkyl, n is 0-2 and R14 is substituted or unsubstituted penyl or heterocyclic; or XR7 together are loweralkylsulfonyl, N3 or Cl, and pharmaceutically acceptable salts thereof.

公开(公告)号：DK514688A

公开(公告)日：1989-03-17

申请号：DK514688

申请日：1988-09-15

Applicant: ABBOTT LAB

Inventor： ROSENBERG SAUL HOWARD ,  SHAM HING LEUNG ,  BAKER WILLIAM R ,  DELLARIA JR JOSEPH F ,  KEMPF DALE J

IPC: C07C271/10 ,  A61K31/395 ,  A61K31/415 ,  A61K31/42 ,  A61K31/421 ,  A61K31/535 ,  A61K31/536 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/54 ,  A61K38/00 ,  A61P9/12 ,  C07C67/00 ,  C07C69/24 ,  C07C213/00 ,  C07C215/10 ,  C07C215/20 ,  C07C215/28 ,  C07C217/08 ,  C07C217/28 ,  C07C229/22 ,  C07C229/26 ,  C07C229/30 ,  C07C229/32 ,  C07C229/34 ,  C07C229/36 ,  C07C231/00 ,  C07C231/02 ,  C07C233/11 ,  C07C233/22 ,  C07C233/40 ,  C07C233/47 ,  C07C233/51 ,  C07C235/20 ,  C07C237/12 ,  C07C237/20 ,  C07C239/20 ,  C07C255/46 ,  C07C265/02 ,  C07C265/04 ,  C07C271/16 ,  C07C271/20 ,  C07C271/22 ,  C07C275/24 ,  C07C317/28 ,  C07C317/44 ,  C07C317/48 ,  C07C323/24 ,  C07C323/41 ,  C07C323/56 ,  C07C323/59 ,  C07C323/60 ,  C07D207/12 ,  C07D211/76 ,  C07D213/40 ,  C07D233/32 ,  C07D233/61 ,  C07D263/04 ,  C07D263/06 ,  C07D263/16 ,  C07D263/22 ,  C07D263/24 ,  C07D263/28 ,  C07D265/10 ,  C07D273/04 ,  C07D277/24 ,  C07D285/10 ,  C07D295/12 ,  C07D295/13 ,  C07D295/185 ,  C07D295/205 ,  C07D295/215 ,  C07D295/22 ,  C07D309/14 ,  C07D319/06 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D521/00 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  C07C125/063 ,  C07C91/02 ,  C07C101/04 ,  C07C103/34 ,  C07C147/06 ,  C07C149/273 ,  C07D207/04 ,  C07D231/12 ,  C07D233/64 ,  C07D239/10 ,  C07D241/02 ,  C07D263/18 ,  C07D265/30 ,  C07D277/30 ,  C07D291/04 ,  C07K5/04

Abstract: A renin inhibiting compound of the formula: wherein A is a substituent; W is C=O, CHOH or NR2 wherein R2 is hydrogen or loweralkyl; U is C=O, CH2 or NR2 wherein R2 is hydrogen or loweralkyl, with the proviso that when W is CHOH then U is CH2 and with the proviso that U is C=O or CH2 when W is NR2; V is CH, C(OH) or C(halogen) with the proviso that V is CH when U is NR2; R1 is loweralkyl, cycloalkylalkyl, benzyl, (alpha, alpha)-dimethylbenzyl, 4-methoxybenzyl, halobenzyl, 4-hydroxybenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (unsubstituted heterocyclic)methyl, (substituted heterocyclic)methyl, phenethyl, 1-benzyloxyethyl, phenoxy, thiophenoxy or anilino, provided that B is CH2 or CHOH or A is hydrogen when R1 is phenoxy, thiophenoxy or anilino; R3 is loweralkyl, loweralkenyl, ((alkoxy)alkoxy)alkyl, carboxyalkyl, (thioalkoxy)alkyl, azidoalkyl, aminoalkyl, (alkyl)aminoalkyl, dialkylaminoalkyl, (alkoxy)(alkyl)aminoalkyl, (alkoxy)aminoalkyl, benzyl or heterocyclic ring substituted methyl; R4 is loweralkyl, cycloalkylmethyl or benzyl; R5 is OH or NH2; and Z is a substituent. Also disclosed are compositions for and a method of treating hypertension, methods of making the renin inhibiting compounds and intermediates useful in making the renin inhibiting compounds.

公开(公告)号：DK483488D0

公开(公告)日：1988-08-30

申请号：DK483488

申请日：1988-08-30

Applicant: ABBOTT LAB

Inventor： FUNG ANTHONY K L ,  KEMPF JOHN DALE ,  LULY JAY RICHARD ,  ROSENBERG SAUL HOWARD ,  PLATTNER JACOB JOHN

IPC: C12N9/99 ,  A61K31/165 ,  A61K31/44 ,  A61K31/4406 ,  A61K38/00 ,  A61P9/12 ,  C07C67/00 ,  C07C235/06 ,  C07C235/08 ,  C07C235/10 ,  C07C235/34 ,  C07C235/74 ,  C07C235/78 ,  C07C237/06 ,  C07C237/08 ,  C07C237/10 ,  C07C237/20 ,  C07C237/22 ,  C07C239/00 ,  C07C271/20 ,  C07C271/24 ,  C07C313/00 ,  C07C317/44 ,  C07C323/60 ,  C07C325/00 ,  C07C327/20 ,  C07C333/02 ,  C07D213/00 ,  C07D213/71 ,  C07D213/78 ,  C07D233/54 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  C07K5/083 ,  C07K5/097 ,  C07K14/81 ,  C07K5/04

Abstract: A renin inhibiting compound of the formula: wherein A is a substituent; W is C=O or CHOH; U is CH2 or NR2, provided that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkylmethyl, benzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, (alpha,alpha)-dimethylbenzyl, 1-benzyloxyethyl, phenethyl, phenoxy, thiophenoxy or anilino; R2 is hydrogen or loweralkyl; R3 is loweralkenyl, [(alkoxy)alkoxy]alkyl, (thioalkoxy)alkyl, lowerakenyl, benzyl or heterocyclic ring substituted methyl; R4 is loweralkyl, cycloalkylmethyl or benzyl; R5 is vinyl, formyl, hydroxymethyl or hydrogen; R7 is hydrogen or loweralkyl; R8 and R9 are independently selected from OH and NH2; and R6 is hydrogen, loweralkyl, vinyl or arylalkyl; provided that when R5 and R7 are both hydrogen and R8 and R9 are OH, the carbon bearing R5 is of the "R" configuration and the carbon bearing R6 is of the "S" configuration, or pharmaceutically acceptable salts or esters thereof. Also disclosed are renin inhibiting compositions, a method of treating hypertension, methods of making the renin inhibiting compounds and intermediates useful in making the renin inhibiting compounds.

公开(公告)号：ZA86444B

公开(公告)日：1986-09-24

申请号：ZA86444

申请日：1986-01-21

Applicant: ABBOTT LAB

Inventor： LULY JAY RICHARD ,  ROSENBERG SAUL HOWARD ,  PLATTNER JOHN JACOB ,  FUNG ANTHONY KI

IPC: A61K20060101 ,  C07K20060101 ,  C07K5/06 ,  A61K ,  C07K

公开(公告)号：ZA8600444B

公开(公告)日：1986-09-24

申请号：ZA8600444

申请日：1986-01-21

Applicant: ABBOTT LAB

Inventor： LULY JAY RICHARD ,  ROSENBERG SAUL HOWARD ,  PLATTNER JOHN JACOB ,  FUNG ANTHONY KI

IPC: A61K20060101 ,  C07K20060101 ,  C07K5/06 ,  A61K ,  C07K

公开(公告)号：AU5274386A

公开(公告)日：1986-07-31

申请号：AU5274386

申请日：1986-01-28

Applicant: ABBOTT LAB

Inventor： LULY JAY RICHARD ,  ROSENBERG SAUL HOWARD ,  PLATTNER JOHN JACOB ,  FUNG ANTHONY KL

IPC: A61K31/16 ,  A61K31/165 ,  A61K31/47 ,  A61K31/55 ,  A61K38/00 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/078

公开(公告)号：DK34086A

公开(公告)日：1986-07-24

申请号：DK34086

申请日：1986-01-22

Applicant: ABBOTT LAB

Inventor： LULY JAY RICHARD ,  ROSENBERG SAUL HOWARD ,  PLATTNER JOHN JACOB ,  FUNG ANTHONY KL

IPC: A61K31/16 ,  A61K31/165 ,  A61K31/47 ,  A61K31/55 ,  A61K38/00 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/078 ,  C07C ,  C07K