公开(公告)号：CL2013001219A1

公开(公告)日：2014-04-04

申请号：CL2013001219

申请日：2013-05-03

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  TSENG YUNG-CHIEH ,  MA CHE

IPC: C12N1/00 ,  C12N7/00 ,  C12N15/09

公开(公告)号：CO6460701A2

公开(公告)日：2012-06-15

申请号：CO11144904

申请日：2011-10-26

Applicant: ACADEMIA SINICA

Inventor： WONG CHI HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

IPC: A61K39/12 ,  A61K39/145 ,  A61K39/155 ,  A61K39/21 ,  A61K39/29 ,  A61P21/02 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  C07K14/11 ,  C07K14/135 ,  C07K14/18 ,  C12P21/02

Abstract: Se proveen composiciones inmunógenas que incluyen glucoproteínas víricas parcialmente glucosiladas para uso como vacunas contra virus. Las vacunas formuladas utilizando glucoproteínas de superficie víricas mono-, di-, o tri-glucosiladas y polipéptidos ofrecen protección amplia y potente contra virus, incluso a través de cepas. Se divulgan composiciones farmacéuticas que contienen polipéptidos de hemaglutinina monoglucosilada, y vacunas generadas a partir de ellos, y métodos de su uso para profilaxis o tratamiento de infecciones virales. Se divulgan métodos y composiciones para HA, NA y M2 del virus de la gripe, proteínas F, G y SH del VRS (virus respiratorio sincitial), glucoproteínas M o E del virus del dengue, glucoproteína E1 o E2 del virus de la hepatitis C y glucoproteínas gp120 y gp41 del VIH (virus de la inmunodeficiencia humana).

公开(公告)号：CL2011002354A1

公开(公告)日：2012-06-15

申请号：CL2011002354

申请日：2011-09-23

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  WANG CHENG-CHI ,  CHEN JUINE-RUEY

IPC: A61K39/145 ,  C07K14/135 ,  C07K14/18

Abstract: Composición inmunogénica que permite aumentar una respuesta inmunitaria a un patógeno de origen viral, bacteriano, fúngico u otro que comprende una glicoproteína parcialmente glicosilada; vacuna que comprende polipéptido inmunogénico parcialmente glicosilado.

公开(公告)号：CA2854619A1

公开(公告)日：2012-05-10

申请号：CA2854619

申请日：2011-11-04

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  TSENG YUNG-CHIEH

IPC: C12N7/00 ,  C07K14/11 ,  C12N7/02 ,  C12N15/09 ,  C12P21/02

Abstract: Methods for production of virus particles with simplified glycosylation on structural or surface proteins are provided. When used as targets for vaccine production, the conserved nature of such sites generates vaccines that are less sensitive to viral mutations. Use of glycosylation inhibitors for production of viruses with simplified glycosylation profiles are disclosed. An exemplary disclosure of influenza viruses and methods for production of mono-glycosylated influenza virus particles is provided. Methods for production of mono-glycosylated forms of influenza A virus, NIBRG-14 (H5N1) are provided.

公开(公告)号：AU2025201644A1

公开(公告)日：2025-03-27

申请号：AU2025201644

申请日：2025-03-06

Applicant: ACADEMIA SINICA

Inventor： LIAO HSIN-YU ,  WANG SHIH-CHI ,  KO YI-AN ,  LIN KUO-I ,  MA CHE ,  CHENG TING-JEN ,  WONG CHI-HUEY

IPC: A61K39/145 ,  A61P31/16 ,  C12N7/04

Abstract: Abstract The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of HI subtype HA (HI HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequences, each having at least 60% homology with a globular head domain consensus sequence of HI subtype HA (HI HA) or H5 subtype HA (H5 HA).

公开(公告)号：MX394274B

公开(公告)日：2025-03-24

申请号：MX2017009717

申请日：2013-05-03

Applicant: ACADEMIA SINICA

Inventor： MA CHE ,  WONG CHI- HUEY ,  TSENG YUNG- CHIEH

IPC: A61K39/145 ,  A61K39/12 ,  A61P31/14 ,  C07K14/005

Abstract: La presente invención se refiere a métodos para producción de partículas de virus con glucosilación simplificada en proteínas estructurales o de superficie. Cuando se utilizan como objetivos para producción de vacunas, la naturaleza conservada de dichos sitios genera vacunas que son más sensibles a mutaciones víricas. Se describe el uso de inhibidores de glucosilación para producción de virus con perfiles de glucosilación simplificados. Se proporciona una descripción de ejemplo de los virus de la influenza y métodos para producción de partículas de virus de influenza monoglucosilada. Se proporcionan métodos para producción de formas monoglucosiladas de virus de influenza A, NIBRG-14 (H5N1).

公开(公告)号：CA2854619C

公开(公告)日：2022-02-01

申请号：CA2854619

申请日：2011-11-04

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  TSENG YUNG-CHIEH

IPC: C12N7/00 ,  C07K14/11 ,  C12N7/02 ,  C12N15/09 ,  C12P21/02

Abstract: Methods for production of virus particles with simplified glycosylation on structural or surface proteins are provided. When used as targets for vaccine production, the conserved nature of such sites generates vaccines that are less sensitive to viral mutations. Use of glycosylation inhibitors for production of viruses with simplified glycosylation profiles are disclosed. An exemplary disclosure of influenza viruses and methods for production of mono-glycosylated influenza virus particles is provided. Methods for production of mono-glycosylated forms of influenza A virus, NIBRG-14 (H5N1) are provided.

公开(公告)号：DK3250590T3

公开(公告)日：2021-10-18

申请号：DK16744256

申请日：2016-01-30

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  WU HAN-CHUNG ,  WU CHUNG-YI

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/30 ,  C12P19/14

公开(公告)号：AU2016211176B2

公开(公告)日：2021-01-28

申请号：AU2016211176

申请日：2016-01-30

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  MA CHE ,  WU HAN-CHUNG

IPC: C07K16/00 ,  A61K39/42 ,  C07K16/10 ,  C07K16/24 ,  C07K16/28 ,  C07K16/30

Abstract: The present disclosure relates to compositions and methods of use comprising antibodies or binding fragments thereof further comprising universal Fc glycoforms.

公开(公告)号：AU2016204276B2

公开(公告)日：2017-10-26

申请号：AU2016204276

申请日：2016-06-23

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  TSENG YUNG-CHIEH

IPC: C12P21/06 ,  C12N15/09

Abstract: Methods for production of virus particles with simplified glycosylation on structural or surface proteins are provided. When used as targets for vaccine production, the conserved nature of such sites generates vaccines that are less sensitive to viral mutations. Use of glycosylation inhibitors for production of viruses with simplified glycosylation profiles are disclosed. An exemplary disclosure of influenza viruses and methods for production of mono-glycosylated influenza virus particles is provided. Methods for production of mono-glycosylated forms of influenza A virus, NIBRG-1 4 (H5N1) are provided.