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公开(公告)号：NO20061171L
公开(公告)日：2006-04-10
申请号：NO20061171
申请日：2006-03-13
Applicant: ARRAY BIOPHARMA INC
Inventor： WALLACE ELI , TOPALOV GEORGE , LYSSIKATOS JOSEPH , BUCKMELTER ALEXANDRE , ZHAO QIAN
IPC: C07D239/94 , A61K31/517 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04 , C07D498/08 , C07D498/10
Abstract: This invention provides quinazoline analogs of Formula I: where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R3 groups. The invention also includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
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公开(公告)号：IS8288A
公开(公告)日：2006-02-07
申请号：IS8288
申请日：2006-02-07
Applicant: ARRAY BIOPHARMA INC
Inventor： WALLACE ELI , TOPALOV GEORGE , LYSSIKATOS JOSEPH , BUCKMELTER ALEXANDRE , ZHAO QIAN
IPC: C07D239/94 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04 , C07D498/08 , A61K31/51 , A61K31/517 , A61K31/535 , C07D403/00 , C07D239/82
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公开(公告)号：ES2420113T3
公开(公告)日：2013-08-22
申请号：ES08744440
申请日：2008-03-27
Applicant: ARRAY BIOPHARMA INC
Inventor： ALLEN SHELLEY , GRESCHUK JULIE , KALLAN NICHOLAS , MARMSAETER FREDRIK , MUNSON MARK , RIZZI JAMES , ROBINSON JOHN , SCHLACHTER STEPHEN , TOPALOV GEORGE , ZHAO QIAN , LYSSIKATOS JOSEPH
IPC: C07D471/04 , A61K31/33 , A61P35/00
Abstract: Compuesto de fórmula general I:**Fórmula** o una sal farmacéuticamente aceptable del mismo, en el que: A es -Z-(CH2)p-(hetCic2a), -Z-(hetCic5 2b), Z-R10 o Z-R11; Z es O o NH; p es 0, 1 o 2; hetCic2a es un anillo heterocíclico de 5 o 6 miembros, sustituido opcionalmente con uno o más grupos R9; hetCic2b es un sistema de anillo heterobicíclico con puentes o espirocíclico de 7 a 12 miembros, sustituidoopcionalmente con uno o más grupos R9; R10 es alquilo-(C1-6) sustituido con NR'R"; R11 es cicloalquilo-(C5-6) sustituido con NR'R"; B es H, CN, ORh, Ar1, hetAr2, C(O)NRiRj, C(O)-hetCic3, C(O)NH(alquil-C1-6)-hetCic3, C(O)(alquil-C1-6)-hetCic3,SRk, SO2N(alquilo-C1-6)2, (alquil-C1-6)NR'R" o alquilo-(C1-3); R1, R2, R3 y R4 son independientemente H, F, Cl, CN, Me, Et, isopropilo, ciclopropilo, C(O)NR'R", CH2OH ohetAr3; R1a es H, F, Cl o Me; R5, R6, R7 y R8 son independientemente H, F, Cl, CN o Me.
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公开(公告)号：PT1660090E
公开(公告)日：2013-01-11
申请号：PT04780990
申请日：2004-08-10
Applicant: ARRAY BIOPHARMA INC
Inventor： ZHAO QIAN , WALLACE ELI , TOPALOV GEORGE , LYSSIKATOS JOSEPH , BUCKMELTER ALEXANDRE
IPC: A61K31/51 , A61K31/517 , A61K31/535 , C07D239/82 , C07D239/94 , C07D401/12 , C07D403/00 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04 , C07D498/08
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公开(公告)号：AU2004264937B2
公开(公告)日：2010-04-29
申请号：AU2004264937
申请日：2004-08-10
Applicant: ARRAY BIOPHARMA INC
Inventor： WALLACE ELI , ZHAO QIAN , BUCKMELTER ALEXANDRE , TOPALOV GEORGE , LYSSIKATOS JOSEPH
IPC: C07D239/94 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04 , C07D498/08
Abstract: This invention provides quinazoline analogs of Formula I: where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R3 groups. The invention also includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
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Patent Agency Ranking
公开(公告)号：MX2007014510A
公开(公告)日：2008-02-05
申请号：MX2007014510
申请日：2006-05-18
Applicant: ARRAY BIOPHARMA INC
Inventor： LYSSIKATOS JOSEPH P , LAIRD ELLEN , WELCH MIKE , GRINA JONAS , HANSEN JOSH , NEWHOUSE BRAD , TOPALOV GEORGE
IPC: C07D487/04 , A61K31/4985 , A61P35/00
Abstract: Los compuestos de la formula (I) son utiles para inhibir la cinasa Raf y para tratar trastornos mediados de este modo. Se describen metodos para usar los compuestos de la formula (I), estereoisomeros, tautomeros, solvatos y sales farmaceuticamente aceptables de los mismos, para diagnosis, prevencion o tratamiento in vitro, in situ e in vivo de estos trastornos en celulas de mamifero o condiciones patologicas asociadas.
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公开(公告)号：AU2003291394A1
公开(公告)日：2004-06-15
申请号：AU2003291394
申请日：2003-11-10
Applicant: ARRAY BIOPHARMA INC
Inventor： WALLACE ELI , TOPALOV GEORGE , ZHAO QIAN
IPC: A61P31/18 , A61P35/00 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/04 , C07D417/14
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公开(公告)号：CA2506503A1
公开(公告)日：2004-06-03
申请号：CA2506503
申请日：2003-11-10
Applicant: ARRAY BIOPHARMA INC
Inventor： ZHAO QIAN , WALLACE ELI , TOPALOV GEORGE , LYSSIKATOS JOSEPH P
IPC: A61P31/18 , A61P35/00 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/04 , C07D417/14 , A61K31/4706 , A61K31/517 , C07D215/42
Abstract: Cyanoguanidine quinazoline and cyanoamidine quinazolamine derivatives that a re useful in the treatment of hyperproliferative diseases are disclosed. Use of the compounds of the invention to manufacture therapeutic compositions for t he treatment of hyperproliferative diseases in mammals is also disclosed.
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公开(公告)号：PL1660090T3
公开(公告)日：2013-04-30
申请号：PL04780990
申请日：2004-08-10
Applicant: ARRAY BIOPHARMA INC
Inventor： WALLACE ELI , TOPALOV GEORGE , LYSSIKATOS JOSEPH , BUCKMELTER ALEXANDRE , ZHAO QIAN
IPC: A61K31/51 , A61K31/517 , A61K31/535 , C07D239/82 , C07D239/94 , C07D401/12 , C07D403/00 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04 , C07D498/08
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公开(公告)号：SI1660090T1
公开(公告)日：2013-02-28
申请号：SI200431985
申请日：2004-08-10
Applicant: ARRAY BIOPHARMA INC
Inventor： WALLACE ELI , TOPALOV GEORGE , LYSSIKATOS JOSEPH , BUCKMELTER ALEXANDRE , ZHAO QIAN
IPC: A61K31/00 , C07D239/00 , C07D239/94 , C07D401/12 , C07D403/00 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04 , C07D498/08
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