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    23.
    发明专利
    未知

    公开(公告)号：ES2176429T3

    公开(公告)日：2002-12-01

    申请号：ES96900601

    申请日：1996-01-20

    Applicant: BASF AG

    Inventor： BALKENHOHL FRIEDHELM ,  DITRICH KLAUS ,  NUBLING CHRISTOPH

    IPC: C12P13/02 ,  C12P41/00

    Abstract: A process for preparing optically active primary and secondary heteroatom-substituted amines from the corresponding racemates, which comprisesa) enantioselective acylation of a racemic heteroatom-substituted amine with an ester whose acid component carries a fluorine, nitrogen, phosphorus, oxygen or sulfur atom in the vicinity of the carbonyl carbon, in the presence of a hydrolase,b) separation of the mixture of optically active heteroatom-substituted amine and optically active acylated heteroatom-substituted amine to obtain one enantiomer of the heteroatom-substituted amine,c) if required isolation of the other enantiomer of the heteroatom-substituted amine from the acylated heteroatom-substituted amine by amide cleavage.

    24.
    发明专利
    未知

    公开(公告)号：DK0850214T3

    公开(公告)日：2000-07-17

    申请号：DK96931783

    申请日：1996-09-09

    Applicant: BASF AG

    Inventor： DITRICH KLAUS ,  BALKENHOHL FRIEDHELM ,  LADNER WOLFGANG

    IPC: C12M1/40 ,  B01J23/04 ,  C07B53/00 ,  C07B61/00 ,  C07C69/708 ,  C07C209/62 ,  C07C211/27

    Abstract: PCT No. PCT/EP96/03948 Sec. 371 Date Jan. 27, 1998 Sec. 102(e) Date Jan. 27, 1998 PCT Filed Sep. 9, 1996 PCT Pub. No. WO97/10201 PCT Pub. Date Mar. 20, 1997The present invention relates to a process for cleaving optically active amides to carboxylic acids and optically active amines with retention of the center of chirality, wherein the amides are hydrolyzed in the presence of a polyol or of an amino alcohol and of an alkali metal or alkaline earth metal hydroxide.

    25.
    发明专利
    未知

    公开(公告)号：ES2141254T3

    公开(公告)日：2000-03-16

    申请号：ES94928365

    申请日：1994-09-16

    Applicant: BASF AG

    Inventor： BALKENHOHL FRIEDHELM ,  HAUER BERNHARD ,  LADNER WOLFGANG ,  PRESSLER UWE ,  NUBLING CHRISTOPH

    IPC: C12P13/02 ,  C12P41/00 ,  C12R1/38

    Abstract: PCT No. PCT/EP94/03102 Sec. 371 Date Mar. 11, 1996 Sec. 102(e) Date Mar. 11, 1996 PCT Filed Sep. 16, 1994 PCT Pub. No. WO95/08636 PCT Pub. Date Mar. 30, 1995A process for producing optically active primary and secondary amines from the corresponding racemates is characterised in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at the proximity of the carbonyl carbon atom; (b) the mixture of optically active amine and optically active acylated amine is separated so that an enantiomer of amine is produced; (c) if desired the other enantiomer of the amine is extracted from the acylated amine by amide cleavage.

    METHOD FOR PRODUCING HETEROAROMATIC ALCOHOLS FREE OF ENANTIOMERS
    29.
    发明专利
    METHOD FOR PRODUCING HETEROAROMATIC ALCOHOLS FREE OF ENANTIOMERS 未知

    公开(公告)号：CA2280833A1

    公开(公告)日：1998-08-27

    申请号：CA2280833

    申请日：1998-02-09

    Applicant: BASF AG

    Inventor： HOLMAN NICHOLAS JOHN ,  BALKENHOHL FRIEDHELM ,  KOSER STEFAN

    IPC: C07D487/04 ,  C12N9/20 ,  C12P17/18 ,  C12P41/00

    Abstract: The invention relates to a method for producing enantiomer-free alcohols of formula (I), where the substituents represent the following: R1 is a hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, or C1-C6-alkanoyl-; R2 and R3 independently of each other represent hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, C1-C6-alkanoyl, C1C6-alkylthio-, C1-C6-alkyl sulfinyl or C1-C6-alkyl sulfonyl-; and R4 is not equal R5 and independently of each other they represent either hydrogen or a substituted or unsubstituted C1-C6-alkyl-, or together with the hydrogen atoms to which they are bound form a substituted or unsubstituted C3-C6-cyclo alkylidene. The method is characterized in that racemic compounds of the formula (II), in which the substituents R1 to R5 have the meanings given above and R6 is a substituted or unsubstituted aryl-, C1-C20-alkyl-, C3-C20-alkenyl-, C3-C20-alkynyl-, are reacted with a lipase or esterase in the presence of an alcohol of the formula R7OH (III), where R7 is a substituted or unsubstituted C1-C10-alkyl-.

    30.
    发明专利
    未知

    公开(公告)号：NO301716B1

    公开(公告)日：1997-12-01

    申请号：NO932860

    申请日：1993-08-11

    Applicant: BASF AG

    Inventor： KAISER KLAUS ,  BALKENHOHL FRIEDHELM ,  PAUST JOACHIM

    IPC: C07F9/655

    Abstract: Process for obtaining the calcium salt of ascorbyl 2-monophosphate from aqueous/alkaline reaction mixtures as they are obtained when ascorbic acid is reacted with a molar excess of phosphorus oxychloride in the presence of a tertiary amine while maintaining a pH of 12 to 13 during the reaction by means of an aqueous alkali metal solution, which process is characterised in that a) starting from a reaction mixture which has been obtained by reacting ascorbic acid with phosphorus oxychloride in the presence of pyridine while maintaining a pH of 12 to 13 by means of an aqueous potassium hydroxide solution, b) the phosphoric acid ions formed during this reaction are precipitated by means of magnesium chloride in amounts of approximately 1 mol per mol of phosphoric acid ions as potassium magnesium phosphate, c) the potassium magnesium phosphate is separated off, d) the pyridine together with some of the water is removed from the remaining aqueous solution by distillation, e) the resulting aqueous solution is reacted with calcium chloride and f) the calcium salt of ascorbyl 2-monophosphate, which crystallises out during this process in the form of the calcium salt, is isolated, or in that, after process step a), the pyridine/water mixture is first removed as described in process step d) and process steps (b), (c), (e) and (f) are subsequently carried out.

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