公开(公告)号：BR9810984A

公开(公告)日：2000-08-15

申请号：BR9810984

申请日：1998-07-03

Applicant: BASF AG

Inventor： STARCK DOROTHEA ,  BLANK STEFAN ,  TREIBER HANS JUERG ,  UNGER LILIANE ,  NEUMANN-SCHULTZ BARBARA ,  BRIS THEOPHILE-MARIE LE ,  TESCHENDORF HANS JUERGEN ,  WICKE KARSTEN

IPC: A61K31/33 ,  A61K31/41 ,  A61K31/4196 ,  A61K31/454 ,  A61K31/506 ,  A61K31/53 ,  A61K31/551 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D249/08 ,  C07D249/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: Triazole compounds of the following formula:where Ar1, A, B and Ar2 have the meanings given in the description, possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to dopamine D3 ligands.

公开(公告)号：ID24639A

公开(公告)日：2000-07-27

申请号：ID20000266

申请日：1998-08-14

Applicant: BASF AG

Inventor： BLANK STEFAN ,  SARCK DOROTHEA ,  TREIBER HANS-JORG ,  KOSER STEFAN ,  SCHAFER BERND ,  HOGER THOMAS

IPC: C07D239/56 ,  A61K20060101 ,  A61K31/395 ,  A61K31/497 ,  A61K31/505 ,  A61K31/506 ,  A61P1/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P43/00 ,  C07D20060101 ,  C07D239/42 ,  C07D239/46 ,  C07D295/125 ,  C07D403/00 ,  C07D403/12 ,  C07D403/14

Abstract: The fumaric acid salt (A) of 2-{3-[4-(2-tert. butyl-6-trifluoromethyl- pyrimidin-4-yl)piperazin-1- yl]propylmercapto}pyrimidin-4-ol (I) is new. The fumarate salt (A) of the pyrimidin-4-ol derivative of formula (I) is new. The tautomers, solvates and hydrates of (A) are also new. ACTIVITY : Neuroleptic; antidepressant; antiemetic; antihistamine. MECHANISM OF ACTION : Dopamine D 3 receptor ligand. (A) has a selectivity Ki D 2/Ki D 3 of 120.

公开(公告)号：BR9811177A

公开(公告)日：2000-07-25

申请号：BR9811177

申请日：1998-08-14

Applicant: BASF AG

Inventor： BLANK STEFAN ,  STACK DOROTHEA ,  TREIBER HANS-JOERG ,  KOSER STEFAN ,  SCHOFER BERND ,  THYES MARCO ,  HOEGER THOMAS

IPC: C07D239/56 ,  A61K20060101 ,  A61K31/395 ,  A61K31/497 ,  A61K31/505 ,  A61K31/506 ,  A61P1/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P43/00 ,  C07D20060101 ,  C07D239/42 ,  C07D239/46 ,  C07D295/125 ,  C07D403/00 ,  C07D403/12 ,  C07D403/14

Abstract: The fumaric acid salt (A) of 2-{3-[4-(2-tert. butyl-6-trifluoromethyl- pyrimidin-4-yl)piperazin-1- yl]propylmercapto}pyrimidin-4-ol (I) is new. The fumarate salt (A) of the pyrimidin-4-ol derivative of formula (I) is new. The tautomers, solvates and hydrates of (A) are also new. ACTIVITY : Neuroleptic; antidepressant; antiemetic; antihistamine. MECHANISM OF ACTION : Dopamine D 3 receptor ligand. (A) has a selectivity Ki D 2/Ki D 3 of 120.

公开(公告)号：ZA9807239B

公开(公告)日：2000-02-14

申请号：ZA9807239

申请日：1998-08-13

Applicant: BASF AG

Inventor： BLANK STEFAN ,  STARCK DOROTHEA ,  TREIBER HANS-JOERG ,  KOSER STEFAN ,  SCHAEFER BERND ,  THYES MARCO ,  HOEGER THOMAS

IPC: C07D239/56 ,  A61K20060101 ,  A61K31/395 ,  A61K31/497 ,  A61K31/505 ,  A61K31/506 ,  A61P1/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P43/00 ,  C07D20060101 ,  C07D239/42 ,  C07D239/46 ,  C07D295/125 ,  C07D403/00 ,  C07D403/12 ,  C07D403/14 ,  C07D ,  A61K

CPC classification number: C07D239/56

公开(公告)号：TR199801302T2

公开(公告)日：1998-11-23

申请号：TR9801302

申请日：1997-01-10

Applicant: BASF AG

Inventor： TREIBER HANS-JOERG ,  BLANK STEFAN ,  STARCK DOROTHEA ,  UNGER LILIANE ,  TESCHENDORF HANS-JURGEN ,  WICKE KARSTEN

IPC: A61K31/00 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/44 ,  C07D243/08 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/505 ,  A61K31/506 ,  A61K31/55 ,  A61K31/551 ,  A61K31/5513 ,  A61P25/18 ,  A61P43/00 ,  C07D213/73 ,  C07D223/04 ,  C07D245/02 ,  C07D401/04 ,  C07D401/14 ,  C07D403/02 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

Abstract: Aza- and diazacyclohexane and -cyclooctane compounds of the following formula:where Ar1, A, B and Ar2 have the meanings stated in the description have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.

公开(公告)号：CA2241787A1

公开(公告)日：1997-07-17

申请号：CA2241787

申请日：1997-01-10

Applicant: BASF AG

Inventor： TREIBER HANS-JOERG ,  BLANK STEFAN ,  STARCK DOROTHEA ,  UNGER LILIANE ,  TESCHEDORF HANS-JUERGEN ,  WICKE KARSTEN

IPC: C07D243/08 ,  A61K31/00 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/505 ,  A61K31/506 ,  A61K31/55 ,  A61K31/551 ,  A61K31/5513 ,  A61P25/18 ,  A61P43/00 ,  C07D213/73 ,  C07D223/04 ,  C07D245/02 ,  C07D401/04 ,  C07D401/14 ,  C07D403/02 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention concerns aza- and diazacycloheptane and cyclooctane compounds from the following formula (I) Ar1-A-B-Ar2 wherein Ar1, A, B, and Ar2 have the meanings given in the description. The compounds according to the invention possess a high affinity with the dopamine-D3-receptors and can therefore be used for the treatment of illness, which react to dopamine-D3-ligands.

公开(公告)号：AU748810B2

公开(公告)日：2002-06-13

申请号：AU8731698

申请日：1998-07-03

Applicant: BASF AG

Inventor： STARCK DOROTHEA ,  BLANK STEFAN ,  TREIBER HANS-JORG ,  UNGER LILIANE ,  NEUMANN-SCHULTZ BARBARA ,  BRIS THEOPHILE-MARIE LE ,  TESCHENDORF HANS-JURGEN ,  WICKE KARSTEN

IPC: A61K31/33 ,  A61K31/41 ,  A61K31/4196 ,  A61K31/454 ,  A61K31/506 ,  A61K31/53 ,  A61K31/551 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D249/08 ,  C07D249/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: Triazole compounds of the following formula:where Ar1, A, B and Ar2 have the meanings given in the description, possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to dopamine D3 ligands.

公开(公告)号：CO5160386A1

公开(公告)日：2002-05-30

申请号：CO00055742

申请日：2000-07-25

Applicant: BASF AG

Inventor： BLANK STEFAN ,  HARTWIG VOB ,  WILFINGER HANS JORG ,  BENDER MICHAEL

IPC: B01D61/14 ,  C01B21/14 ,  C07C209/86

Abstract: Un proceso para la separación de partículas sólidas de una mezcla de reacción acuosa formadas en la preparación de hidroxilamina con la ayuda de un catalizador soportado, que comprendea) conducir la mezcla de reacción en dirección de flujo cruzado a una velocidad de 1,5 a 2,5 m/s sobre una membrana que comprende polietileno, polipropileno, poliamida, politetrafluorotileno, fluoruro de polivinilideno, polisulfona o un copolímero de los anteriores y que tiene un tamaño de poro entre 0,01 y 50 µm, yb) obtener un retenido que contiene catalizador y un permeado libre de catalizador.

公开(公告)号：DE59803292D1

公开(公告)日：2002-04-11

申请号：DE59803292

申请日：1998-07-03

Applicant: BASF AG

Inventor： STARCK DOROTHEA ,  BLANK STEFAN ,  TREIBER HANS-JOERG ,  UNGER LILIANE ,  NEUMANN-SCHULTZ BARBARA ,  LE BRIS THEOPHILE-MARIE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN

IPC: A61K31/33 ,  A61K31/41 ,  A61K31/4196 ,  A61K31/454 ,  A61K31/506 ,  A61K31/53 ,  A61K31/551 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D249/08 ,  C07D249/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: Triazole compounds of the following formula:where Ar1, A, B and Ar2 have the meanings given in the description, possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to dopamine D3 ligands.

公开(公告)号：HU0003710A2

公开(公告)日：2001-10-28

申请号：HU0003710

申请日：1998-08-14

Applicant: BASF AG

Inventor： BLANK STEFAN ,  HOEGER THOMAS ,  KOSER STEFAN ,  SCHAEFER BERND ,  STARCK DOROTHEA ,  THYES MARCO ,  TREIBER HANS-JOERG

IPC: C07D239/56 ,  A61K20060101 ,  A61K31/395 ,  A61K31/497 ,  A61K31/505 ,  A61K31/506 ,  A61P1/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P43/00 ,  C07D20060101 ,  C07D239/42 ,  C07D239/46 ,  C07D295/125 ,  C07D403/00 ,  C07D403/12 ,  C07D403/14

Abstract: The fumaric acid salt (A) of 2-{3-[4-(2-tert. butyl-6-trifluoromethyl- pyrimidin-4-yl)piperazin-1- yl]propylmercapto}pyrimidin-4-ol (I) is new. The fumarate salt (A) of the pyrimidin-4-ol derivative of formula (I) is new. The tautomers, solvates and hydrates of (A) are also new. ACTIVITY : Neuroleptic; antidepressant; antiemetic; antihistamine. MECHANISM OF ACTION : Dopamine D 3 receptor ligand. (A) has a selectivity Ki D 2/Ki D 3 of 120.