公开(公告)号：SK3872000A3

公开(公告)日：2000-09-12

申请号：SK3872000

申请日：1998-10-05

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  STEINER GERD ,  BACH ALFRED ,  EMLING FRANZ ,  GARCIA-LADONA XAVIER ,  TESCHENDORF HANS-JURGEN ,  WICKE KARSTEN

IPC: A61K31/519 ,  A61P1/00 ,  A61P1/14 ,  A61P3/04 ,  A61P5/00 ,  A61P9/12 ,  A61P15/00 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D471/00 ,  C07D471/04

Abstract: 3-substituted tetrahydropyridopyrimidinone derivatives of the formula (I) wherein the radicals have the meanings given in the Description, to a method for producing said derivatives and, to their use for producing active ingredients for drugs.

公开(公告)号：ZA989571B

公开(公告)日：2000-04-25

申请号：ZA989571

申请日：1998-10-21

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  STEINER GERD ,  BACH ALFRED ,  EMLING FRANZ ,  GARCIA-LADONA XAVIER ,  TESCHENDORF HANS JUERGEN ,  WICKE KARSTEN

IPC: A61K31/428 ,  A61P25/24 ,  A61P43/00 ,  C07D275/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D ,  A61K

Abstract: where the substituents have the meanings indicated in the description, their preparation and use as serotonin antagonists.

公开(公告)号：ZA9809664B

公开(公告)日：2000-04-25

申请号：ZA9809664

申请日：1998-10-23

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  STEINER GERD ,  BACH ALFRED ,  EMLING FRANZ ,  GARCIA-LADONA XAVIER ,  TESCHENDORF HANS JUERGEN ,  WICKE KARSTEN

IPC: A61K31/519 ,  A61P1/00 ,  A61P1/14 ,  A61P3/04 ,  A61P5/00 ,  A61P9/12 ,  A61P15/00 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D471/04 ,  C07D ,  A61K

CPC classification number: C07D471/04

公开(公告)号：AU9748498A

公开(公告)日：1999-05-17

申请号：AU9748498

申请日：1998-10-05

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  STEINER GERD ,  BACH ALFRED ,  EMLING FRANZ ,  GARCIA-LADONA XAVIER ,  TESCHENDORF HANS-JURGEN ,  WICKE KARSTEN

IPC: A61K31/519 ,  A61P1/00 ,  A61P1/14 ,  A61P3/04 ,  A61P5/00 ,  A61P9/12 ,  A61P15/00 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D471/00 ,  C07D471/04

Abstract: 3-substituted tetrahydropyridopyrimidinone derivatives of the formula (I) wherein the radicals have the meanings given in the Description, to a method for producing said derivatives and, to their use for producing active ingredients for drugs.

公开(公告)号：CA2305258A1

公开(公告)日：1999-05-06

申请号：CA2305258

申请日：1998-10-05

Applicant: BASF AG

Inventor： STEINER GERD ,  STARCK DOROTHEA ,  DULLWEBER UTA ,  BACH ALFRED ,  LUBISCH WILFRIED ,  EMLING FRANZ ,  GARCIA-LADONA XAVIER ,  TESCHENDORF HANS-JURGEN ,  WICKE KARSTEN

IPC: A61K31/519 ,  A61P1/00 ,  A61P1/14 ,  A61P3/04 ,  A61P5/00 ,  A61P9/12 ,  A61P15/00 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D471/00 ,  C07D471/04

Abstract: The invention relates to 3-substituted tetrahydropyridopyrimidinone derivatives of formula (I) wherein the radicals have the meanings given in the Description, to a method for producing said derivatives, and to their use as selective 5HT1B-and 5HT1A antagonists.

公开(公告)号：CZ290678B6

公开(公告)日：2002-09-11

申请号：CZ2000462

申请日：1998-07-23

Applicant: BASF AG

Inventor： STEINER GERD ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  BACH ALFRED ,  WICKE KARSTEN ,  TESCHENDORF HANS-JUERGEN ,  GARCIA-LADONA XAVIER ,  EMLING FRANZ

IPC: A61K31/435 ,  A61P25/24 ,  C07D495/14 ,  A61K31/4365

Abstract: In the present invention there are disclosed 3,4,5,7-tetrahydropyrrolo[3?, 4?:4,5]thieno[2,3-d]pyrimidine derivatives substituted in position 3 of the general formula I in which the substituents have specific meaning, and their use as a medicament for treating depressions and related disorders with effect as the selective antagonists 5-HTi1A and 5-HTi1B.

公开(公告)号：AU748666B2

公开(公告)日：2002-06-06

申请号：AU9748498

申请日：1998-10-05

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  STEINER GERD ,  BACH ALFRED ,  EMLING FRANZ ,  GARCIA-LADONA XAVIER ,  TESCHENDORF HANS-JURGEN ,  WICKE KARSTEN

IPC: A61K31/519 ,  A61P1/00 ,  A61P1/14 ,  A61P3/04 ,  A61P5/00 ,  A61P9/12 ,  A61P15/00 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D471/00 ,  C07D471/04

Abstract: 3-substituted tetrahydropyridopyrimidinone derivatives of the formula (I) wherein the radicals have the meanings given in the Description, to a method for producing said derivatives and, to their use for producing active ingredients for drugs.

公开(公告)号：NZ503604A

公开(公告)日：2002-03-01

申请号：NZ50360498

申请日：1998-10-05

Applicant: BASF AG

Inventor： BACH ALFRED ,  EMLING FRANZ ,  GARCIA-LADONA XAVIER ,  TESCHENDORF HANS-JURGEN ,  WICKE KARSTEN ,  LUBISCH WILFRED ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  STEINER GERD

IPC: A61K31/428 ,  A61P25/24 ,  A61P43/00 ,  C07D275/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  A61K31/425

Abstract: 2-Substituted 1,2-benzisothiazole derivatives of formula (I) and their enantiomers, diastereomers, tautomers and acid salts are disclosed. R1 and R2 are independently C1-6 alkyl; R3 and R4 are independently H, C1-6 alkyl, OH, C1-6 alkoxy, F, Cl, Br, I, CF3, NR5R6, CO2R7, NO2, CN, pyrrolo, or phenyl-(C1-4 alkyl), which may itself be ring-substituted by F, Cl, Br, I, C1-4 alkyl, C1-4 alkoxy, CF3, OH, NH2, CN or NO2; R5 and R6 are independently H, C1-6 alkyl, benzoyl, CO2-tert.-butyl, (C1-4 alkyl)carbonyl or together form a 5- or 6-membered ring, which may contain a second N atom (e.g. piperazinyl); R7 is H or C1-6 alkyl; A is C1-10 alkylene or C2-10 alkylene containing one or more Z groups; Z is O, S, NR7, cyclopropyl, CHOH, or a double or triple bond; B is 4-piperidine, 4-(1,2,3,6-tetrahydropyridine), 4-piperazine or one of these rings N-bound to A via a methylene group; Ar is phenyl (optionally substituted by C1-6 alkyl, C1-6 alkoxy, OH, F, Cl, Br, I, CF3, NR5R6, CO2R7, CN or phenyl), tetralinyl, indanyl, other condensed aromatic moieties e.g. naphthalinyl (optionally substituted by C1-4 alkyl or C1-4 alkoxy), anthracenyl, or a 5- or 6-membered aromatic heterocycle with 1 or 2 O or N heteroatoms, which can be fused with other aromatic groups.

公开(公告)号：HU0003758A2

公开(公告)日：2001-10-28

申请号：HU0003758

申请日：1998-10-05

Applicant: BASF AG

Inventor： DR BACH ALFRED ,  DULLWEBER UTA ,  DR EMLING FRANZ ,  GARCIA-LADONA XAVIER ,  DR LUBISCH WILFRIED ,  STARCK DOROTHEA ,  DR STEINER GERD ,  DR TESCHENDORF HANS-JUERGEN ,  DR WICKE KARSTEN

IPC: A61K31/428 ,  A61P25/24 ,  A61P43/00 ,  C07D275/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

Abstract: where the substituents have the meanings indicated in the description, their preparation and use as serotonin antagonists.

公开(公告)号：NZ503486A

公开(公告)日：2001-04-27

申请号：NZ50348698

申请日：1998-10-05

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  STEINER GERD ,  BACH ALFRED ,  EMLING FRANZ ,  GARCIA-LADONA XAVIER ,  TESCHENDORF HANS-JURGEN ,  WICKE KARSTEN

IPC: A61K31/519 ,  A61P1/00 ,  A61P1/14 ,  A61P3/04 ,  A61P5/00 ,  A61P9/12 ,  A61P15/00 ,  A61P25/00 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D471/00 ,  C07D471/04 ,  C07D295/04

Abstract: A 3-substituted tetrahydropyridopyrimidione derivative of the formula shown as a therapeutic composition having a high affinity for 5-HT1B, 5-HT1D and 5-HT1A serotonin receptors. The compounds are suitable for treating pathological states in which the serotonin concentration is reduced such as depression, mood disturbances with central nervous causation (dysthymia), anxiety such as panic attacks, sociophobia, obsessive-compulsive neuroses and post-traumatic stress symptoms, memory disturbances such as dementia, amnesias and age-related loss of memory and psychogenic eating disorders such as anorexia nervosa and bulimia nervosa. Wherein; one of the two radicals X and Y is CH2 and the other is NR1, R1 is hydrogen, C1-6alkyl branched or unbranched, CO-C1-4alkyl, CO2tBu, CO-phenyl and a phenylalkyl-C1-4 radical which in turn may be substituted on the aromatic system by F, Cl, Br, I, C1-4alkyl, C1-4alkoxy, trifluoromethyl, hydroxyl, amino, cyano or nitro, A is branched or unbranched C1-10alkylene or straight-chain or branched C2-10alkylene which comprises at least one group Z which is selected from O, S, NR2, cyclopropyl, CO2, CHOH, a double or triple bond, R2 is hydrogen and C1-4alkyl, B is 4-piperidine, 4-tetrahydro-1,2,3,6 pyridine, 4-piperazine or the corresponding cyclic compounds enlarged by one methylene group, with the linkage to A being via an N atom of B, and Ar is phenyl which is unsubstituted or substituted by C1-6alkyl branched or unbranched, O-C1-6alkyl branched or unbranched, OH, F, Cl, Br, I, trifluoromethyl, NR22, CO2R2, cyano or phenyl, or is tetralin, indan, naphthalene which is unsubstituted or substituted by C1-4alkyl or O-C1-4alkyl, anthracene or 5- or 6-membered aromatic heterocycles having 1 or 2 heteroatoms which are selected, independently of one another, from O and N.