公开(公告)号：CA2176962C

公开(公告)日：2005-12-20

申请号：CA2176962

申请日：1994-11-26

Applicant: BASF AG

Inventor： STEINER GERD ,  MUNSCHAUER RAINER ,  UNGER LILIANE ,  TESCHENDORF HANS-JURGEN ,  HOGER THOMAS

IPC: A61K31/395 ,  C07D209/44 ,  C07D403/00 ,  C07D405/00 ,  C07D409/00 ,  C07D413/00 ,  C07D417/00

Abstract: The invention pertains to compounds of formula (I) where the substituents are as indicated in the description, and to their preparation. The new compounds can be used to combat diseases.

公开(公告)号：AU755694B2

公开(公告)日：2002-12-19

申请号：AU1379800

申请日：1999-11-05

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS

IPC: C07D235/18 ,  A61K20060101 ,  A61K31/10 ,  A61K31/404 ,  A61K31/41 ,  A61K31/4184 ,  A61K31/454 ,  A61P20060101 ,  A61P3/10 ,  A61P7/02 ,  A61P9/00 ,  A61P13/12 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/02 ,  A61P43/00 ,  C07D20060101 ,  C07D209/14 ,  C07D235/04

Abstract: 2-Phenylbenzimidazoles and 2-phenylindoles of formula IwhereinA is N or CH,R1 is hydrogen or alkyl which optionally carries an OR11 group,R11 is hydrogen or alkyl,R2 is hydrogen, chlorine, fluorine, bromine, iodine, alkyl, nitro, CF3, CN, NR21R22, NH-CO-R23, OR21,R21 and R22 are each hydrogen or alkyl,R23 is hydrogen, alkyl or phenyl,R3 is -(CH2)q-NR31R32,q is 0, 1, 2 or 3,R31 is hydrogen, alkyl, (CH2)rNR33R34,R32 is (CH2)rNR33R34,r is 2, 3, 4, 5 or 6,R33 and R34 are each hydrogen, alkyl or phenylalkyl wherein the phenyl ring is optionally substituted, orR33 and R34 and the nitrogen atom form a 3- to 8-membered ring,R4 is hydrogen, alkyl, chlorine, bromine, fluorine, nitro, cyano, NR41R42, NH-CO-R43, OR41,R41 and R42 are each hydrogen or alkyl, andR43 is alkyl or phenyl,are useful as inhibitors of poly(ADP-ribose)polymerase and for the production of drugs.

公开(公告)号：CO5170517A1

公开(公告)日：2002-06-27

申请号：CO00032472

申请日：2000-05-05

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  MCIHAEL KOCK ,  HOGER THOMAS ,  GRANDEL ROLAND ,  UTA HOLZENKAMP ,  SCHULT SABINE ,  MULLER REINHOLD

IPC: C07D235/20 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61P3/10 ,  A61P9/00 ,  A61P13/12 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/10 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07D235/18 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04

Abstract: Compuesto de la fórmula I ó II dondeA significa naftalina, indol, benzimidazol, pirrol, imidazol, furano, tiofeno, benzotiofeno, benzofurano, pirazol, tiazol, benzotiazol, ftalamida, indazol, benzotriazol, ftalicina, indolina, isoindolina, piridina, quinolina, pirimidina, piridacina, isoquinolina, quinoxalina, quinozolina, isoxazol, oxasol, imidazopiridina, piracina, y pudiendo A estar sustituido todavía por hasta tres radicales R3 idénticos o diferentes y adicionalmente por un radical R4 yR1 significa hidrógeno, cloro, fluoro, bromo, yodo, C1-C6-alquilo ramificado o sin ramificar, OH, nitro, CF3, CN, NR11R12, NH-CO-R13, O-C1-C4-alquilo, pudiendo R11 R12 significar independientemente hidrógeno o C1-C4-alquil-fenilo o fenilo, yR2 significa hidrógeno, C1-C6-alquilo ramificado o sin ramificar yR3 significa hidrógeno, cloro, bromo, yodo, fluoro, CF3, OCF3, nitro, NH2, CO-R8, CO2-R8, SO2-R8, OH, OC1-C4-alquilo, O-C0-C4-alquil-fenilo, una cadena de 1 a 6 átomos de carbono, que puede estar saturada no saturada o parcialmente insaturada, y estar sustituida adicionalmente por un radical R33, fenilo, pudiendo los anillos fenilo estar sustituidos por hasta tres radicales R31 idénticos o diferentes, y piridilo, que puede estar sustituido por hasta tres radicales R132, yR31 significa OH, C1-C6-alquilo, O-C1-C4-alquilo, cloro yodo, fluoro, CF3, nitro, NH2, yR32 significa OH, C1-C6-alquilo, O-C1-C4-alquilo, cloro, bromo, yodo, fluoro, CF3, nitro, NH2, CN, yR33 significa CO-NH-R8, OH, OC1-C6-alquilo, O-CO-R8, yR4 significa -(D)p-(E)s,-(CH2)q -B, dondeD significa S, NR43 y 0E significa fenilo ys es 0 y 1 y ...

公开(公告)号：CZ2001465A3

公开(公告)日：2001-08-15

申请号：CZ2001465

申请日：1999-07-20

Applicant: BASF AG

Inventor： STEINER GERD ,  HOGER THOMAS ,  UNGER LILIANE ,  TESCHENDORF HANS-JURGEN ,  JUCHELKA FRIEDER

IPC: A61K31/4184 ,  A61P25/20 ,  A61P25/24 ,  A61P25/30 ,  C07D403/06

Abstract: The invention relates to compounds of formula (1), wherein R , R and R have the meaning cited in the description. The novel substances are suitable for use in disease control.

公开(公告)号：CZ2001508A3

公开(公告)日：2001-07-11

申请号：CZ2001508

申请日：1999-07-20

Applicant: BASF AG

Inventor： STEINER GERD ,  HOGER THOMAS ,  UNGER LILIANE ,  TESCHENDORF HANS-JUGEN ,  JUCHELKA FRIEDER

IPC: A61K31/427 ,  A61P25/00 ,  C07D417/06

公开(公告)号：ID27964A

公开(公告)日：2001-05-03

申请号：ID20010348

申请日：1999-07-20

Applicant: BASF AG

Inventor： STEINER GERD ,  HOGER THOMAS ,  UNGER LILIANE ,  TESCHENDORF HANS JURGEN ,  JUCHELKA FRIEDER

IPC: A61K31/4184 ,  A61P25/20 ,  A61P25/24 ,  A61P25/30 ,  C07D403/06

Abstract: The invention relates to compounds of formula (1), wherein R , R and R have the meaning cited in the description. The novel substances are suitable for use in disease control.

公开(公告)号：ID27819A

公开(公告)日：2001-04-26

申请号：ID20002542

申请日：1999-06-04

Applicant: BASF AG

Inventor： KOCK MICHAEL ,  HOGER THOMAS ,  KROGER BURKHARD ,  OTTERBACH BERND ,  LUBISCH WILFRIED ,  LEMAIRE HANS GEORG

IPC: A01K67/027 ,  A61K38/00 ,  A61K38/45 ,  A61K48/00 ,  A61K49/00 ,  A61P43/00 ,  C07K14/455 ,  C12N1/15 ,  C12N1/19 ,  C12N5/10 ,  C12N9/10 ,  C12N15/09 ,  C12N15/54 ,  C12Q1/68 ,  G01N33/53 ,  C12N15/10 ,  A61K31/70

Abstract: The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has a) a functional NAD+ binding domain and b) no zinc finger sequence motif of the general formula CX2CXmHX2C in which m is an integral value from 28 or 30, and the X radicals are, independently of one another, any amino acid; and the functional equivalents thereof; nucleic acids coding therefor; antibodies with specificity for the novel protein; pharmaceutical and gene therapy compositions which comprise products according to the invention; methods for the analytical determination of the proteins and nucleic acids according to the invention; methods for identifying effectors or binding partners of the proteins according to the invention; novel PARP effectors; and methods for determining the activity of such effectors.

公开(公告)号：CA2384265A1

公开(公告)日：2001-04-05

申请号：CA2384265

申请日：2000-09-15

Applicant: BASF AG

Inventor： HOGER THOMAS ,  LUBISCH WILFRIED ,  KOCK MICHAEL ,  SCHULT SABINE ,  MULLER REINHOLD ,  GRANDEL ROLAND

IPC: A61K31/5517 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P11/00 ,  A61P13/12 ,  A61P17/02 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/10 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/04 ,  A61P37/02 ,  A61P43/00 ,  C07D487/06 ,  C07D519/00 ,  A61K31/519 ,  C07D235/00 ,  C07D239/00 ,  C07D243/00 ,  C07D243/14 ,  C07D245/00

Abstract: The invention relates to compounds of formula (I) as well as to the tautomer ic forms thereof, possible enantiomeric and diastereomeric forms and the prodru gs thereof, the production and use thereof, whereby the values have the meaning as given in the description.

公开(公告)号：CA2352194A1

公开(公告)日：2001-04-05

申请号：CA2352194

申请日：2000-09-15

Applicant: BASF AG

Inventor： KOCK MICHAEL ,  LUBISCH WILFRIED ,  GRANDEL ROLAND ,  MULLER REINHOLD ,  HOGER THOMAS ,  SCHULT SABINE

IPC: A61K31/55 ,  A61P3/10 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/10 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  C07D487/06 ,  C07D209/00 ,  C07D223/00

Abstract: The invention relates to compounds of formula (I) as well as to the tautomer ic forms thereof, possible enantiomeric and diastereomeric forms and the prodru gs thereof, the production and use thereof, whereby the values have the meaning as given in the description.

公开(公告)号：AU5064000A

公开(公告)日：2000-11-21

申请号：AU5064000

申请日：2000-05-03

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  SADOWSKI JENS ,  KOCK MICHAEL ,  HOGER THOMAS

IPC: C07D237/32 ,  A61K31/502 ,  A61P1/10 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P17/02 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/10 ,  A61P25/12 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  A61P41/00 ,  A61P43/00 ,  C07D401/12 ,  C07D403/12 ,  A61K31/00

Abstract: The present invention relates to the use of phthalazine derivatives as inhibitors of the enzyme poly(ADP-ribose) polymerase or PARP (EC 2.4.2.30), to the use as inhibitors of PARP-homologous enzymes and, in particular, these phthalazine derivatives also show a selective inhibition of PARP-homologous enzymes.