公开(公告)号：GR3023791T3

公开(公告)日：1997-09-30

申请号：GR970401431

申请日：1997-06-18

Applicant: BASF AG

Inventor： STAUDENMAIER HORST RALF DR ,  HAUER BERNHARD DR ,  BALKENHOHL FRIEDHELM DR ,  LADNER WOLFGANG DR ,  SCHNELL URSULA DR ,  PRESSLER UWE DR

IPC: C12P17/10 ,  C12P41/00 ,  C12R1/01 ,  C12R1/38

Abstract: Prodn. of enantiomeric lactams of formula (I) comprises reacting a racemate (I) with a biocatalyst which reacts with one enantiomer and isolating the unreacted enantiomer from the mixt. obtd. R1, R2 = 1-4C alkyl, 2-4C alkenyl or aryl (all opt. substd.), H or (CH2)n-COOH; n = 0-3; x = 1-5. Pref. the biocatalyst is a microorganism, esp. from Pseudomonas or Rhodococcus.

公开(公告)号：DE19517421A1

公开(公告)日：1996-11-14

申请号：DE19517421

申请日：1995-05-12

Applicant: BASF AG

Inventor： NUEBLING CHRISTOPH DR ,  LADNER WOLFGANG DR

IPC: C07C213/02 ,  C07C213/08 ,  C07C213/10 ,  C07C217/52 ,  C07C233/23 ,  C07C271/24 ,  C07C271/56 ,  C07C215/44 ,  C07B57/00

Abstract: A process for preparing enantiomer-pure cis1-amino-2-hydroxyindane is characterised in that: (a) racemic trans1-aminoindan-2-ol is reacted according to known processes with acids or acid derivatives having the general formula RCOX, yielding type (A) amides, in which the substituents have the following meanings: R stands for hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl and phenyl, groups that may carry one to three halogen atoms and/or one to three among the following residues: cyano, C1-C6 alkoxy, C1-C6 alkylthio phenyl, phenylthio and phenoxy, the phenyl residues in turn carrying one to three among the following groups: C1-C4 alkyl, C1-C4 alkoxy, halogen, cyano and nitro; X stands for OH, halogen, OR and SR , in which R stands for alkyl C1-C6, phenyl and COR. In a second step (b), a supersaturated solution or melt of racemic amide (A) is blended with seed crystals of an enantiomer, then (c) the precipitated crystals are isolated and the remaining mother liquor or melt is again supersaturated, after separation of racemic amide (A), and blended with seed crystals of the other enantiomer in order to selectively crystallise said enantiomer. Finally (d), the thus obtained enantiomer-pure transamide is reacted according to known methods to yield enantiomer-pure cis1-amino-2-hydroxyindane.

公开(公告)号：DE4328231C1

公开(公告)日：1994-07-28

申请号：DE4328231

申请日：1993-08-23

Applicant: BASF AG

Inventor： LADNER WOLFGANG DR ,  RETTENMAIER HANSJOERG DR ,  ZIPPERER BERNHARD DR ,  HANSEN HANSPETER DR

IPC: C12P7/52 ,  C07C51/09 ,  C07C53/19 ,  C12P7/40 ,  C12P41/00 ,  C12P7/62 ,  C07C51/48 ,  C07C53/15

Abstract: PCT No. PCT/EP94/02738 Sec. 371 Date Feb. 15, 1996 Sec. 102(e) Date Feb. 15, 1996 PCT Filed Aug. 17, 1994 PCT Pub. No. WO95/06130 PCT Pub. Date Mar. 2, 1995A process for the preparation of (L)-2-chloropropionic acid and its alkali metal, alkaline earth metal or ammonium salts which comprises hydrolyzing isobutyl L-chloropropionate at a pH of from 4 to 8 in the presence of a lipase from Pseudomonas spec. DSM 8246 and isolating the optically active reaction product from the reaction mixture either directly or after conversion of the salt into the acid in a conventional way, or further reacting it in situ. The optically active products are important intermediates for preparing crop protection agents.\!

公开(公告)号：DE4204204A1

公开(公告)日：1993-08-19

申请号：DE4204204

申请日：1992-02-13

Applicant: BASF AG

Inventor： MISSLITZ ULF DR ,  MEYER NORBERT DR ,  KAST JUERGEN DR ,  LADNER WOLFGANG DR ,  WALTER HELMUT DR ,  WESTPHALEN KARL-OTTO DR ,  KARDORFF UWE DR ,  GERBER MATTHIAS DR

IPC: A01N35/10 ,  A01N39/00 ,  A01N43/16 ,  A01N43/18 ,  A01N43/40 ,  A01N43/56 ,  A01N43/60 ,  A01N43/76 ,  A01N43/78 ,  A01N43/80 ,  C07C239/20 ,  C07C251/54 ,  C07C323/28 ,  C07D213/64 ,  C07D231/12 ,  C07D239/20 ,  C07D241/44 ,  C07D263/58 ,  C07D277/68 ,  C07D309/06 ,  C07D335/02 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: Mixtures of optically active cyclohexenone oxime ethers, with an R and S configuration in the oxime ether section of formula (I) where R = C1-C6 alkyl; Z = (a), (b), (c), (d), (e); X = C1-C4 alkyl, C1-C4 halogen alkyl; m = 0-3 or 1-4 if all X substituents are halogen; n = 0-3 or 1-5 if all X substituents are halogen; R = C1-C4-alkoxy-C1-C6-alkyl, C1-C4-alkylthio-C1-C6-alkyl, optionally substituted C3-C7 cycloalkyl, optionally substituted C5-C7 cycloalkenyl, optionally substituted 5-membered saturated heterocylic ring, optionally substituted 6 or 7-membered heterocylic ring, optionally substituted aromatic 5-membered heterocylic ring, optionally substituted phenyl or pyridyl; and their agriculturally usable salts, and esters of C1-C10 carboxylic acids and inorganic acids.

公开(公告)号：DE3737335A1

公开(公告)日：1989-05-18

申请号：DE3737335

申请日：1987-11-04

Applicant: BASF AG

Inventor： URBAN DIETER DR ,  LADNER WOLFGANG DR ,  PAUL AXEL DR

IPC: C12N11/08 ,  C12P41/00

Abstract: A biocatalyst is produced by mixing… a) an insoluble, only slightly swellable copolymer of an N-vinyllactam with a cyclic amide which contains at least two ethylenically unsaturated copolymerisable groups, of which at least one is bonded directly to the amide nitrogen,… b) crude pig pancreatic lipase,… c) at least one water-soluble dihydric to hexahydric alcohol with 2 to 6 carbon atoms and… d) an aqueous buffer solution of pH 5 to 9… at 0 to 40 DEG C, filtering after 1 minute to 3 days and washing the filter cake, and is used for resolving esters of racemic alcohols.

公开(公告)号：DE3737333A1

公开(公告)日：1989-05-18

申请号：DE3737333

申请日：1987-11-04

Applicant: BASF AG

Inventor： URBAN DIETER DR ,  LADNER WOLFGANG DR ,  PAUL AXEL DR ,  SANNER AXEL DR

IPC: C12N11/08 ,  C12P17/02 ,  C12P41/00

Abstract: Process for the production of a biocatalyst by mixing a small-particle, porous, aliphatic polyamide, a lipase and an aqueous buffer solution at pH 5 and 9 and 0 to 40@C and, after 1 minute to 3 days, filtering and washing the filter cake, employing as lipase crude pig pancreatic lipase and adding to the aqueous mixture at least one water-soluble 1- to 6-hydric alcohol with 1 to 6 carbon atoms.