公开(公告)号：ZA8006282B

公开(公告)日：1981-10-28

申请号：ZA8006282

申请日：1980-10-13

Applicant: BASF AG

Inventor： FRICKEL F ,  VON PHILIPSBORN G ,  MUELLER C ,  LENKE D ,  FRANKE A

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/454 ,  A61K31/47 ,  A61P9/00 ,  A61P9/06 ,  C07C271/22 ,  C07D207/34 ,  C07D207/36 ,  C07D209/42 ,  C07D401/12 ,  C07D401/14 ,  A61K ,  C07D

CPC classification number: C07D209/42 ,  C07C271/22 ,  C07D207/36 ,  Y10S514/821

公开(公告)号：DK130081A

公开(公告)日：1981-09-25

申请号：DK130081

申请日：1981-03-23

Applicant: BASF AG

Inventor： MAY H J ,  LENKE D ,  GRIES J ,  TESCHENDORF H J ,  WORSTMANN W

IPC: C07D409/06 ,  A61K31/33 ,  A61K31/415 ,  A61K31/465 ,  A61K31/47 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P43/00 ,  C07D233/54 ,  C07D233/64 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  C07D

Abstract: 1-Aroyl-2-phenylamino-2-imidazolines of the general formula where R1 and R2 are identical or different and each is chlorine, bromine, fluorine, methyl, ethyl, methoxy, trifluoromethyl or cyano, R3 has the meanings given for R1 and R2 or is hydrogen and Ar is an unsubstituted or substituted monocyclic or bicyclic heteroaromatic radical containing 1, 2 or 3 nitrogen and/or oxygen and/or sulfur atoms, their salts with physiologically tolerated acids, their preparation, and drugs containing these compounds. The compounds have, inter alia, a blood pressure-reducing action.

公开(公告)号：DK76881A

公开(公告)日：1981-08-24

申请号：DK76881

申请日：1981-02-20

Applicant: BASF AG

Inventor： SCHLECKER R ,  FRICKEL F F ,  FRANKE A ,  LENKE D

IPC: A61K31/42 ,  A61P9/00 ,  A61P9/12 ,  A61P25/02 ,  C07D261/08 ,  C07D261/10 ,  C07D261/18 ,  C07F9/653 ,  C07D

公开(公告)号：ZA7905716B

公开(公告)日：1980-11-26

申请号：ZA7905716

申请日：1979-10-25

Applicant: BASF AG

Inventor： TREIBER H ,  WORSTMANN W ,  LENKE D

IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/00 ,  C07D267/12 ,  C07D267/14 ,  C07D ,  A61K

CPC classification number: C07D267/12 ,  C07D267/14

公开(公告)号：DK13280A

公开(公告)日：1980-07-14

申请号：DK13280

申请日：1980-01-11

Applicant: BASF AG

Inventor： TREIBER H J ,  LENKE D ,  WORSTMANN W

IPC: A61K31/55 ,  A61K31/553 ,  A61P25/04 ,  C07D267/10 ,  C07D

Abstract: Novel hexahydro-1,4-oxazepines of the general formula I I where R1 is hydrogen, or alkyl or acyl each of 1 to 4 carbon atoms, R2 is alkyl of 1 to 4 carbon atoms and R3 and R4 are identical or different and each is hydrogen or methyl, and their salts with physiologically acceptable acids, processes for their preparation, drugs which contain these compounds, and their use in therapy. The compounds may be used for the pharmacotherapy of pain of various geneses.

公开(公告)号：ZA792028B

公开(公告)日：1980-06-25

申请号：ZA792028

申请日：1979-04-27

Applicant: BASF AG

Inventor： FRICKEL F ,  FRANKE A ,  LENKE D ,  THIEME P ,  HAGEN H ,  GRIES J

IPC: A61K31/41 ,  A61K31/433 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  C07D285/12 ,  C07D417/12 ,  C07D ,  A61K

Abstract: Alkylaminopropanol derivatives of 2-methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazole and their addition salts with acids, their preparation, and pharmaceutical formulations, containing these compounds, which may be used for the treatment of coronary diseases of the heart, of hypertonia and of cardiac arrhythmias.

公开(公告)号：DK532579A

公开(公告)日：1980-06-16

申请号：DK532579

申请日：1979-12-14

Applicant: BASF AG

Inventor： THYES M ,  GRIES J ,  LEHMANN H D ,  LENKE D ,  KUNZE J

IPC: A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D

公开(公告)号：DK486879A

公开(公告)日：1980-05-19

申请号：DK486879

申请日：1979-11-16

Applicant: BASF AG

Inventor： FRANKE A ,  LENKE D ,  GRIES J ,  LEHMANN H D

IPC: A61K31/55 ,  C07D223/16 ,  C07D405/12 ,  C07D

公开(公告)号：ZA783464B

公开(公告)日：1979-07-25

申请号：ZA783464

申请日：1978-06-16

Applicant: BASF AG

Inventor： KOENIG H ,  THYES M ,  LEHMANN H ,  LEBKUECHER R ,  KUNZE J ,  GRIES J ,  LENKE D

IPC: A61K31/50 ,  C07D237/00 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D

Abstract: 6-(p-Acylaminophenyl)-4,5-dihydropyridaz-3-ones of the formula I I where R1 is hydrogen or alkyl of 1 to 3 carbon atoms and R2, if R1 is hydrogen, is halogen-substituted alkyl of 3 to 6 carbon atoms or beta -haloethyl or, if R1 is alkyl of 1 to 3 carbon atoms, is halogen-substituted alkyl of 1 to 6 carbon atoms, their manufacture, and therapeutic agents which contain, as the active ingredient, a compound of the formula I, where R2 may also be halomethyl or alpha -haloethyl if R1 is hydrogen. These compounds may be used as anti-hypertensive agents and for the prophylaxis and therapy of thromboembolic disorders.

公开(公告)号：DK50078A

公开(公告)日：1978-08-06

申请号：DK50078

申请日：1978-02-03

Applicant: BASF AG

Inventor： FRICKEL F F ,  HAGEN H ,  OHNSORGE U ,  FRANKE A ,  LENKE D ,  GRIES J ,  LEHMANN H D

IPC: A61K31/428 ,  C07D275/04 ,  C07D

Abstract: New aminopropanol derivatives of 4-hydroxy-1,2-benzisothiazole and their addition salts with acids, their preparation, and pharmaceutical formulations which contain the said compounds and may be used for the treatment and prophylaxis of cardiac and circulatory disorders.