公开(公告)号：AT108775T

公开(公告)日：1994-08-15

申请号：AT91116915

申请日：1991-10-04

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/445 ,  A61K31/4427 ,  A61K31/4468 ,  A61P9/00 ,  C07D211/58 ,  C07D401/12

Abstract: Phenylpiperidylamines of the formula I I R1 is H, NO2, R4SO2NH, N=C, CF3, CF3O, F, Cl, Br, C1-C4-alkyl, R3O, CO2R3, CHO, CH=NOR3, CH3OR3 and R2 is H, F, Cl, Br, C1-C4-alkyl or R4O, where R1 and R2 are not both H, R3 is H or R4, R4 is C1-C4-alkyl or phenyl, n is 1, 2, 3 or 4 and Ar is and the physiologically tolerated salts thereof, are used as active ingredients in drugs.

公开(公告)号：DE4032766A1

公开(公告)日：1992-04-30

申请号：DE4032766

申请日：1990-10-16

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/445 ,  A61K31/4427 ,  A61K31/4468 ,  A61P9/00 ,  C07D211/58 ,  C07D401/12

Abstract: Phenylpiperidylamines of the formula I I R1 is H, NO2, R4SO2NH, N=C, CF3, CF3O, F, Cl, Br, C1-C4-alkyl, R3O, CO2R3, CHO, CH=NOR3, CH3OR3 and R2 is H, F, Cl, Br, C1-C4-alkyl or R4O, where R1 and R2 are not both H, R3 is H or R4, R4 is C1-C4-alkyl or phenyl, n is 1, 2, 3 or 4 and Ar is and the physiologically tolerated salts thereof, are used as active ingredients in drugs.

公开(公告)号：DE19611476A1

公开(公告)日：1997-09-25

申请号：DE19611476

申请日：1996-03-22

Applicant: BASF AG

Inventor： TREIBER HANS-JOERG DR ,  LUBISCH WILFRIED DR ,  BEHL BERTHOLD DR ,  HOFMANN HANS PETER DR

IPC: C07D487/04 ,  C07D521/00 ,  C07F9/6561 ,  A61K31/645 ,  C07F9/143

Abstract: The invention concerns imidazoloquinoxalinones of formula (I) in which R to R have the meanings given in the description and R is a five-member optionally substituted heterocycle with between 1 and 4 nitrogen atoms or with 1 or 2 nitrogen atoms and an oxygen or sulphur atom, or an R -substituted phenyl ring. The novel substances are suitable for combating neurodegenerative diseases, neurotoxic disorders of the central nervous system, in particular after strokes, traumatic lesions of the brain and spinal cord, as well as epilepsy, anxiety states and depression.

公开(公告)号：CZ9700942A3

公开(公告)日：1997-08-13

申请号：CZ94297

申请日：1995-09-19

Applicant: BASF AG

Inventor： TREIBER HANS JORG DR ,  LUBISCH WILFRIED DR ,  BEHL BERTHOLD DR ,  HOFMANN HANS PETER DR

IPC: A61K31/495 ,  A61P9/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/24 ,  A61P25/26 ,  C07D487/04

CPC classification number: C07D487/04

公开(公告)号：CZ94297A3

公开(公告)日：1997-08-13

申请号：CZ94297

申请日：1995-09-19

Applicant: BASF AG

Inventor： TREIBER HANS JORG DR ,  LUBISCH WILFRIED DR ,  BEHL BERTHOLD DR ,  HOFMANN HANS PETER DR

IPC: A61K31/495 ,  A61P9/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/24 ,  A61P25/26 ,  C07D487/04

公开(公告)号：DE59204456D1

公开(公告)日：1996-01-11

申请号：DE59204456

申请日：1992-02-29

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BEHL BERTHOLD DR ,  KIRCHENGAST MICHAEL DR

IPC: A61K31/445 ,  A61K31/4427 ,  A61K31/4465 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/495 ,  A61K31/496 ,  A61P9/06 ,  C07D211/26 ,  C07D211/56 ,  C07D211/58 ,  C07D401/04 ,  C07D401/06

公开(公告)号：DE59106082D1

公开(公告)日：1995-08-31

申请号：DE59106082

申请日：1991-10-02

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/445 ,  A61K31/4468 ,  A61P9/00 ,  C07D211/58

Abstract: Phenylpiperidinylamines of the formula I I where R1 is -NHSO2R4 or R2 and R3 are each, independently of one another, H or C1-C4-alkyl or together are a (CH2)n chain with n=4 or 5, and R4 is C1-C4-alkyl or phenyl, and the physiologically tolerated salts thereof, and pharmaceutical compositions containing these are described.

公开(公告)号：AT125531T

公开(公告)日：1995-08-15

申请号：AT91116812

申请日：1991-10-02

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  SCHULT SABINE DR ,  BINDER RUDOLF DR ,  RASCHACK MANFRED DR ,  REINHARDT ROLAND DR ,  SEEMANN DIETMAR DR

IPC: A61K31/445 ,  A61K31/4468 ,  A61P9/00 ,  C07D211/58

Abstract: Phenylpiperidinylamines of the formula I I where R1 is -NHSO2R4 or R2 and R3 are each, independently of one another, H or C1-C4-alkyl or together are a (CH2)n chain with n=4 or 5, and R4 is C1-C4-alkyl or phenyl, and the physiologically tolerated salts thereof, and pharmaceutical compositions containing these are described.

公开(公告)号：DE3886327D1

公开(公告)日：1994-01-27

申请号：DE3886327

申请日：1988-09-17

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  BINNIG FRITZ DR ,  VON PHILIPSBORN GERDA DR

IPC: A61K31/435 ,  A61K31/44 ,  A61P9/06 ,  C07D471/08

Abstract: Bispidine derivatives of the formula I I where R, R1 and R3 are identical or different and are each H, C1-C4-alkyl, halogen or C1-C4-alkoxy, when Y is R2 is C1-C4-alkyl, halogen, -CN, C1-C4-alkoxy, -NHSO2CH3, -CF3, NH-acetyl or -NR4R5 where R4 and R5 are each C1-C4-alkyl, when Y is R2 is C1-C4-alkyl, halogen, -CN1C1-C4-alkoxy, -NHSO2CH3, -CF3, NH-acetyl or -NR9R10 where R9 is C1-C4-alkyl and R10 is H or C1-C4-alkyl, and when X is not CH2 R2 may also be NO2 or NH2, X is -CH2-, -C(O)- or -C(R6)OR7- (where R6 is H or C1-C4-alkyl and R7 is H, C1-C4-alkyl or where R8 is H, C1-C4-alkyl, halogen or C1 -C4-alkoxy), Y is -C(O) or -CONH- and Z is C1-C4-alkylene which may be olefinically unsaturated and/or branched, and their physiologically tolerated salts, and drugs containing these compounds as active compounds are described.

公开(公告)号：DE58904697D1

公开(公告)日：1993-07-22

申请号：DE58904697

申请日：1989-07-21

Applicant: BASF AG

Inventor： LUBISCH WILFRIED DR ,  VON PHILIPSBORN GERDA DR

IPC: C07D209/08 ,  A61K31/135 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/415 ,  A61K31/445 ,  A61K31/495 ,  A61P9/06 ,  C07C217/22 ,  C07D207/32 ,  C07D207/323 ,  C07D207/333 ,  C07D209/12 ,  C07D231/12 ,  C07D295/08 ,  C07D295/092 ,  C07D333/22

Abstract: Abstract of the disclosure: p-hydroxy phenone derivatives of the formula I I where X is where R1=F, Cl, Br or trifluoromethyl or a heteroaryl of the structure +TR with R2=C1-C4-alkyl, Y is a bridging member of the formula -CH=CH-, -CH2CH2- or -CH2-, is one of the numbers 2, 3 or 4 and is an amino group of the formula -NR2R3 or N-pyrrolidyl or N-piperidyl, where R2 and R3 are, independently of one another, C1-C4-alkyl, as well as the physiologically tolerated salts thereof, are used for preparing antiarrhythmic drugs.