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公开(公告)号：AT236138T
公开(公告)日：2003-04-15
申请号：AT97948371
申请日：1997-11-18
Inventor： ANNEN ULRICH , DELINE JAMES E , FOLAND LAFAYETTE D , KLOTTER KEVIN A , MUELLER JOSEF , MUELLER MICHAEL , MUENDINGER KLAUS , PHILLIPPI MARTIN A , RULAND ALFRED , SCHAEFER WOLFGANG , SCHUERMANN GREGOR , WIDDER RUDI , ZIELSKE ALFRED G
IPC: C07D295/14 , C07D265/12 , C07D291/00 , C07D295/15 , C11D3/39 , C07D295/12 , C07D211/26 , C07D211/34
Abstract: A process for the preparation of a compound having the structure of Formula (I) wherein A, R1, R2, R3, Y and Z are as defined in the disclosure. The process includes reacting a heterocyclic amine with a monoaldehyde or a dialdehyde in a pH range of from about 8 to 14 and then quaternizing the so-reacted heterocyclic amine with an alkylating agent at a pH of not less than about 2. The use of a pH control substantially prevents formation of an undesirable protonated intermediate.
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公开(公告)号：NO166855B
公开(公告)日：1991-06-03
申请号：NO883506
申请日：1988-08-05
Applicant: BASF AG
Inventor： BIRNBACH STEFAN , MUELLER JOSEF , WULZ KLAUS , HOUBEN JOCHEN
Abstract: Etherified polyoxyalkylene derivatives of the formula where R1 is hydrogen, C1-C20-alkyl or C3-C5-alkenyl, R2 and R3 independently of one another are each hydrogen, methyl or ethyl, R4 is C1-C4-alkyl and m and n are identical or different and are each greater than or equal to 0, with the proviso that the sum of m and n is from 3 to 300, are prepared by reacting the corresponding hydroxyl-containing polyoxyalkylene derivative with a dialkyl sulfate in the presence of an alkali metal hydroxide by a process in which the reaction is carried out at from 20 DEG to 60 DEG C. in the presence of an aqueous solution of an alkali metal hydroxide, the concentration of alkali metal hydroxide during the entire duration of the reaction being not less than 35% by weight, based on the aqueous phase, and not less than 1 mole of dialkyl sulfate and not less than one mole of alkali metal hydroxide are used per mole equivalent of organic hydroxyl groups.
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公开(公告)号：NO883506A
公开(公告)日：1989-02-07
申请号：NO883506
申请日：1988-08-05
Applicant: BASF AG
Inventor： BIRNBACH STEFAN , MUELLER JOSEF , WULZ KLAUS , HOUBEN JOCHEN
CPC classification number: C08G65/3344 , C08G65/2609
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公开(公告)号：FI883664A0
公开(公告)日：1988-08-05
申请号：FI883664
申请日：1988-08-05
Applicant: BASF AG
Inventor： BIRNBACH STEFAN , MUELLER JOSEF , WULZ KLAUS , HOUBEN JOCHEN
Abstract: Etherified polyoxyalkylene derivatives of the formula where R1 is hydrogen, C1-C20-alkyl or C3-C5-alkenyl, R2 and R3 independently of one another are each hydrogen, methyl or ethyl, R4 is C1-C4-alkyl and m and n are identical or different and are each greater than or equal to 0, with the proviso that the sum of m and n is from 3 to 300, are prepared by reacting the corresponding hydroxyl-containing polyoxyalkylene derivative with a dialkyl sulfate in the presence of an alkali metal hydroxide by a process in which the reaction is carried out at from 20 DEG to 60 DEG C. in the presence of an aqueous solution of an alkali metal hydroxide, the concentration of alkali metal hydroxide during the entire duration of the reaction being not less than 35% by weight, based on the aqueous phase, and not less than 1 mole of dialkyl sulfate and not less than one mole of alkali metal hydroxide are used per mole equivalent of organic hydroxyl groups.
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公开(公告)号：NO155771B
公开(公告)日：1987-02-16
申请号：NO823161
申请日：1982-09-17
Applicant: BASF AG
Inventor： FRANKE ALBRECHT , MUELLER JOSEF , LIETZ HELMUT , WIERSDORFF WALTER-WIELANT , HEGE HANS-GUENTHER , MUELLER CLAUS D , GRIES JOSEF , LENKE DIETER , PHILIPSBORN GERDA VON , RASCHACK MANFRED
IPC: A61K31/13 , A61K31/445 , A61K31/495 , C07C45/62 , C07C45/71 , C07C45/73 , C07C45/74 , C07C49/83 , C07C49/835 , C07C49/84 , C07D211/46 , C07D211/52 , C07D295/08 , C07D295/092 , C07D303/22 , C07D303/24 , C07C97/10
Abstract: Novel aminopropanol derivatives of 2-hydroxy- beta -phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.
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Patent Agency Ranking
公开(公告)号：HU186576B
公开(公告)日：1985-08-28
申请号：HU297582
申请日：1982-09-17
Applicant: BASF AG
Inventor： FRANKE ALBRECHT , MUELLER JOSEF , LIETZ HELMUT , WIERSDORF WALTER-WIELANT , HEGE HANS-GUENTER , MUELLER CLAUS , GRIES JOSEF , LENKE DIETER , VON PHILIPSBORN GERDA , RASCHACK MANFRED
IPC: A61K31/13 , A61K31/445 , A61K31/495 , C07C45/62 , C07C45/71 , C07C45/73 , C07C45/74 , C07C49/83 , C07C49/835 , C07C49/84 , C07D211/46 , C07D211/52 , C07D295/08 , C07D295/092 , C07D303/22 , C07D303/24 , C07C93/06 , C07C97/10 , C07D295/10
Abstract: Novel aminopropanol derivatives of 2-hydroxy- beta -phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.
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公开(公告)号：DE69720509T2
公开(公告)日：2003-11-13
申请号：DE69720509
申请日：1997-11-18
Applicant: MID AMERICA COMMERCIALIZATION , BASF AG
Inventor： ANNEN ULRICH , DELINE E , FOLAND D , KLOTTER A , MUELLER JOSEF , MUELLER MICHAEL , MUENDINGER KLAUS , PHILLIPPI A , RULAND ALFRED , SCHAEFER WOLFGANG , SCHUERMANN GREGOR , WIDDER RUDI , ZIELSKE G
IPC: C07D295/14 , C07D265/12 , C07D291/00 , C07D295/15 , C11D3/39 , C07D295/12 , C07D211/26 , C07D211/34
Abstract: A process for the preparation of a compound having the structure of Formula (I) wherein A, R1, R2, R3, Y and Z are as defined in the disclosure. The process includes reacting a heterocyclic amine with a monoaldehyde or a dialdehyde in a pH range of from about 8 to 14 and then quaternizing the so-reacted heterocyclic amine with an alkylating agent at a pH of not less than about 2. The use of a pH control substantially prevents formation of an undesirable protonated intermediate.
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公开(公告)号：MX217031B
公开(公告)日：2003-10-20
申请号：MX9905076
申请日：1999-05-31
Inventor： ANNEN ULRICH , DELINE JAMES E , FOLAND LAFAYETTE D , KLOTTER KEVIN A , MUELLER JOSEF , MUELLER MICHAEL , MUENDINGER KLAUS , PHILLIPPI MARTIN A , RULAND ALFRED , SCHAEFER WOLFGANG , SCHUERMANN GREGOR , WIDDER RUDI , ZIELSKE ALFRED G
IPC: C07D295/14 , C07D265/12 , C07D291/00 , C07D295/15 , C11D3/39
Abstract: A process for the preparation of a compound having the structure of Formula (I) wherein A, R1, R2, R3, Y and Z are as defined in the disclosure. The process includes reacting a heterocyclic amine with a monoaldehyde or a dialdehyde in a pH range of from about 8 to 14 and then quaternizing the so-reacted heterocyclic amine with an alkylating agent at a pH of not less than about 2. The use of a pH control substantially prevents formation of an undesirable protonated intermediate.
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公开(公告)号：FI88026B
公开(公告)日：1992-12-15
申请号：FI883664
申请日：1988-08-05
Applicant: BASF AG
Inventor： BIRNBACH STEFAN , MUELLER JOSEF , WULZ KLAUS , HOUBEN JOCHEN
Abstract: Etherified polyoxyalkylene derivatives of the formula where R1 is hydrogen, C1-C20-alkyl or C3-C5-alkenyl, R2 and R3 independently of one another are each hydrogen, methyl or ethyl, R4 is C1-C4-alkyl and m and n are identical or different and are each greater than or equal to 0, with the proviso that the sum of m and n is from 3 to 300, are prepared by reacting the corresponding hydroxyl-containing polyoxyalkylene derivative with a dialkyl sulfate in the presence of an alkali metal hydroxide by a process in which the reaction is carried out at from 20 DEG to 60 DEG C. in the presence of an aqueous solution of an alkali metal hydroxide, the concentration of alkali metal hydroxide during the entire duration of the reaction being not less than 35% by weight, based on the aqueous phase, and not less than 1 mole of dialkyl sulfate and not less than one mole of alkali metal hydroxide are used per mole equivalent of organic hydroxyl groups.
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公开(公告)号：NO166855C
公开(公告)日：1991-09-11
申请号：NO883506
申请日：1988-08-05
Applicant: BASF AG
Inventor： BIRNBACH STEFAN , MUELLER JOSEF , WULZ KLAUS , HOUBEN JOCHEN
Abstract: Etherified polyoxyalkylene derivatives of the formula where R1 is hydrogen, C1-C20-alkyl or C3-C5-alkenyl, R2 and R3 independently of one another are each hydrogen, methyl or ethyl, R4 is C1-C4-alkyl and m and n are identical or different and are each greater than or equal to 0, with the proviso that the sum of m and n is from 3 to 300, are prepared by reacting the corresponding hydroxyl-containing polyoxyalkylene derivative with a dialkyl sulfate in the presence of an alkali metal hydroxide by a process in which the reaction is carried out at from 20 DEG to 60 DEG C. in the presence of an aqueous solution of an alkali metal hydroxide, the concentration of alkali metal hydroxide during the entire duration of the reaction being not less than 35% by weight, based on the aqueous phase, and not less than 1 mole of dialkyl sulfate and not less than one mole of alkali metal hydroxide are used per mole equivalent of organic hydroxyl groups.
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