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    TETRACYCLIC QUINAZOLINE DERIVATIVES, THEIR PREPARATION AND USE
    23.
    发明专利
    TETRACYCLIC QUINAZOLINE DERIVATIVES, THEIR PREPARATION AND USE 未知

    公开(公告)号：CA1331608C

    公开(公告)日：1994-08-23

    申请号：CA576970

    申请日：1988-09-09

    Applicant: BASF AG

    Inventor： OSTERSEHLT BERND ,  SCHLECKER RAINER ,  RENDENBACH BEATRICE ,  VON PHILIPSBORN GERDA ,  FRANKE ALBRECHT

    IPC: A61K31/505 ,  A61K31/55 ,  A61P9/06 ,  C07D471/14 ,  C07D487/14

    Abstract: New tetracyclic quinazoline derivatives are disclosed, of the formula I: (I) where A is alkylene which may be substituted by alkyl and in which two adjacent methylene groups may additionally be closed to a ring via a alkylene group which may be substituted by alkyl, X is a phenyl or naphthyl ring which may be substituted by halogen, nitro, amino, alkylamino, sulfonylamino, acylamino, hydroxyl, alkoxy, -O(CH2)2-4 -NR1R2 (with R1 and R2 meaning hydrogen or alkyl), alkyl or alkylsulfonyl, or is a 5-membered heterocyclic ring which may be substituted, and R is hydrogen, halogen, nitro, amino, alkylamino, sulfonylamino, acylamino, hydroxyl, alkoxy, -O-(CH2)2-4 -NR3R4 (with R3 and R4 meaning hydrogen or alkyl), alkyl or alkylsulfonyl. These derivatives and their salts with physiologicallly tolerated acids are useful for preparing drugs for controlling atrial and ventricular dysrythmias.

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