公开(公告)号：AU9732901A

公开(公告)日：2002-07-11

申请号：AU9732901

申请日：2001-12-19

Applicant: BASF AG

Inventor： HEIDENFELDER THOMAS ,  WUNSCH THOMAS ,  TIEFENSEE KRISTIN

IPC: A61K8/00 ,  A61K8/29 ,  A61K8/33 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/41 ,  A61K8/44 ,  A61K8/49 ,  A61K8/58 ,  A61K8/89 ,  A61K8/892 ,  A61K8/895 ,  A61Q1/04 ,  A61Q5/00 ,  A61Q17/04 ,  A61Q19/00 ,  C08L83/07 ,  A61K7/44

Abstract: Sunscreen combinations which compriseA) effective amounts of a compound of formula I andB) effective amounts of one or more compounds selected from a group consisting of: zinc oxide, titanium oxide and the compounds of formulae II to XVI which are specified in the description,are suitable as photostable UV filters in cosmetic and pharmaceutical compositions for protecting human skin or human hair against solar rays. The combinations are optionally used together with other conventional UV absorbing ingredients which are known per se for cosmetic and pharmaceutical compositions.

公开(公告)号：AU745291B2

公开(公告)日：2002-03-21

申请号：AU4540697

申请日：1997-11-27

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  AUMULLER ALEXANDER ,  SCHEHLMANN VOLKER ,  WESTENFELDER HORST ,  WUNSCH THOMAS

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/41 ,  A61K8/42 ,  A61K8/46 ,  A61K8/49 ,  A61K31/13 ,  A61K31/22 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  A61Q19/00 ,  C07C225/14 ,  C07C229/30 ,  C07C229/56 ,  C07C229/60 ,  C07C255/30 ,  C07C255/58 ,  C07C309/46 ,  C07D275/02 ,  C07D275/03 ,  C07D319/06 ,  C07D333/38 ,  A61K7/42 ,  A61K7/06 ,  C07C57/00

Abstract: Use of enamine derivatives of formula (R )(R NH)C=C(R )(R ) (I) as UV filters in cosmetic and pharmaceutical preparations for protection of hair or skin against sun-radiation, alone or in combination with UV absorbers is new: R = COOR , COR , CONR R , CN, SO2R , SO2OR or P(=O)OR OR ; R = COOR , COR , CONR R , CN, SO2R , SO2OR or P(=O)OR OR ; R = H, or optionally substituted aliphatic, cycloaliphatic, arylaliphatic or aromatic residue with up to 18C; R = optionally substituted 5-12C aromatic or heteroaromatic residue; and R , R = H or aliphatic, arylaliphatic, cycloaliphatic, or optionally substituted aromatic with up to 18C; or R -R together with their bonded carbon atoms may form a 5-6 membered ring which may be further annelated.

公开(公告)号：BR0101085A

公开(公告)日：2001-11-06

申请号：BR0101085

申请日：2001-03-15

Applicant: BASF AG

Inventor： HEIDENFELDER THOMAS ,  HABECK THORSTEN ,  WUNSCH THOMAS

IPC: A61K47/02 ,  A61K8/00 ,  A61K8/29 ,  A61K8/33 ,  A61K8/35 ,  A61K8/37 ,  A61K8/41 ,  A61K8/44 ,  A61K8/49 ,  A61K8/58 ,  A61K8/893 ,  A61K8/896 ,  A61K8/898 ,  A61K47/08 ,  A61K47/14 ,  A61K47/18 ,  A61K47/22 ,  A61K47/24 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q1/06 ,  A61Q5/00 ,  A61Q17/04 ,  C08L83/06 ,  A61K7/40

Abstract: A photostable ultraviolet (UV) filter for protecting human skin or hair against sunlight contains as UV-A absorbing components a combination of a hydroxybenzophenone (I), optionally together with a 4,4-diaryl-butadiene (II); and other UV protectant(s) i.e. dibenzoylmethane, triazine, benzotriazole, benzimidazole, tetrahydroxybenzophenone and/or organosiloxane-benzal malonate derivatives. Use of a light-protectant combination of a UV-A absorber and further UV-A and/or UV-B absorbers is claimed as a photostable UV-filter in cosmetic or pharmaceutical preparations for protecting human skin or hair against sunlight, optionally used together with other conventional light protectants. First UV light absorber is a hydroxybenzophenone of formula (I), optionally together with a 4,4-diaryl-butadiene of formula (II); and other UV protectants including 4-(R6)-4'-(R7)-dibenzoylmethane, 1,3,5-triazine derivatives of formula (III), 2,4,6-triphenyl-1,3,5-triazines, in which the phenyl rings are bonded with at least one o-hydroxy group and at least one p-(1-20C) alkoxy group, 2,2'-dihydroxy-3,3'-bis-(1,2,3-benzotriazol-2-yl)-5,5'-bis-(1,1,3,3-te tramethylbutyl)-diphenylmethane, 1,4-bis-(5,6-disulfo-benzimidazol-2-yl)-benzene or its salts, 2-(2-hydroxy-3-(2-methyl-4,4-bis-(trimethylsilyloxy)-4-silapentyl)-5-m ethyl)-1,2,3-benzotriazole, 2,2',4,4'-tetrahydroxybenzophenone and/or siloxanes of formula (IV). R1, R2 = H, 1-20C alkyl, 3-10C cycloalkyl or 3-10C cycloalkenyl; or NR1R2 = 5-6 membered ring; R3 = 1-20C alkyl; R4, R5 = H, 1-20C alkyl, 3-10C cycloalkyl or 3-10C cycloalkenyl; R6 = 1-12C alkyl; R7 = H, 1-12C alkyl or 1-12C alkoxy; R8-R10 = optionally substituted 1-20C alkyl, 5-10C aryl, 5-10C heteroaryl or -Sp-Sil; Sp = spacer; Sil = silane, oligosilane or polysiloxane residue; X = O or NR11; R11 = H or optionally substituted 1-20C alkyl, 5-10C aryl, 5-10C heteroaryl; V = 3-(4-(2,2-bis-(ethoxycarbonyl)-vinyl)-phenoxy)-prop-1-en-1-yl or 3-(4-(2,2-bis-(ethoxycarbonyl)-vinyl)-phenoxy)-prop-1-en-2-yl; V' = V or Me; t = up to 100; u = up to 20; provided that u = 0 if V' = V or u = 1-20 if V' = Me. An Independent claim is also included for cosmetic or pharmaceutical preparations for protecting human epidermis or hair against UV light in the 280-400 nm range, comprising the UV absorbing combination, a carrier and optionally other conventional light protectants.

公开(公告)号：BR9706035A

公开(公告)日：1999-05-18

申请号：BR9706035

申请日：1997-11-27

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  AUMULLER ALEXANDER ,  SCHEHLMANN VOLKER ,  WESTENFELDER HORST ,  WUNSCH THOMAS

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/41 ,  A61K8/42 ,  A61K8/46 ,  A61K8/49 ,  A61K31/13 ,  A61K31/22 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  A61Q19/00 ,  C07C225/14 ,  C07C229/30 ,  C07C229/56 ,  C07C229/60 ,  C07C255/30 ,  C07C255/58 ,  C07C309/46 ,  C07D275/02 ,  C07D275/03 ,  C07D319/06 ,  C07D333/38 ,  C07C409/22 ,  C07C211/49 ,  A61K7/40 ,  C07C22/00 ,  C07C217/54

Abstract: Use of enamine derivatives of formula (R )(R NH)C=C(R )(R ) (I) as UV filters in cosmetic and pharmaceutical preparations for protection of hair or skin against sun-radiation, alone or in combination with UV absorbers is new: R = COOR , COR , CONR R , CN, SO2R , SO2OR or P(=O)OR OR ; R = COOR , COR , CONR R , CN, SO2R , SO2OR or P(=O)OR OR ; R = H, or optionally substituted aliphatic, cycloaliphatic, arylaliphatic or aromatic residue with up to 18C; R = optionally substituted 5-12C aromatic or heteroaromatic residue; and R , R = H or aliphatic, arylaliphatic, cycloaliphatic, or optionally substituted aromatic with up to 18C; or R -R together with their bonded carbon atoms may form a 5-6 membered ring which may be further annelated.

公开(公告)号：AU4540697A

公开(公告)日：1998-06-04

申请号：AU4540697

申请日：1997-11-27

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  AUMULLER ALEXANDER ,  SCHEHLMANN VOLKER ,  WESTENFELDER HORST ,  WUNSCH THOMAS

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/41 ,  A61K8/42 ,  A61K8/46 ,  A61K8/49 ,  A61K31/13 ,  A61K31/22 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  A61Q19/00 ,  C07C225/14 ,  C07C229/30 ,  C07C229/56 ,  C07C229/60 ,  C07C255/30 ,  C07C255/58 ,  C07C309/46 ,  C07D275/02 ,  C07D275/03 ,  C07D319/06 ,  C07D333/38 ,  A61K7/42 ,  A61K7/06 ,  C07C57/00

Abstract: Use of enamine derivatives of formula (R )(R NH)C=C(R )(R ) (I) as UV filters in cosmetic and pharmaceutical preparations for protection of hair or skin against sun-radiation, alone or in combination with UV absorbers is new: R = COOR , COR , CONR R , CN, SO2R , SO2OR or P(=O)OR OR ; R = COOR , COR , CONR R , CN, SO2R , SO2OR or P(=O)OR OR ; R = H, or optionally substituted aliphatic, cycloaliphatic, arylaliphatic or aromatic residue with up to 18C; R = optionally substituted 5-12C aromatic or heteroaromatic residue; and R , R = H or aliphatic, arylaliphatic, cycloaliphatic, or optionally substituted aromatic with up to 18C; or R -R together with their bonded carbon atoms may form a 5-6 membered ring which may be further annelated.

公开(公告)号：AU748711B2

公开(公告)日：2002-06-13

申请号：AU7997798

申请日：1998-08-13

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  HAREMZA SYLKE ,  SCHEHLMANN VOLKER ,  WESTENFELDER HORST ,  WUNSCH THOMAS ,  DROGEMULLER MICHAEL ,  BOMM VOLKER

IPC: A61K8/00 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K31/12 ,  A61K31/122 ,  A61K31/216 ,  A61K31/277 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07C69/618 ,  C07C69/76 ,  C07C233/00 ,  C07C233/11 ,  C07C235/34 ,  A61K7/44 ,  A61K31/165 ,  A61K31/215 ,  C07C57/48 ,  C07C57/30

Abstract: Use of 4,4-diarylbutadienes (I) as photostable UV filters in cosmetics for protecting the skin and hair from the sun's rays. The use of 4,4-diarylbutadiene derivatives of formula (I) as a cosmetic preparation is new: Where the diene system is Z,Z; Z,E; E,Z or E,E; R1, R2 = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, 1-12C alkylamino, 1-12C dialkylamino, aryl, heteroaryl (optionally substituted by carboxylate, sulfonate or ammonium residues); R3 = H, COOR5, COR5, CONR5,R6, CN, O=S(R5)=O, O=S(OR5)=O, R7OP(OR8)=O, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); R4 = COOR6, COR6, CONR5,R6, CN, O=S(R6)=O, O=S(OR6)=O, R7OP(OR8)=O, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); R5-R8 = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); and n = 1-3; where R3-R8 may in each case together with the C atoms to which they are bonded, form a 5- or 6-membered ring which may be further fused.

公开(公告)号：AU3680199A

公开(公告)日：2000-06-08

申请号：AU3680199

申请日：1999-06-25

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  WUNSCH THOMAS ,  WESTENFELDER HORST

IPC: A61K47/06 ,  A61K8/00 ,  A61K8/30 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K8/46 ,  A61K31/00 ,  A61K31/075 ,  A61K31/16 ,  A61K31/165 ,  A61K31/19 ,  A61K31/215 ,  A61K31/275 ,  A61P17/00 ,  A61P17/16 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q5/00 ,  A61Q17/04 ,  C07C59/40 ,  C07C69/612 ,  C07C69/618 ,  C07C69/73 ,  C07C69/734 ,  C07C69/738 ,  C07C233/40 ,  C07C309/12 ,  C07C309/58 ,  C07C309/59 ,  C09K3/00 ,  A61K7/42 ,  A61K7/06 ,  C07C233/22

公开(公告)号：AU706868B2

公开(公告)日：1999-06-24

申请号：AU7491996

申请日：1996-10-25

Applicant: BASF AG

Inventor： HOLDERBAUM MARTIN ,  AUMULLER ALEXANDER ,  SPERLING KARIN ,  WESTENFELDER HORST ,  WUNSCH THOMAS

IPC: A61K8/00 ,  A61K8/40 ,  A61K8/92 ,  A61Q1/04 ,  A61Q17/04 ,  A61K7/42

Abstract: PCT No. PCT/EP96/04637 Sec. 371 Date Apr. 29, 1998 Sec. 102(e) Date Apr. 29, 1998 PCT Filed Oct. 25, 1996 PCT Pub. No. WO97/17054 PCT Pub. Date May 15, 1997A sunscreen-containing cosmetic formulation to protect the human epidermis from UV light in the range from 280 to 400 nm, which formulation includes a cosmetically suitable carrier, together with compounds which absorb in the UV-B region and as photostable UV-A filters effective amounts of compounds of the formula I as defined in the specification.

公开(公告)号：AU7997798A

公开(公告)日：1999-02-25

申请号：AU7997798

申请日：1998-08-13

Applicant: BASF AG

Inventor： HABECK THORSTEN ,  HAREMZA SYLKE ,  SCHEHLMANN VOLKER ,  WESTENFELDER HORST ,  WUNSCH THOMAS ,  DROGEMULLER MICHAEL ,  BOMM VOLKER

IPC: A61K8/00 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K31/12 ,  A61K31/122 ,  A61K31/216 ,  A61K31/277 ,  A61Q1/00 ,  A61Q1/04 ,  A61Q17/04 ,  C07C69/618 ,  C07C69/76 ,  C07C233/00 ,  C07C233/11 ,  C07C235/34 ,  A61K7/44 ,  A61K31/165 ,  A61K31/215 ,  C07C57/48 ,  C07C57/30

Abstract: Use of 4,4-diarylbutadienes (I) as photostable UV filters in cosmetics for protecting the skin and hair from the sun's rays. The use of 4,4-diarylbutadiene derivatives of formula (I) as a cosmetic preparation is new: Where the diene system is Z,Z; Z,E; E,Z or E,E; R1, R2 = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, 1-12C alkylamino, 1-12C dialkylamino, aryl, heteroaryl (optionally substituted by carboxylate, sulfonate or ammonium residues); R3 = H, COOR5, COR5, CONR5,R6, CN, O=S(R5)=O, O=S(OR5)=O, R7OP(OR8)=O, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); R4 = COOR6, COR6, CONR5,R6, CN, O=S(R6)=O, O=S(OR6)=O, R7OP(OR8)=O, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); R5-R8 = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl (optionally substituted); and n = 1-3; where R3-R8 may in each case together with the C atoms to which they are bonded, form a 5- or 6-membered ring which may be further fused.