Abstract:
The present invention relates to a process for the preparation of substituted aromatic carboxamides of formula I, (formula I) which can be obtained through reaction of an aromatic carboxylic acid halide and an amine, whereas the process is conducted in the absence of an auxiliary base in a carboxylic acid ester as solvent.
Abstract:
The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof, (formula X) wherein the variables of compound of formula X are as defined in the claims and the description.
Abstract:
The present invention relates to a process for preparing N-pyridylpyrazole carboxanilides carrying a sulfiminocarbonyl group in the ortho position with respect to the amide group, which are represented by formula (I), the process comprising reacting a N-pyridylpyrazole carbooxanilide precursor of formula (II) or (II*) with a sulfimine of formula (III) or a salt thereof. Moreover, the present invention relates to a process for preparing N-pyridylpyrazole carbooxanilide precursors of formula (II) by reacting a compound of formula (IV) with a compound of formula (V). Furthermore, the present invention relates to N-pyridylpyrazole carbooxanilide precursors of formulae (II.A'), (II*.A'), (II.A'') and (II*.A'').
Abstract:
The present invention relates to a process for preparing pyndylpyrazole compounds of the formula (I) starting from pyridylhydrazine of formula (II) The present invention relates also to processes comprising further preceding and/or subsequent reaction steps, leading to anthranilamide pesticides or to precursors for them.
Abstract:
The invention pertains to processes to produce dry biomass of pyripyropene producer organisms, processes to obtain pyripyropenes from such dry biomass, as well as to processes to produce compounds of Formula (III) and/or Formula (IV) and/or Formula (V) from the pyripyropenes obtained from the dry biomass. The invention does further pertain to the dry biomass itself, as well as processes using said dry biomass to obtain pyripyropenes for the production of compounds of Formula (III) and/or Formula (IV) and/or Formula (V), including processes using said dry biomass to obtain pyripyropenes or compounds of Formula III and/or Formula (IV) and/or Formula (V) in order to produce pest control compositions, in particular insecticides, comprising such compounds.
Abstract:
The present invention relates to a method for preparing the pyripyropene compound of the formula (I) which method comprises the following steps: i) subjecting a pyripyropene compound of formula Pyripyropene A to an alkaline hydrolysis to yield a 1,7,11-trideacetylpyripyropene A, ii) reacting 1,7,11-trideacetylpyripyropene A obtained in step i) with cyclopropane carbonyl chloride to yield a raw product containing the pyripyropene compound of formula (I); iii) subjecting the raw product of step ii) to crystallization to yield a crystalline pyripyropene compound of formula (I) and a mother liquor;and iv) recycling the mother liquor or a pyripyropene compound containing fraction thereof to the alkaline hydrolysis of step i).
Abstract:
Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von 1,3-substituierten Pyrazolverbindungen der Formel (I), worin X insbesondere für eine Gruppe CX 1 X 2 X 3 steht, worin X 1 , X 2 und X 3 unabhängig voneinander insbesondere für Wasserstoff, Fluor oder Chlor stehen, R 1 für C 1 -C 4 -Alkyl oder Cyclopropyl steht, und R 2 für Wasserstoff, CN oder eine Gruppe CO 2 R 2a steht, worin R 2a für insbesondere für C 1 -C 6 -Alkyl steht, umfassend die folgenden Schritte: i) Umsetzung eine Verbindung der Formel Il mit einem Hydrazon der Formel (III), wobei in Formel (Il) die Variablen X und R 2 die für Formel (I) angegebenen Bedeutungen aufweisen, Y für Sauerstoff, eine Gruppe NR y1 oder eine Gruppe [NR y2 R y3 ] + Z - steht, R 3 für OR 3a oder eine Gruppe NR 3b R 3c steht, und wobei in Formel (III) die Variable R 1 die für Formel (I) angegebenen Bedeutungen aufweist, R 4 und R 5 unabhängig voneinander für Wasserstoff, C 1 -C 6 -Alkyl, gegebenenfalls substituiertes Phenyl stehen, wobei wenigstens einer der Reste R 4 oder R 5 von Wasserstoff verschieden ist und wobei R 4 und R 5 gemeinsam mit dem Kohlenstoffatom, an das sie gebunden sind, auch für einen 5 bis 10-gliedrigen gesättigten Carbocyclus stehen können; Behandlung des dabei erhaltenen Reaktionsprodukts mit einer Säure in Gegenwart von Wasser.
Abstract:
The present invention relates to azolin-2-ylamino compounds of formulae (I) and (II), wherein n is 0 to 3; Ar is phenyl; A is a radical of formulae A 1 or A 2 , wherein * indicates the point of attachment; X is S, O or N(R 10 ); R 7a-d are H, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylamino or C 3 -C 6 -cycloalkyl; R 8-10 are H, CN, NO 2 , C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, Ar 3 , -B-C(=O)R a , -B-C(=S)R a , -B-C(=NR f )R a , etc., wherein B is a single bond or C 1 -C 4 -alkanediyl; R 1 is H, halogen, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 6 -cycloalkyl, phenyl or benzyl; R 2,3 are H, halogen, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 6 -cycloalkyl, phenyl or benzyl; R 4 is H, halogen, CN, N 3 , NO 2 , C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, a heterocycle, Ar 5 , -C(=O)R a, -C(=S)R a , -C(=NR f )R a , etc.; or R 4 and R 5 together form a carbocycle or heterocycle; R 5,6 are H, halogen, CN, N 3 , NO 2 , C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, heterocycle, Ar 8 , -C(=O)R a , -C(=S)R a , -C(=NR f )R a , etc.; or R 5 and R 6 together form a carbocycle or heterocycle; R a-h are H, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, heterocycles or Ar 10 ; Ar 1 to 11 are phenyl, naphthyl or heteroaryl; and A' is a radical of formula A 3 , wherein W is halogen or OR 11 ; R 11 is H or -C(=O)-R i ; R i is H, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C3-C8-cycloalkyl, heterocycle or Ar 12 ; and Ar 12 is phenyl, naphthyl or heteroaryl; as well as to agricultural composition containing such compounds, the use of such compounds for controlling animal pests, seed, comprising such compounds, a method for controlling animal pests and a method for treating or protecting an animal from infestation or infection by parasites.
Abstract:
The present invention relates to the use of aminoazoline and urea derivatives for com- bating animal pests. The invention also relates to a method for controlling animal pests by using these compounds, to seed and to an agricultural and veterinary composition comprising said compounds and to specific azoline and urea derivatives.
Abstract:
The present invention relates to a method for preparing an enantiomerically enriched form of 2-[2-(2-chlorothiazol-5-yl)-2- hydroxy-ethyl]sulfanyl-6-hydroxy-3-methyl-5-phenyl-pyrimidin-4-one of the formula (I) by hydrogenation of 2-[2-(2-chlorothiazol-5-yl)-2-oxo-ethyl]sulfanyl-6- hydroxy-3-methyl-5-phenyl-pyrimidin-4-one (1) in the presence of a chiral transition metal catalyst.