公开(公告)号：WO2021197880A1

公开(公告)日：2021-10-07

申请号：PCT/EP2021/057228

申请日：2021-03-22

Applicant: BASF SE

Inventor： KÖRBER, Karsten ,  GARZA SANCHEZ, Rosario Aleyda ,  BORATE, Kailaskumar ,  HUWYLER, Nikolas ,  SCHRÖDER, Birte ,  RACK, Michael

IPC: C07D261/04 ,  C07D401/14 ,  A01N43/80

Abstract: The invention relates to a process for preparing optically enriched isoxazoline compounds of formula (I), formula (I), wherein the variables are as defined in the specification, and the shown enantiomer has at least 55% ee; by oxo-Michael addition of hydroxyl amine or its salt to an enone of formula (II), formula (II), wherein the variables have the meanings given for formula (I), in the presence of a catalyst of formula (III), formula (III), and a base, the invention furthermore relates to novel compounds of formula (III).

公开(公告)号：WO2023280630A1

公开(公告)日：2023-01-12

申请号：PCT/EP2022/067677

申请日：2022-06-28

Applicant: BASF SE

Inventor： GEBHARDT, Joachim ,  GARIVET, Guillaume Michel Jacques ,  BORATE, Kailaskumar ,  KNOLL, Daniel Maximilian ,  GOETZ, Roland

IPC: C07D231/14 ,  C07C251/40 ,  C07D271/06

Abstract: The present invention relates to a process for the preparation of substituted amidoximes of formula I, which can be obtained through reaction of nitrile compounds of formula II with free hydroxylamine in the presence of a solvent.

公开(公告)号：WO2021209377A1

公开(公告)日：2021-10-21

申请号：PCT/EP2021/059424

申请日：2021-04-12

Applicant: BASF SE

Inventor： VOGT, Florian ,  GEBHARDT, Joachim ,  BORATE, Kailaskumar ,  WOLF, Bernd ,  SUTORIS, Heinz Friedrich ,  GOETZ, Roland

IPC: C07C255/50

Abstract: The present invention relates to a process for the preparation of 4-cyanobenzoyl chlorides of formula I through reaction of compounds of formula II with a chlorinating agent.

公开(公告)号：WO2021156175A1

公开(公告)日：2021-08-12

申请号：PCT/EP2021/052257

申请日：2021-02-01

Applicant: BASF SE

Inventor： VOGT, Florian ,  BORATE, Kailaskumar ,  WOLF, Bernd ,  KORADIN, Christopher ,  GOETZ, Roland ,  SHINDE, Harish

IPC: C07D271/06 ,  A01N43/82

Abstract: The present invention relates to a process for the preparation of substituted 3-aryl-5- trifluoromethyl-1,2,4-oxadiazoles of formula (I), which can be obtained through reaction of amidoxime compounds of formula (II) with a haloacetic ester in the presence of a base.

公开(公告)号：WO2021110498A1

公开(公告)日：2021-06-10

申请号：PCT/EP2020/083279

申请日：2020-11-25

Applicant: BASF SE

Inventor： BORATE, Kailaskumar ,  WOLF, Bernd ,  VOGT, Florian ,  KORADIN, Christopher ,  GOETZ, Roland ,  SHINDE, Harish

IPC: C07D271/06

Abstract: The present invention relates to a process for the preparation of substituted aromatic carboxamides of formula I, (formula I) which can be obtained through reaction of an aromatic carboxylic acid halide and an amine, whereas the process is conducted in the absence of an auxiliary base in a carboxylic acid ester as solvent.

公开(公告)号：WO2022157106A1

公开(公告)日：2022-07-28

申请号：PCT/EP2022/050851

申请日：2022-01-17

Applicant: BASF SE

Inventor： KADUSKAR, Rahul ,  BORATE, Kailaskumar ,  ADHAV, Suyog ,  THIRUNAVUKKARASU, Saravanan ,  SHINDE, Harish ,  GOETZ, Roland

IPC: C07C231/12 ,  C07D213/00 ,  C07C233/15

Abstract: The presently claimed invention relates to a process for the preparation of mono-, di-, tri-, fluoro arylamide or hetroarylamide.

公开(公告)号：WO2021228673A1

公开(公告)日：2021-11-18

申请号：PCT/EP2021/061970

申请日：2021-05-06

Applicant: BASF SE

Inventor： BORATE, Kailaskumar ,  KOERBER, Karsten ,  HUWYLER, Nikolas ,  GOCKEL, Birgit ,  KARALKAR, Ritesh ,  SHINDE, Harish ,  GOETZ, Roland

IPC: C07D261/04 ,  C07D413/04 ,  C07D453/04

Abstract: The invention relates to a process for preparing optically enriched isoxazoline compounds of formula (I) wherein the variables are as defined in the specification, and the shown enantiomer has at least 75% ee; by oxo-Michael addition of hydroxyl amine or its salt to an enone of formula (II),wherein the variables have the meanings given for formula (I), in the presence of a catalyst of formula (III) and a base.

公开(公告)号：WO2020088949A1

公开(公告)日：2020-05-07

申请号：PCT/EP2019/078309

申请日：2019-10-18

Applicant: BASF SE

Inventor： KOERBER, Karsten ,  HUWYLER, Nikolas ,  NARINE, Arun ,  MCLAUGHLIN, Martin John ,  BORATE, Kailaskumar

IPC: C07C67/30 ,  C07B53/00 ,  C07D261/04

Abstract: The present invention relates to a process for preparing benzylic amidesof formula (I) wherein the variables are as defined in the specification, and the shown enantiomer has at least 50 % ee; by condensation of a ketone o formula (II) with an acetyl compound of formula (III) in the presence of a catalystof formula (IV) wherein the variables are as defined in the specification.

公开(公告)号：WO2021239568A1

公开(公告)日：2021-12-02

申请号：PCT/EP2021/063439

申请日：2021-05-20

Applicant: BASF SE

Inventor： VOGT, Florian ,  BORATE, Kailaskumar ,  WOLF, Bernd ,  GEBHARDT, Joachim ,  GARIVET, Guillaume Michel Jacques ,  SHINDE, Harish ,  GOETZ, Roland

IPC: C07D271/06 ,  C07C255/57 ,  C07C51/08 ,  C07C249/04 ,  C07C251/32

Abstract: The present invention relates to a process for the preparation of substituted 4-(N'-hydroxy- carbamimidoyl)benzoic acids, which can be obtained by nitrilase catalyzed hydration of substituted terephthalonitriles of formula (II) in an aqueous medium to afford (ammonium) 4- cyanobenzoic acids (Ila). The hydration is followed by treatment of the aqueous reaction medium with hydroxylamine or a salt thereof to afford amidoximes (I).

公开(公告)号：WO2021204774A1

公开(公告)日：2021-10-14

申请号：PCT/EP2021/058892

申请日：2021-04-06

Applicant: BASF SE

Inventor： BORATE, Kailaskumar ,  THIRUNAVUKKARASU, Saravanan ,  KADUSKAR, Rahul ,  SHINDE, Harish ,  GOETZ, Roland

IPC: C07C209/10 ,  C07C211/52

Abstract: The presently claimed invention relates to a process for the preparation of di-, tri-, or tetra fluoroarylamine by reacting polyfluorinated aryl chlorides with ammonia in the presence of a base, a metal catalyst and a ligand. Di-, tri-, tetrafluoroarylamines are valuable intermediates and find application in several areas, mainly in epoxy polymers, colorants, dyes, polyurethanes, agrochemicals and pharmaceutical active agents.