公开(公告)号：EP2659552A4

公开(公告)日：2014-08-13

申请号：EP11852463

申请日：2011-12-30

Applicant: BIO RAD LABORATORIES

Inventor： HENG XIN

IPC: B01L3/00 ,  G01N15/14 ,  G01N21/64 ,  G01N33/543 ,  H01S3/00

CPC classification number: G01N33/54366 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0454 ,  B01L2400/0487 ,  G01N15/1463 ,  G01N15/1484 ,  G01N21/6458 ,  G01N21/648 ,  G01N2021/6441 ,  Y10T436/143333

公开(公告)号：EP2473948A4

公开(公告)日：2014-07-09

申请号：EP10812708

申请日：2010-08-30

Applicant: BIO RAD LABORATORIES

Inventor： MCCOLLUM TOM ,  PATT PAUL ,  SHEN FRANK ,  CHU DANIEL Y ,  FLORY DON ,  GRIFFIN MIKE ,  HENG XIN ,  HEFNER ELI

IPC: G06K9/00 ,  C12M1/34 ,  G01N15/02 ,  G01N15/06 ,  G01N21/64 ,  G02B21/34 ,  G06T7/00

CPC classification number: C12Q1/06 ,  G01N15/1434 ,  G02B21/0008 ,  G02B21/34

Abstract: Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000,000 pixels each having an area of 2×2 mum or less and that images a field of view of at least 3 mm2. The sensor enables the counter to compress the optical components into an optical path of less than 20 cm in height when arranged vertically with no changes in direction of the optical path as a whole, and the entire instrument has a footprint of less than 300 cm2. Activation of the light source, automated focusing of the sensor image, and digital cell counting are all initiated by the simple insertion of the sample holder into the instrument. The suspension is placed in a sample chamber in the form of a slide that is shaped to ensure proper orientation of the slide in the cell counter.

公开(公告)号：EP2478466A4

公开(公告)日：2014-04-16

申请号：EP10816257

申请日：2010-09-14

Applicant: BIO RAD LABORATORIES

Inventor： HENG XIN

IPC: G03H1/00 ,  A61B18/00 ,  A61B18/20 ,  A61N5/06 ,  A61N5/067 ,  G01N21/47 ,  G02B26/06

CPC classification number: A61B18/203 ,  A61B2018/00452 ,  A61B2018/00642 ,  A61B2018/00779 ,  G01N21/4795 ,  G01N2201/0675 ,  G02B26/06 ,  G03H1/0443 ,  G03H1/2294 ,  G03H2001/0072

Abstract: An optical system and associated method enable near real time optical phase conjugation. In the method, a translucent medium is illuminated by a sample illumination beam. Light scattered by the medium is directed to an electronic image sensor while a reference beam is also directed to the electronic image sensor. The scattered light and the reference beam form an interference pattern at the electronic image sensor. A digital representation of the interference pattern is recorded using the electronic image sensor, and the characteristics of a conjugate of the sample beam are computed from the numerical representation. A conjugate beam having the computed characteristics is generated using a configurable optical element and directed back to the translucent medium. The generation of the conjugate beam may be accomplished using a spatial light modulator.