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公开(公告)号：CA2772376A1
公开(公告)日：2011-03-03
申请号：CA2772376
申请日：2010-08-30
Applicant: BIO RAD LABORATORIES
Inventor： MCCOLLUM TOM , PATT PAUL , SHEN FRANK , CHU DANIEL Y , FLORY DON , GRIFFIN MIKE , HENG XIN , HEFNER ELI
Abstract: Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000,000 pixels each having an area of 2 x 2 µm or less and that images a field of view of at least 3 mm2. The sensor enables the counter to compress the optical components into an optical path of less than 20 cm in height when arranged vertically with no changes in direction of the optical path as a whole, and the entire instrument has a footprint of less than 300 cm2. Activation of the light source, automated focusing of the sensor image, and digital cell counting are all initiated by the simple insertion of the sample holder into the instrument. The suspension is placed in a sample chamber in the form of a slide that is shaped to ensure proper orientation of the slide in the cell counter.
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公开(公告)号：CA2772376C
公开(公告)日：2019-10-22
申请号：CA2772376
申请日：2010-08-30
Applicant: BIO RAD LABORATORIES
Inventor： MCCOLLUM TOM , PATT PAUL , SHEN FRANK , CHU DANIEL Y , FLORY DON , GRIFFIN MIKE , HENG XIN , HEFNER ELI
Abstract: Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000,000 pixels each having an area of 2 x 2 µm or less and that images a field of view of at least 3 mm2. The sensor enables the counter to compress the optical components into an optical path of less than 20 cm in height when arranged vertically with no changes in direction of the optical path as a whole, and the entire instrument has a footprint of less than 300 cm2. Activation of the light source, automated focusing of the sensor image, and digital cell counting are all initiated by the simple insertion of the sample holder into the instrument. The suspension is placed in a sample chamber in the form of a slide that is shaped to ensure proper orientation of the slide in the cell counter.
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公开(公告)号：CA2766102C
公开(公告)日：2016-10-11
申请号：CA2766102
申请日：2010-06-28
Applicant: BIO-RAD LABORATORIES INC
Inventor： GRIFFIN MICHAEL , CHU DANIEL YUE MAN , MCCOLLUM TOM
Abstract: A system, apparatus and method for using modular microscopes is disclosed. Connecting the housings of the individual microscope modules provide the structural framework of the modular microscope. Furthermore, the modular microscope can include specialized software, the distribution and use of which can be controlled using security keys or identifiers stored on one or more of the microscope modules. The security keys and identifiers can be based on calibration data associated with the physical, electrical, or optical properties of one of more of the modules. The illumination modules disclosed provide for selectable wavelengths and controllable levels of output illumination for both bright field and dark field illumination.
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公开(公告)号：AU2010286499B2
公开(公告)日：2016-05-26
申请号：AU2010286499
申请日：2010-08-30
Applicant: BIO RAD LABORATORIES
Inventor： MCCOLLUM TOM , PATT PAUL , SHEN FRANK , CHU DANIEL Y , FLORY DON , GRIFFIN MIKE , HENG XIN , HEFNER ELI
Abstract: Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000,000 pixels each having an area of 2 x 2 μm or less and that images a field of view of at least 3 mm
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公开(公告)号：AU2010286499A1
公开(公告)日：2012-03-15
申请号：AU2010286499
申请日：2010-08-30
Applicant: BIO RAD LABORATORIES
Inventor： MCCOLLUM TOM , PATT PAUL , SHEN FRANK , CHU DANIEL Y , FLORY DON , GRIFFIN MIKE , HENG XIN , HEFNER ELI
Abstract: Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000,000 pixels each having an area of 2 x 2 μm or less and that images a field of view of at least 3 mm. The sensor enables the counter to compress the optical components into an optical path of less than 20 cm in height when arranged vertically with no changes in direction of the optical path as a whole, and the entire instrument has a footprint of less than 300 cm. Activation of the light source, automated focusing of the sensor image, and digital cell counting are all initiated by the simple insertion of the sample holder into the instrument. The suspension is placed in a sample chamber in the form of a slide that is shaped to ensure proper orientation of the slide in the cell counter.
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Patent Agency Ranking
公开(公告)号：CA2833299A1
公开(公告)日：2012-11-01
申请号：CA2833299
申请日：2012-04-30
Applicant: BIO RAD LABORATORIES
Inventor： MCCOLLUM TOM
IPC: G01N21/64
Abstract: In a scanning system for the detection and discrimination of a plurality of targets in each of a plurality of samples, one or more multiband fluorescence detection channels each of which contains a single multiband emission filter and a single detector replaces multiple detection components in scanning heads of the prior art. In certain embodiments, a single multi-emitter light source is used as well, to illuminate each sample with excitation light at a variety of distinct wavelengths in succession.
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公开(公告)号：SG178555A1
公开(公告)日：2012-03-29
申请号：SG2012013009
申请日：2010-08-30
Applicant: BIO RAD LABORATORIES
Inventor： MCCOLLUM TOM , PATT PAUL , SHEN FRANK , CHU DANIEL Y , FLORY DON , GRIFFIN MIKE , HENG XIN , HEFNER ELI
Abstract: Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000,000 pixels each having an area of 2 x 2 μm or less and that images a field of view of at least 3 mm2. The sensor enables the counter to compress the optical components into an optical path of less than 20 cm in height when arranged vertically with no changes in direction of the optical path as a whole, and the entire instrument has a footprint of less than 300 cm2. Activation of the light source, automated focusing of the sensor image, and digital cell counting are all initiated by the simple insertion of the sample holder into the instrument. The suspension is placed in a sample chamber in the form of a slide that is shaped to ensure proper orientation of the slide in the cell counter.
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公开(公告)号：WO2010151885A3
公开(公告)日：2011-04-21
申请号：PCT/US2010040235
申请日：2010-06-28
Applicant: BIO RAD LABORATORIES , GRIFFIN MICHAEL , CHU DANIEL YUE MAN , MCCOLLUM TOM
Inventor： GRIFFIN MICHAEL , CHU DANIEL YUE MAN , MCCOLLUM TOM
CPC classification number: G02B21/06 , G02B21/125 , G02B21/16 , G02B21/24 , G02B21/365
Abstract: A system, apparatus and method for using modular microscopes is disclosed. Connecting the housings of the individual microscope modules provide the structural framework of the modular microscope. Furthermore, the modular microscope can include specialized software, the distribution and use of which can be controlled using security keys or identifiers stored on one or more of the microscope modules. The security keys and identifiers can be based on calibration data associated with the physical, electrical, or optical properties of one of more of the modules. The illumination modules disclosed provide for selectable wavelengths and controllable levels of output illumination for both bright field and dark field illumination.
Abstract translation: 公开了一种使用模块显微镜的系统，装置和方法。 连接各个显微镜模块的外壳提供了模块化显微镜的结构框架。 此外，模块化显微镜可以包括专门的软件，可以使用存储在一个或多个显微镜模块上的安全密钥或标识符来控制其分布和使用。 安全密钥和标识符可以基于与多个模块之一的物理，电或光学特性相关联的校准数据。 所公开的照明模块为亮场和暗场照明提供了可选择的波长和输出照明的可控电平。
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公开(公告)号：CA2833299C
公开(公告)日：2019-01-08
申请号：CA2833299
申请日：2012-04-30
Applicant: BIO RAD LABORATORIES
Inventor： MCCOLLUM TOM
IPC: G01J3/443
Abstract: In a scanning system for the detection and discrimination of a plurality of targets in each of a plurality of samples, one or more multiband fluorescence detection channels each of which contains a single multiband emission filter and a single detector replaces multiple detection components in scanning heads of the prior art. In certam embodiments, a single multi-emitter light source is used as well, to illuminate each sample with excitation light at a variety of distinct wavelengths in succession.
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公开(公告)号：CA2766102A1
公开(公告)日：2010-12-29
申请号：CA2766102
申请日：2010-06-28
Applicant: BIO RAD LABORATORIES
Inventor： GRIFFIN MICHAEL , CHU DANIEL YUE MAN , MCCOLLUM TOM
Abstract: A system, apparatus and method for using modular microscopes is disclosed. Connecting the housings of the individual microscope modules provide the structural framework of the modular microscope. Furthermore, the modular microscope can include specialized software, the distribution and use of which can be controlled using security keys or identifiers stored on one or more of the microscope modules. The security keys and identifiers can be based on calibration data associated with the physical, electrical, or optical properties of one of more of the modules. The illumination modules disclosed provide for selectable wavelengths and controllable levels of output illumination for both bright field and dark field illumination.
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