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公开(公告)号：WO2012115979A9
公开(公告)日：2013-02-28
申请号：PCT/US2012025969
申请日：2012-02-21
Applicant: BIO RAD LABORATORIES , HENG XIN , PATT PAUL
IPC: G01N21/00
CPC classification number: G01N15/1459 , G01N15/1434 , G01N2015/144
Abstract: Systems and methods for performing cytometry using a linear light sensor. An illumination field, a line scanned by the linear light sensor, or both are swept across a cell to be imaged. Relative motion between the cell and the swept illumination may be created using a movable optical component or components, by adhering cells to a plate and transporting the plate or by other techniques.
Abstract translation: 使用线性光传感器进行细胞计数的系统和方法。 照明场，由线性光传感器扫描的线或两者都扫过要成像的细胞。 电池和扫描照明之间的相对运动可以通过使用可移动的光学部件或组件，通过将电池附着到板上并传送该板或通过其它技术来产生。
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公开(公告)号：CA2817887C
公开(公告)日：2019-01-08
申请号：CA2817887
申请日：2011-11-18
Applicant: BIO RAD LABORATORIES
Inventor： HENG XIN , BRENIMAN EUGENE
Abstract: Cell counts that distinguish between live and dead cells while providing an accurate count of the total of live and dead cells are obtained by the use of a vital stain in conjunction with illumination of the cell population and the taking of light images at different wavelengths, one which is not absorbed by the stain and one that is absorbed by the stain. Masking and inaccuracies in the counting of dead cells is thereby avoided.
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公开(公告)号：CA2772376A1
公开(公告)日：2011-03-03
申请号：CA2772376
申请日：2010-08-30
Applicant: BIO RAD LABORATORIES
Inventor： MCCOLLUM TOM , PATT PAUL , SHEN FRANK , CHU DANIEL Y , FLORY DON , GRIFFIN MIKE , HENG XIN , HEFNER ELI
Abstract: Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000,000 pixels each having an area of 2 x 2 µm or less and that images a field of view of at least 3 mm2. The sensor enables the counter to compress the optical components into an optical path of less than 20 cm in height when arranged vertically with no changes in direction of the optical path as a whole, and the entire instrument has a footprint of less than 300 cm2. Activation of the light source, automated focusing of the sensor image, and digital cell counting are all initiated by the simple insertion of the sample holder into the instrument. The suspension is placed in a sample chamber in the form of a slide that is shaped to ensure proper orientation of the slide in the cell counter.
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公开(公告)号：SG178555A1
公开(公告)日：2012-03-29
申请号：SG2012013009
申请日：2010-08-30
Applicant: BIO RAD LABORATORIES
Inventor： MCCOLLUM TOM , PATT PAUL , SHEN FRANK , CHU DANIEL Y , FLORY DON , GRIFFIN MIKE , HENG XIN , HEFNER ELI
Abstract: Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000,000 pixels each having an area of 2 x 2 μm or less and that images a field of view of at least 3 mm2. The sensor enables the counter to compress the optical components into an optical path of less than 20 cm in height when arranged vertically with no changes in direction of the optical path as a whole, and the entire instrument has a footprint of less than 300 cm2. Activation of the light source, automated focusing of the sensor image, and digital cell counting are all initiated by the simple insertion of the sample holder into the instrument. The suspension is placed in a sample chamber in the form of a slide that is shaped to ensure proper orientation of the slide in the cell counter.
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公开(公告)号：SG174439A1
公开(公告)日：2011-10-28
申请号：SG2011066958
申请日：2010-03-18
Applicant: BIO RAD LABORATORIES
Abstract: A system for performing high-speed, high-resolution imaging cytometry utilizes a line-scan sensor. A cell to be characterized is transported past a scan region. An optical system focuses an image of a portion of the scan region onto at least one linear light sensor, and repeated readings of light falling on the sensor are taken while a cell is transported though the scan region. The system may image cells directly, or may excite fluorescence in the cells and image the resulting light emitted from the cell by fluorescence. The system may provide a narrow band of illumination at the scan region. The system may include various filters and imaging optics that enable simultaneous multicolor fluorescence imaging cytometry. Multiple linear sensors may be provided, and images gathered by the individual sensors may be combined to construct an image having improved signal-to-noise characteristics.
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Patent Agency Ranking
公开(公告)号：CA2774237A1
公开(公告)日：2011-03-17
申请号：CA2774237
申请日：2010-09-14
Applicant: BIO RAD LABORATORIES
Inventor： HENG XIN
IPC: G06K9/00
Abstract: An optical system and associated method enable near real time optical phase conjugation. In the method, a translucent medium is illuminated by a sample illumination beam. Light scattered by the medium is directed to an electronic image sensor while a reference beam is also directed to the electronic image sensor. The scattered light and the reference beam form an interference pattern at the electronic image sensor. A digital representation of the interference pattern is recorded using the electronic image sensor, and the characteristics of a conjugate of the sample beam are computed from the numerical representation. A conjugate beam having the computed characteristics is generated using a configurable optical element and directed back to the translucent medium. The generation of the conjugate beam may be accomplished using a spatial light modulator.
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公开(公告)号：CA2827726C
公开(公告)日：2017-06-13
申请号：CA2827726
申请日：2012-02-21
Applicant: BIO-RAD LABORATORIES INC
IPC: G01N15/10
Abstract: Systems and methods for performing cytometry using a linear light sensor. An illumination field, a line scanned by the linear light sensor, or both are swept across a cell to be imaged. Relative motion between the cell and the swept illumination may be created using a movable optical component or components, by adhering cells to a plate and transporting the plate or by other techniques.
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公开(公告)号：AU2010286499B2
公开(公告)日：2016-05-26
申请号：AU2010286499
申请日：2010-08-30
Applicant: BIO RAD LABORATORIES
Inventor： MCCOLLUM TOM , PATT PAUL , SHEN FRANK , CHU DANIEL Y , FLORY DON , GRIFFIN MIKE , HENG XIN , HEFNER ELI
Abstract: Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000,000 pixels each having an area of 2 x 2 μm or less and that images a field of view of at least 3 mm
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公开(公告)号：AU2010286499A1
公开(公告)日：2012-03-15
申请号：AU2010286499
申请日：2010-08-30
Applicant: BIO RAD LABORATORIES
Inventor： MCCOLLUM TOM , PATT PAUL , SHEN FRANK , CHU DANIEL Y , FLORY DON , GRIFFIN MIKE , HENG XIN , HEFNER ELI
Abstract: Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000,000 pixels each having an area of 2 x 2 μm or less and that images a field of view of at least 3 mm. The sensor enables the counter to compress the optical components into an optical path of less than 20 cm in height when arranged vertically with no changes in direction of the optical path as a whole, and the entire instrument has a footprint of less than 300 cm. Activation of the light source, automated focusing of the sensor image, and digital cell counting are all initiated by the simple insertion of the sample holder into the instrument. The suspension is placed in a sample chamber in the form of a slide that is shaped to ensure proper orientation of the slide in the cell counter.
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公开(公告)号：CA2772376C
公开(公告)日：2019-10-22
申请号：CA2772376
申请日：2010-08-30
Applicant: BIO RAD LABORATORIES
Inventor： MCCOLLUM TOM , PATT PAUL , SHEN FRANK , CHU DANIEL Y , FLORY DON , GRIFFIN MIKE , HENG XIN , HEFNER ELI
Abstract: Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000,000 pixels each having an area of 2 x 2 µm or less and that images a field of view of at least 3 mm2. The sensor enables the counter to compress the optical components into an optical path of less than 20 cm in height when arranged vertically with no changes in direction of the optical path as a whole, and the entire instrument has a footprint of less than 300 cm2. Activation of the light source, automated focusing of the sensor image, and digital cell counting are all initiated by the simple insertion of the sample holder into the instrument. The suspension is placed in a sample chamber in the form of a slide that is shaped to ensure proper orientation of the slide in the cell counter.
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