公开(公告)号：EP3183556A4

公开(公告)日：2018-06-06

申请号：EP15834450

申请日：2015-08-19

Applicant: BIO RAD LABORATORIES

Inventor： CHU DANIEL Y ,  PATT PAUL J ,  TONG ROGER

IPC: G01N15/14 ,  B01L3/00 ,  C12Q1/04 ,  G01N15/10 ,  G01N21/31

CPC classification number: G01N15/1404 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2400/0424 ,  B01L2400/0454 ,  C12Q1/04 ,  G01N2015/1006 ,  G01N2015/1415

Abstract: A method is provided for transporting a plurality of cells through a flow chamber, wherein the cells are initially immobilized on an internal surface of the flow chamber. The method comprises: selectively releasing the cells from the internal surface of the flow chamber; and flowing liquid through the flow chamber such that the released cells travel with the liquid, thereby transporting the cells through the flow chamber. Cells can be immobilized on or selectively released from the internal surface by applying or removing a trapping potential. The trapping potential can arise from an electric field gradient or an optical field gradient. Alternatively, cells can be selectively released from the surface using photocatalysis. Selective release allows cells to be individually observed or analyzed downstream, and can be based on a signal detected from one or more cells immobilized on the surface.

公开(公告)号：EP2247714A4

公开(公告)日：2011-12-28

申请号：EP09709650

申请日：2009-02-13

Applicant: BIO RAD LABORATORIES

Inventor： CEREMONY JEFFRY MARK ,  CHU DANIEL Y ,  DOSHI DEEPAK KUMAR ,  RUMBAOA RHOEL ,  LORING DENNIS WAYNE ,  PATT PAUL J ,  BALDWIN CLIFF

IPC: C12M1/38 ,  B01L7/00

CPC classification number: B01L7/52 ,  B01L2300/043 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/14 ,  B01L2300/1827

公开(公告)号：EP2704835A4

公开(公告)日：2014-12-24

申请号：EP12782793

申请日：2012-05-01

Applicant: BIO RAD LABORATORIES

Inventor： GUO KUN ,  CHU DANIEL Y ,  PATT PAUL J ,  SADRI AMIR ,  TONG ROGER

IPC: B01L7/00

CPC classification number: B01L7/52 ,  B01L2300/0829 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1855

公开(公告)号：EP2836815A4

公开(公告)日：2015-11-11

申请号：EP13775579

申请日：2013-04-11

Applicant: BIO RAD LABORATORIES

Inventor： GUO KUN ,  PATT PAUL J

IPC: G01N15/02 ,  B01L3/02 ,  G01N15/10 ,  G01N15/12 ,  G01N15/14

CPC classification number: G06F17/00 ,  B01L3/0289 ,  B01L2200/0652 ,  B01L2200/0657 ,  B01L2200/143 ,  B01L2400/0439 ,  B01L2400/0478 ,  B01L2400/0481 ,  G01N15/02 ,  G01N15/0205 ,  G01N2015/1062 ,  G01N2015/1486

Abstract: Particles are dispensed under controlled conditions to achieve an accurate number of particles by passing a suspension of the particles through a particle detecting device, obtaining a cumulative particle count, comparing the cumulative particle count with a target value, and shutting off the suspension flow once the particle count reaches the target value, all performed by automated means.

Abstract translation: 在受控条件下分配颗粒以通过使颗粒的悬浮液通过颗粒检测装置获得准确数量的颗粒，获得累积颗粒数，将累积颗粒数与目标值进行比较，并一旦关闭悬浮液流 粒子数达到目标值，全部以自动化方式进行。

公开(公告)号：EP2004291A4

公开(公告)日：2010-12-22

申请号：EP07759950

申请日：2007-04-02

Applicant: BIO RAD LABORATORIES

Inventor： CHU DANIEL Y ,  PATT PAUL J

IPC: G01N21/64

CPC classification number: G01N21/253 ,  B01L7/52 ,  G01N2201/101

公开(公告)号：EP3042178A4

公开(公告)日：2017-04-05

申请号：EP14841752

申请日：2014-09-05

Applicant: BIO-RAD LABORATORIES INC

Inventor： SADRI AMIR M ,  GUO KUN ,  CHU DANIEL Y ,  KIRCANSKI NENAD ,  PATT PAUL J ,  ROSENZWEIG TAL

IPC: G01N15/10 ,  B01L3/00

CPC classification number: G01N15/1459 ,  B01L3/0265 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/027 ,  B01L2200/0652 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/088 ,  B01L2300/165 ,  B01L2300/18 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/0457 ,  B01L2400/0644 ,  B01L2400/065 ,  B01L2400/0655 ,  B01L2400/0688 ,  B01L2400/082 ,  B01L2400/084 ,  C12Q1/24 ,  G01N15/1404 ,  G01N2015/1413 ,  G01N2015/149 ,  Y10T436/25 ,  Y10T436/25375

Abstract: Systems, including apparatus and methods, for the microfluidic manipulation, dispensing, and/or sorting of particles, such as cells and/or beads.

Abstract translation: 用于微流体操纵，分配和/或分选颗粒（例如细胞和/或珠）的系统，包括设备和方法。

公开(公告)号：EP1986781A4

公开(公告)日：2014-12-10

申请号：EP07797114

申请日：2007-01-31

Applicant: BIO RAD LABORATORIES

Inventor： CHU DANIEL Y ,  PATT PAUL J ,  CEREMONY JEFFRY M

IPC: B01L9/00 ,  B32B5/02 ,  B32B27/04 ,  B32B27/12

CPC classification number: G01N35/028 ,  B01L9/523 ,  B01L2200/025 ,  B01L2300/0829

公开(公告)号：EP1880241A4

公开(公告)日：2010-12-08

申请号：EP06752462

申请日：2006-05-09

Applicant: BIO RAD LABORATORIES

Inventor： PATT PAUL J ,  ARCINIEGAS GERMAN ,  CEREMONY JEFFRY

IPC: G01N21/64 ,  G02B5/08

CPC classification number: G02B27/0927 ,  G02B27/0977